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Article ; Online: Non-invasive assessment of left ventricular relaxation property using color M-mode-derived intraventricular pressure gradients in cats.

Matsuura, K / Bach, M B T / Takahashi, K / Willesen, J L / Koch, J / Tanaka, R

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

2022 Volume 41, Page(s) 236–248

Abstract: ... intraventricular pressure gradient (IVPG). The study objectives were to evaluate color Doppler M-mode-derived IVPG ... cross-sectional study. Quantitative analysis of color Doppler M-mode images was used to estimate total and segmental ... in feline HCM are needed to evaluate the clinical applicability of color Doppler M-mode estimated IVPGs ...

Abstract	Introduction: Diastolic dysfunction is an early clinical feature of feline hypertrophic cardiomyopathy (HCM). The left ventricular filling in early diastole is facilitated by the diastolic intraventricular pressure gradient (IVPG). The study objectives were to evaluate color Doppler M-mode-derived IVPG calculation in cats as a non-invasive assessment of the left ventricular relaxation property to determine the normal ranges of peak IVPG in cats and investigate the influence of left ventricular function and heart rate (HR). Animals: One hundred and six client-owned apparently healthy cats. Methods: Prospective cross-sectional study. Quantitative analysis of color Doppler M-mode images was used to estimate total and segmental IVPGs non-invasively. Results: The total IVPG was 0.76 mmHg (95% reference interval (RI): 0.28-1.29 mmHg), the basal IVPG 0.34 mmHg (95% RI: 0.07-0.63 mmHg), and the mid-apical IVPG 0.42 mmHg (95% RI: 0.15-0.71 mmHg). Total and segmental IVPG increased with HR (P < 0.003), while segmental percent IVPG was HR independent. A short isovolumic relaxation time (IVRT) and a high mitral annular velocity in early diastole were associated with an increase in total IVPG (P = 0.008 and P = 0.009, respectively) adjusted for HR. An increase in IVPG was associated with an increase in mitral inflow velocity (P < 0.001). Conclusions: Feline IVPGs increase with HR and a short IVRT, which was believed to be a normal physiologic adrenergic response associated with an increased sympathetic tone. Future studies of segmental IVPG changes in feline HCM are needed to evaluate the clinical applicability of color Doppler M-mode estimated IVPGs in feline cardiology.
MeSH term(s)	Animals ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/veterinary ; Cat Diseases/diagnostic imaging ; Cats ; Cross-Sectional Studies ; Diastole/physiology ; Echocardiography, Doppler/veterinary ; Heart Rate ; Heart Ventricles/diagnostic imaging ; Prospective Studies ; Ventricular Function, Left/physiology ; Ventricular Pressure/physiology
Language	English
Publishing date	2022-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2198278-8
ISSN	1875-0834 ; 1760-2734
ISSN (online)	1875-0834
ISSN	1760-2734
DOI	10.1016/j.jvc.2022.03.006
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Article ; Online: M-CSFR expression in the embryonal component of hepatoblastoma and cell-to-cell interaction between macrophages and hepatoblastoma.

Li, Lianbo / Irie, Tomoaki / Yoshii, Daiki / Komohara, Yoshihiro / Fujiwara, Yukio / Esumi, Shigeyuki / Kadohisa, Masashi / Honda, Masaki / Suzu, Shinya / Matsuura, Toshiharu / Kohashi, Kenichi / Oda, Yoshinao / Hibi, Taizo

Medical molecular morphology

2022 Volume 55, Issue 3, Page(s) 236–247

Abstract: ... derived macrophages (HMDMs) showed that macrophage-colony-stimulating factor receptor (M-CSFR) was ... strongly up-regulated in the Huh6 cells that were directly co-cultured with HMDMs. The expressions of M ... CSFR ligands (interleukin-34 and M-CSF) were also increased by co-culture with HMDMs. The proliferation ...

