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  1. Article ; Online: Fire/flames mortality in Australian children 1968-2016, trends and prevention.

    Chang, Susan S M / Freemantle, Jane / Drummer, Olaf H

    Burns : journal of the International Society for Burn Injuries

    2021  Volume 48, Issue 5, Page(s) 1253–1260

    Abstract: Introduction: Mortality attributed to fire and flame for children (0-14 years) over a fifty-year period has not been previously analyzed in Australia. The literature has focused on these deaths over a shorter time period or disaggregated with other ... ...

    Abstract Introduction: Mortality attributed to fire and flame for children (0-14 years) over a fifty-year period has not been previously analyzed in Australia. The literature has focused on these deaths over a shorter time period or disaggregated with other causes of burns or deaths in one burns center. However, mortality associated with fire/flames affects this age group the greatest. The aims of this study are to: (1) develop a trends analysis of fire and flames mortality between1968 to 2016, using the Australian Bureau of Statistics (ABS) mortality database and, (2) determine the association of interventions with fire and flames mortality using the Haddon's categorical intervention framework.
    Methods: International Classification of Disease (ICD) codes were extracted and code equivalencies between ICD 8, 9, 10 and the Australian Bureau of Statistics for fire/flames data between 1968--2016 were assessed. To determine whether population changes affected the risks of mortality, the frequency and, rates per 100,000 were used. A literature review was conducted that summarized the current knowledge of interventions associated with the major decreases in the fire and flames mortality rate.
    Results: In Australia, we found was a downward trend for the period although with significant variation from year to year when compared to external cause mortality. Additionally, there were multiple successful interventions associated with a sustained decrease in mortality. After 2016, child fire-related mortality remains a problem particularly in low socioeconomic groups and indigenous peoples. A combination of research, public awareness, engineering, legal enforcement, advancements in burns care and, evidence-based policy development all have a role to play in future injury prevention initiatives. Although direct causation to an individual is not possible, associations can be drawn from interventions on a population level to decreases in mortality.
    Conclusion: We found was a steady decline in both rates and frequency of childhood fire and flames mortality from 1968 to 2016 associated with multiple interventions.
    MeSH term(s) Australia/epidemiology ; Burns ; Child ; Databases, Factual ; Fires ; Humans ; International Classification of Diseases
    Language English
    Publishing date 2021-08-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2021.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Health outcomes for Australian Aboriginal and Torres Strait Islander children born preterm, low birthweight or small for gestational age: A nationwide cohort study.

    Westrupp, Elizabeth M / D'Esposito, Fabrizio / Freemantle, Jane / Mensah, Fiona K / Nicholson, Jan M

    PloS one

    2019  Volume 14, Issue 2, Page(s) e0212130

    Abstract: Objective: To examine health outcomes in Australian Aboriginal and Torres Strait Islander children experiencing perinatal risk and identify protective factors in the antenatal period.: Methods: Baby/Child cohorts of the Longitudinal Study of ... ...

    Abstract Objective: To examine health outcomes in Australian Aboriginal and Torres Strait Islander children experiencing perinatal risk and identify protective factors in the antenatal period.
    Methods: Baby/Child cohorts of the Longitudinal Study of Indigenous Children, born 2001-2008, across four annual surveys (aged 0-8 years, N = 1483). Children with 'mild' and 'moderate-to-high' perinatal risk were compared to children born normal weight at term for maternal-rated global health and disability, and body-mass-index measured by the interviewer.
    Results: Almost one third of children had experienced mild (22%) or moderate-to-high perinatal risk (8%). Perinatal risk was associated with lower body-mass-index z-scores (regression coefficients adjusted for pregnancy and environment factors: mild = -0.21, 95% CI = -0.34, -0.07; moderate-to-high = -0.42, 95% CI = -0.63, -0.21). Moderate-to-high perinatal risk was associated with poorer global health, with associations becoming less evident in models adjusted for pregnancy and environment factors; but not evident for disability. A range of protective factors, including cultural-based resilience and smoking cessation, were associated with lower risk of adverse outcomes.
    Conclusions: Perinatal risks are associated with Australian Aboriginal and Torres Strait children experiencing adverse health particularly lower body weight. Cultural-based resilience and smoking cessation may be two modifiable pathways to ameliorating health problems associated with perinatal risk.
    MeSH term(s) Australia/epidemiology ; Australia/ethnology ; Body Mass Index ; Child ; Child, Preschool ; Cohort Studies ; Female ; Health Services Accessibility/statistics & numerical data ; Health Services, Indigenous ; Health Surveys ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Small for Gestational Age ; Longitudinal Studies ; Male ; Oceanic Ancestry Group/statistics & numerical data ; Premature Birth/epidemiology ; Risk
    Language English
    Publishing date 2019-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0212130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals' perspectives.

