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Article ; Online: Severity rating of specific skin lesions in hidradenitis suppurativa: the ptient perspective.

Thorlacius, Linnea / Riis, Peter Theut / Musaeus, Katrine D / Saunte, Ditte M / Esmann, Solveig / Jemec, Gregor B E / Hansen, Stine Thestrup

The British journal of dermatology

2023 Volume 190, Issue 4, Page(s) 579–581

MeSH term(s)	Humans ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/pathology ; Severity of Illness Index
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljad491
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Article: No effect of the turmeric root phenol curcumin on prednisolone-induced glucometabolic perturbations in men with overweight or obesity.

Hellmann, Pernille H / Bagger, Jonatan I / Carlander, Katrine R / Hansen, Katrine B / Forman, Julie L / Størling, Joachim / Chabanova, Elizaveta / Holst, Jens / Vilsbøll, Tina / Knop, Filip K

Endocrine connections

2023 Volume 12, Issue 4

Abstract: ... randomised to one of three intervention groups (A) prednisolone placebo+curcumin placebo, (B) prednisolone ...

Abstract	Objectives: Preclinically, curcumin has been shown to protect against glucocorticoid-induced insulin resistance. We evaluated the effect of curcumin administered with prednisolone in healthy overweight or obese men. Methods: In a double-blind, parallel-group trial, 24 overweight/obese non-diabetic men were randomised to one of three intervention groups (A) prednisolone placebo+curcumin placebo, (B) prednisolone (50 mg/day)+curcumin placebo or (C) prednisolone and curcumin (400 mg/day). Curcumin or curcumin placebo treatment started 1 day prior to 10-day prednisolone or prednisolone placebo treatment. The primary endpoint was change in prednisolone-induced insulin resistance assessed by homeostatic model assessment of insulin resistance (HOMA2-IR). Other endpoints included anthropometric measurements, magnetic resonance spectroscopy-assessed hepatic fat content, blood pressure, circulating metabolic markers and continuous glucose monitoring measures. Results: Baseline characteristics (mean ± s.d): age 44.2 ± 13.7 years, BMI 30.1 ± 3.5 kg/m2, HbAlc 33.3 ± 3.2 mmol/mol, HOMA2-IR 1.10 ± 0.45 and fasting plasma glucose 5.2 ± 0.4 mmol/L. Prednisolone significantly increased HOMA2-IR (estimated treatment difference 0.36 (95% CI 0.16; 0.57)). Co-treatment with curcumin had no effect on HOMA2-IR (estimated treatment difference 0.08 (95% CI -0.13; 0.39)). Prednisolone increased HbAlc, insulin, C-peptide, glucagon, blood pressure, mean interstitial glucose, time spent in hyperglycaemia and glucose variability, but no protective effect of curcumin on any of these measures was observed. Conclusions: In this double-blind, placebo-controlled parallel-group study involving 24 overweight or obese men randomised to one of three treatment arms, curcumin treatment had no protective effect on prednisolone-induced insulin resistance or other glucometabolic perturbations.
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2668428-7
ISSN	2049-3614
ISSN	2049-3614
DOI	10.1530/EC-22-0334
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Article ; Online: Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial.

Kornum, Ditte S / Bertoli, Davide / Kufaishi, Huda / Wegeberg, Anne-Marie / Okdahl, Tina / Mark, Esben B / Høyer, Katrine L / Frøkjær, Jens B / Brock, Birgitte / Krogh, Klaus / Hansen, Christian S / Knop, Filip K / Brock, Christina / Drewes, Asbjørn M

Diabetologia

2024 Volume 67, Issue 6, Page(s) 1122–1137

Abstract: Aims/hypothesis: Diabetic gastroenteropathy frequently causes debilitating gastrointestinal symptoms. Previous uncontrolled studies have shown that transcutaneous vagal nerve stimulation (tVNS) may improve gastrointestinal symptoms. To investigate the ... ...