Abstract	Tumor-associated macrophages (TAMs) have protumor functions in various cancers. However, their significance in hepatoblastoma, the most common liver tumor in children, remains unclear. The aim of this study was to explore the potential roles of TAMs in hepatoblastoma. Immunohistochemical analysis revealed that the density of CD204-positive TAMs was significantly higher in the embryonal component than in other histological subtypes of hepatoblastoma. An in vitro co-culture study with Huh6 cells and human monocyte-derived macrophages (HMDMs) showed that macrophage-colony-stimulating factor receptor (M-CSFR) was strongly up-regulated in the Huh6 cells that were directly co-cultured with HMDMs. The expressions of M-CSFR ligands (interleukin-34 and M-CSF) were also increased by co-culture with HMDMs. The proliferation of HepG2 cells (another hepatoblastoma cell line expressing M-CSFR) was inhibited by an M-CSFR inhibitor. M-CSFR was found to be highly expressed in the embryonal component and in recurrent lesions. The number of CD204-positive macrophages was also higher in the M-CSFR-positive areas than in the M-CSFR-negative areas. Thus, M-CSFR expression appeared to be induced by cell-cell contact with macrophages in hepatoblastoma cells, and M-CSFR inhibitor is potentially effective against M-CSFR-positive hepatoblastoma, especially recurrent cases.
MeSH term(s)	Cell Communication ; Cell Line, Tumor ; Hepatoblastoma/genetics ; Hepatoblastoma/metabolism ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Macrophages/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/metabolism
Chemical Substances	Receptor, Macrophage Colony-Stimulating Factor (EC 2.7.10.1)
Language	English
Publishing date	2022-05-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2190059-0
ISSN	1860-1499 ; 1860-1480
ISSN (online)	1860-1499
ISSN	1860-1480
DOI	10.1007/s00795-022-00323-y
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Article: Novel color M-mode echocardiography for non-invasive assessment of the intraventricular pressure in goats: Feasibility, repeatability, and the effect of sedation.

Mandour, Ahmed S / Samir, Haney / Yoshida, Tomohiko / Matsuura, Katsuhiro / Hamabe, Lina / Shimada, Kazumi / Abdelmageed, Hend A / Elbadawy, Mohamed / Uemura, Akiko / Takahashi, Ken / Watanabe, Gen / Tanaka, Ryou

Frontiers in veterinary science

2022 Volume 9, Page(s) 935437

Abstract: ... gradients (IVPG), estimated from color M-mode echocardiography (CMME) of the transmitral flow, have been ...

Abstract	Background: The intraventricular pressure difference (IVPD) and intraventricular pressure gradients (IVPG), estimated from color M-mode echocardiography (CMME) of the transmitral flow, have been introduced as novel indices for the evaluation of heart functions. Until now, no study demonstrated the feasibility of the CMME approach to measure IVPD and IVPG in any farm animals. The aim of this study was to assess the feasibility and repeatability of CMME-derived IVPD and IVPG variables in goats and explore the effect of sedation on the measured variables. Materials and methods: Sixteen male Shiba goats were included in this study and underwent conventional echocardiography. Eight goats were used in the repeatability of IVPD/IVPG variables. Another eight goats were used to evaluate the effect of sedation by xylazine on IVPD/IVPG measurements. CMME between the base and the apex of the left ventricle was carried out. The IVPD and IVPG were analyzed using in-house code software. The IVPD and IVPG were expressed as total, basal, mid-to-apical, mid, and apical segments. Data analysis including the imaging quality score (IQS), repeatability, variability, intraclass correlation coefficient (ICC), as well as the effect size of sedation on the measured variables was calculated. Results: IVPD and IVPG variables from CMME were feasible in all goats. Low to moderate variability of IVPD and IVPG variables was observed (CV 95% <25%) except for the apical IVPD and apical IVPG. The IVPD/IVPG measurements were repeatable without a significant effect of animal or time on the obtained measurements. The overall ICC was higher than 0.75 in all variables except for the apical segment. Xylazine administration reduced the total, basal, and mid parts of IVPD and IVPG with a large effect size (biserial ranked correlation; rc > 0.8). Conclusion: We reported, for the first time, IVPD and IVPG measurements by CMME in goats. The assessment of IVPD and IVPG by CMME is feasible in goats which can be evaluated in further cardiovascular or pharmacological studies in this species.
Language	English
Publishing date	2022-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2022.935437
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Article: Color M-Mode Echocardiography for Non-Invasive Assessment of the Intraventricular Pressure in Dogs Before and After Ductus Arteriosus Occlusion: A Retrospective Study.

