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Article: Ray of Hope for Decreased Ovarian Reserve: India's First Two Spontaneous Conceptions After Autologous Bone Marrow-Derived Stem Cells Therapy for Ovarian Rejuvenation.

Tandulwadkar, Sunita / Mishra, Sneha / Jain, Himanshi / Mane, Nupur

Journal of obstetrics and gynaecology of India

2022 Volume 72, Issue Suppl 2, Page(s) 458–460

Language	English
Publishing date	2022-09-07
Publishing country	India
Document type	Case Reports
ZDB-ID	410688-x
ISSN	0971-9202 ; 0022-3190
ISSN	0971-9202 ; 0022-3190
DOI	10.1007/s13224-022-01682-3
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Article ; Online: The S-S bridge mutation between the A2 and A4 loops (T416C-I432C) of Cel7A of

Dodda, Subba Reddy / Hossain, Musaddique / Mondal, Sudipa / Das, Shalini / Khator Jain, Sneha / Aikat, Kaustav / Mukhopadhyay, Sudit S

Applied and environmental microbiology

2024 Volume 90, Issue 4, Page(s) e0232923

Abstract: Disulfide bonds are important for maintaining the structural conformation and stability of the protein. The introduction of the disulfide bond is a promising strategy to increase the thermostability of the protein. In this report, cysteine residues are ... ...

Abstract	Disulfide bonds are important for maintaining the structural conformation and stability of the protein. The introduction of the disulfide bond is a promising strategy to increase the thermostability of the protein. In this report, cysteine residues are introduced to form disulfide bonds in the Glycoside Hydrolase family GH 7 cellobiohydrolase (GH7 CBHs) or Cel7A of
MeSH term(s)	Aspergillus fumigatus/genetics ; Aspergillus fumigatus/metabolism ; Cellulose 1,4-beta-Cellobiosidase/genetics ; Cellulose 1,4-beta-Cellobiosidase/metabolism ; Cysteine ; Mutation ; Disulfides ; Enzyme Stability
Chemical Substances	Cellulose 1,4-beta-Cellobiosidase (EC 3.2.1.91) ; Cysteine (K848JZ4886) ; Disulfides
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.02329-23
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Article: A Survey to Assess the Impact of COVID-19 Pandemic on Lifestyle in an Adult Age Group.

Sharma, Dharmendra / Alekar, Asmita / Pawar, Sneha / Jain, Annie

Alternative therapies in health and medicine

2022 Volume 29, Issue 3, Page(s) 60–66

Abstract: ... created a survey with 13 multiple-choice questions.: Results: The pandemic has taken a toll on people's ... affected people's mental health.: Conclusions: Efforts need to be made by individuals to focus not only ...

Abstract	Context: A healthy lifestyle has been the need of the hour during the COVID 19 pandemic. Analyzing the current lifestyle patterns of many individuals can be the basis for finding solutions toward building a healthy future for India. Objectives: The study intended to evaluate the current lifestyles of adults in an urban setting in the midst of a pandemic and to examine the diseases that people could face with respect to their current lifestyles. Design: The research team performed a cross-sectional study. Setting: The survey was conducted in an urban setting in the Pimpri Chinchwad area of Pune, India. Participants: Participants were 500 men and women between the ages of 18 and 25. Outcome measures: The research team created a survey with 13 multiple-choice questions. Results: The pandemic has taken a toll on people's mental and physical health. Social distancing and staying indoors for long periods are factors that have affected people's mental health. Conclusions: Efforts need to be made by individuals to focus not only on their physical health but also on their mental health.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Adolescent ; Young Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics ; Cross-Sectional Studies ; India/epidemiology ; Life Style
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Treatment effect of canagliflozin for patients on therapy for heart failure: Pooled analysis of the CANVAS program and CREDENCE trial.

Jain, Sneha S / Yu, Jie / Arnott, Clare / Neal, Bruce / Perkovic, Vlado / Neuen, Brendon L / Jardine, Meg / Mahaffey, Kenneth W

International journal of cardiology

2023 Volume 395, Page(s) 131444

Abstract: Background: Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that has been shown to reduce cardiovascular events in diabetic patients with and without heart failure (HF). Whether the clinical benefits and safety profile of canagliflozin are ... ...

