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Book ; Thesis: Comparison of different approaches in lumbosacral spinal fusion surgery

Mohamud, Kaliye / Scheyerer, Max Joseph / Michael, Joern William-Patrick

a meta-analysis

2021

Institution	Universitätsklinikum Köln / Klinik und Poliklinik für Orthopädie und Unfallchirurgie
Author's details	vorgelegt von Kaliye Mohamud ; 1. Gutachter: Privatdozent Dr. med. M. Scheyerer, 2. Gutachter: Professor Dr. med. J.W.P. Michael ; aus der Klinik und Poliklinik für Orthopädie und Unfallchirurgie der Universität zu Köln
Subject code	610
Language	English
Size	58 Seiten, Illustrationen
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität zu Köln, 2021
Note	Zusammenfassung in deutscher und englischer Sprache
HBZ-ID	HT020989335
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2021 D 438	order for loan	Magazin

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Book: Neurobiology of brain disorders

Zigmond, Michael J. / Rowland, Lewis P. / Coyle, Joseph T.

biological basis of neurological and psychiatric disorders

2015

Author's details	ed. by Michael J. Zigmond ; Lewis P. Rowland ; Joseph T. Coyle
Language	English
Size	XIX, 801 S. : Ill., graph. Darst.
Publisher	Elsevier AP
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT018490941
ISBN	978-0-12-398270-4 ; 0-12-398270-7
Database	Catalogue ZB MED Medicine, Health

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2014 A 4637	available for loan (reading room)	Lesesaal EG

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Article ; Online: ChatGPT: A Valuable Tool for Emergency Medical Assistance.

Dahdah, Joseph El / Kassab, Joseph / Helou, Michel Chedid El / Gaballa, Andrew / Sayles, Stephen / Phelan, Michael P

Annals of emergency medicine

2023 Volume 82, Issue 3, Page(s) 411–413

Language	English
Publishing date	2023-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2023.04.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1344: Show issues

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Article ; Online: Advances in Stroke: Treatments-Acute.

Broderick, Joseph P / Hill, Michael J

Stroke

2022 Volume 53, Issue 3, Page(s) 999–1003

MeSH term(s)	Humans ; Stroke/surgery ; Stroke/therapy ; Thrombectomy ; Treatment Outcome
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.122.036976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 448: Show issues

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Article ; Online: Titanium(II) as a Fuel Atom in Energetic Materials.

Bacon, Alexandra M / Tomlinson, Warren / Hooper, Joseph P / Zdilla, Michael J

Inorganic chemistry

2023 Volume 62, Issue 24, Page(s) 9285–9290

Abstract: The energetic content of the compounds ... ...

Abstract	The energetic content of the compounds MgTp
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.2c04367
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Article ; Online: Advances in Acute Stroke Treatment 2020.

Broderick, Joseph P / Hill, Michael D

Stroke

2021 Volume 52, Issue 2, Page(s) 729–734

MeSH term(s)	Humans ; Stroke/economics ; Stroke/therapy ; Stroke Rehabilitation/economics ; Stroke Rehabilitation/trends ; Treatment Outcome
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.120.033744
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Article ; Online: Lens-specific βA3/A1-conditional knockout mice: Phenotypic characteristics and calpain activation causing protein degradation and insolubilization.

Joseph, Roy / Robinson, Michael L / Lambert, Laura / Srivastava, Om P

PloS one

2023 Volume 18, Issue 3, Page(s) e0281386

Abstract: βA3/A1-crystallin is a lens structural protein that plays an important role in maintaining lens transparency via interactions with other crystallins. While the function of βA3/A1-crystallin in the retina is well studied, its functions in the lens, other ... ...

Abstract	βA3/A1-crystallin is a lens structural protein that plays an important role in maintaining lens transparency via interactions with other crystallins. While the function of βA3/A1-crystallin in the retina is well studied, its functions in the lens, other than as a structural protein, remain unclear. In the current study, we generated the lens-specific βA3/A1-crystallin conditional knockout mouse (named βA3/A1ckO) and explored phenotypic changes and the function of the crystallin in the lens. The βA3/A1ckO mice showed congenital cataract at birth and exhibited truncation of lens proteins. Several truncated protein fragments were recovered as a pellet during a low-speed centrifugation (800 rpm, 70 x g) followed by a relatively higher speed centrifugation (5000 rpm, 2744 x g). Mass spectrometric analysis of pellets recovered following the two centrifugations showed that among the fragments with Mr < 20 kDa, the majority of these were from β-tubulin, and some from phakinin, αA-crystallin, and calpain-3. Further, we observed that in vitro activation of calpain-3 by calcium treatment of the wild-type-lens homogenate resulted in the degradation of calpain-3, αA-crystallin and β-tubulin and insolubilization of these proteins. Based on these results, it was concluded that the activation of calpain 3 resulted in proteolysis of β-tubulin, which disrupted cellular microtubular structure, and caused proteolysis of other lens proteins (αA-crystallin and phakinin). These proteolyzed protein fragments become insoluble, and together with the disruption of microtubular structure, and could be the causative factors in the development of congenital nuclear cataract in βA3/A1cKO mice.
MeSH term(s)	Animals ; Mice ; Calpain/genetics ; Calpain/metabolism ; Cataract/genetics ; Cataract/metabolism ; Crystallins/genetics ; Crystallins/metabolism ; Lens, Crystalline/metabolism ; Mice, Knockout ; Proteolysis ; Tubulin/metabolism
Chemical Substances	Calpain (EC 3.4.22.-) ; Crystallins ; Tubulin ; Cryba1 protein, mouse
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281386
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Perioperative oxygenation-what's the stress?