    Freemantle, Alison / Seymour, Jane

    BMC research notes

    2012  Volume 5, Page(s) 524

    Abstract: Background: Despite evidence suggesting that the Liverpool Care Pathway for the Dying Patient is a structured and proficient means of supporting care delivery in the last hours or days of life, discrepancies in uptake are widespread. This exploratory ... ...

    Abstract Background: Despite evidence suggesting that the Liverpool Care Pathway for the Dying Patient is a structured and proficient means of supporting care delivery in the last hours or days of life, discrepancies in uptake are widespread. This exploratory study sought to understand why patients dying of cancer in oncology wards of one hospital trust were, or were not, supported by the LCP. A purposive qualitative case study design was used; each case represented a patient who had died and their most involved nurse and doctor. In-depth interviews explored both recollections of the 'case' and wider experiences of using the Pathway in end-of-life care. Eleven healthcare professionals were interviewed about their involvement in the end-of-life care of six patients. For four of these patients care was supported by the LCP.
    Findings: Although doctors and nurses reported they preferred to use the Pathway to ensure comfortable death, an important factor influencing their decisions was time of death. Access to timely senior review was regarded as an essential preliminary to placing patients on the Pathway but delayed access 'out of hours' was commonly experienced and tensions arose from balancing conflicting priorities. Consequently, the needs of dying patients sometimes failed to compete with those receiving curative treatment.
    Conclusions: This study suggests that greater attention should be focused on 'out of hours' care in hospitals to ensure regular senior review of all patients at risk of dying and to support front line staff to communicate effectively and make contingency plans focused on patients' best interests.
    MeSH term(s) Adult ; Aged ; Critical Pathways ; England ; Female ; Health Personnel ; Humans ; Male ; Middle Aged ; Terminal Care
    Language English
    Publishing date 2012-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/1756-0500-5-524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Australian indigenous health

    Freemantle, Jane

    within an international context

    2007  

    Institution Telethon Institute for Child Health Research.
    Onemda VicHealth Koori Health Unit.
    Cooperative Research Centre for Aboriginal Health (Australia)
    Author's details Jane Freemantle ... [et al.]
    MeSH term(s) Health Services, Indigenous/organization & administration ; Health Status ; Medicine, Traditional ; Internationality ; Oceanic Ancestry Group ; Indians, North American
    Language English
    Size iv, 86 p.
    Publisher Cooperative Research Centre for Aboriginal Health
    Publishing place Casuarina, N.T
    Document type Book
    Note "This work is a collaboration between Telethon Institute for Child Health Research and Onemda VicHealth Koori Health Unit, the University of Melbourne"--T.p. verso.
    ISBN 9780734038876 ; 0734038879
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Health outcomes for Australian Aboriginal and Torres Strait Islander children born preterm, low birthweight or small for gestational age

    Elizabeth M Westrupp / Fabrizio D'Esposito / Jane Freemantle / Fiona K Mensah / Jan M Nicholson

    PLoS ONE, Vol 14, Iss 2, p e

    A nationwide cohort study.

    2019  Volume 0212130

    Abstract: Objective To examine health outcomes in Australian Aboriginal and Torres Strait Islander children experiencing perinatal risk and identify protective factors in the antenatal period. Methods Baby/Child cohorts of the Longitudinal Study of Indigenous ... ...

