LIVIVO - Search results -

Search results

Result 1 - 10 of total 6345

Search options

Article ; Online: PROphylaxis for paTiEnts at risk of COVID-19 infecTion (PROTECT-V).

Humphrey, Toby J L / Dosanjh, Davinder / Hiemstra, Thomas F / Richter, Alex / Chen-Xu, Michael / Qian, Wendi / Jha, Vivekanand / Gatley, Katrina / Adhikari, Rakshya / Dowling, Francis / Smith, Rona M

Trials

2023 Volume 24, Issue 1, Page(s) 185

Abstract: ... Methods: PROTECT-V is a platform trial testing pre-exposure prophylactic interventions against SARS-CoV-2 ...

Abstract	Background: Despite the introduction of vaccination, there remains a need for pre-exposure prophylactic agents against SARS-CoV-2. Several patient groups are more vulnerable to SARS-CoV-2 infection by virtue of underlying health conditions, treatments received or suboptimal responses to vaccination. Methods: PROTECT-V is a platform trial testing pre-exposure prophylactic interventions against SARS-CoV-2 infection in vulnerable patient populations (organ transplant recipients; individuals with oncological/haematological diagnoses, immune deficiency or autoimmune diseases requiring immunosuppression or on dialysis). Multiple agents can be evaluated across multiple vulnerable populations sharing placebo groups, with the option of adding additional treatments at later time points as these become available. The primary endpoint is symptomatic SARS-CoV-2 infection, and each agent will be independently evaluated in real time when the required number of events occurs. Presently, three agents are approved in the platform: intranasal niclosamide, nasal and inhaled ciclesonide and intravenous sotrovimab. Discussion: Despite the introduction of vaccination, there remains a need for pre-exposure prophylactic agents against SARS-CoV-2. Several patient groups are more vulnerable to COVID-19 disease by virtue of underlying health conditions, treatments received or suboptimal responses to vaccination. Trial registration: ClinicalTrials.gov NCT04870333. EudraCT 2020-004144-28.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-023-07128-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: In Vitro Effects of Zirconia Nanoparticles: Uptake, Genotoxicity, and Mutagenicity in V-79 cells.

Mourya, Durgesh / Dubey, Kavita / Jha, Shambhavi / Maurya, Renuka / Pandey, Alok Kumar

Biological trace element research

2023 Volume 202, Issue 3, Page(s) 927–940

Abstract: ... designed to determine the genotoxic and mutagenic effect of zirconia NPs in V-79 lung cells. Zirconia ... nanoparticles showed low cytotoxicity and were found to generate ROS in V-79 cells. In alkaline comet assay ... in the V-79 cell line. In MN assay, zirconia nanoparticles resulted in no significant micronuclei induction ...

Abstract	Zirconia nanoparticles are used in various industrial and biomedical applications such as dental implants, thermal barrier sprays, and fuel cells. The interaction of nanoparticles with the environment and humans is inevitable. Despite the enormous application potential of these nanoparticles, there are still some gaps in the literature regarding potential toxicological mechanisms and the genotoxicity of zirconia nanoparticles. The lung is one of the main exposure routes to nanomaterials; therefore, the present study was designed to determine the genotoxic and mutagenic effect of zirconia NPs in V-79 lung cells. Zirconia nanoparticles showed significant internalization in cells at 100 μg/mL and 150 μg/mL concentrations. Zirconia nanoparticles showed low cytotoxicity and were found to generate ROS in V-79 cells. In alkaline comet assay, zirconia nanoparticles (10 μg/mL, 50 μg/mL, and 100 μg/mL) exposed cells exhibited significant DNA strand breaks, while the neutral comet assay, which was used for double-strand break assessment, only revealed significant damage at 100 μg/mL. Chromosomal aberration induced by zirconia nanoparticles mainly resulted in the generation of gaps, few fragments, and breaks which signifies the low clastogenic activity of these nanoparticles in the V-79 cell line. In MN assay, zirconia nanoparticles resulted in no significant micronuclei induction at any given concentration. In the HPRT mutation assay, the particle shows a dose-dependent increase in the mutant frequency. It is evident from the result that zirconia nanoparticles cause dose-dependent cytotoxicity and genotoxicity, but still, more studies are needed to evaluate the clastogenic potential and the possible mechanism involved.
MeSH term(s)	Humans ; Mutagens/toxicity ; Micronucleus Tests ; DNA Damage ; Nanoparticles/toxicity ; Comet Assay ; Metal Nanoparticles/toxicity ; Zirconium
Chemical Substances	Mutagens ; zirconium oxide (S38N85C5G0) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-023-03739-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2323: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Inclusive $\alpha$ Production for $^{6}$Li+$^{51}$V System

Joshi, C. / Kumawat, H. / Parkar, V. V. / Dutta, D. / Suryanarayana, S. V. / Jha, V. / Singh, R. K. / Singh, N. L. / Kailas, S.

