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  1. Article: [Besprechung von:] Rowley, J. C. R. and P. K. Trivedi: Econometrics of investment. London, New York 1975

    Adams, F. Gerard / Rowley, J. C. R / Trivedi, P. K

    Journal of economic literature Vol. 15, No. 4 , p. 1-1369

    Wiley Monographs in Applied Econometrics

    1977  Volume 15, Issue 4, Page(s) 1–1369

    Author's details F. Gerard Adams
    Language Undetermined
    Publisher Assoc
    Publishing place Nashville, Tenn
    Document type Article
    ZDB-ID 3076-4 ; 2010159-4
    ISSN 0022-0515
    ISSN 0022-0515
    Database ECONomics Information System

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  2. Article ; Online: Integrated Pathogenesis of Vascular and Cardiac Valve Disease.

    Cashman, Timothy J / Fitzgibbons, Timothy P / Trivedi, Chinmay M

    Circulation research

    2023  Volume 133, Issue 6, Page(s) 481–483

    MeSH term(s) Humans ; Heart Valve Diseases ; Heart Valves ; Transcription Factors
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.323451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Evaluation of Type 1 Interferon Related Genes in Male and Female-Matched, SARS-CoV-2 Infected Individuals Early in the COVID-19 Pandemic.

    Huecksteadt, Tom P / Myers, Elizabeth J / Aamodt, Samuel E / Trivedi, Shubhanshi / Warren, Kristi J

    Viruses

    2024  Volume 16, Issue 3

    Abstract: SARS-CoV-2 infection has claimed just over 1.1 million lives in the US since 2020. Globally, the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in 6.9 million individuals to date. Much of the early literature showed ... ...

    Abstract SARS-CoV-2 infection has claimed just over 1.1 million lives in the US since 2020. Globally, the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in 6.9 million individuals to date. Much of the early literature showed that SARS-CoV-2 immunity was defective in the early stages of the pandemic, leading to heightened and, sometimes, chronic inflammatory responses in the lungs. This lung-associated 'cytokine storm' or 'cytokine release syndrome' led to the need for oxygen supplementation, respiratory distress syndrome, and mechanical ventilation in a relatively high number of people. In this study, we evaluated circulating PBMC from non-hospitalized, male and female, COVID-19+ individuals over the course of infection, from the day of diagnosis (day 0) to one-week post diagnosis (day 7), and finally 4 weeks after diagnosis (day 28). In our early studies, we included hospitalized and critically care patient PBMC; however, most of these individuals were lymphopenic, which limited our assessments of their immune integrity. We chose a panel of 30 interferon-stimulated genes (ISG) to evaluate by PCR and completed flow analysis for immune populations present in those PBMC. Lastly, we assessed immune activation by stimulating PBMC with common TLR ligands. We identified changes in innate cells, primarily the innate lymphoid cells (ILC, NK cells) and adaptive immune cells (CD4+ and CD8+ T cells) over this time course of infection. We found that the TLR-7 agonist, Resiquimod, and the TLR-4 ligand, LPS, induced significantly better IFNα and IFNγ responses in the later phase (day 28) of SARS-CoV-2 infection in those non-hospitalized COVID-19+ individuals as compared to early infection (day 0 and day 7). We concluded that TLR-7 and TLR-4 agonists may be effective adjuvants in COVID-19 vaccines for mounting immunity that is long-lasting against SARS-CoV-2 infection.
    MeSH term(s) Humans ; Male ; Female ; COVID-19 ; SARS-CoV-2/genetics ; Pandemics ; Immunity, Innate ; COVID-19 Vaccines ; Toll-Like Receptor 4/genetics ; Leukocytes, Mononuclear ; Toll-Like Receptor 7 ; Lymphocytes ; Interferons ; Cytokine Release Syndrome
    Chemical Substances COVID-19 Vaccines ; Toll-Like Receptor 4 ; Toll-Like Receptor 7 ; Interferons (9008-11-1)
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outcomes After Initiation of Medications for Alcohol Use Disorder at Hospital Discharge.