Larvin, Joseph / Edwards, Mark / Martin, Daniel S / Feelisch, Martin / Grocott, Michael P W / Cumpstey, Andrew F

BJA open

2024 Volume 10, Page(s) 100277

Abstract: Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. Notwithstanding a Cochrane ... ...

Abstract	Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. Notwithstanding a Cochrane review concluding that routinely administering a fractional inspired oxygen concentration (FiO
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article ; Review
ISSN	2772-6096
ISSN (online)	2772-6096
DOI	10.1016/j.bjao.2024.100277
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Utilizing timed categorical recall (naming US cities) for rapid bedside dementia screening.

Joseph, Charles R / Cargill, Michael P / Lee, Chansoon D

Medicine

2022 Volume 101, Issue 31, Page(s) e29518

Abstract: The availability of fast validated screening for dementia is a critical clinical need to improve neurologic examination time efficiency. This study validated a 1-minute timed categorical recall (TCR) method, naming as many US cities as possible and ... ...

Abstract	The availability of fast validated screening for dementia is a critical clinical need to improve neurologic examination time efficiency. This study validated a 1-minute timed categorical recall (TCR) method, naming as many US cities as possible and compared TCR to the Folstein Minimental Status Exam (MMSE) as a preliminary cognitive screening tool. Random uncompensated 349 volunteers were recruited ages 18 to 97 from local free clinics, retirement homes, university faculty, and students in Lynchburg, Virginia 2015 to 2020. Participants' demographic and medical information were collected. After 1 minute preparation, participants were rapidly named as many US cities as possible until they were told to stop (1 minute). The time limitation was withheld in advance. Number of cities and organizational strategies were recorded. Folstein MMSE administration immediately after TCR was administered to 122 subjects recruited in the final 2 study years as a comparison benchmark. A multiple linear regression model and a regression tree model were used to identify important variables for the number of cities named and determine subgroups and their thresholds. TCR resulted in accuracy rate (0.80), sensitivity (0.78), and specificity (0.81). The global TCR threshold (9 cities named) is superseded by 4 subgroup thresholds, categorized by statistically important variables (age, education level, and number of states visited) as follows: For those visiting ≥8 states and 1. 18 to 71 ages with a master's degree or above, the threshold was naming 20 cities; 2. 18 to 29 ages with a bachelor's degree or below, the threshold was naming 17 cities; 3. 30 to 71 ages with a bachelor's degree or below, the threshold was naming 10 cities. For those visiting <8 states or for ages 72 to 97 (regardless of education levels and number of states visited), the threshold was naming 8 cities. American cities are common knowledge across ages and backgrounds, making it a useful bedside screen for dementia. In clinical practice, patients who report fewer cities than the threshold of 9 cities should receive further cognitive testing. If the patient meets the criteria for a subgroup, then the higher subgroup thresholds apply. TCR is a more time-efficient preliminary dementia screening tool with improved sensitivity and similar specificity compared with MMSE.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cities ; Dementia/diagnosis ; Humans ; Mental Recall ; Middle Aged ; Neuropsychological Tests ; Receptors, Antigen, T-Cell ; Young Adult
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029518
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.171: Show issues

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Article ; Online: Harnessing human genetics and stem cells for precision cardiovascular medicine.

Caudal, Arianne / Snyder, Michael P / Wu, Joseph C

Cell genomics

2023 Volume 4, Issue 2, Page(s) 100445

Abstract: Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and pharmaceutical research by providing tissue-specific human cells that retain patients' genetic integrity and display disease phenotypes in a dish. Looking forward, ... ...

Abstract	Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and pharmaceutical research by providing tissue-specific human cells that retain patients' genetic integrity and display disease phenotypes in a dish. Looking forward, combining iPSC phenotyping platforms with genomic and screening technologies will continue to pave new directions for precision medicine, including genetic prediction, visualization, and treatment of heart disease. This review summarizes the recent use of iPSC technology to unpack the influence of genetic variants in cardiovascular pathology. We focus on various state-of-the-art genomic tools for cardiovascular therapies-including the expansion of genetic toolkits for molecular interrogation, in vitro population studies, and function-based drug screening-and their current applications in patient- and genome-edited iPSC platforms that are heralding new avenues for cardiovascular research.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells ; Precision Medicine ; Heart ; Human Genetics
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-979X
ISSN (online)	2666-979X
DOI	10.1016/j.xgen.2023.100445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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