2021

Abstract: ... have been measured for $^6$Li + $^{51}$V system near Coulomb barrier energies. Theoretical calculations ...

Abstract	Measurement of angular distributions and energy spectra of $\alpha$ and deuterons through breakup, transfer and incomplete fusion processes to dis-entangle their relative contributions and to investigate relative importance of breakup-fusion compared to transfer. Inclusive $\alpha$ production cross-sections have been measured for $^6$Li + $^{51}$V system near Coulomb barrier energies. Theoretical calculations for estimation of various reaction channels contributing to $\alpha$ production have been performed with finite range coupled reaction method using \textsc{FRESCO} code. The cross-sections from non-capture breakup (NCBU) ($\alpha$ + \textit{d}) and 1\textit{n}, 1\textit{p}, and 1\textit{d} transfer channels, compound nuclear decay channel and incomplete fusion (ICF) leading to $\alpha$ production were estimated to get the cumulative production cross-sections. Contributions from breakup, transfer and incomplete fusion channels could reproduce the integral direct $\alpha$ production cross-sections and their angular distributions quite well. The direct $\alpha$ production cross-sections are in agreement with other targets. The $\alpha$ production cross-sections are higher compared to the deuteron production. Kinematic analysis of the energy spectra of $\alpha$ particles and deuterons suggest that $\alpha$ particle spectra is dominated by breakp-fusion and deuteron spectra have contribution of breakup and transfer reactions. A systematic study of direct $\alpha$ production with various targets follow a universal behavior on average but noticeable differences are observed for different targets. A ratio of $\alpha$ and deuteron yields for a wide mass range of targets shows a saturation above barrier and an increasing production of $\alpha$ particles relative to deuteron around Coulomb barrier. Comment: 10 pages, 11 figures
Keywords	Nuclear Experiment ; Nuclear Theory
Subject code	660
Publishing date	2021-06-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Acquired Factor V Inhibitor After Antibiotic Therapy: A Clinical Case Report and Review of the Literature.

Chartier, Alexander R / Hillert, Conor J / Gill, Harpreet / Jha, Pinky

Cureus

2020 Volume 12, Issue 7, Page(s) e9481

Abstract: Acquired factor V inhibitor (aFVi) is an exceptionally rare hematologic condition that can range ... between factor V and the damaged phospholipid membranes. This case highlights the evolving causes of aFVi ...

Abstract	Acquired factor V inhibitor (aFVi) is an exceptionally rare hematologic condition that can range from incidental laboratory abnormalities to life-threatening hemorrhage. Bovine thrombin was formerly the most common cause of this condition; however, the decreased use of bovine thrombin in surgical procedures has led to a shift in the cause of aFVi toward antibiotic use and malignancies. Here we present a case of an 80-year-old Caucasian female on long-term warfarin therapy who presented with epistaxis and an elevated international normalized ratio, and a history of cephalosporin antibiotic use. We review the published literature beginning in 2016 to identify the evolving causes of aFVi. Additionally, we propose that stress-mediated immune regulation may contribute to antibody formation, preventing the interaction between factor V and the damaged phospholipid membranes. This case highlights the evolving causes of aFVi and should prompt physicians to consider this diagnosis in coagulopathies that do not correct with traditional therapies.
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.9481
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Modified PCR-based assay for the differentiation of members of Anopheles fluviatilis complex in consequence of the discovery of a new cryptic species (species V).

Singh, Om P / Nanda, Nutan / Chandra, Dinesh / Jha, Deepa / Adak, Tridibes / Dua, Virendra K / Subbarao, Sarala K

Malaria journal

2020 Volume 19, Issue 1, Page(s) 96

Abstract: ... provisionally designated as species S, T, U and V. Earlier, a 28S-rDNA based allele-specific polymerase chain ... of a new cryptic member, species V, in the Fluviatilis Complex to include identification of new species ... digestion of PCR product with an enzyme BamH I, which cleaves specifically PCR amplicon of species V and ...