    Bernstein, Eden Y / Baggett, Travis P / Trivedi, Shrunjal / Herzig, Shoshana J / Anderson, Timothy S

    JAMA network open

    2024  Volume 7, Issue 3, Page(s) e243387

    Abstract: Importance: US Food and Drug Administration-approved medications for alcohol use disorder (MAUD) are significantly underused. Hospitalizations may provide an unmet opportunity to initiate MAUD, but few studies have examined clinical outcomes of patients ...

    Abstract Importance: US Food and Drug Administration-approved medications for alcohol use disorder (MAUD) are significantly underused. Hospitalizations may provide an unmet opportunity to initiate MAUD, but few studies have examined clinical outcomes of patients who initiate these medications at hospital discharge.
    Objective: To investigate the association between discharge MAUD initiation and 30-day posthospitalization outcomes.
    Design, setting, and participants: This cohort study was conducted among patients with Medicare Part D who had alcohol-related hospitalizations in 2016. Data were analyzed from October 2022 to December 2023.
    Exposures: Discharge MAUD initiation was defined as oral naltrexone, acamprosate, or disulfiram pharmacy fills within 2 days of discharge.
    Main outcomes: The primary outcome was a composite of all-cause mortality or return to hospital (emergency department visits and hospital readmissions) within 30 days of discharge. Secondary outcomes included these components separately, return to hospital for alcohol-related diagnoses, and primary care or mental health follow-up within 30 days of discharge. Propensity score 3:1 matching and modified Poisson regressions were used to compare outcomes between patients who received and did not receive discharge MAUD.
    Results: There were 6794 unique individuals representing 9834 alcohol-related hospitalizations (median [IQR] age, 54 [46-62] years; 3205 hospitalizations among females [32.6%]; 1754 hospitalizations among Black [17.8%], 712 hospitalizations among Hispanic [7.2%], and 7060 hospitalizations among White [71.8%] patients). Of these, 192 hospitalizations (2.0%) involved discharge MAUD initiation. After propensity matching, discharge MAUD initiation was associated with a 42% decreased incidence of the primary outcome (incident rate ratio, 0.58 [95% CI, 0.45 to 0.76]; absolute risk difference, -0.18 [95% CI, -0.26 to -0.11]). These findings were consistent among secondary outcomes (eg, incident rate ratio for all-cause return to hospital, 0.56 [95% CI, 0.43 to 0.73]) except for mortality, which was rare in both groups (incident rate ratio, 3.00 [95% CI, 0.42 to 21.22]). Discharge MAUD initiation was associated with a 51% decreased incidence of alcohol-related return to hospital (incident rate ratio, 0.49 [95% CI, 0.34 to 0.71]; absolute risk difference, -0.15 [95% CI, -0.22 to -0.09]).
    Conclusion and relevance: In this cohort study, discharge initiation of MAUD after alcohol-related hospitalization was associated with a large absolute reduction in return to hospital within 30 days. These findings support efforts to increase uptake of MAUD initiation at hospital discharge.
    MeSH term(s) Female ; Humans ; Aged ; United States/epidemiology ; Middle Aged ; Patient Discharge ; Alcoholism/drug therapy ; Alcoholism/epidemiology ; Cohort Studies ; Medicare ; Hospitals
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.3387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An application of the hybrid AHP-PROMETHEE approach to evaluate the severity of the factors influencing road accidents.

    Trivedi, Priyank / Shah, Jiten / Moslem, Sarbast / Pilla, Francesco

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21187

    Abstract: The evaluation of the severity of the factors influencing road accidents with a detailed severity distribution is critical to plan evidence-based road safety improvements and strategies. However, currently available studies use statistical and machine ... ...