Hirose, Miki / Mandour, Ahmed S / Goya, Seijirow / Hamabe, Lina / Matsuura, Katsuhiro / Yoshida, Tomohiko / Watanabe, Momoko / Shimada, Kazumi / Uemura, Akiko / Takahashi, Ken / Tanaka, Ryou

Frontiers in veterinary science

2022 Volume 9, Page(s) 908829

Abstract: ... gradients (IVPD and IVPG) by color M-mode echocardiography (CMME) is a promising method in diastolic ...

Abstract	Background: Novel non-invasive evaluation of the intraventricular pressure differences and gradients (IVPD and IVPG) by color M-mode echocardiography (CMME) is a promising method in diastolic function evaluation. Patent ductus arteriosus (PDA) is a congenital heart defect which is associated with increased preload. The present work provides a clinical trial for the assessment of IVPD and IVPG changes in dogs before and after surgical occlusion of PDA. Materials and methods: A total of 12 client-owned dogs were enrolled in this study. PDA was confirmed using echocardiography, and all dogs underwent PDA occlusion. Conventional echocardiography and CMME were conducted on each patient on the operation day (Pre-PDA) and 48 h after its occlusion (Post-PDA). The total IVPD and total IVPG, as well as segmental intraventricular pressure (basal, mid-to-apical, mid, and apical) were measured from Euler's equation using specific software (MATLAB). Data were analyzed for variability and for the difference between pre- and post-PDA. The effect of PDA occlusion on the measured variables was calculated using biserial ranked correlation (rc). Results: There was a significant reduction in end-diastolic volume, fraction shortening, stroke volume, and mitral inflow velocities (early and late) after PDA closure. CMME was feasible in all dogs, and the CMME indices showed moderate variability, except for the apical segment of IVPD and IVPG. After PDA closure, in comparison with the pre-PDA occlusion, there was a significant reduction in total IVPD (2.285 ± 0.374 vs. 1.748 ± 0.436 mmHg; Conclusion: The current clinical study revealed matched response of IVPD and IVPG to the reduced preload rather than left ventricular relaxation. This result is an initial step in the clinical utility of CMME-derived IVPD and IVPG measurements in the diastolic function evaluation in dogs with PDA that warrants further clinical studies.
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2022.908829
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Article ; Online: M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening.

Yamada, Hiroshi / Taniguchi, Satoshi / Shimojima, Masayuki / Tan, Long / Kimura, Miyuki / Morinaga, Yoshitomo / Fukuhara, Takasuke / Matsuura, Yoshiharu / Komeno, Takashi / Furuta, Yousuke / Saijo, Masayuki / Tani, Hideki

Viruses

2021 Volume 13, Issue 6

Abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case fatality rates of approximately 30%. There are few treatment options for SFTSV infection. SFTSV RNA synthesis is ...

Abstract	Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case fatality rates of approximately 30%. There are few treatment options for SFTSV infection. SFTSV RNA synthesis is conducted using a virus-encoded complex with RNA-dependent RNA polymerase activity that is required for viral propagation. This complex and its activities are, therefore, potential antiviral targets. A library of small molecule compounds was processed using a high-throughput screening (HTS) based on an SFTSV minigenome assay (MGA) in a 96-well microplate format to identify potential lead inhibitors of SFTSV RNA synthesis. The assay confirmed inhibitory activities of previously reported SFTSV inhibitors, favipiravir and ribavirin. A small-scale screening using MGA identified four candidate inhibitors that inhibited SFTSV minigenome activity by more than 80% while exhibiting less than 20% cell cytotoxicity with selectivity index (SI) values of more than 100. These included mycophenolate mofetil, methotrexate, clofarabine, and bleomycin. Overall, these data demonstrate that the SFTSV MGA is useful for anti-SFTSV drug development research.
MeSH term(s)	Antiviral Agents/pharmacology ; Cell Line ; Drug Evaluation, Preclinical/methods ; Genome, Viral ; HEK293 Cells ; High-Throughput Screening Assays/methods ; Humans ; Phlebovirus/drug effects ; Phlebovirus/genetics ; Severe Fever with Thrombocytopenia Syndrome
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-06-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13061061
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Article: Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats.

