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Article: Comparative Evaluation of Oxidative Stress Modulating and DNA Protective Activities of Aqueous and Methanolic Extracts of Acacia catechu.

Patil, Ashwini / Modak, Manisha

2017 Volume 4, Issue 3

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2017-09-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777965-8
ISSN	2305-6320
ISSN	2305-6320
DOI	10.3390/medicines4030065
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2.

Deshpande, Rujuta R / Tiwari, Arpita Pandey / Nyayanit, Narendra / Modak, Manisha

European journal of pharmacology

2020 Volume 886, Page(s) 173430

Abstract: SARS-CoV-2 has devastated the world with its rapid spread and fatality. The researchers across the globe are struggling hard to search a drug to treat this infection. Understanding the time constraint, the best approach is to study clinically approved ... ...

Abstract	SARS-CoV-2 has devastated the world with its rapid spread and fatality. The researchers across the globe are struggling hard to search a drug to treat this infection. Understanding the time constraint, the best approach is to study clinically approved drugs for control of this deadly pandemic of COVID 19. The repurposing of such drugs can be supported with the study of molecular interactions to enhance the possibility of application. The present work is a molecular docking study of proteins responsible for viral propagation namely 3Clpro, Nsp10/16, Spike protein, SARS protein receptor binding domain, Nsp 9 viral single strand binding protein and viral helicase. The protein through virus enters the host cell-human angiotensin-converting enzyme 2 (ACE2) receptor, is also used as a target for molecular docking. The docking was done with most discussed drugs for SARS-CoV-2 like Ritonavir, Lopinavir, Remdesivir, Chloroquine, Hydroxychloroquine (HCQ), routine antiviral drugs like Oseltamivir and Ribavirin. In addition, small molecules with anti-inflammatory actions like Mycophenolic acid (MPA), Pemirolast, Isoniazid and Eriodictyol were also tested. The generated data confirms the potential of Ritonavir, Lopinavir and Remdesivir as a therapeutic candidate against SARS-CoV-2. It is observed that Eriodictyol binds to almost all selected target proteins with good binding energy, suggesting its importance in treatment of COVID 19. Molecular interactions of Ritonavir, Lopinavir and Remdesivir against SARS-CoV-2 proteins enhanced their potential as a candidate drug for treatment of COVID-19. Eriodictyol had emerged as a new repurposing drug that can be used in COVID-19.
MeSH term(s)	Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; Betacoronavirus/metabolism ; Computer Simulation ; Drug Repositioning ; Molecular Docking Simulation ; Protein Conformation ; SARS-CoV-2 ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Chemical Substances	Antiviral Agents ; Viral Proteins
Keywords	covid19
Language	English
Publishing date	2020-08-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2020.173430
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Article ; Online: Comparative Evaluation of Oxidative Stress Modulating and DNA Protective Activities of Aqueous and Methanolic Extracts of Acacia catechu

Ashwini Patil / Manisha Modak

Medicines, Vol 4, Iss 3, p

2017 Volume 65

Abstract: Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as ... ...

Abstract	Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases. Natural antioxidants are in high demand because of their lesser side effects. This study aims to compare the antioxidant activity of aqueous and methanolic extracts of Acacia catechu—a traditional medicinal plant. Methods: The activity was examined using different in vitro systems including radical scavenging activity, lipid peroxidation and inhibition of •OH radical induced DNA damage using standard protocols. Results: Both aqueous and methanolic extracts of Acacia catechu show significant activities with no differences in the efficacies of water and methanol soluble bioactive compounds. Conclusions: Present study revealed that aqueous extract of A. catechu has equal potential to be used as antioxidants as compared to methanolic extract. This can contribute to increased demand of physiologically compatible bioactive compounds of natural origin.
Keywords	Acacia catechu ; aqueous extract and oxidative stress modulating activity ; oxidative stress ; in vitro assays for oxidative radical scavenging activity ; Medicine ; R
Subject code	500
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2

Deshpande, Rujuta R. / Tiwari, Arpita Pandey / Nyayanit, Narendra / Modak, Manisha

European Journal of Pharmacology

2020 Volume 886, Page(s) 173430

Keywords	Pharmacology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2020.173430
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: First report of F1534C kdr mutation in deltamethrin resistant Aedes albopictus from northern part of West Bengal, India.

Modak, Manas Pratim / Saha, Dhiraj

Scientific reports

2022 Volume 12, Issue 1, Page(s) 13653

Abstract: Dengue is the most rapidly spreading vector-borne disease with an estimated 100-400 million cases each year. Control of Dengue vectors largely depends upon synthetic pyrethroids. Development of insecticide resistance in Aedes mosquitoes however, poses ... ...

