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Article ; Online: Investigation of structural and reflective characteristics of short-period Mo/B

Shaposhnikov, Roman / Polkovnikov, Vladimir / Garakhin, Sergey / Vainer, Yuliy / Chkhalo, Nikolay / Smertin, Ruslan / Durov, Kirill / Glushkov, Egor / Yakunin, Sergey / Borisov, Mikhail

Journal of synchrotron radiation

2024 Volume 31, Issue Pt 2, Page(s) 268–275

Abstract: The results of a study of the structural and reflective characteristics of short-period multilayer X-ray mirrors based on Mo/ ... ...

Abstract	The results of a study of the structural and reflective characteristics of short-period multilayer X-ray mirrors based on Mo/B
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577524000419
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Article ; Online: An ecotoxicological assessment of a strigolactone mimic used as the active ingredient in a plant biostimulant formulation.

Brooks, Steven J / Gomes, Tânia / Almeida, Ana Catarina / Christou, Maria / Zheng, Congying / Shaposhnikov, Sergey / Popa, Daria G / Georgescu, Florentina / Oancea, Florin

Ecotoxicology and environmental safety

2024 Volume 275, Page(s) 116244

Abstract: A risk assessment on the aquatic toxicity of the plant biostimulant strigolactone mimic (2-(4-methyl-5-oxo-2,5-dihydro-furan-2-yloxy)-benzo[de]isoquinoline-1,3-dione (SL-6) was performed using a suite of standardised bioassays representing different ... ...

Abstract	A risk assessment on the aquatic toxicity of the plant biostimulant strigolactone mimic (2-(4-methyl-5-oxo-2,5-dihydro-furan-2-yloxy)-benzo[de]isoquinoline-1,3-dione (SL-6) was performed using a suite of standardised bioassays representing different trophic groups and acute and chronic endpoints. In freshwater, three trophic groups of algae, crustacea and fish were used. Whilst in seawater, algae (unicellular and macroalgae), Crustacea and Mollusca were employed. In addition, the genotoxicity of SL-6 was determined with the comet assessment performed on unicellular marine algae, oysters, and fish embryos. This was the first time ecotoxicity tests have been performed on SL-6. In freshwater, the lowest LOEC was measured in the unicellular algae at 0.31 mg/L SL-6. Although, similar LOEC values were found for embryo malformations and impacts on hatching rate in zebrafish (LOEC 0.31-0.33 mg/L). Consistent malformations of pericardial and yolk sac oedemas were identified in the zebrafish embryos at 0.31 mg/L. In marine species, the lowest LOEC was found for both Tisbe battagliai mortality and microalgae growth at an SL-6 concentration of 1.0 mg/L. Significant genotoxicity was observed above control levels at 0.0031 mg/L SL-6 in the unicellular algae and 0.001 mg/L SL-6 in the oyster and zebrafish larvae. When applying the simple risk assessment, based on the lowest NOECs and appropriate assessment factors, the calculated predicted no effect concentration (PNEC), for the ecotoxicity and the genotoxicity tests were 1.0 µg/L and 0.01 µg/L respectively.
MeSH term(s)	Animals ; Zebrafish ; Larva ; Crustacea ; Mutagenicity Tests ; Water Pollutants, Chemical/toxicity ; Heterocyclic Compounds, 3-Ring ; Lactones
Chemical Substances	GR24 strigolactone ; Water Pollutants, Chemical ; Heterocyclic Compounds, 3-Ring ; Lactones
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116244
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Zs.A 1418: Show issues

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Article ; Online: Comparison of comet-based approaches to assess base excision repair.

Zheng, Congying / Shaposhnikov, Sergey / Collins, Andrew / Brunborg, Gunnar / Oancea, Florin / Van Schooten, Frederik-Jan / Godschalk, Roger

Archives of toxicology

2023 Volume 97, Issue 8, Page(s) 2273–2281

Abstract: DNA repair plays an essential role in maintaining genomic stability, and can be assessed by various comet assay-based approaches, including the cellular repair assay and the in vitro repair assay. In the cellular repair assay, cells are challenged with a ...