Yairo, Akira / Mandour, Ahmed S / Matsuura, Katsuhiro / Yoshida, Tomohiko / Ma, Danfu / Kitpipatkun, Pitipat / Kato, Konosuke / Cheng, Chieh-Jen / El-Husseiny, Hussein M / Tanaka, Takashi / Shimada, Kazumi / Hamabe, Lina / Uemura, Akiko / Takahashi, Ken / Tanaka, Ryou

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 8

Abstract: ... echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode ...

Abstract	Evaluation of diastolic function is a pivotal challenge due to limitations of the conventional echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular pressure difference (IVPD) and intraventricular pressure gradient (IVPG) in early diastole can be generated and are available as echocardiographic indices. These indices are expected to be useful for the early diagnosis of heart failure (HF), especially diastolic dysfunction. There have not been any studies demonstrating changes in IVPD and IVPG in response to changes in loading conditions in rats. Therefore, the present study aims to evaluate CMME-derived IVPD and IVPG changes in rats under various loading conditions. Twenty rats were included, divided into two groups for two different experiments, and underwent jugular vein catheterization under inhalational anesthetics. Conventional echocardiography, CMME, and 2D speckle tracking echocardiography were measured at the baseline (BL), after intravenous infusion of milrinone (MIL,
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11081403
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Article ; Online: Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats

Akira Yairo / Ahmed S. Mandour / Katsuhiro Matsuura / Tomohiko Yoshida / Danfu Ma / Pitipat Kitpipatkun / Konosuke Kato / Chieh-Jen Cheng / Hussein M. El-Husseiny / Takashi Tanaka / Kazumi Shimada / Lina Hamabe / Akiko Uemura / Ken Takahashi / Ryou Tanaka

Diagnostics, Vol 11, Iss 1403, p

2021 Volume 1403

Abstract: ... echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode ... Left ventricular IVPD and IVPG were calculated from color M-mode images and categorized into total, basal, mid ...

Abstract	Evaluation of diastolic function is a pivotal challenge due to limitations of the conventional echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular pressure difference (IVPD) and intraventricular pressure gradient (IVPG) in early diastole can be generated and are available as echocardiographic indices. These indices are expected to be useful for the early diagnosis of heart failure (HF), especially diastolic dysfunction. There have not been any studies demonstrating changes in IVPD and IVPG in response to changes in loading conditions in rats. Therefore, the present study aims to evaluate CMME-derived IVPD and IVPG changes in rats under various loading conditions. Twenty rats were included, divided into two groups for two different experiments, and underwent jugular vein catheterization under inhalational anesthetics. Conventional echocardiography, CMME, and 2D speckle tracking echocardiography were measured at the baseline (BL), after intravenous infusion of milrinone (MIL, n = 10), and after the infusion of hydroxyethyl starch (HES, n = 10). Left ventricular IVPD and IVPG were calculated from color M-mode images and categorized into total, basal, mid-to-apical, mid, and apical parts, and the percentage of the corresponding part was calculated. In comparison to the BL, the ejection fraction, mid-to-apical IVPG, mid IVPG, and apical IVPD were significantly increased after MIL administration ( p < 0.05); meanwhile, the end-diastolic volume, E-wave velocity, total IVPD, and basal IVPD were significantly increased with the administration of HES ( p < 0.05). The increase in mid-to-apical IVPD, mid IVPD, and apical IVPD indicated increased relaxation. A significant increase in basal IVPD reflected volume overloading by HES. CMME-derived IVPD and IVPG are useful tools for the evaluation of various loading conditions in rats. The approach used in this study provides a model for continuous data acquisition in chronic ...
Keywords	heart failure ; color m-mode echocardiography ; diastolic function ; preload ; intraventricular pressure ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Non-invasive assessment of left ventricular relaxation property using color M-mode-derived intraventricular pressure gradients in cats

Matsuura, Katsuo / Bach, Maiken B.T. / Takahashi, Ken / Willesen, Jakob L. / Koch, Jørgen / Tanaka, Ryou

Journal of veterinary cardiology. 2022 Mar. 31,

2022

Abstract: ... The study objectives were to evaluate color Doppler M-mode derived IVPG calculation in cats as a non ... M-mode images were used to estimate total and segmental IVPGs noninvasively. The total IVPG was 0.76 ... of color Doppler M-mode estimated IVPGs in feline cardiology. ...

