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  1. Article: Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL.

    Pillai, Sneha S / Pereira, Duane G / Zhang, Jue / Huang, Wenxin / Beg, Mirza Ahmar / Knaack, Darcy A / de Souza Goncalves, Bruno / Sahoo, Daisy / Silverstein, Roy L / Shapiro, Joseph I / Sodhi, Komal / Chen, Yiliang

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1046495

    Abstract: ... a scavenger receptor for oxidized LDL, formed a signaling complex with another membrane signal transducer Na/K-ATPase ...

    Abstract Introduction: Adipose tissue constantly secretes adipokines and extracellular vesicles including exosomes to crosstalk with distinct tissues and organs for whole-body homeostasis. However, dysfunctional adipose tissue under chronic inflammatory conditions such as obesity, atherosclerosis, and diabetes shows pro-inflammatory phenotypes accompanied by oxidative stress and abnormal secretion. Nevertheless, molecular mechanisms of how adipocytes are stimulated to secrete exosomes under those conditions remain poorly understood.
    Methods: Mouse and human
    Results and discussion: In this work, we report that CD36, a scavenger receptor for oxidized LDL, formed a signaling complex with another membrane signal transducer Na/K-ATPase in adipocytes. The atherogenic oxidized LDL induced a pro-inflammatory response in
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1046495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Survival and modelled cancer antigen-125 ELIMination rate constant K score in ovarian cancer patients in first-line before poly(ADP-ribose) polymerase inhibitor era: A Gynaecologic Cancer Intergroup meta-analysis.

    Corbaux, Pauline / You, Benoit / Glasspool, Rosalind M / Yanaihara, Nozomu / Tinker, Anna V / Lindemann, Kristina / Ray-Coquard, Isabelle L / Mirza, Mansoor R / Subtil, Fabien / Colomban, Olivier / Péron, Julien / Karamouza, Eleni / McNeish, Iain / Kelly, Caroline / Kagimura, Tatsuo / Welch, Stephen / Lewsley, Liz-Anne / Paoletti, Xavier / Cook, Adrian

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 191, Page(s) 112966

    Abstract: ... constant K (KELIM) is an early indicator of the tumour intrinsic chemosensitivity. We assessed ...

    Abstract Background: In patients with advanced ovarian cancer, the modelled CA-125 ELIMination rate constant K (KELIM) is an early indicator of the tumour intrinsic chemosensitivity. We assessed the prognostic and surrogate values of KELIM with respect to those of surgery outcome (based on post-operative residual lesions) in the Gynaecologic Cancer Intergroup (GCIG) individual patient data meta-analysis MAOV (Meta-Analysis in OVarian cancer) built before the emergence of poly(ADP-ribose) polymerase (PARP) inhibitors.
    Methods: The dataset was split into learning and validation cohorts (ratio 1:2). The individual modelled KELIM values were estimated, standardised by the median value, then scored as unfavourable (<1.0) or favourable (≥1.0). Overall survival (OS) and progression-free survival (PFS) analyses were performed with a two-step meta-analytic approach and surrogacy through a two-level meta-analytic model.
    Results: KELIM was assessed in 5884 patients from eight first-line trials (learning, 1962; validation, 3922). A favourable KELIM score was significantly associated with longer OS (validation set, median, 78.8 versus 28.4 months, hazard-ratios [HR] 0.46, 95% confidence interval [CI], 0.41-0.50, C-index 0.68), and longer PFS (validation set, median 30.5 versus 9.8 months, HR 0.49, 95% CI, 0.45-0.54, C-index 0.68), as were International Federation of Gynaecology and Obstetrics (FIGO) stage and debulking surgery outcome. Three prognostic groups were identified based on the surgery outcome and KELIM score, with large differences in OS (105.1, ∼45.0, and 22.1 months) and PFS (58.1, ∼15.0, and 8.0 months). Surrogacy for OS and for PFS was not established.
    Conclusion: KELIM is an independent prognostic biomarker for survival, complementary to surgery outcome, representing a new determinant of first-line treatment success.
    MeSH term(s) Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; CA-125 Antigen ; Disease-Free Survival ; Antineoplastic Agents/therapeutic use ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; CA-125 Antigen ; Antineoplastic Agents
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.112966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 456: Show issues Location:
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  3. Article ; Online: RETRACTED: Liposomal valinomycin mediated cellular K

    Zhang, Qian-Wen / Baig, Mirza Muhammad Faran Ashraf / Zhang, Tian-Qi / Zhai, Ting-Ting / Qin, Xiang / Xia, Xing-Hua

    Journal of controlled release : official journal of the Controlled Release Society

    2021  Volume 337, Page(s) 317–328

    MeSH term(s) Apoptosis ; Cell Line ; Humans ; Liposomes ; Liver Neoplasms/drug therapy ; Valinomycin
    Chemical Substances Liposomes ; Valinomycin (2001-95-8)
    Language English
    Publishing date 2021-07-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2021.07.037
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  4. Article ; Online: Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn.