Abstract	DNA repair plays an essential role in maintaining genomic stability, and can be assessed by various comet assay-based approaches, including the cellular repair assay and the in vitro repair assay. In the cellular repair assay, cells are challenged with a DNA-damaging compound and DNA damage removal over time is assessed. In the in vitro repair assay, an early step in the repair process is assessed as the ability of a cellular extract to recognize and incise damaged DNA in substrate nucleoids from cells treated with a DNA-damaging compound. Our direct comparison of both assays in eight cell lines and human peripheral blood lymphocytes indicated no significant relationship between these DNA repair assays (R
MeSH term(s)	Humans ; Comet Assay ; DNA Repair ; DNA Damage ; Cell Line ; DNA
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-06-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-023-03543-y
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Uf I Zs.90: Show issues

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Article ; Online: Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay.

Zheng, Congying / Collins, Andrew / Brunborg, Gunnar / van Schooten, Frederik-Jan / Nordengen, Anne Lene / Shaposhnikov, Sergey / Godschalk, Roger

Cell biology and toxicology

2023 Volume 39, Issue 6, Page(s) 2775–2786

Abstract: DNA repair is an essential agent in cancer development, progression, prognosis, and response to therapy. We have adapted a cellular repair assay based on the formamidopyrimidine DNA glycosylase (Fpg)-modified comet assay to assess DNA repair kinetics. ... ...

Abstract	DNA repair is an essential agent in cancer development, progression, prognosis, and response to therapy. We have adapted a cellular repair assay based on the formamidopyrimidine DNA glycosylase (Fpg)-modified comet assay to assess DNA repair kinetics. The removal of oxidized nucleobases over time (0-480 min) was analyzed in peripheral blood mononuclear cells (PBMCs) and 8 cell lines. DNA damage was induced by exposure to either Ro19-8022 plus visible light or potassium bromate (KBrO
MeSH term(s)	DNA-Formamidopyrimidine Glycosylase/metabolism ; Comet Assay ; Leukocytes, Mononuclear ; DNA Repair ; DNA Damage
Chemical Substances	DNA-Formamidopyrimidine Glycosylase (EC 3.2.2.23)
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	48824-0
ISSN	1573-6822 ; 0742-2091
ISSN (online)	1573-6822
ISSN	0742-2091
DOI	10.1007/s10565-023-09801-0
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Zs.B 3024: Show issues

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Article ; Online: Effect of a personalized intensive dietary intervention on base excision repair (BER) in colorectal cancer patients: Results from a randomized controlled trial.

Nordengen, Anne Lene / Zheng, Congying / Krutto, Annika / Kværner, Ane S / Alavi, Dena T / Henriksen, Hege B / Henriksen, Christine / Smeland, Sigbjørn / Bøhn, Siv K / Paur, Ingvild / Shaposhnikov, Sergey / Collins, Andrew R / Blomhoff, Rune

Free radical biology & medicine

2024 Volume 218, Page(s) 178–189

Abstract: DNA repair is essential to maintain genomic integrity and may affect colorectal cancer (CRC) patients' risk of secondary cancers, treatment efficiency, and susceptibility to various comorbidities. Bioactive compounds identified in plant foods have the ... ...

Abstract	DNA repair is essential to maintain genomic integrity and may affect colorectal cancer (CRC) patients' risk of secondary cancers, treatment efficiency, and susceptibility to various comorbidities. Bioactive compounds identified in plant foods have the potential to modulate DNA repair mechanisms, but there is limited evidence of how dietary factors may affect DNA repair activity in CRC patients in remission after surgery. The aim of this study was to investigate the effect of a 6-month personalized intensive dietary intervention on DNA repair activity in post-surgery CRC patients (stage I-III). The present study included patients from the randomized controlled trial CRC-NORDIET, enrolled 2-9 months after surgery. The intervention group received an intensive dietary intervention emphasizing a prudent diet with specific plant-based foods suggested to dampen inflammation and oxidative stress, while the control group received only standard care advice. The comet-based in vitro repair assay was applied to assess DNA repair activity, specifically base excision repair (BER), in peripheral blood mononuclear cells (PBMCs). Statistical analyses were conducted using gamma generalized linear mixed models (Gamma GLMM). A total of 138 CRC patients were included, 72 from the intervention group and 66 from the control group. The BER activity in the intervention group did not change significantly compared to the control group. Our findings revealed a substantial range in both inter- and intra-individual levels of BER. In conclusion, the results do not support an effect of dietary intervention on BER activity in post-surgery CRC patients during a 6-month intervention period.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2024.04.211
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Zs.A 2109: Show issues

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Article ; Online: Twelve-Gel Comet Assay Format for Quick Examination of DNA Damage and Repair.