Abstract	Diastolic dysfunction is an early clinical feature of feline hypertrophic cardiomyopathy (HCM). The left ventricular filling in early diastole is facilitated by the diastolic intraventricular pressure gradient (IVPG). The study objectives were to evaluate color Doppler M-mode derived IVPG calculation in cats as a non-invasive assessment of the left ventricular relaxation property, to determine the normal ranges of peak IVPG in cats and investigate the influence of left ventricular function and heart rate (HR). 106 client-owned apparently healthy cats. Prospective cross-sectional study. Quantitative analysis of color Doppler M-mode images were used to estimate total and segmental IVPGs noninvasively. The total IVPG was 0.76 mmHg (95% reference interval (RI): 0.28–1.29 mmHg), the basal IVPG 0.34 mmHg (95%RI: 0.07–0.63 mmHg) and the mid-apical IVPG 0.42mmHg (95%RI: 0.15–0.71 mmHg). Total and segmental IVPG increased with HR (P <0.003), while segmental percent IVPG was HR independent. A short isovolumic relaxation time (IVRT) and a high mitral annular velocity in early diastole were associated with an increase in total IVPG (P = 0.008 and P = 0.009, respectively) adjusted for HR. An increase in IVPG was associated with an increase in mitral inflow velocity (P <0.001). Feline IVPGs increases with HR and a short IVRT, which was believed to be a normal physiologic adrenergic response associated with an increased sympathetic tone. Future studies of segmental IVPG changes in feline HCM are needed to evaluate the clinical applicability of color Doppler M-mode estimated IVPGs in feline cardiology.
Keywords	cardiomyopathy ; cats ; color ; cross-sectional studies ; heart rate ; quantitative analysis
Language	English
Dates of publication	2022-0331
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2198278-8
ISSN	1875-0834 ; 1760-2734
ISSN (online)	1875-0834
ISSN	1760-2734
DOI	10.1016/j.jvc.2022.03.006
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Response to letter to editor from Dr O.M.P. Jolobe.

Matsuura, H / Yamaji, Y

QJM : monthly journal of the Association of Physicians

2017 Volume 111, Issue 5, Page(s) 351

Language	English
Publishing date	2017-11-21
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcx212
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Article: M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening

Viruses. 2021 June 03, v. 13, no. 6

2021

Abstract	Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case fatality rates of approximately 30%. There are few treatment options for SFTSV infection. SFTSV RNA synthesis is conducted using a virus-encoded complex with RNA-dependent RNA polymerase activity that is required for viral propagation. This complex and its activities are, therefore, potential antiviral targets. A library of small molecule compounds was processed using a high-throughput screening (HTS) based on an SFTSV minigenome assay (MGA) in a 96-well microplate format to identify potential lead inhibitors of SFTSV RNA synthesis. The assay confirmed inhibitory activities of previously reported SFTSV inhibitors, favipiravir and ribavirin. A small-scale screening using MGA identified four candidate inhibitors that inhibited SFTSV minigenome activity by more than 80% while exhibiting less than 20% cell cytotoxicity with selectivity index (SI) values of more than 100. These included mycophenolate mofetil, methotrexate, clofarabine, and bleomycin. Overall, these data demonstrate that the SFTSV MGA is useful for anti-SFTSV drug development research.
Keywords	Huaiyangshan banyangvirus ; Orthobunyavirus ; RNA ; RNA-directed RNA polymerase ; antiviral agents ; cytotoxicity ; death ; disease severity ; drug development ; lead ; methotrexate
Language	English
Dates of publication	2021-0603
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13061061
Database	NAL-Catalogue (AGRICOLA)

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