    Zhang, Jue / Chang, Jackie / Beg, Mirza Ahmar / Huang, Wenxin / Zhao, Yiqiong / Dai, Wen / Wu, Xiaopeng / Cui, Weiguo / Pillai, Sneha S / Lakhani, Hari Vishal / Sodhi, Komal / Shapiro, Joseph I / Sahoo, Daisy / Zheng, Ze / Silverstein, Roy L / Chen, Yiliang

    iScience

    2022  Volume 25, Issue 9, Page(s) 104963

    Abstract: Na/K-ATPase (NKA), besides its ion transporter function, is a signal transducer by regulating ...

    Abstract Na/K-ATPase (NKA), besides its ion transporter function, is a signal transducer by regulating Src family kinases (SFK). The signaling NKA contributes to oxidized LDL-induced macrophage foam cell formation and interacts with TLR4. However, its role in lipopolysaccharides (LPS)-induced signaling and glycolytic switch in macrophages remains unclear. Using peritoneal macrophages from NKA α1 haploinsufficient mice (NKA α1
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.104963
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  5. Article: Parents' refusal to vitamin-K supplementation among neonates and its association with vaccine refusal: A systematic review and meta-analysis.

    Khan, Tahir Mehmood / Mubarak, Naeem / Suleimen, Amal / Jaber, Ammar Ali Saleh / Baig, Mirza Rafi

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 72, Issue 11, Page(s) 2251–2258

    Abstract: ... vitamin K prophylaxis refusal among parents and its possible association with subsequent vaccine hesitancy ... such as "vitamin K", "refusal", "decline", "hesitancy", and "vaccination" were used to identify potential studies ... refused to opt for the vitamin K prophylaxis. Meta-analysis concluded that refusal to vitamin K ...

    Abstract Objective: This systematic review and meta-analysis aims to estimate the prevalence of neonatal vitamin K prophylaxis refusal among parents and its possible association with subsequent vaccine hesitancy or refusal.
    Methods: The databases searched included PubMed, Cochrane Library, Embase via Ovid, CINAHL Plus and Medline via EBSCOhost, ProQuest and PsycINFO from inception to 31 August 2017. Keywords, such as "vitamin K", "refusal", "decline", "hesitancy", and "vaccination" were used to identify potential studies. Analysis of proportions was conducted, while odd ratios and relative risks were estimated using the random effect model.
    Results: Of the 2216 studies identified, 8(0.36%) were subjected to qualitative analysis; 4(50%) retrospective cohort studies and 4(50%) cross-sectional studies. Overall, 6(75%) studies were of good quality, while 2(25%) were ranked as of fair quality. Of the 273,714 parents, 3,136(1.14%) refused to opt for the vitamin K prophylaxis. Meta-analysis concluded that refusal to vitamin K prophylaxis was significant among the included studies ((p<0.184).
    Conclusions: The overall risk of refusal to essential vaccination among vitamin K prophylaxis refusal group was 6.45 times compared to the group that accepted vitamin K prophylaxis.
    MeSH term(s) Infant, Newborn ; Humans ; Vitamin K ; Retrospective Studies ; Cross-Sectional Studies ; Treatment Refusal ; Vaccination Refusal ; Parents ; Vitamins ; Dietary Supplements
    Chemical Substances Vitamin K (12001-79-5) ; Vitamins
    Language English
    Publishing date 2023-01-12
    Publishing country Pakistan
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.3914
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  6. Article ; Online: Hydrothermal Synthesis and Crystal Structure of a Novel Bismuth Oxide: (K

    Hossain, Khandaker Monower / Saiduzzaman, Md / Kumada, Nobuhiro / Takei, Takahiro / Yamane, Hisanori / Kabir Rubel, Mirza Humaun

    ACS omega

    2021  Volume 6, Issue 24, Page(s) 15975–15980

    Abstract: A novel distorted perovskite-type (K ...

    Abstract A novel distorted perovskite-type (K
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c01694
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  7. Article ; Online: Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn

    Jue Zhang / Jackie Chang / Mirza Ahmar Beg / Wenxin Huang / Yiqiong Zhao / Wen Dai / Xiaopeng Wu / Weiguo Cui / Sneha S. Pillai / Hari Vishal Lakhani / Komal Sodhi / Joseph I. Shapiro / Daisy Sahoo / Ze Zheng / Roy L. Silverstein / Yiliang Chen

    iScience, Vol 25, Iss 9, Pp 104963- (2022)

    2022  

    Abstract: Summary: Na/K-ATPase (NKA), besides its ion transporter function, is a signal transducer ...