Shaposhnikov, Sergey / Collins, Andrew

Methods in molecular biology (Clifton, N.J.)

2017 Volume 1644, Page(s) 181–186

Abstract: The comet assay (single cell gel electrophoresis) is a sensitive, versatile method for detecting DNA damage in eukaryotic cells. The traditional comet assay format has 1 or 2 gels on a microscope slide, 1 sample per slide, and there is a limit of 40 gels ...

Abstract	The comet assay (single cell gel electrophoresis) is a sensitive, versatile method for detecting DNA damage in eukaryotic cells. The traditional comet assay format has 1 or 2 gels on a microscope slide, 1 sample per slide, and there is a limit of 40 gels per experiment given the size of a typical electrophoresis tank. To increase throughput, we have designed and tested a system with 12 minigels on one slide, allowing analysis of up to 12 times more samples in one electrophoresis run. The novel comet assay format compares well with the traditional technology. The various steps are suitable for further automation, and the formats can be adapted to fully automated scoring. The new procedures save time at all stages as fewer slides are handled, and the amounts of reagents needed are reduced significantly. This format is particularly useful for testing of numerous genotoxic agents and nanomaterials at different concentrations and on different types of cells; simultaneous analysis of different lesions using a range of enzymes; and analysis of cell extracts for DNA repair activity.
MeSH term(s)	Comet Assay/instrumentation ; Comet Assay/methods ; DNA Damage ; DNA Repair ; Electrophoresis, Agar Gel/instrumentation ; Humans
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7187-9_16
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Article ; Online: Sources of Potential Geroprotectors in the Flora of the European Northeast

Babak, Tatyana V. / Plyusnin, Sergey N. / Orlovskaya, Nadezhda V. / Alekseev, Alexey / Shaposhnikov, Mikhail V. / Moskalev, A. A.

Journal of Herbal Medicine. 2023 Aug. 03, p.100717-

2023 , Page(s) 100717–

Abstract: ... A., Shaposhnikov, M., Krut'ko, V., Zhavoronkov, A., Kennedy, B.K., 2016. Developing criteria for evaluation ...

Abstract	The aim of the new study is to select promising plants containing substances exhibiting geroprotective properties. The study is based on an integrated approach, including analysis of pharmacological, chemical, and botanical data. We analyzed geroprotectors databases, reference books, list of plants growing in the European Northeast in terms of the presence of significant amounts of potential geroprotectors in them or metformin and rapamycin mimetics (predicted in Moskalev, A., Chernyagina, E., Tsvetkov, V., Fedintsev, A., Shaposhnikov, M., Krut'ko, V., Zhavoronkov, A., Kennedy, B.K., 2016. Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging cell 15(3), 407-415.). We identified twelve families with the largest number of potential species containing geroprotectors. Based on the analyzed list of plants growing in the European Northeast (Komi Republic), plant species with the largest number of geroprotector-substances were identified, of which 29 plant species containing 16 or more geroprotector-substances, 116 plant species containing 8 or more geroprotector-substances. The families containing the largest set of geroprotective substances include Rosaceae, Asteraceae, Fabaceae, Apiaceae, Brassicaceae, Lamiaceae, Ericaceae, and Polygonaceae.
Keywords	Apiaceae ; Asteraceae ; Brassicaceae ; Ericaceae ; Fabaceae ; Lamiaceae ; Polygonaceae ; Rosaceae ; Russia ; flora ; herbal medicines ; metformin ; rapamycin ; Geroprotectors ; Aging ; Longevity ; Plant substances
Language	English
Dates of publication	2023-0803
Publishing place	Elsevier GmbH
Document type	Article ; Online
Note	Pre-press version
ISSN	2210-8033
DOI	10.1016/j.hermed.2023.100717
Database	NAL-Catalogue (AGRICOLA)

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Article: Antioxidant Properties and Geroprotective Potential of Wheat Bran Extracts with Increased Content of Anthocyanins.

Mikhailova, Daria V / Shevchenko, Oksana G / Golubev, Denis A / Platonova, Elena Y / Zemskaya, Nadezhda V / Shoeva, Olesya Yu / Gordeeva, Elena I / Patov, Sergey A / Shaposhnikov, Mikhail V / Khlestkina, Elena K / Moskalev, Alexey

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 11

Abstract: In recent years, there has been a focus on breeding wheat with high anthocyanin levels in order to improve food quality and human health. The objective of this study was to examine the antioxidant and geroprotective properties of wheat bran extracts ... ...