    Abstract Objective To examine health outcomes in Australian Aboriginal and Torres Strait Islander children experiencing perinatal risk and identify protective factors in the antenatal period. Methods Baby/Child cohorts of the Longitudinal Study of Indigenous Children, born 2001-2008, across four annual surveys (aged 0-8 years, N = 1483). Children with 'mild' and 'moderate-to-high' perinatal risk were compared to children born normal weight at term for maternal-rated global health and disability, and body-mass-index measured by the interviewer. Results Almost one third of children had experienced mild (22%) or moderate-to-high perinatal risk (8%). Perinatal risk was associated with lower body-mass-index z-scores (regression coefficients adjusted for pregnancy and environment factors: mild = -0.21, 95% CI = -0.34, -0.07; moderate-to-high = -0.42, 95% CI = -0.63, -0.21). Moderate-to-high perinatal risk was associated with poorer global health, with associations becoming less evident in models adjusted for pregnancy and environment factors; but not evident for disability. A range of protective factors, including cultural-based resilience and smoking cessation, were associated with lower risk of adverse outcomes. Conclusions Perinatal risks are associated with Australian Aboriginal and Torres Strait children experiencing adverse health particularly lower body weight. Cultural-based resilience and smoking cessation may be two modifiable pathways to ameliorating health problems associated with perinatal risk.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360 ; 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Administrative data and the manitoba centre for health policy: some reflections.

    Roos, Noralou P / Roos, Leslie L / Freemantle, Jane

    Healthcare policy = Politiques de sante

    2014  Volume 6, Issue Spec Issue, Page(s) 16–28

    Abstract: The authors review their 30 years' experience in determining the best research applications for routinely collected data from ministries of health, education and social services. They describe the rich research opportunities afforded by 40 years of data ... ...

    Title translation Données administratives au Centre des politiques de santé du Manitoba: réflexions.
    Abstract The authors review their 30 years' experience in determining the best research applications for routinely collected data from ministries of health, education and social services. They describe the rich research opportunities afforded by 40 years of data on health - i.e., every patient contact with hospitals, physicians, drugs and more - from the problems encountered in convincing an academic journal that meaningful findings could be culled from information collected on paying bills and tracking patients, through studies on education (enrolment, grades, standardized tests for grades 1 to 12), family characteristics (residential moves, marital formation and breakdown, number and timing of births) and social services (welfare recipients, children taken into care, protection services offered children in the family). They also detail how and why the Manitoba Centre for Health Policy was founded, and how it has continued through multiple ministerial, deputy and government changes.
    Language English
    Publishing date 2014-06-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2481657-7
    ISSN 1715-6572
    ISSN 1715-6572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: iGlarLixi (insulin glargine 100 U/ml plus lixisenatide) is effective and well tolerated in people with uncontrolled type 2 diabetes regardless of age: A REALI pooled analysis of prospective real-world data.

    Guja, Cristian / Kis, János Tibor / Haluzík, Martin / Bonnemaire, Mireille / Bigot, Gregory / Tournay, Mathilde / Freemantle, Nick / Seufert, Jochen

    Diabetes, obesity & metabolism

    2023  Volume 25, Issue 6, Page(s) 1723–1730

    Abstract: Aim: To evaluate the effectiveness and safety in routine clinical practice of insulin glargine/lixisenatide (iGlarLixi) in people with type 2 diabetes (T2D) according to age.: Methods: Patient-level data were pooled from 1316 adults with T2D ... ...