Abstract	Background: Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that has been shown to reduce cardiovascular events in diabetic patients with and without heart failure (HF). Whether the clinical benefits and safety profile of canagliflozin are different in those on a beta blocker and an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (BB + RAASi) is unknown. Methods: We pooled participants with HF at baseline from the CANVAS Program and CREDENCE trial and assessed major adverse cardiovascular events and its components; hospitalization for heart failure (HHF); HHF or CV death; all-cause mortality; a renal composite; and a combined renal and CV composite. Results: Of 14,543 participants, 2113 had HF at baseline, and 1280 were on BB + RAASi. In those with a history of HF, participants on BB + RAASi therapy were more likely to have coronary atherosclerotic disease (82 vs 72%, p < 0.001), history of myocardial infarction (42 vs 29%, p < 0.001), higher mean body mass index (34 vs 32 kg/m Conclusion: Canagliflozin mostly improved CV and kidney outcomes in participants with a history of HF irrespective of use of BB + RAASi at baseline, with possible greater benefit on HHF/CV death in participants on BB + RAASi.
MeSH term(s)	Humans ; Canagliflozin/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Cardiovascular Diseases ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/chemically induced ; Myocardial Infarction/drug therapy
Chemical Substances	Canagliflozin (0SAC974Z85) ; Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2023-10-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131444
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Article ; Online: Behenic Acid as a multi-target inhibiting antibacterial phytochemical against

Ravi, Lokesh / Kumar K, Ajith / G R, Shree Kumari / Mathew, Jesna / S, Harshitha / Panda, Mukti / S, Shivani / Paul, Ayona / Ts, Chandana / Anil, Aswani / J K, Megha / Mukherjee, Taanusiya / Bhattacharjee, Sneha / Raveendran Nair, Manu / V, Subhanjan / V, Mohanasrinivasan / Jain, Pratishtha

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–16

Abstract: Multi-Target Inhibitors are the upcoming frontrunners of the antibiotic world as they provide significant advantage over drug resistance development. Antibacterial drug discovery research, requires more robust and innovative approaches such as multi- ... ...

Abstract	Multi-Target Inhibitors are the upcoming frontrunners of the antibiotic world as they provide significant advantage over drug resistance development. Antibacterial drug discovery research, requires more robust and innovative approaches such as multi-target inhibiting drugs, which over comes the innate hurdles in the field of antibiotics. In this current study, a curated set of 5,112 phytochemical molecules were virtually screened for its multi-target inhibition potential against 7 antibacterial protein drug-targets. Behenic Acid was identified to be the most significant phytochemical molecule with potential to inhibit Catalase Peroxidase (KatG), Adenylosuccinate Synthetase (ADSS) and Pyridoxine 5'-Phosphate Synthase (PdxJ), based on SeeSAR and AutoDock Vina results. Further, the inhibition potential of Behenic Acid was validated using 500 ns Molecular Dynamics (MD) Simulation based on Desmond analysis. Behenic Acid was further investigated in-vitro using agar-well-diffusion and Minimal Inhibitory Concentration (MIC) assay, where it demonstrated 20 ± 1mm zone-of-inhibition and 50 µg/ml MIC value against both
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2317988
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Zs.A 2093: Show issues

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Article ; Online: Biosorption of arsenic (III) from aqueous solution using calcium alginate immobilized dead biomass of Acinetobacter sp. strain Sp2b.

Khandelwal, Renu / Keelka, Sneha / Jain, Neha / Jain, Prachi / Kumar Sharma, Mukesh / Kaushik, Pallavi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9972

Abstract: This study presents a novel biosorbent developed by immobilizing dead Sp2b bacterial biomass into calcium alginate (CASp2b) to efficiently remove arsenic ( ... ...

Abstract	This study presents a novel biosorbent developed by immobilizing dead Sp2b bacterial biomass into calcium alginate (CASp2b) to efficiently remove arsenic (As
MeSH term(s)	Alginates/chemistry ; Alginates/metabolism ; Acinetobacter/metabolism ; Acinetobacter/genetics ; Arsenic/metabolism ; Biomass ; Water Pollutants, Chemical/metabolism ; Biodegradation, Environmental ; Adsorption ; Kinetics ; Hydrogen-Ion Concentration ; Water Purification/methods ; Temperature ; Thermodynamics
Chemical Substances	Alginates ; Arsenic (N712M78A8G) ; Water Pollutants, Chemical
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60329-7
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Article ; Online: Comparative assessment of dentin removal following hand and rotary instrumentation in primary molars using cone-beam computed tomography.

