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  1. Article ; Online: MHC Class I Immunopeptidome: Past, Present, and Future.

    Yewdell, Jonathan W

    Molecular & cellular proteomics : MCP

    2022  Volume 21, Issue 7, Page(s) 100230

    Abstract: In the 35 years since the revelation that short peptides bound to major histocompatibility complex class I and II molecules are the secret of the major histocompatibility complex-restricted nature of T-cell recognition, there has been enormous progress ... ...

    Abstract In the 35 years since the revelation that short peptides bound to major histocompatibility complex class I and II molecules are the secret of the major histocompatibility complex-restricted nature of T-cell recognition, there has been enormous progress in characterizing the immunopeptidome, the repertoire of peptide presented for immunosurveillance. Here, the major milestones in the journey are marked, the contribution of proteasome-mediated splicing to the immunopeptidome is discussed, and exciting recent findings relating the immunopeptidome to the translatome revealed by ribosome profiling (RiboSeq) is detailed. Finally, what is needed for continued progress is opined about, which includes the infusion of talented young scientists into the antigen-processing field, currently undergoing a renaissance; thanks in part to the astounding success of T-cell-based cancer immunotherapy.
    MeSH term(s) Antigen Presentation ; HLA Antigens ; Histocompatibility Antigens Class I/metabolism ; Immunotherapy ; Peptides/metabolism
    Chemical Substances HLA Antigens ; Histocompatibility Antigens Class I ; Peptides
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2075924-1
    ISSN 1535-9484 ; 1535-9476
    ISSN (online) 1535-9484
    ISSN 1535-9476
    DOI 10.1016/j.mcpro.2022.100230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5599: Show issues Location:
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  2. Article ; Online: Unconventionally presenting an unconventional viral peptide.

    Holly, Jaroslav / Yewdell, Jonathan W

    Nature immunology

    2023  Volume 24, Issue 11, Page(s) 1787–1789

    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01652-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5294: Show issues Location:
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  3. Article ; Online: Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread.

    Yewdell, Jonathan W

    PLoS pathogens

    2021  Volume 17, Issue 4, Page(s) e1009509

    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/transmission ; Humans ; Immunity, Herd/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Virus Diseases/immunology ; Virus Diseases/transmission
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009509
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  4. Article ; Online: SUS(d6)pending MHC class I peptide presentation for cancer immunoevasion.

    Dersh, Devin / Yewdell, Jonathan W

    Cell research

    2023  Volume 34, Issue 2, Page(s) 97–98

    MeSH term(s) Histocompatibility Antigens Class I ; Peptides ; Antigen Presentation ; Neoplasms
    Chemical Substances Histocompatibility Antigens Class I ; Peptides
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00882-4
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  5. Article ; Online: Antigenic drift: Understanding COVID-19.

    Yewdell, Jonathan W

    Immunity

    2021  Volume 54, Issue 12, Page(s) 2681–2687

    Abstract: Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity ... ...

    Abstract Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I explain the factors contributing to the rapid antigenic drift of the SARS-CoV-2 spike protein and receptor proteins of other viruses and discuss the implications for SARS-CoV-2 evolution and immunity.
    MeSH term(s) Adaptive Immunity ; Animals ; Antigenic Drift and Shift ; Biological Evolution ; COVID-19/immunology ; Host-Pathogen Interactions ; Humans ; Mutation/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.11.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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  6. Article ; Online: Game of Omes: ribosome profiling expands the MHC-I immunopeptidome.

    Holly, Jaroslav / Yewdell, Jonathan W

    Current opinion in immunology

    2023  Volume 83, Page(s) 102342

    Abstract: Peptide ligands presented by cell-surface MHC class-I molecules enable T cells to eradicate intracellular pathogens and cancers. The presented peptide repertoire, the class-I immunopeptidome, is generated from each cell's translatome in a highly biased ... ...

    Abstract Peptide ligands presented by cell-surface MHC class-I molecules enable T cells to eradicate intracellular pathogens and cancers. The presented peptide repertoire, the class-I immunopeptidome, is generated from each cell's translatome in a highly biased manner to avoid overrepresenting highly abundant translation products. The immunopeptidome can only be defined by mass spectrometry (MS). Here, we review recent advances in immunopeptidomics, focusing on using ribosome profiling as the optimal MS database to optimize the false- and failed-discovery rates and relate these findings to the contribution of defective ribosomal products and cellular quality control mechanisms to MHC class-I antigen processing and presentation.
    MeSH term(s) Humans ; Ribosome Profiling ; Histocompatibility Antigens Class I ; Peptides ; Neoplasms ; Mass Spectrometry ; Antigen Presentation
    Chemical Substances Histocompatibility Antigens Class I ; Peptides
    Language English
    Publishing date 2023-05-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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  7. Article ; Online: Individuals cannot rely on COVID-19 herd immunity

    Jonathan W Yewdell

    PLoS Pathogens, Vol 17, Iss 4, p e

    Durable immunity to viral disease is limited to viruses with obligate viremic spread.

    2021  Volume 1009509

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: What's Fair Is Fair: Leveling the Playing Field for Young Scientists.

    Yewdell, Jonathan W

    Vaccines

    2018  Volume 6, Issue 2

    Abstract: Like every MD Ph.D. pup, I was faced with the BIG decision: medicine or science?[ ... ]. ...

    Abstract Like every MD Ph.D. pup, I was faced with the BIG decision: medicine or science?[...].
    Language English
    Publishing date 2018-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines6020033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Influenza virus antibodies inhibit antigen-specific

    Goodwin, Eileen / Gibbs, James S / Yewdell, Jonathan W / Eisenlohr, Laurence C / Hensley, Scott E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Antibody responses to influenza vaccines tend to be focused on epitopes encountered during prior influenza exposures, with little production ... ...

    Abstract Antibody responses to influenza vaccines tend to be focused on epitopes encountered during prior influenza exposures, with little production of
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.12.589218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation.

    Dersh, Devin / Yewdell, Jonathan W

    The Journal of clinical investigation

    2021  Volume 131, Issue 1

    Abstract: The success of tumor immunotherapy, while partial, confirms the existence and importance of tumor immunosurveillance. CD8+ T cell recognition of tumor-specific peptides bound to MHC class I (MHC-I) molecules is central to this process. In this issue of ... ...

    Abstract The success of tumor immunotherapy, while partial, confirms the existence and importance of tumor immunosurveillance. CD8+ T cell recognition of tumor-specific peptides bound to MHC class I (MHC-I) molecules is central to this process. In this issue of the JCI, Fang, Wang, et al. describe a unique tumor immunoevasion strategy based on endocytosis and degradation of MHC-I complexes mediated by the trafficking factor MAL2. Notably, MAL2 expression was associated with poor prognosis of breast cancer, and its downregulation enhanced CD8+ T cell recognition of breast cancer in various experimental models. This work demonstrates that a deeper understanding of tumor interference with MHC-I stability and trafficking has considerable potential for enhancing immunotherapies.
    MeSH term(s) Antigens, Neoplasm ; Breast Neoplasms ; CD8-Positive T-Lymphocytes/immunology ; Female ; Histocompatibility Antigens Class I/genetics ; Humans ; Immunotherapy ; Myelin and Lymphocyte-Associated Proteolipid Proteins
    Chemical Substances Antigens, Neoplasm ; Histocompatibility Antigens Class I ; MAL2 protein, human ; Myelin and Lymphocyte-Associated Proteolipid Proteins
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI144344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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