    Abstract Aim: To evaluate the effectiveness and safety in routine clinical practice of insulin glargine/lixisenatide (iGlarLixi) in people with type 2 diabetes (T2D) according to age.
    Methods: Patient-level data were pooled from 1316 adults with T2D inadequately controlled on oral antidiabetic drugs with or without basal insulin who initiated iGlarLixi for 24 weeks. Participants were classified into age subgroups of younger than 65 years (N = 806) and 65 years or older (N = 510).
    Results: Compared with participants aged younger than 65 years, those aged 65 years or older had a numerically lower mean body mass index (31.6 vs. 32.6 kg/m
    Conclusions: iGlarLixi is effective and well tolerated in both younger and older people with uncontrolled T2D.
    MeSH term(s) Adult ; Humans ; Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Insulin Glargine/adverse effects ; Glycated Hemoglobin ; Prospective Studies ; Blood Glucose ; Drug Combinations ; Hypoglycemic Agents/adverse effects
    Chemical Substances lixisenatide (74O62BB01U) ; Insulin Glargine (2ZM8CX04RZ) ; Glycated Hemoglobin ; Blood Glucose ; Drug Combinations ; Hypoglycemic Agents
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effectiveness and Safety of iGlarLixi (Insulin Glargine 100 U/mL Plus Lixisenatide) in Type 2 Diabetes According to the Timing of Daily Administration: Data from the REALI Pooled Analysis.

    Haluzík, Martin / Seufert, Jochen / Guja, Cristian / Bonnemaire, Mireille / Bigot, Gregory / Tournay, Mathilde / Kis, János Tibor / Freemantle, Nick

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2023  Volume 14, Issue 4, Page(s) 639–652

    Abstract: Introduction: iGlarLixi (insulin glargine 100 U/mL plus lixisenatide) has demonstrated glycaemic efficacy and safety in adults with inadequately controlled type 2 diabetes mellitus (T2DM). Per the European Medicines Agency's product label, iGlarLixi ... ...

    Abstract Introduction: iGlarLixi (insulin glargine 100 U/mL plus lixisenatide) has demonstrated glycaemic efficacy and safety in adults with inadequately controlled type 2 diabetes mellitus (T2DM). Per the European Medicines Agency's product label, iGlarLixi should be injected once a day within 1 h prior to a meal, preferably the same meal every day when the most convenient meal has been chosen. It is however unknown whether iGlarLixi administration timing affects glycaemic control and safety, as clinical trial evidence is mainly based on pre-breakfast iGlarLixi administration. Therefore, we assessed the effectiveness and safety of iGlarLixi in clinical practice, according to its administration timing.
    Methods: Data were pooled from two prospective observational studies including 1303 European participants with T2DM inadequately controlled on oral antidiabetic drugs with or without basal insulin who initiated iGlarLixi therapy for 24 weeks. Participants were classified into four subgroups based on daily timing of iGlarLixi injection: pre-breakfast (N = 436), pre-lunch (N = 262), pre-dinner (N = 399), and those who switched iGlarLixi injection time during the study (N = 206).
    Results: No meaningful differences in baseline characteristics were observed between the study groups. Least-squares mean reductions in haemoglobin A1c (HbA1c) from baseline to week 24 were substantial in all groups, with the numerically largest decrease observed in the pre-breakfast group (1.57%) compared with the pre-lunch (1.27%), pre-dinner (1.42%), or changed injection time (1.33%) groups. Pre-breakfast iGlarLixi injection also resulted in a numerically greater proportion of participants achieving HbA1c < 7.0% at week 24 (33.7% versus 19.0% for pre-lunch, 25.6% pre-dinner, and 23.2% changed injection time). iGlarLixi was well tolerated across all groups, with low rates of gastrointestinal disorders and hypoglycaemia. Mean body weight decreased similarly in all groups (by 1.3-2.3 kg).
    Conclusion: iGlarLixi was effective and safe regardless of its daily administration time. However, pre-breakfast iGlarLixi injection resulted in a more effective glycaemic control.
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-023-01375-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Investigating potential confounding by indication when considering the association between proton pump inhibitor use, infection, hepatic encephalopathy and mortality in hospitalised decompensated cirrhosis: a post-hoc analysis of the ATTIRE trial.

    China, Louise / Tittanegro, Thais / Crocombe, Dominic / Forrest, Ewan / Kallis, Yiannis / Ryder, Stephen D / Wright, Gavin / Freemantle, Nick / O'Brien, Alastair

    EClinicalMedicine

    2023  Volume 58, Page(s) 101924

    Abstract: ... complications and albumin <30 g/L. Study recruitment was between Jan 25, 2016, and June 28, 2019, at 35 ...