    Abstract The evaluation of the severity of the factors influencing road accidents with a detailed severity distribution is critical to plan evidence-based road safety improvements and strategies. However, currently available studies use statistical and machine learning (ML) models to evaluate the severity of factors causing road accidents without a detailed severity distribution. Further, most of these available models require significant pre-data processing and have certain data-centric limitations. However, the multi criteria decision-making (MCDM) techniques have the potential to combine expert opinions for robust analysis without any pre-data processing calculations. Thus, this study uses a hybrid analytic hierarchy process (AHP) and the preference ranking organisation method for enrichment evaluation (PROMETHEE) approach to analyse the severity of factors and characteristics that influence road accidents within the Gujarat state, using injury types as criteria and minor road accident influencing factors as alternatives. These 82 minor factors have been further characterised into 18 characteristics and 4 major factors. Further, AHP integrated 40 expert inputs to determine criterion weights, while PROMETHEE ranked all minor variables. Then, after applying k-mean clustering, each ranked factor has been classified as very severe, moderately severe, or severe. The result clearly highlights that overspeeding, male gender, and clear weather conditions have been concluded to be the highly severe factors for Gujarat state. Thus, by providing a clear severity analysis and distribution of factors influencing road accidents, the proposed research may help government stakeholders, researchers, and politicians build severity-based road safety reforms and strategies with clarity.
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Besprechung von:] Rowley, J. C. R. and P. K. Trivedi: Econometrics of investment. Chichester 1975. Brechling F.: Investment and employment decisions. Manchester 1975

    Hebden, Julia / Brechling, F / Rowley, J. C. R / Trivedi, P. K

    The economic journal : the journal of the Royal Economic Society Vol. 86 , p. 393-396

    1976  Volume 86, Page(s) 393–396

    Author's details Julia Hebden
    Publisher Blackwell
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 3025-9
    Database ECONomics Information System

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  7. Article ; Online: Lasiurus sindicus Henr., a key perennial fodder grass for desert ecosystem

    Rani, Reena / Singh, J. P. / Sanyal, Archana / Rajora, M. P. / Trivedī, Aṅkita

    Arid Land Research and Management. 2023 Jan. 2, v. 37, no. 1 p.1-19

    2023  

    Abstract: Lasiurus sindicus Henr. is one of the most prominent grass species, occupying 80% area of the desert grassland. Average dry forage production of L. sindicus at the mature stage is 2.5–3.5 t ha⁻¹ (with 93% dry matter, 4.6% crude protein, 31% crude fiber, ... ...

    Abstract Lasiurus sindicus Henr. is one of the most prominent grass species, occupying 80% area of the desert grassland. Average dry forage production of L. sindicus at the mature stage is 2.5–3.5 t ha⁻¹ (with 93% dry matter, 4.6% crude protein, 31% crude fiber, and 4.5% ash) and the carrying capacity of L. sindicus grasslands ranges from 0.8 to 1.2 active cattle units ha⁻¹ in the normal rainfall years. A large number of diazotrophs, as well as endophytes, have been found associated with L. sindicus rhizosphere, which play a crucial role in maintaining the plant-soil ecological interaction. L. sindicus has a prominent place as a perennial component in silvo-pastural, agro-pastural, agro-silvo-pastural, and horti-pastural production systems. Considering its importance, much emphasis should be given to utilization of L. sindicus based grasslands according to their carrying capacity and to avoid overgrazing.
    Keywords administrative management ; arid lands ; cattle ; crude fiber ; crude protein ; ecological competition ; ecosystems ; endophytes ; forage ; forage production ; grasses ; grasslands ; nitrogen-fixing bacteria ; rain ; research ; rhizosphere ; Carrying capacity ; desert ; Lasiurus sindicus and overgrazing
    Language English
    Dates of publication 2023-0102
    Size p. 1-19.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1490766-5
    ISSN 1532-4990 ; 1532-4982
    ISSN (online) 1532-4990
    ISSN 1532-4982
    DOI 10.1080/15324982.2022.2060149
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: When to settle for SETTLE! A lesson learned from our cases.