Abstract	In recent years, there has been a focus on breeding wheat with high anthocyanin levels in order to improve food quality and human health. The objective of this study was to examine the antioxidant and geroprotective properties of wheat bran extracts using both in vitro and in vivo research methods. Two wheat lines were used: one with uncolored pericarp (anthocyanin-free) and another with colored pericarp (anthocyanin-containing). These lines differed in a specific region of chromosome 2A containing the
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12112010
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Article ; Online: Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster.

Golubev, Denis / Zemskaya, Nadezhda / Shevchenko, Oksana / Shaposhnikov, Mikhail / Kukuman, Daria / Patov, Sergey / Punegov, Vasily / Moskalev, Alexey

Biogerontology

2022 Volume 23, Issue 2, Page(s) 215–235

Abstract: Honeysuckle Lonicera pallasii (Lonicera caerulea L.) is an excellent source of anthocyanins which have a number of health-promoting properties mainly associated with antioxidant and anti-inflammatory activities. Cyanidin-3-O-glucoside (C3G) is one of the ...

Abstract	Honeysuckle Lonicera pallasii (Lonicera caerulea L.) is an excellent source of anthocyanins which have a number of health-promoting properties mainly associated with antioxidant and anti-inflammatory activities. Cyanidin-3-O-glucoside (C3G) is one of the most common anthocyanins naturally found in honeysuckle. The goal of the present study was to investigate antioxidant and anti-aging properties of Lonicera pallasii (Lonicera caerulea L.) extract (LE) and C3G using red blood cells (RBC) and Drosophila melanogaster models. LE and C3G treatment at a concentration of 100 μM induced enhancement of median and maximum lifespan up to 8%. LE and C3G supplementation at a concentration of 100 μM increased stress resistance up to 10%. The locomotor activity decreased during LE and C3G treatment in 4 and 6 weeks up to 52% in females. The integrity of the intestinal barrier was increased by 4% after LE treatment. These effects were accompanied by increased expression of Hif1 (pro-longevity gene) in response to C3G treatment and decreased expression of Keap1 (anti-longevity gene) after C3G and LE supplementation. RNA interference-mediated knockdown of Sirt6 completely abolished the positive effect obtained of LE and C3G supplementation in males which indicates that lifespan-extending effect is associated with Sirt6 activation. The experiments on the various in-vitro models (including radical scavenging activity and oxidative hemolysis of RBC demonstrated antioxidant and membrane-protective activities of LE and C3G. The present study indicates that Lonicera extract can prolong the lifespan and improve the healthspan of Drosophila model through biological and antioxidant activities.
MeSH term(s)	Animals ; Anthocyanins/pharmacology ; Antioxidants/pharmacology ; Drosophila melanogaster ; Female ; Kelch-Like ECH-Associated Protein 1 ; Longevity ; Lonicera ; Male ; NF-E2-Related Factor 2 ; Plant Extracts/pharmacology ; Sirtuins
Chemical Substances	Anthocyanins ; Antioxidants ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Plant Extracts ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2022-02-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-022-09954-1
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Zs.A 5706: Show issues

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Article ; Online: Plant Biostimulants for Enhanced Sustainability of High-Residue Farming Systems

Diana Constantinescu-Aruxandei / Steven Brooks / Alina Nicolescu / Sergey Shaposhnikov / Florentina Georgescu / Liliana Adriana Pairault / Luminița Marin / Călin Deleanu / Florin Oancea

Chemistry Proceedings, Vol 7, Iss 16, p

2022 Volume 16

Abstract: Besides multiple benefits, high-residue farming systems have drawbacks: delayed development of the plant in early stages, nutrient availability, and enhanced risks for soil-borne diseases [.] ...

Abstract	Besides multiple benefits, high-residue farming systems have drawbacks: delayed development of the plant in early stages, nutrient availability, and enhanced risks for soil-borne diseases [.]
Keywords	high-residue farming system ; plant biostimulants ; Trichoderma ; Paenibacillus ; chitosan hydrogel ; strigolactone mimics ; Chemistry ; QD1-999
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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