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  1. Book ; Online ; E-Book: Microorganisms and mental health

    Savitz, Jonathan / Yolken, Robert H.

    (Current topics in behavioral neurosciences ; 61)

    2023  

    Author's details Jonathan Savitz, Robert H. Yolken editors
    Series title Current topics in behavioral neurosciences ; 61
    Collection
    Keywords Psychiatry ; Neurology ; Neuroimmunology ; Inflammation
    Language English
    Size 1 Online-Ressource (x, 351 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021742632
    ISBN 978-3-031-24333-2 ; 9783031243325 ; 3-031-24333-1 ; 3031243323
    DOI 10.1007/978-3-031-24333-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Infections and neuropsychiatric disorders: new studies document pathways to prevention and treatment.

    Yolken, Robert

    Molecular psychiatry

    2023  Volume 28, Issue 7, Page(s) 2624–2626

    MeSH term(s) Humans ; Mental Disorders/prevention & control ; Obsessive-Compulsive Disorder/therapy
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type News
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02072-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Maternal Inflammation in Pregnancy: Setting the Pattern for Brain Development during Infancy and Beyond.

    Yolken, Robert H

    The Journal of pediatrics

    2021  Volume 238, Page(s) 13–15

    MeSH term(s) Brain/diagnostic imaging ; Family ; Female ; Humans ; Infant ; Inflammation ; Pregnancy
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.116: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: COVID-19 and psychiatry: can electronic medical records provide the answers?

    Yolken, Robert

    The lancet. Psychiatry

    2020  Volume 8, Issue 2, Page(s) 89–91

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Comorbidity ; Electronic Health Records/organization & administration ; Electronic Health Records/standards ; Humans ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Mental Disorders/therapy ; Psychiatry/organization & administration ; Psychiatry/standards ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-11-09
    Publishing country England
    Document type Journal Article
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(20)30479-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Elevated matrix Metalloproteinase-9 associated with reduced cerebellar perineuronal nets in female mice with toxoplasmosis.

    Xiao, Jianchun / Huang, Jing / Yolken, Robert H

    Brain, behavior, & immunity - health

    2024  Volume 36, Page(s) 100728

    Abstract: Brain infection by the ... ...

    Abstract Brain infection by the parasite
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2024.100728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: COVID-19 and psychiatry

    Yolken, Robert

    The Lancet Psychiatry ; ISSN 2215-0366

    can electronic medical records provide the answers?

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/s2215-0366(20)30479-x
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Therapeutic Implications of the Microbial Hypothesis of Mental Illness.

    Savitz, Jonathan / Yolken, Robert H

    Current topics in behavioral neurosciences

    2022  Volume 61, Page(s) 315–351

    Abstract: There is increasingly compelling evidence that microorganisms may play an etiological role in the emergence of mental illness in a subset of the population. Historically, most work has focused on the neurotrophic herpesviruses, herpes simplex virus type ... ...

    Abstract There is increasingly compelling evidence that microorganisms may play an etiological role in the emergence of mental illness in a subset of the population. Historically, most work has focused on the neurotrophic herpesviruses, herpes simplex virus type 1 (HSV-1), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) as well as the protozoan, Toxoplasma gondii. In this chapter, we provide an umbrella review of this literature and additionally highlight prospective studies that allow more mechanistic conclusions to be drawn. Next, we focus on clinical trials of anti-microbial medications for the treatment of psychiatric disorders. We critically evaluate six trials that tested the impact of anti-herpes medications on inflammatory outcomes in the context of a medical disorder, nine clinical trials utilizing anti-herpetic medications for the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or schizophrenia, and four clinical trials utilizing anti-parasitic medications for the treatment of schizophrenia. We then turn our attention to evidence for a gut dysbiosis and altered microbiome in psychiatric disorders, and the potential therapeutic effects of probiotics, including an analysis of more than 10 randomized controlled trials of probiotics in the context of schizophrenia, bipolar disorder (BD), and major depressive disorder (MDD).
    MeSH term(s) Humans ; Depressive Disorder, Major ; Epstein-Barr Virus Infections ; Fatigue Syndrome, Chronic ; Herpesvirus 4, Human ; Prospective Studies
    Language English
    Publishing date 2022-05-26
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2022_368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Levels of Matrix Metalloproteinase 9 Are Elevated in Persons With Schizophrenia or Bipolar Disorder: The Role of Modifiable Factors.

    Dickerson, Faith / Vaidya, Dhananjay / Liu, Yisi / Yolken, Robert

    Biological psychiatry global open science

    2023  Volume 3, Issue 4, Page(s) 766–772

    Abstract: Background: Matrix metalloproteinases (MMPs) are a diverse set of enzymes associated with inflammation. MMP-9 is of particular interest because it has been associated with autoimmune and cardiopulmonary disorders, tobacco smoking, and obesity, prevalent ...

    Abstract Background: Matrix metalloproteinases (MMPs) are a diverse set of enzymes associated with inflammation. MMP-9 is of particular interest because it has been associated with autoimmune and cardiopulmonary disorders, tobacco smoking, and obesity, prevalent in psychiatric populations.
    Methods: Sensitive enzyme immunoassays measured MMP-9 in blood samples from 1121 individuals (mean age = 35.6 [SD = 13.0] years; 47.7% male; 440 with schizophrenia, 399 with bipolar disorder, and 282 without a psychiatric disorder). We estimated the odds of diagnosis associated with MMP-9, demographic variables, tobacco smoking, and obesity, and also the partial explained variance using regression methods. We also determined the association between psychiatric medications and MMP-9 levels.
    Results: Individuals with elevated MMP-9 levels had higher odds of schizophrenia or bipolar disorder compared with the nonpsychiatric group adjusted for demographic variables. Partial correlation analyses indicated the demographic-adjusted variance associated with MMP-9, smoking, obesity, and their interaction explained 59.6% for schizophrenia and 39.9% for bipolar disorder. Levels of MMP-9 were substantially lower in individuals receiving valproate, particularly relatively high doses.
    Conclusions: Individuals with higher levels of MMP-9 have significantly higher odds of schizophrenia or bipolar disorder. Individuals receiving valproate had substantially lower levels of MMP-9, possibly related to its ability to inhibit histone deacetylation. A substantial portion of the variance in clinical disorders associated with MMP-9 can be attributed to smoking or obesity. Interventions to reduce smoking and obesity might reduce the morbidity and mortality associated with elevated MMP-9 levels and improve the health outcomes of individuals with these disorders.
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 2667-1743
    ISSN (online) 2667-1743
    DOI 10.1016/j.bpsgos.2023.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Guest Editorial: Binning bugs and beyond: The state of the schizophrenia microbiome.

    Severance, Emily G / Yolken, Robert H

    Schizophrenia research

    2021  Volume 234, Page(s) 1–3

    MeSH term(s) Brain ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Schizophrenia
    Language English
    Publishing date 2021-05-15
    Publishing country Netherlands
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2021.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 543: Show issues

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