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  1. Article ; Online: Induced Pluripotent Stem Cells (iPSCs) Derived 3D Human Lung Organoids from Different Ethnicities to Understand the SARS-CoV2 Severity/Infectivity Percentage.

    Bose, Bipasha

    Stem cell reviews and reports

    2020  Volume 17, Issue 1, Page(s) 293–295

    MeSH term(s) COVID-19/virology ; Ethnicity ; Humans ; Induced Pluripotent Stem Cells/cytology ; Lung/cytology ; Organoids/cytology ; SARS-CoV-2/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-020-09989-2
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  2. Article: Induced Pluripotent Stem Cells (iPSCs) Derived 3D Human Lung Organoids from Different Ethnicities to Understand the SARS-CoV2 Severity/Infectivity Percentage

    Bose, Bipasha
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #526697
    Database COVID19

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  3. Article ; Online: Unlocking the Potential of Obestatin: A Novel Peptide Intervention for Skeletal Muscle Regeneration and Prevention of Atrophy.

    Mitra, Akash / Mandal, Samanwita / Bose, Bipasha / Shenoy P, Sudheer

    Molecular biotechnology

    2024  

    Abstract: Obestatin is derived from the same gene as that of ghrelin and their functions were perceived to be antagonistic. Recent developments have shown that although they are known to have contradictory functions, effect of obestatin on skeletal muscle ... ...

    Abstract Obestatin is derived from the same gene as that of ghrelin and their functions were perceived to be antagonistic. Recent developments have shown that although they are known to have contradictory functions, effect of obestatin on skeletal muscle regeneration is similar to that of ghrelin. Obestatin works through a receptor called GPR39, a ghrelin and motilin family receptor and transduces signals in skeletal muscle similar to that of ghrelin. Not only there is a similarity in the receptor family, but also obestatin targets similar proteins and transcription factors as that of ghrelin (for example, FoxO family members) for salvaging skeletal muscle atrophy. Moreover, like ghrelin, obestatin also works by inducing the transcription of Pax7 which is required for muscle stem cell mobilisation. Hence, there are quite some evidences which points to the fact that obestatin can be purposed as a peptide intervention to prevent skeletal muscle wasting and induce myogenesis. This review elaborates these aspects of obestatin which can be further exploited and addressed to bring obestatin as a clinical intervention towards preventing skeletal muscle atrophy and sarcopenia.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1193057-3
    ISSN 1559-0305 ; 1073-6085
    ISSN (online) 1559-0305
    ISSN 1073-6085
    DOI 10.1007/s12033-023-01011-7
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  4. Article ; Online: Induced Pluripotent Stem Cells (iPSCs) Derived 3D Human Lung Organoids from Different Ethnicities to Understand the SARS-CoV2 Severity/Infectivity Percentage

    Bose, Bipasha

    Stem Cell Reviews and Reports ; ISSN 2629-3269 2629-3277

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s12015-020-09989-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Pluripotent stem cells: Basic biology or else differentiations aimed at translational research and the role of flow cytometry.

    Bose, Bipasha / Nihad, Muhammad / P, Sudheer Shenoy

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2023  Volume 103, Issue 5, Page(s) 368–377

    Abstract: Pluripotent stem cell research has revolutionized the modern era for the past 14 years with the advent of induced pluripotent stem cells. Before this time, scientists had access to human and mouse embryonic stem cells primarily for basic research and an ... ...