Musale, Prasad K / Jain, Krutika R / Kothare, Sneha S

Journal of the Indian Society of Pedodontics and Preventive Dentistry

2019 Volume 37, Issue 1, Page(s) 80–86

Abstract: Objective: Pediatric endodontics has witnessed many advances in recent years, thus facilitating a faster and efficient treatment option in root canal therapy in children. This in vitro evaluation aims to determine the amount of dentin removal in primary ...

Abstract	Objective: Pediatric endodontics has witnessed many advances in recent years, thus facilitating a faster and efficient treatment option in root canal therapy in children. This in vitro evaluation aims to determine the amount of dentin removal in primary mandibular first and second molars instrumented with hand and rotary files using cone-beam computed tomography (CBCT). Materials and method: Sixty primary mandibular molars were divided into two groups: Group I was prepared by manual instrumentation using K-type files and Group II was prepared with rotary instrumentation using 0.04 Hero Shaper Classics. Both these groups were further divided into two subgroups, namely (a) primary mandibular first molar and (b) primary mandibular second molar. All the root canals were prepared up to size 30 using the stepback technique. They were mounted on silicone-based impression material and subjected to CBCT scans for the evaluation of dentin removal before and after instrumentation. Dentin removal was calculated by superimposing images using the InVivo 5.1 Anatomage software. Data were statistically analyzed using independent samples t- test. Results: An average amount of dentin removed was found to be significantly higher in manual instrumentation compared to rotary instrumentation in both primary mandibular first and second molars (P < 0.001). Conclusions: Rotary technique serves as an efficient alternative to the traditional manual instrumentation by overcoming its shortcomings in terms of conservation of the remaining dentin thickness and the time required for its preparation.
MeSH term(s)	Cone-Beam Computed Tomography/methods ; Dentin/surgery ; Humans ; In Vitro Techniques ; Molar/diagnostic imaging ; Molar/surgery ; Radiography, Dental/methods ; Root Canal Preparation/instrumentation ; Root Canal Preparation/methods ; Tooth, Deciduous/surgery
Language	English
Publishing date	2019-02-25
Publishing country	India
Document type	Comparative Study ; Journal Article
ZDB-ID	1425154-1
ISSN	1998-3905 ; 0970-4388
ISSN (online)	1998-3905
ISSN	0970-4388
DOI	10.4103/JISPPD.JISPPD_210_18
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Article: Non-COVID-19 Cutaneous Mucormycosis from a Plastic Surgical Perspective

Brajesh, Vimalendu / Sharma, Sneha / Aggarwal, Aditya / Singh, Sukhdeep / Mahendru, Sanjay / Singh, Hardeep / Jain, Ankit / Jain, Rahul / Khazanchi, Rakesh Kumar

Indian Journal of Plastic Surgery

2023 Volume 56, Issue 04, Page(s) 350–356

Abstract: ... to this infection's rarity and aggressive course, it is essential to initiate prompt multidisciplinary management ...

Abstract	Background: Cutaneous mucormycosis is a rare and fulminant infection associated with high mortality. Plastic surgeons come across this infection in the settings of road traffic accidents, surgical site infections, and as a secondary infection with underlying bacterial soft tissue infections. Due to this infection's rarity and aggressive course, it is essential to initiate prompt multidisciplinary management at the first presentation. With this study, we aim to present a protocol for managing the condition. Methods: This is a retrospective observational study of patients with cutaneous mucormycosis managed at a tertiary care hospital from January 1, 2016 to November 30, 2022 excluding patients with mucormycosis who tested positive for coronavirus disease 2019. Results: Of 24 patients, 22 were males, and most were in the age group of 41 to 60 years. Sixteen patients survived and five out of eight deceased had comorbidities, six presented primarily without prior debridement, and six had trunk involvement. Conclusion: A high index of clinical suspicion is necessary for early diagnosis and management of patients with invasive cutaneous mucormycosis. A multidisciplinary approach with appropriate medical and surgical management can improve outcomes in cases that otherwise carry a high mortality rate.
Keywords	mucormycosis ; fungal infection ; cutaneous mucormycosis ; invasive cutaneous mucormycosis
Language	English
Publishing date	2023-07-28
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2118680-7
ISSN	1998-376X ; 0970-0358
ISSN (online)	1998-376X
ISSN	0970-0358
DOI	10.1055/s-0043-1771294
Database	Thieme publisher's database

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Article: Mini-Incision Parotidectomy-Our Technique.