Abstract	Dengue is the most rapidly spreading vector-borne disease with an estimated 100-400 million cases each year. Control of Dengue vectors largely depends upon synthetic pyrethroids. Development of insecticide resistance in Aedes mosquitoes however, poses severe threat to insecticide-based vector management programme. Mutations in the Voltage Gated Sodium Channel gene (vgsc) serve as the primary machinery behind this resistance development. In Aedes albopictus, at least four such kdr (knock down resistance) mutations had already been documented. Here, we describe the occurrence of F1534C kdr mutation in wild population of Ae. albopictus from northern part of West Bengal, India including a novel T1520I mutation. Four populations of Ae. albopictus from the studied region were found resistant against DDT and synthetic pyrethroids, among them only one population possessed F1534C kdr mutation. A total of 200 successful amplification followed by partial sequencing of vgsc gene further revealed the presence of F1534C kdr mutation in both phenotypically susceptible and resistant mosquito specimen. Studied populations were found 81% homozygote susceptible (1534F/F), 12.5% heterozygote (1534F/C) and 6% homozygote resistant (1534C/C) for F1534C kdr mutation. The findings of the current study will help to uncover the mechanisms underlying insecticide resistance and hence to reduce errors in vector control measurements.
MeSH term(s)	Aedes/genetics ; Animals ; Dengue ; Insecticide Resistance/genetics ; Insecticides/pharmacology ; Mosquito Vectors/genetics ; Mutation ; Nitriles ; Pyrethrins/pharmacology ; Voltage-Gated Sodium Channels/genetics
Chemical Substances	Insecticides ; Nitriles ; Pyrethrins ; Voltage-Gated Sodium Channels ; decamethrin (2JTS8R821G)
Language	English
Publishing date	2022-08-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-17739-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2

Deshpande, Rujuta R / Tiwari, Arpita Pandey / Nyayanit, Narendra / Modak, Manisha

Eur J Pharmacol

Abstract	SARS-CoV-2 has devastated the world with its rapid spread and fatality. The researchers across the globe are struggling hard to search a drug to treat this infection. Understanding the time constraint, the best approach is to study clinically approved drugs for control of this deadly pandemic of COVID 19. The repurposing of such drugs can be supported with the study of molecular interactions to enhance the possibility of application. The present work is a molecular docking study of proteins responsible for viral propagation namely 3Clpro, Nsp10/16, Spike protein, SARS protein receptor binding domain, Nsp 9 viral single strand binding protein and viral helicase. The protein through virus enters the host cell-human angiotensin-converting enzyme 2 (ACE2) receptor, is also used as a target for molecular docking. The docking was done with most discussed drugs for SARS-CoV-2 like Ritonavir, Lopinavir, Remdesivir, Chloroquine, Hydroxychloroquine (HCQ), routine antiviral drugs like Oseltamivir and Ribavirin. In addition, small molecules with anti-inflammatory actions like Mycophenolic acid (MPA), Pemirolast, Isoniazid and Eriodictyol were also tested. The generated data confirms the potential of Ritonavir, Lopinavir and Remdesivir as a therapeutic candidate against SARS-CoV-2. It is observed that Eriodictyol binds to almost all selected target proteins with good binding energy, suggesting its importance in treatment of COVID 19. Molecular interactions of Ritonavir, Lopinavir and Remdesivir against SARS-CoV-2 proteins enhanced their potential as a candidate drug for treatment of COVID-19. Eriodictyol had emerged as a new repurposing drug that can be used in COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #691915
Database	COVID19

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Article ; Online: A common presentation of an uncommon pathology: Kimura disease.

Solomon, Lydia / Modak, Ketan / Paul, Preethi Anni Mercy / John, Joseph

Tropical doctor

2023 Volume 53, Issue 4, Page(s) 512–516

Abstract: Kimura's disease is a chronic, benign inflammatory condition of the subcutaneous tissue. It presents as painless, subcutaneous nodules of the head and neck, which are firm, painless, and may be single or multiple. It is most commonly seen in young adult ... ...

Abstract	Kimura's disease is a chronic, benign inflammatory condition of the subcutaneous tissue. It presents as painless, subcutaneous nodules of the head and neck, which are firm, painless, and may be single or multiple. It is most commonly seen in young adult Asian men. The nodes remain stable or may slowly enlarge over time. Elevated serum immunoglobulin E (IgE) levels, peripheral blood eosinophilia and lymphoid proliferation with eosinophilic infiltration on histopathological examination are the characteristic features. Spontaneous regression is usually seen. The diagnosis of Kimura's disease can be difficult and misleading, and it is important not to ignore histopathological features.
MeSH term(s)	Male ; Young Adult ; Humans ; Angiolymphoid Hyperplasia with Eosinophilia/diagnosis ; Angiolymphoid Hyperplasia with Eosinophilia/pathology ; Kimura Disease/diagnosis ; Diagnosis, Differential
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Journal Article
ZDB-ID	193169-6
ISSN	1758-1133 ; 0049-4755
ISSN (online)	1758-1133
ISSN	0049-4755
DOI	10.1177/00494755231177487
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Article ; Online: The heparin-binding hemagglutinin protein of Mycobacterium tuberculosis is a nucleoid-associated protein.