    Abstract Pluripotent stem cell research has revolutionized the modern era for the past 14 years with the advent of induced pluripotent stem cells. Before this time, scientists had access to human and mouse embryonic stem cells primarily for basic research and an attempt towards lineage-specific differentiations for cell therapy applications. Regarding pluripotent stem cells, expression of bonafide marker proteins such as Oct4, Nanog, Sox2, Klf4, c-Myc, and Lin28 have been considered giving a perfect readout for pluripotent stem cells and assessed using an analytical flow cytometer. In addition to the intracellular markers, surface markers such as stage-specific embryonic antigen-1 for mouse cells and SSEA-4 for human cells are needed to sort pure populations of stem cells for further downstream applications for cell therapy. The surface marker SSEA-4 is the most appropriate for obtaining pure populations of human pluripotent stem cells. When differentiated in a controlled manner using growth factors or small molecules, it is mandatory to assess the downregulation of pluripotency markers (Oct4, Nanog, Sox2, and Klf4) with subsequent up-regulation of stage-specific differentiation markers. Such assessments are done using flow cytometry. Pluripotent stem cells have a high teratoma-forming potential in vivo. Small amounts of undifferentiated PSCs might lead to dangerous teratomas upon transplantation if leftover in the pool of differentiated cells. Hence, flow cytometry is essential for sorting out PSC populations with teratoma-forming potential. The pure populations of differentiated progenitors need to be flow-sorted before differentiating them further for cell therapy applications. For example, Glycoprotein 2 is a specific cell-surface marker for pancreatic progenitors that enables one to sort the pancreatic progenitors differentiated from human PSCs. Taken together, analytical flow cytometry, and cell sorting provide indispensable tools in PSC research and cell therapy.
    MeSH term(s) Animals ; Humans ; Mice ; Flow Cytometry ; Translational Research, Biomedical ; Pluripotent Stem Cells ; Cell Differentiation/physiology ; Induced Pluripotent Stem Cells ; Teratoma/metabolism ; Biology
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24726
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  6. Article ; Online: The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis.

    Mitra, Akash / Qaisar, Rizwan / Bose, Bipasha / Sudheer, Shenoy P

    Osteoporosis and sarcopenia

    2023  Volume 9, Issue 1, Page(s) 1–7

    Abstract: Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which works in synergy with the bones. Long skeletal muscles provide stability and mobility to the human body and are primarily composed of proteins. Conversely, improper ... ...

    Abstract Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which works in synergy with the bones. Long skeletal muscles provide stability and mobility to the human body and are primarily composed of proteins. Conversely, improper functioning of various skeletal muscles leads to diseases and disorders, namely, age-related muscle disorder called sarcopenia, a group of genetic muscle disorders such as muscular dystrophies, and severe muscle wasting in cancer known as cachexia. However, skeletal muscle has an excellent ability to undergo hypertrophy and enhanced functioning during sustained exercise over time. Indeed, these processes of skeletal muscle regeneration/hypertrophy, as well as degeneration and atrophy, involve an interplay of various signaling pathways. Myostatin is one such chemokine/myokine with a significant contribution to muscle regeneration or atrophy in multiple conditions. In this review, we try to put together the role and regulation of myostatin as a function of muscle regeneration extrapolated to multiple aspects of its molecular functions.
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2023.03.008
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  7. Article ; Online: Corrigendum for "Differential sensitivities of triple-negative breast cancer stem cell towards various doses of vitamin C: An insight into the internal antioxidant systems".

    Sen, Utsav / Chaudhury, Debajit / Shenoy P, Sudheer / Bose, Bipasha

    Journal of cellular biochemistry

    2022  Volume 123, Issue 3, Page(s) 697

    Language English
    Publishing date 2022-03-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 392402-6
    ISSN 1097-4644 ; 0730-2312
    ISSN (online) 1097-4644
    ISSN 0730-2312
    DOI 10.1002/jcb.30228
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  8. Article ; Online: Mitigation of chronic glucotoxicity-mediated skeletal muscle atrophy by arachidonic acid.

    Mitra, Akash / Shanavas, Shanooja / Chaudhury, Debajit / Bose, Bipasha / Das, Undurti N / Shenoy P, Sudheer

    Life sciences

    2023  Volume 333, Page(s) 122141

    Abstract: Toxicity caused by chronic hyperglycemia is a significant factor affecting skeletal muscle myogenesis, resulting in diabetic myopathy. Chronic and persistent hyperglycemia causes activation of the atrophy-related pathways in the skeletal muscles, which ... ...