Nair, Satish / Aishwarya, J G / Jain, Aditya / Pavithra, V / Mohan, Sneha

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2021 Volume 74, Issue Suppl 3, Page(s) 6174–6179

Abstract: ... Frey's syndrome. Patient related quality of life (QOL) outcomes were assessed in terms of post-operative pain ... with Frey's syndrome. Mean post-operative pain score at 0, 6 and 24 h were 4.8, 3.4 and 1.8 out of 10 respectively ...

Abstract	Traditional parotidectomy incision was devised by Blair (1912) which was modified by Bailey (1941). Over the years various approaches and techniques have evolved to improve the aesthetic outcome and at the same time for complete disease clearance with reduced complications. In this study, we evaluated the feasibility of our mini-incision parotidectomy technique along with the surgical and quality of life (QOL) outcomes. This prospective case series was conducted at Apollo Hospitals, Bangalore over a period of 2 years (June 2018-August 2020) and includes 20 patients. The surgical outcomes were assessed in terms of feasibility of mini-incision technique with respect to levels of parotid involved and functional outcomes in terms of presence or absence of complications like facial palsy (temporary or permanent), seroma and Frey's syndrome. Patient related quality of life (QOL) outcomes were assessed in terms of post-operative pain score, patient comfort score and cosmetic score by using numerical rating scale-11 (NRS-11). The mini-incision parotidectomy technique is feasible for lesions in all the parotid levels and conversion or lengthening of incision was not needed in any of the cases. 2(10%) patients had temporary facial palsy (House-Brackman grade III) which was recovered within 3 weeks after surgery. One patient (5%) with adenoid cystic carcinoma had permanent facial palsy. Out of 20 patients 2(10%) had seroma and 1(5%) patient presented with Frey's syndrome. Mean post-operative pain score at 0, 6 and 24 h were 4.8, 3.4 and 1.8 out of 10 respectively. Mean comfort score was 9 out of 10 and mean cosmetic score was 9.5 out of 10. Mini-incision parotidectomy technique can render improved functional as well as aesthetic outcomes after parotidectomy without compromising the surgical clearance of the disease process.
Language	English
Publishing date	2021-09-30
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-021-02882-5
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Zs.A 5300: Show issues

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Article: Pediatric cardiac surgery following severe acute respiratory syndrome coronavirus-2 infection: Early experience and lessons learnt.

Sen, Supratim / Joshi, Vinay / Majhi, Lopamudra / Pradhan, Priya M / Jain, Sneha / Dhabe, Vaibhav / Trivedi, Dipesh / Kaushik, Pradeep K

Annals of pediatric cardiology

2022 Volume 15, Issue 1, Page(s) 27–33

Abstract: ... low-molecular weight heparin postoperatively. This patient's postoperative recovery was also prolonged due to lung changes ...

Abstract	Background: We evaluated our early experience of cardiac procedures in children with congenital heart defects (CHD) after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to understand whether recent reverse transcription-polymerase chain reaction (RT-PCR) positivity had a negative impact on their postprocedural recovery and outcomes. Materials and methods: In this retrospective observational study, all patients with CHD who underwent cardiac surgery or transcatheter intervention at our institution between March 2020 and June 2021 who were detected to have asymptomatic SARS-CoV-2 infection on routine RT-PCR were included. Details of the cardiac procedure and postprocedural recovery were reviewed and compared with RT-PCR-negative patients who concurrently underwent similar cardiac surgeries or interventions at our center. Results: Thirteen patients underwent cardiac surgery after recent SARS-CoV-2 positivity after a mean interval of 25.4 ± 12.9 days. One patient expired with multiorgan dysfunction and systemic inflammatory response with elevated D-dimer, serum Ferritin, C-reactive protein, and significant ground-glass opacities on chest radiograph. Another patient developed spontaneous thrombosis of the infrarenal abdominal aorta, bilateral iliac arteries, and bilateral femoral veins, requiring low-molecular weight heparin postoperatively. This patient's postoperative recovery was also prolonged due to lung changes delaying extubation. All other patients had uneventful postprocedural recovery with intensive care unit and hospital stays comparable to non-SARS-CoV-2-infected patients. Conclusions: From our early experience, we can surmise that an interval of 2-3 weeks after asymptomatic SARS-CoV-2 infection is adequate to undertake elective or semi-elective pediatric cardiac surgeries. For patients requiring emergent cardiac surgery prior to this interval, there is potentially increased risk of inflammatory and/or thrombotic complications.
Language	English
Publishing date	2022-06-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2430956-4
ISSN	0974-5149 ; 0974-2069
ISSN (online)	0974-5149
ISSN	0974-2069
DOI	10.4103/apc.apc_162_21
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