The Journal of biological chemistry

2023 Volume 299, Issue 12, Page(s) 105364

Abstract: Nucleoid-associated proteins (NAPs) regulate multiple cellular processes such as gene expression, virulence, and dormancy throughout bacterial species. NAPs help in the survival and adaptation of Mycobacterium tuberculosis (Mtb) within the host. Fourteen ...

Abstract	Nucleoid-associated proteins (NAPs) regulate multiple cellular processes such as gene expression, virulence, and dormancy throughout bacterial species. NAPs help in the survival and adaptation of Mycobacterium tuberculosis (Mtb) within the host. Fourteen NAPs have been identified in Escherichia coli; however, only seven NAPs are documented in Mtb. Given its complex lifestyle, it is reasonable to assume that Mtb would encode for more NAPs. Using bioinformatics tools and biochemical experiments, we have identified the heparin-binding hemagglutinin (HbhA) protein of Mtb as a novel sequence-independent DNA-binding protein which has previously been characterized as an adhesion molecule required for extrapulmonary dissemination. Deleting the carboxy-terminal domain of HbhA resulted in a complete loss of its DNA-binding activity. Atomic force microscopy showed HbhA-mediated architectural modulations in the DNA, which may play a regulatory role in transcription and genome organization. Our results showed that HbhA colocalizes with the nucleoid region of Mtb. Transcriptomics analyses of a hbhA KO strain revealed that it regulates the expression of ∼36% of total and ∼29% of essential genes. Deletion of hbhA resulted in the upregulation of ∼73% of all differentially expressed genes, belonging to multiple pathways suggesting it to be a global repressor. The results show that HbhA is a nonessential NAP regulating gene expression globally and acting as a plausible transcriptional repressor.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA/chemistry ; DNA/metabolism ; Hemagglutinins/genetics ; Hemagglutinins/metabolism ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Gene Expression Regulation, Bacterial/genetics ; Gene Deletion ; DNA-Binding Proteins/genetics ; Protein Domains/genetics ; Microscopy, Atomic Force
Chemical Substances	Bacterial Proteins ; DNA (9007-49-2) ; Hemagglutinins ; heparin-binding hemagglutinin ; DNA-Binding Proteins
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.105364
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Article ; Online: Maximizing the potential of randomized controlled trials on heart rate recovery following aerobic exercise in treated hypertensive men.

Philip, Michele / Modak, Anurag / Patel, Jai C

Blood pressure monitoring

2022 Volume 27, Issue 3, Page(s) 212

MeSH term(s)	Blood Pressure/physiology ; Exercise/physiology ; Heart Rate ; Humans ; Hypertension/drug therapy ; Male ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-04-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1324472-3
ISSN	1473-5725 ; 1359-5237
ISSN (online)	1473-5725
ISSN	1359-5237
DOI	10.1097/MBP.0000000000000587
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Article ; Online: Tissue specific oxidative stress profile in relation to glycaemic regulation in mice.

Modak, Manisha A / Parab, P B / Ghaskadbi, Saroj S

Diabetes/metabolism research and reviews

2014 Volume 30, Issue 1, Page(s) 31–41

Abstract: Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia resulting from uncontrolled glucose regulation. Reactive oxygen species are recognized as one link between hyperglycaemia and diabetic complications. Studies have ... ...

Abstract	Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia resulting from uncontrolled glucose regulation. Reactive oxygen species are recognized as one link between hyperglycaemia and diabetic complications. Studies have shown that diabetes mellitus is associated with decreases in antioxidant potential and increased formation of free radicals leading to oxidative stress. The present study was undertaken because an unequivocal demonstration that control of hyperglycaemia can reduce oxidative stress is still lacking. Methods: In the present study, we investigated oxidative stress profile of normal, streptozotocin-induced diabetic, insulin-treated and untreated diabetic animals. On the one hand, oxidative damage caused to lipids, proteins and DNA was measured. On other hand, antioxidant defense was measured in terms of specific activities of antioxidant enzymes (AOEs) and antioxidant molecules. Results: It was observed that the damage to lipids, proteins and DNA caused by free radicals increased in diabetic animals compared with that in controls. In diabetic animals not treated with insulin, damage to all biological molecules increased further significantly (p ≤ 0.005). Changes in AOEs from different tissues were complex depicting a varied AOE level in different tissues. Insulin treatment significantly improved the oxidative stress profile in all tissues studies. Conclusions: The control of hyperglycaemia improves oxidative stress profile, that is, the ability of cells to cope up with oxidative stress.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Blood Glucose/metabolism ; DNA Damage ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Female ; Hyperglycemia/physiopathology ; In Vitro Techniques ; Lipid Peroxidation ; Male ; Mice ; Oxidation-Reduction ; Oxidative Stress/physiology ; Protein Carbonylation/physiology ; Reactive Oxygen Species/metabolism ; Streptozocin
Chemical Substances	Antioxidants ; Blood Glucose ; Reactive Oxygen Species ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.2460
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