Abstract	Aims/hypothesis: Diabetic gastroenteropathy frequently causes debilitating gastrointestinal symptoms. Previous uncontrolled studies have shown that transcutaneous vagal nerve stimulation (tVNS) may improve gastrointestinal symptoms. To investigate the effect of cervical tVNS in individuals with diabetes suffering from autonomic neuropathy and gastrointestinal symptoms, we conducted a randomised, sham-controlled, double-blind (participants and investigators were blinded to the allocated treatment) study. Methods: This study included adults (aged 20-86) with type 1 or 2 diabetes, gastrointestinal symptoms and autonomic neuropathy recruited from three Steno Diabetes Centres in Denmark. Participants were randomly allocated 1:1 to receive active or sham stimulation. Active cervical tVNS or sham stimulation was self-administered over two successive study periods: 1 week of four daily stimulations and 8 weeks of two daily stimulations. The primary outcome measures were gastrointestinal symptom changes as measured using the gastroparesis cardinal symptom index (GCSI) and the gastrointestinal symptom rating scale (GSRS). Secondary outcomes included gastrointestinal transit times and cardiovascular autonomic function. Results: Sixty-eight participants were randomised to the active group, while 77 were randomised to the sham group. Sixty-three in the active and 68 in the sham group remained for analysis in study period 1, while 62 in each group were analysed in study period 2. In study period 1, active and sham tVNS resulted in similar symptom reductions (GCSI: -0.26 ± 0.64 vs -0.17 ± 0.62, p=0.44; GSRS: -0.35 ± 0.62 vs -0.32 ± 0.59, p=0.77; mean ± SD). In study period 2, active stimulation also caused a mean symptom decrease that was comparable to that observed after sham stimulation (GCSI: -0.47 ± 0.78 vs -0.33 ± 0.75, p=0.34; GSRS: -0.46 ± 0.90 vs -0.35 ± 0.79, p=0.50). Gastric emptying time was increased in the active group compared with sham (23 min vs -19 min, p=0.04). Segmental intestinal transit times and cardiovascular autonomic measurements did not differ between treatment groups (all p>0.05). The tVNS was well-tolerated. Conclusions/interpretation: Cervical tVNS, compared with sham stimulation, does not improve gastrointestinal symptoms among individuals with diabetes and autonomic neuropathy. Trial registration: ClinicalTrials.gov NCT04143269 FUNDING: The study was funded by the Novo Nordisk Foundation (grant number NNF180C0052045).
MeSH term(s)	Humans ; Female ; Male ; Middle Aged ; Double-Blind Method ; Vagus Nerve Stimulation/methods ; Adult ; Aged ; Transcutaneous Electric Nerve Stimulation/methods ; Diabetic Neuropathies/therapy ; Diabetic Neuropathies/physiopathology ; Gastrointestinal Diseases/therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy ; Aged, 80 and over ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/therapy ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Multicenter Study
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-024-06129-0
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Article ; Online: Healthy brain aging assessed with [

Andersen, Katrine B / Hansen, Allan K / Knudsen, Karoline / Schacht, Anna Christina / Damholdt, Malene F / Brooks, David J / Borghammer, Per

Nuclear medicine and biology

2022 Volume 112-113, Page(s) 52–58

Abstract: Background: The average human lifespan has increased dramatically over the past century. However, molecular and physiological alterations of the healthy brain during aging remain incompletely understood. Generalized synaptic restructuring may contribute ...