    Nagarjun, Bangalore Rammohan / Mehta, Shailee / Gandhi, Jahnavi / Trivedi, Priti / Rathod, Priyank

    Thyroid research

    2024  Volume 17, Issue 1, Page(s) 6

    Abstract: Spindle epithelial tumor with thymic like elements (SETTLE) is a biphasic tumor composed of epithelial and spindle cell components. It is an uncommon indolent tumor arising in the thyroid gland and most commonly affects the children and young adults. ... ...

    Abstract Spindle epithelial tumor with thymic like elements (SETTLE) is a biphasic tumor composed of epithelial and spindle cell components. It is an uncommon indolent tumor arising in the thyroid gland and most commonly affects the children and young adults. This entity is mostly overlooked because of its rarity and diagnostic difficulty on morphology. We discuss two cases of SETTLE with varied presentation, diagnostic challenges and lessons learnt from them.SETTLE should be considered as a differential especially when dealing with a thyroid lesion in young and adolescent. The article discusses the histologic details and common mimickers to be borne in mind aiding in arrival at the final diagnosis on biopsy specimens.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2454440-1
    ISSN 1756-6614
    ISSN 1756-6614
    DOI 10.1186/s13044-023-00189-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: No skin off your back: the sampling and extraction of sebum for metabolomics.

    Géhin, C / Tokarska, J / Fowler, S J / Barran, P E / Trivedi, D K

    Metabolomics : Official journal of the Metabolomic Society

    2023  Volume 19, Issue 4, Page(s) 21

    Abstract: Introduction: Sebum-based metabolomics (a subset of "sebomics") is a developing field that involves the sampling, identification, and quantification of metabolites found in human sebum. Sebum is a lipid-rich oily substance secreted by the sebaceous ... ...

    Abstract Introduction: Sebum-based metabolomics (a subset of "sebomics") is a developing field that involves the sampling, identification, and quantification of metabolites found in human sebum. Sebum is a lipid-rich oily substance secreted by the sebaceous glands onto the skin surface for skin homeostasis, lubrication, thermoregulation, and environmental protection. Interest in sebomics has grown over the last decade due to its potential for rapid analysis following non-invasive sampling for a range of clinical and environmental applications.
    Objectives: To provide an overview of various sebum sampling techniques with their associated challenges. To evaluate applications of sebum for clinical research, drug monitoring, and human biomonitoring. To provide a commentary of the opportunities of using sebum as a diagnostic biofluid in the future.
    Methods: Bibliometric analyses of selected keywords regarding skin surface analysis using the Scopus search engine from 1960 to 2022 was performed on 12th January 2023. The published literature was compartmentalised based on what the work contributed to in the following areas: the understanding about sebum, its composition, the analytical technologies used, or the purpose of use of sebum. The findings were summarised in this review.
    Results: Historically, about 15 methods of sampling have been used for sebum collection. The sample preparation approaches vary depending on the analytes of interest and are summarised. The use of sebum is not limited to just skin diseases or drug monitoring but also demonstrated for other systemic disease. Most of the work carried out for untargeted analysis of metabolites associated with sebum has been in the recent two decades.
    Conclusion: Sebum has a huge potential beyond skin research and understanding how one's physiological state affects or reflects on the skin metabolome via the sebaceous glands itself or by interactions with sebaceous secretion, will open doors for simpler biomonitoring. Sebum acts as a sink to environmental metabolites and has applications awaiting to be explored, such as biosecurity, cross-border migration, localised exposure to harmful substances, and high-throughput population screening. These applications will be possible with rapid advances in volatile headspace and lipidomics method development as well as the ability of the metabolomics community to annotate unknown species better. A key issue with skin surface analysis that remains unsolved is attributing the source of the metabolites found on the skin surface before meaningful biological interpretation.
    MeSH term(s) Humans ; Sebum ; Metabolomics ; Sebaceous Glands/metabolism
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250617-2
    ISSN 1573-3890 ; 1573-3882
    ISSN (online) 1573-3890
    ISSN 1573-3882
    DOI 10.1007/s11306-023-01982-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Medicare Advantage Enrollment and Disenrollment Among Persons With Alzheimer Disease and Related Dementias.