    Abstract Summary: Na/K-ATPase (NKA), besides its ion transporter function, is a signal transducer by regulating Src family kinases (SFK). The signaling NKA contributes to oxidized LDL-induced macrophage foam cell formation and interacts with TLR4. However, its role in lipopolysaccharides (LPS)-induced signaling and glycolytic switch in macrophages remains unclear. Using peritoneal macrophages from NKA α1 haploinsufficient mice (NKA α1+/−), we found that NKA α1 haploinsufficiency led to enhanced LPS-stimulated NF-κB pathway, ROS signaling, and pro-inflammatory cytokines. Intraperitoneal injection of LPS resulted in more severe lung inflammation and injury with lower survival rate in NKA α1+/− mice. Additionally, LPS induced a higher extent of the metabolic switch from oxidative phosphorylation to glycolysis. Mechanistically, NKA α1 interacted with TLR4 and Lyn. The presence of NKA α1 in this complex attenuated Lyn activation by LPS, which subsequently restricted the downstream ROS and NF-κB signaling. In conclusion, we demonstrated that NKA α1 suppresses LPS-induced macrophage pro-inflammatory signaling through Lyn.
    Keywords Biological sciences ; immunology ; molecular biology ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Calcium Supplementation Improves Na(+)/K(+) Ratio, Antioxidant Defense and Glyoxalase Systems in Salt-Stressed Rice Seedlings.

    Rahman, Anisur / Nahar, Kamrun / Hasanuzzaman, Mirza / Fujita, Masayuki

    Frontiers in plant science

    2016  Volume 7, Page(s) 609

    Abstract: ... K(+) efflux, and decreased other mineral nutrient uptake. Salt stress caused oxidative stress ... rice seedlings improved ion homeostasis by inhibition of Na(+) influx and K(+) leakage. Exogenous Ca ...

    Abstract The present study investigates the regulatory role of exogenous calcium (Ca) in developing salt stress tolerance in rice seedlings. Hydroponically grown 13-day-old rice (Oryza sativa L. cv. BRRI dhan47) seedlings were exposed to 200 mM NaCl alone and combined with 2 mM CaCl2 and 2 mM ethylene glycol tetraacetic acid (EGTA, a Ca scavenger) for 3 days. The salt stress caused growth inhibition, chlorosis and water shortage in the rice seedlings. The salt-induced stress disrupted ion homeostasis through Na(+) influx and K(+) efflux, and decreased other mineral nutrient uptake. Salt stress caused oxidative stress in seedlings through lipid peroxidation, loss of plasma membrane integrity, higher reactive oxygen species (ROS) production and methylglyoxal (MG) formation. The salt-stressed seedlings supplemented with exogenous Ca recovered from water loss, chlorosis and growth inhibition. Calcium supplementation in the salt-stressed rice seedlings improved ion homeostasis by inhibition of Na(+) influx and K(+) leakage. Exogenous Ca also improved ROS and MG detoxification by improving the antioxidant defense and glyoxalase systems, respectively. On the other hand, applying EGTA along with salt and Ca again negatively affected the seedlings as EGTA negated Ca activity. It confirms that, the positive responses in salt-stressed rice seedlings to exogenous Ca were for Ca mediated improvement of ion homeostasis, antioxidant defense and glyoxalase system.
    Language English
    Publishing date 2016-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2016.00609
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  9. Article ; Online: Near-Quantitative Predictions of the First-Shell Coordination Structure of Hydrated First-Row Transition Metal Ions Using K-Edge X-ray Absorption Near-Edge Spectroscopy.

    Ghosh, Soumen / Agarwal, Harsh / Galib, Mirza / Tran, Ba / Balasubramanian, Mahalingam / Singh, Nirala / Fulton, John L / Govind, Niranjan

    The journal of physical chemistry letters

    2022  Volume 13, Issue 27, Page(s) 6323–6330

    Abstract: ... spectra at the K-edge of a nearly complete series of hydrated first-row transition metal ions with d ...

    Abstract The solvation structure of transition metal ions is important for applications in geochemistry, biochemistry, energy storage, and environmental chemistry. We study the X-ray absorption pre-edge and near-edge spectra at the K-edge of a nearly complete series of hydrated first-row transition metal ions with d orbital occupancy from d
    MeSH term(s) Ions ; Ligands ; Transition Elements/chemistry ; X-Ray Absorption Spectroscopy ; X-Rays
    Chemical Substances Ions ; Ligands ; Transition Elements
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c01532
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  10. Article: Fear of floating in Asia and the credibility of true floaters?S.K.A. Rizvi, Bushra Naqvi, Nawazish Mirza, Christian Bordes

    Rizvi, S. K. A / Bordes, Christian / Mirza, Nawazish / Naqvi, Bushra

    Research in international business and finance Vol. 42 , p. 149-160

    2017  Volume 42, Page(s) 149–160

    Keywords Exchange rate regime ; Flexibility ; Fear of floating ; Asia ; Pegging
    Language English
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 424514-3
    ISSN 0275-5319
    Database ECONomics Information System

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