    Abstract Toxicity caused by chronic hyperglycemia is a significant factor affecting skeletal muscle myogenesis, resulting in diabetic myopathy. Chronic and persistent hyperglycemia causes activation of the atrophy-related pathways in the skeletal muscles, which eventually results in inflammation and muscle degeneration. To counteract this process, various bioactive compound has been studied for their reversal or hypertrophic effect. In this study, we explored the molecular mechanisms associated with reversing glucotoxicity's effect in C2C12 cells by arachidonic acid (AA). We found a substantial increase in the pro-inflammatory cytokines and ROS production in hyperglycemic conditions, mitigated by AA supplementation. We found that AA supplementation restored protein synthesis that was downregulated under glucotoxicity conditions. AA enhanced myogenesis by suppressing high glucose induced inflammation and ROS production and enhancing protein synthesis. These results imply that AA has cytoprotective actions against hyperglycemia-induced cytotoxicity.
    MeSH term(s) Humans ; Arachidonic Acid/metabolism ; Reactive Oxygen Species/metabolism ; Muscular Atrophy/metabolism ; Muscle, Skeletal/metabolism ; Hyperglycemia/metabolism ; Inflammation/pathology
    Chemical Substances Arachidonic Acid (27YG812J1I) ; Reactive Oxygen Species
    Language English
    Publishing date 2023-10-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.122141
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  9. Article ; Online: Arachidonic acid modulates the cellular energetics of human pluripotent stem cells and protects the embryoid bodies from embryotoxicity effects in vitro.

    Nihad, Muhammad / Sen, Utsav / Chaudhury, Debajit / Das, Undurti N / Shenoy P, Sudheer / Bose, Bipasha

    Reproductive toxicology (Elmsford, N.Y.)

    2023  Volume 120, Page(s) 108438

    Abstract: Arachidonic acid (AA), an ω-6 polyunsaturated fatty acid involved in signalling pathways that drive cell fate decisions, has an enhancing role in the immunomodulatory effect on mesenchymal stem cells and the vasculogenesis of embryonic stem cells. 3D ... ...

    Abstract Arachidonic acid (AA), an ω-6 polyunsaturated fatty acid involved in signalling pathways that drive cell fate decisions, has an enhancing role in the immunomodulatory effect on mesenchymal stem cells and the vasculogenesis of embryonic stem cells. 3D embryoid bodies (EBs) from pluripotent stem cells (PSCs) have been used as in vitro models for embryotoxicity for various compounds/drugs. Valproic acid (VA), a common anti-epileptic drug, is known to be embryotoxic and cause malformations in embryos. As early embryogenesis depends on AA, we investigated the embryo protective effects of AA against the embryotoxic drug VA in this study. The effects of AA on the proliferation and cell cycle parameters of PSCs were studied. In particular, the potential of AA to abrogate VA-induced embryotoxicity in vitro was evaluated using ROS detection and antioxidant assays. In response to AA, we observed modulation in cell proliferation of induced pluripotent stem cells (iPSCs) and pluripotent NTERA-2 embryonal carcinoma (EC) cells. The present study substantiates the cytoprotective effects of AA against VA. These results imply that AA plays a critical role in the proliferation and differentiation of iPSCs and EC cells and protects the EBs from cytotoxic damage, thereby ensuring normal embryogenesis. Thus, the bioactive lipid AA may be explored for supplementation to benefit pregnant women treated with long-term anti-epileptic drugs to prevent in-utero fetal growth malformations.
    MeSH term(s) Humans ; Female ; Pregnancy ; Embryoid Bodies ; Arachidonic Acid/metabolism ; Arachidonic Acid/pharmacology ; Pluripotent Stem Cells ; Embryonic Stem Cells ; Cell Differentiation
    Chemical Substances Arachidonic Acid (27YG812J1I)
    Language English
    Publishing date 2023-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2023.108438
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  10. Article ; Online: Sca1

    Kapoor, Saketh / Subba, Pratigya / Shenoy P, Sudheer / Bose, Bipasha

    Stem cell reviews and reports

    2021  Volume 17, Issue 5, Page(s) 1754–1767

    Abstract: Stem cell antigen-1 (Sca-1) is a glycosyl-phosphatidylinositol-anchored membrane protein that is expressed in a sub-population of muscle stem and progenitor cell types. Reportedly, Sca-1 regulates the myogenic property of myoblasts and Sca- ... ...

    Abstract Stem cell antigen-1 (Sca-1) is a glycosyl-phosphatidylinositol-anchored membrane protein that is expressed in a sub-population of muscle stem and progenitor cell types. Reportedly, Sca-1 regulates the myogenic property of myoblasts and Sca-1
    MeSH term(s) Animals ; Mice ; Muscle, Skeletal ; Proteome ; Proteomics ; Stem Cells
    Chemical Substances Proteome
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-021-10134-w
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