Abstract	Background: The average human lifespan has increased dramatically over the past century. However, molecular and physiological alterations of the healthy brain during aging remain incompletely understood. Generalized synaptic restructuring may contribute to healthy aging and the reduced metabolism observed in the aged brain. The aim of this study was to assess healthy brain aging using [ Method: Using in vivo PET imaging and the novel synaptic-vesicle-glycoprotein 2A (SV2A) radioligand [ Results: We found widespread cortical reduction of synaptic density in a cohort of older HC subjects (N = 15) compared with young HC subjects (N = 11). However, no reduction persisted after partial volume correction and corrections for multiple comparison. Our study confirms previously reported synaptic stability during aging. Regional differences in relative [ Conclusion: In vivo PET using [
MeSH term(s)	Aged ; Brain/diagnostic imaging ; Brain/metabolism ; Fluorodeoxyglucose F18/metabolism ; Glucose/metabolism ; Glycoproteins/metabolism ; Healthy Aging ; Humans ; Positron-Emission Tomography/methods
Chemical Substances	Glycoproteins ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2022.06.007
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Article ; Online: Quadratus lumborum block for total hip arthroplasty: anatomical knowledge is always key for choice of blocks and execution.

Steingrimsdottir, Gudny / Hansen, Christian K / Dam, Mette / Tanggaard, Katrine B / Nielsen, Martin Vedel / Børglum, Jens

Regional anesthesia and pain medicine

2020 Volume 46, Issue 1, Page(s) 92–93

MeSH term(s)	Analgesia ; Arthroplasty, Replacement, Hip/adverse effects ; Humans ; Nerve Block/adverse effects ; Pain Management
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2019-101222
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Article ; Online: Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists.

Valentini, Alice / Schultz-Knudsen, Katrine / Højgaard Hansen, Anders / Tsakoumagkou, Argyro / Jenkins, Laura / Christensen, Henriette B / Manandhar, Asmita / Milligan, Graeme / Ulven, Trond / Rexen Ulven, Elisabeth

Journal of medicinal chemistry

2023 Volume 66, Issue 9, Page(s) 6105–6121

Abstract: The free fatty acid receptor 2 (FFA2), also known as GPR43, mediates effects of short-chain fatty acids and has attracted interest as a potential target for treatment of various metabolic and inflammatory diseases. Herein, we report the results from ... ...

Abstract	The free fatty acid receptor 2 (FFA2), also known as GPR43, mediates effects of short-chain fatty acids and has attracted interest as a potential target for treatment of various metabolic and inflammatory diseases. Herein, we report the results from bioisosteric replacement of the carboxylic acid group of the established FFA2 antagonist CATPB and SAR investigations around these compounds, leading to the discovery of the first high-potency FFA2 antagonists, with the preferred compound TUG-2304 (
MeSH term(s)	Fatty Acids, Nonesterified ; Propionates ; Receptors, Cell Surface/antagonists & inhibitors ; Receptors, Cell Surface/chemistry ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Fatty Acids, Nonesterified ; Propionates ; Receptors, Cell Surface ; Receptors, G-Protein-Coupled ; FFA2R protein, human
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c01935
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Article ; Online: Once-weekly subcutaneous semaglutide treatment for persons with type 2 diabetes: Real-world data from a diabetes out-patient clinic.

Hansen, Katrine B / Svendstrup, Mathilde / Lund, Asger / Knop, Filip K / Vilsbøll, Tina / Vestergaard, Henrik

Diabetic medicine : a journal of the British Diabetic Association

2021 Volume 38, Issue 10, Page(s) e14655

Abstract: Aims: The once-weekly administered glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) semaglutide, has, in clinical trials, demonstrated significant reductions in glycated haemoglobin A: Methods: This retrospective observational cohort study ... ...

Abstract	Aims: The once-weekly administered glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) semaglutide, has, in clinical trials, demonstrated significant reductions in glycated haemoglobin A Methods: This retrospective observational cohort study included persons with type 2 diabetes (n = 119) on a broad range of antidiabetic medicine: GLP-1RA naïve persons (n = 37) and GLP-1RA-experienced persons (n = 82). Person characteristics at inclusion: age [median (quartiles)]: 65 (57, 72) years; body weight 99 (86, 118) kg; body mass index (BMI) 33 (29, 38) kg/m²; HbA Results: After 12 months, the reductions in HbA Conclusion: We observed effects of semaglutide once weekly on HbA
MeSH term(s)	Aged ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Drug Administration Schedule ; Female ; Glucagon-Like Peptide 1/agonists ; Glucagon-Like Peptides/administration & dosage ; Glucagon-Like Peptides/pharmacology ; Glycated Hemoglobin A/metabolism ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Outpatients ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Glycated Hemoglobin A ; hemoglobin A1c protein, human ; semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8) ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.14655
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Article ; Online: Connecting the αα-hubs: same fold, disordered ligands, new functions.