Abstract	Background: Anopheles fluviatilis is a species-complex comprising of four cryptic species provisionally designated as species S, T, U and V. Earlier, a 28S-rDNA based allele-specific polymerase chain reaction (ASPCR) assay was developed for the differentiation of the then known three members of the An. fluviatilis complex, i.e., species S, T, and U. This assay was modified in consequence of the discovery of a new cryptic member, species V, in the Fluviatilis Complex to include identification of new species. Methods: In the modified procedure, the ASPCR assay was performed first, followed by restriction digestion of PCR product with an enzyme BamH I, which cleaves specifically PCR amplicon of species V and the resultant PCR-RFLP products can differentiate all the four cryptic members of the complex. Morphologically identified An. fluviatilis samples were subjected to sibling species identification by modified PCR-based assay and standard cytotaxonomy. The result of PCR-based assay was validated through cytotaxonomy as well as DNA sequencing of some representative samples. Results: The modified PCR-based assay differentiates all four sibling species. The result of modified PCR-based assay tested on field samples was in agreement with results of cytotaxonomy as well as DNA sequencing of representative samples. Conclusions: The modified PCR-based assay unambiguously differentiates all four known members of the An. fluviatilis species complex. This assay will be useful in studies related to bionomics of members of the Fluviatilis Complex in their role in malaria transmission.
MeSH term(s)	Animals ; Anopheles/classification ; Female ; Malaria ; Male ; Mosquito Vectors/classification ; Polymerase Chain Reaction/methods ; RNA, Ribosomal, 28S/analysis
Chemical Substances	RNA, Ribosomal, 28S
Language	English
Publishing date	2020-02-27
Publishing country	England
Document type	Journal Article
ISSN	1475-2875
ISSN (online)	1475-2875
DOI	10.1186/s12936-020-03172-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study.

Psychological medicine

2018 Volume 49, Issue 7, Page(s) 1118–1127

Abstract: ... anhedonia, and cognitive control deficits.: Methods: Within an 8-week multisite trial of sertraline v ...

Abstract	Background: Major depressive disorder (MDD) is a highly heterogeneous condition in terms of symptom presentation and, likely, underlying pathophysiology. Accordingly, it is possible that only certain individuals with MDD are well-suited to antidepressants. A potentially fruitful approach to parsing this heterogeneity is to focus on promising endophenotypes of depression, such as neuroticism, anhedonia, and cognitive control deficits. Methods: Within an 8-week multisite trial of sertraline v. placebo for depressed adults (n = 216), we examined whether the combination of machine learning with a Personalized Advantage Index (PAI) can generate individualized treatment recommendations on the basis of endophenotype profiles coupled with clinical and demographic characteristics. Results: Five pre-treatment variables moderated treatment response. Higher depression severity and neuroticism, older age, less impairment in cognitive control, and being employed were each associated with better outcomes to sertraline than placebo. Across 1000 iterations of a 10-fold cross-validation, the PAI model predicted that 31% of the sample would exhibit a clinically meaningful advantage [post-treatment Hamilton Rating Scale for Depression (HRSD) difference ⩾3] with sertraline relative to placebo. Although there were no overall outcome differences between treatment groups (d = 0.15), those identified as optimally suited to sertraline at pre-treatment had better week 8 HRSD scores if randomized to sertraline (10.7) than placebo (14.7) (d = 0.58). Conclusions: A subset of MDD patients optimally suited to sertraline can be identified on the basis of pre-treatment characteristics. This model must be tested prospectively before it can be used to inform treatment selection. However, findings demonstrate the potential to improve individual outcomes through algorithm-guided treatment recommendations.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antidepressive Agents/therapeutic use ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/psychology ; Double-Blind Method ; Endophenotypes ; Female ; Humans ; Machine Learning ; Male ; Middle Aged ; Patient Outcome Assessment ; Precision Medicine ; Prospective Studies ; Sertraline/therapeutic use ; Treatment Outcome ; Young Adult
Chemical Substances	Antidepressive Agents ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2018-07-02
Publishing country	England
Document type	Controlled Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291718001708
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1003: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online ; E-Book: Water resources management and reservoir operation

Jha, Ramakar

hydraulics, water resources and coastal engineering

(Water Science and Technology Library ; v.107)

2021

Abstract: This book explores many recent techniques including ANN, fuzzy logic, hydraulic models and IWRM utilized for integrated water resources management, a real challenge in India for obtaining high irrigation efficiency. The book deals with topics of current ... ...