    James, Hannah O / Trivedi, Amal N / Meyers, David J

    JAMA health forum

    2023  Volume 4, Issue 9, Page(s) e233080

    Abstract: ... from their Medicare Advantage contract to traditional Medicare (4.4% vs 3.2% in 2017-2018; P < .001) in adjusted analyses ...

    Abstract Importance: Large enrollment growth has been observed in the Medicare Advantage program, but less is known about enrollment patterns among persons with Alzheimer disease and related dementias (ADRD).
    Objective: To evaluate patterns in Medicare Advantage enrollment and disenrollment among beneficiaries with or without ADRD.
    Design, setting, and participants: This cross-sectional study used 6 national data sources between January 1, 2011, and December 31, 2018. Analyses were performed between June 2021 and August 2022. The cohort comprised US Medicare beneficiaries with acute or postacute care utilization between 2013 and 2018.
    Exposure: ADRD diagnosis from an acute or postacute care encounter Medicare data source.
    Main outcomes and measures: Enrollment in Medicare Advantage, disenrollment from Medicare Advantage to traditional Medicare, and contract exit (leaving a Medicare Advantage contract for traditional Medicare or a different Medicare Advantage contract).
    Results: The 32 796 872 Medicare beneficiaries in the cohort had a mean (SD) age of 74.0 (12.5) years and included 18 228 513 females (55.6%). Enrollment in Medicare Advantage among beneficiaries with ADRD increased from 24.7% (95% CI, 24.7%-24.8%) in 2013 to 33.0% (95% CI, 32.9%-33.1%) in 2018, an absolute increase of 8.3 percentage points and a 33.4% relative increase after adjusting for demographic characteristics, comorbid conditions, and utilization and including county fixed effects. Among beneficiaries without ADRD, enrollment in Medicare Advantage increased by 8.2 percentage points from 27.6% (95% CI, 27.6%-27.6%) in 2013 to 35.8% (95% CI, 35.8%-35.8%) in 2018, a 29.7% relative increase over the study period. Beneficiaries with ADRD were 1.4 times as likely to disenroll from their Medicare Advantage contract to traditional Medicare (4.4% vs 3.2% in 2017-2018; P < .001) in adjusted analyses. Regardless of ADRD status, beneficiaries had similar rates of switching to a new Medicare Advantage contract. Differences in contract exit rates were associated with higher rates of disenrollment from Medicare Advantage to traditional Medicare among beneficiaries with ADRD vs those without ADRD (16.3% [95% CI, 16.2%-16.3%] vs 15.1% [95% CI, 15.1%-15.1%]). Beneficiaries with ADRD and dual eligibility for Medicaid enrollment had higher rates of contract exit than those without dual eligibility (19.7% [95% CI, 19.6%-19.7%] vs 14.9% [95% CI, 14.8%-14.9%]), and these differences were even greater than those among beneficiaries without ADRD and with and without dual-eligibility status, respectively (18.3% [95% CI, 18.2%-18.3%] vs 13.8% [95% CI, 13.7%-13.8%]).
    Conclusions and relevance: In this cross-sectional study of the Medicare population with acute and postacute care use, beneficiaries with ADRD had increasing enrollment in the Medicare Advantage program, proportional to the growth in overall enrollment, but their disenrollment from Medicare Advantage in the following year remained higher compared with beneficiaries without ADRD. The findings highlight the need to understand the factors associated with higher disenrollment rates and determine whether such rates reflect access or quality challenges for beneficiaries with ADRD.
    MeSH term(s) Aged ; United States/epidemiology ; Female ; Humans ; Medicare Part C ; Alzheimer Disease/epidemiology ; Cross-Sectional Studies ; Eligibility Determination ; Medicaid
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.3080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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