Staby, Lasse / Bugge, Katrine / Falbe-Hansen, Rasmus Greve / Salladini, Edoardo / Skriver, Karen / Kragelund, Birthe B

Cell communication and signaling : CCS

2021 Volume 19, Issue 1, Page(s) 2

Abstract: Background: Signal fidelity depends on protein-protein interaction-'hubs' integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-helical domains of large, modular ... ...

Abstract	Background: Signal fidelity depends on protein-protein interaction-'hubs' integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-helical domains of large, modular proteins binding intrinsically disordered transcriptional regulators. Methods: Comparative structural biology. Results: We assign the harmonin-homology-domain (HHD, also named the harmonin N-terminal domain, NTD) present in large proteins such as harmonin, whirlin, cerebral cavernous malformation 2, and regulator of telomere elongation 1 to the αα-hubs. The new member of the αα-hubs expands functionality to include scaffolding of supra-modular complexes mediating sensory perception, neurovascular integrity and telomere regulation, and reveal novel features of the αα-hubs. As a common trait, the αα-hubs bind intrinsically disordered ligands of similar properties integrating similar cellular cues, but without cross-talk. Conclusion: The inclusion of the HHD in the αα-hubs has uncovered new features, exemplifying the utility of identifying groups of hub domains, whereby discoveries in one member may cross-fertilize discoveries in others. These features make the αα-hubs unique models for decomposing signal specificity and fidelity. Using these as models, together with other suitable hub domain, we may advance the functional understanding of hub proteins and their role in cellular communication and signaling, as well as the role of intrinsically disordered proteins in signaling networks. Video Abstract.
MeSH term(s)	Intrinsically Disordered Proteins/chemistry ; Ligands ; Protein Interaction Domains and Motifs ; Protein Interaction Mapping
Chemical Substances	Intrinsically Disordered Proteins ; Ligands
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1478-811X
ISSN (online)	1478-811X
DOI	10.1186/s12964-020-00686-8
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Article ; Online: Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial.

Larsen, Mads S / Witard, Oliver C / Holm, Lars / Scaife, Paula / Hansen, Rikke / Smith, Kenneth / Tipton, Kevin D / Mose, Maike / Bengtsen, Mads B / Lauritsen, Katrine M / Mikkelsen, Ulla R / Hansen, Mette

The Journal of nutrition

2023 Volume 153, Issue 11, Page(s) 3173–3184

Abstract: Background: Diet-induced weight loss is associated with a decline in lean body mass, as mediated by an impaired response of muscle protein synthesis (MPS). The dose-response of MPS to ingested protein, with or without resistance exercise, is well ... ...

Abstract	Background: Diet-induced weight loss is associated with a decline in lean body mass, as mediated by an impaired response of muscle protein synthesis (MPS). The dose-response of MPS to ingested protein, with or without resistance exercise, is well characterized during energy balance but limited data exist under conditions of energy restriction in clinical populations. Objective: To determine the dose-response of MPS to ingested whey protein following short-term diet-induced energy restriction in overweight, postmenopausal, women at rest and postexercise. Design: Forty middle-aged (58.6±0.4 y), overweight (BMI: 28.6±0.4), postmenopausal women were randomly assigned to 1 of 4 groups: Three groups underwent 5 d of energy restriction (∼800 kcal/d). On day 6, participants performed a unilateral leg resistance exercise bout before ingesting either a bolus of 15g (ERW15, n = 10), 35g (ERW35, n = 10) or 60g (ERW60, n = 10) of whey protein. The fourth group (n = 10) ingested a 35g whey protein bolus after 5 d of an energy balanced diet (EBW35, n = 10). Myofibrillar fractional synthetic rate (FSR) was calculated under basal, fed (FED) and postexercise (FED-EX) conditions by combining an L-[ring- Results: Myofibrillar FSR was greater in ERW35 (0.043±0.003%/h, P = 0.013) and ERW60 (0.042±0.003%/h, P = 0.026) than ERW15 (0.032 ± 0.003%/h), with no differences between ERW35 and ERW60 (P = 1.000). Myofibrillar FSR was greater in FED (0.044 ± 0.003%/h, P < 0.001) and FED-EX (0.048 ± 0.003%/h, P < 0.001) than BASAL (0.027 ± 0.003%/h), but no differences were detected between FED and FED-EX (P = 0.732) conditions. No differences in myofibrillar FSR were observed between EBW35 (0.042 ± 0.003%/h) and ERW35 (0.043 ± 0.003%/h, P = 0.744). Conclusion: A 35 g dose of whey protein, ingested with or without resistance exercise, is sufficient to stimulate a maximal acute response of MPS following short-term energy restriction in overweight, postmenopausal women, and thus may provide a per serving protein recommendation to mitigate muscle loss during a weight loss program. Trial registry: clinicaltrials.gov (ID: NCT03326284).
MeSH term(s)	Middle Aged ; Humans ; Female ; Whey Proteins ; Overweight/metabolism ; Postmenopause ; Diet, Reducing ; Muscle, Skeletal/metabolism ; Muscle Proteins/metabolism ; Resistance Training
Chemical Substances	Whey Proteins ; Muscle Proteins
Language	English
Publishing date	2023-08-19
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.08.011
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Article ; Online: Distribution of cholinergic nerve terminals in the aged human brain measured with [

Okkels, Niels / Horsager, Jacob / Labrador-Espinosa, Miguel A / Hansen, Frederik O / Andersen, Katrine B / Just, Mie Kristine / Fedorova, Tatyana D / Skjærbæk, Casper / Munk, Ole L / Hansen, Kim V / Gottrup, Hanne / Hansen, Allan K / Grothe, Michel J / Borghammer, Per

NeuroImage

2023 Volume 269, Page(s) 119908

Abstract: Introduction: [: Materials and methods: [: Results: Twenty participants of both sexes and a mean age of 73.9 ± 6.0 years, age-range [64; 86], were recruited. Highest tracer binding was present in the striatum, some thalamic nuclei, and the basal ... ...

Abstract	Introduction: [ Materials and methods: [ Results: Twenty participants of both sexes and a mean age of 73.9 ± 6.0 years, age-range [64; 86], were recruited. Highest tracer binding was present in the striatum, some thalamic nuclei, and the basal forebrain. Intermediate binding was found in most nuclei of the brainstem, thalamus, and hypothalamus; the vermis and flocculonodular lobe; and the hippocampus, amygdala, insula, cingulate, olfactory cortex, and Heschl's gyrus. Lowest binding was present in most areas of the cerebral cortex, and in the cerebellar nuclei and hemispheres. The spatial distribution of tracer correlated with immunohistochemical post-mortem data, as well as with regional expression levels of SLC18A3, the VAChT coding gene. Discussion: Our in vivo findings confirm the regional cholinergic distribution in specific brain structures as described post-mortem. A positive spatial correlation between tracer distribution and regional gene expression levels further corroborates [
MeSH term(s)	Aged ; Female ; Humans ; Male ; Middle Aged ; Brain/metabolism ; Cholinergic Agents ; Electrons ; Piperidines ; Positron-Emission Tomography/methods ; Vesicular Acetylcholine Transport Proteins/metabolism ; Fluorine Radioisotopes
Chemical Substances	Cholinergic Agents ; Piperidines ; Vesicular Acetylcholine Transport Proteins ; benzovesamicol ; Fluorine Radioisotopes
Language	English
Publishing date	2023-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.119908
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