    Abstract Background: Proton pump inhibitors (PPIs) are commonly prescribed to prevent and treat upper gastrointestinal ulceration and bleeding. Studies have identified increased incidence of spontaneous bacterial peritonitis and hepatic encephalopathy (HE) in cirrhosis patients taking PPIs. However, results are conflicting, and as PPIs are prescribed for variceal bleeding, a major risk factor for infection and HE, it is challenging to discern whether these associations are causal.
    Methods: In this post-hoc analysis of the ATTIRE trial, we pooled all patient data to investigate the effects of PPI use on clinical outcomes. ATTIRE was a multicentre, open-label, randomised trial of targeted 20% human albumin solution (HAS) daily infusions versus standard care involving 777 adults with decompensated cirrhosis hospitalised with acute complications and albumin <30 g/L. Study recruitment was between Jan 25, 2016, and June 28, 2019, at 35 hospitals across England, Scotland, and Wales. Key exclusion criteria were advanced hepatocellular carcinoma with life expectancy <8 weeks and patients receiving palliative care. In ATTIRE, patients were grouped by PPI use at trial entry. We studied infection and HE at baseline and incidence of hospital acquired infection, new onset HE, renal dysfunction and mortality. We attempted with propensity score matching to account for differences in disease severity.
    Findings: Overall PPI use at baseline was not associated with increased incidence of infection, renal dysfunction or mortality, but was associated with significantly increased incidence of grade III/IV HE during hospital stay (
    Interpretations: Our real-world data from a completed randomised trial show that PPIs are widely prescribed in the UK and judicious use appears safe in patients hospitalised with decompensated cirrhosis. However, patients prescribed PPIs had fundamentally different phenotypes to those not prescribed PPIs, a form of confounding by indication, which should be strongly considered when interpreting studies and making recommendations about their use.
    Funding: Wellcome Trust and Department of Health and Social Care.
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2023.101924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Why is the Liverpool care pathway used for some dying cancer patients and not others? Healthcare professionals’ perspectives

    Freemantle Alison / Seymour Jane

    BMC Research Notes, Vol 5, Iss 1, p

    2012  Volume 524

    Abstract: Abstract Background Despite evidence suggesting that the Liverpool Care Pathway for the Dying Patient is a structured and proficient means of supporting care delivery in the last hours or days of life, discrepancies in uptake are widespread. This ... ...

    Abstract Abstract Background Despite evidence suggesting that the Liverpool Care Pathway for the Dying Patient is a structured and proficient means of supporting care delivery in the last hours or days of life, discrepancies in uptake are widespread. This exploratory study sought to understand why patients dying of cancer in oncology wards of one hospital trust were, or were not, supported by the LCP. A purposive qualitative case study design was used; each case represented a patient who had died and their most involved nurse and doctor. In-depth interviews explored both recollections of the ‘case’ and wider experiences of using the Pathway in end-of-life care. Eleven healthcare professionals were interviewed about their involvement in the end-of-life care of six patients. For four of these patients care was supported by the LCP. Findings Although doctors and nurses reported they preferred to use the Pathway to ensure comfortable death, an important factor influencing their decisions was time of death. Access to timely senior review was regarded as an essential preliminary to placing patients on the Pathway but delayed access ‘out of hours’ was commonly experienced and tensions arose from balancing conflicting priorities. Consequently, the needs of dying patients sometimes failed to compete with those receiving curative treatment. Conclusions This study suggests that greater attention should be focused on ‘out of hours’ care in hospitals to ensure regular senior review of all patients at risk of dying and to support front line staff to communicate effectively and make contingency plans focused on patients’ best interests.
    Keywords Liverpool care pathway ; End-of-life care ; Hospital ; Qualitative research ; Cancer ; Healthcare professionals ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Subject code 360
    Language English
    Publishing date 2012-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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