Author's details	edited by Ramakar Jha [and three others]
Series title	Water Science and Technology Library ; v.107
Abstract	This book explores many recent techniques including ANN, fuzzy logic, hydraulic models and IWRM utilized for integrated water resources management, a real challenge in India for obtaining high irrigation efficiency. The book deals with topics of current interest, such as climate change, floods, drought, and hydrological extremes. The impact of climate change on water resources is drawing worldwide attention these days; for water resources, many countries are already stressed and climate change along with burgeoning population, rising standard of living, and increasing demand are adding to the stress. Further, river basins are becoming less resilient to climatic vagaries. Fundamental to addressing these issues is hydrological modelling which is covered in this book Further, integrated water resources management is vital to ensure water and food security. Integral to the management is groundwater and solute transport. The book encompasses tools that will be useful to mitigate the adverse consequences of natural disasters.
Keywords	Water-supply/Management ; Water resources development
Language	English
Size	x, 288 pages:, illustrations, maps;, 24 cm
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	9783030793999 ; 3030793990
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Book ; Online ; E-Book: Geospatial technologies for resources planning and management

Jha, C. S.

(Water Science and Technology Library ; v.115)

2022

Author's details	edited by Chandra Shekhar Jha [and three others]
Series title	Water Science and Technology Library ; v.115
Keywords	Geographic information systems
Subject code	910.285
Language	English
Size	1 online resource (748 pages)
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-98981-X ; 9783030989804 ; 978-3-030-98981-1 ; 3030989801
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: Wide angled 'V' is the perfect disposition of a TIVAD catheter when right internal jugular vein is cannulated to gain central access.

Kumar, Chitresh / Jha, Chandan Kumar / Bichoo, Raouef Ahmed / Yadav, Sanjay Kumar

Gastroenterology report

2019 Volume 7, Issue 5, Page(s) 374–375

Language	English
Publishing date	2019-07-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/goz027
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Marine bacteria-based polyvinyl chloride (PVC) degradation by-products: Toxicity analysis on Vigna radiata and edible seaweed Ulva lactuca [Corrigendum: July 2022, v. 180, p. 113835]

Khandare, Shrikant D. / Chaudhary, Doongar R. / Jha, Bhavanath

Marine Pollution Bulletin. 2022 Feb., v. 175, p. 113366

2022 , Page(s) 113366

Abstract: Biodegradation of polyvinyl chloride (PVC) by marine bacteria is a sustainable approach that leads to the production of different by-products but their toxicity needs to be evaluated. In the present study, polyvinyl chloride degradation products (PVCDP) ... ...

Abstract	Biodegradation of polyvinyl chloride (PVC) by marine bacteria is a sustainable approach that leads to the production of different by-products but their toxicity needs to be evaluated. In the present study, polyvinyl chloride degradation products (PVCDP) produced by three marine bacterial isolates (T-1.3, BP-4.3 and S-237) in the culture supernatant were evaluated for toxicity on the germination of Vigna radiata and growth of Ulva lactuca. A total of 24 compounds comprising of benzene, fatty acid, ether, ester and plastic stabilizer (tris (2, 4-di-tert-butylphenyl) phosphate) were identified by GC–MS using diethyl ether solvent extraction from the supernatant. The per cent germination rate of the seed treated with PVCDP showed no significant effect but germination index and elongation inhibition rate were influenced significantly by PVCDP treatments. In seaweed (U. lactuca), PVCDP showed improvement in the daily growth rate. After ten days of treatment with PVCDP, pigment contents were improved in seaweed and PVCDP (2%) of isolate T-1.3 recorded the highest chlorophyll-a and chlorophyll-b.
Keywords	Ulva lactuca ; Vigna radiata ; benzene ; biodegradation ; chlorophyll ; edible seaweed ; ethyl ether ; fatty acids ; germination ; macroalgae ; marine pollution ; phosphates ; poly(vinyl chloride) ; solvents ; stabilizers ; toxicity ; By-product of PVC
Language	English
Dates of publication	2022-02
Size	p. 113366
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2022.113366
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito