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Article ; Online: Genetic variants associated with osteosarcoma risk: a systematic review and meta-analysis.

Hassanain, Omneya / Alaa, Mahmoud / Khalifa, Mohamed K / Kamal, Nehal / Albagoury, Aseel / El Ghoneimy, Ahmed M

2024 Volume 14, Issue 1, Page(s) 3828

Abstract: Osteosarcoma (OS) is the most common type of primary bone malignancy. Common genetic variants including single nucleotide polymorphisms (SNPs) have been associated with osteosarcoma risk, however, the results of published studies are inconsistent. The ... ...

Abstract	Osteosarcoma (OS) is the most common type of primary bone malignancy. Common genetic variants including single nucleotide polymorphisms (SNPs) have been associated with osteosarcoma risk, however, the results of published studies are inconsistent. The aim of this study was to systematically review genetic association studies to identify SNPs associated with osteosarcoma risk and the effect of race on these associations. We searched the Medline, Embase, Scopus from inception to the end of 2019. Seventy-five articles were eligible for inclusion. These studies investigated the association of 190 SNPs across 79 genes with osteosarcoma, 18 SNPs were associated with the risk of osteosarcoma in the main analysis or in subgroup analysis. Subgroup analysis displayed conflicting effects between Asians and Caucasians. Our review comprehensively summarized the results of published studies investigating the association of genetic variants with osteosarcoma susceptibility, however, their potential value should be confirmed in larger cohorts in different ethnicities.
MeSH term(s)	Humans ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Genetic Predisposition to Disease ; Osteosarcoma/genetics ; Osteosarcoma/pathology ; Polymorphism, Single Nucleotide ; Asian People ; White People
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53802-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Attenuation properties of poly methyl methacrylate reinforced with micro/nano ZrO

Alabsy, Mahmoud T / Abbas, Mahmoud I / El-Khatib, Alaa Y / El-Khatib, Ahmed M

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1279

Abstract: This research aimed to examine the radiation shielding properties of unique polymer composites for medical and non-medical applications. For this purpose, polymer composites, based on poly methyl methacrylate (PMMA) as a matrix, were prepared and ... ...

Abstract	This research aimed to examine the radiation shielding properties of unique polymer composites for medical and non-medical applications. For this purpose, polymer composites, based on poly methyl methacrylate (PMMA) as a matrix, were prepared and reinforced with micro- and nanoparticles of ZrO
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51551-4
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Article ; Online: Synthesis AgO Nanoparticles by Nd:Yag Laser with Different Pulse Energies

Munaf S. Majeed / Shaymaa M. Mahmoud Mahmoud / Raghad Majeed Rasheed / Alaa Adnan Rashad

Baghdad Science Journal, Vol 21, Iss

2024 Volume 1

Abstract: One technique used to prepare nanoparticles material is Pulsed Laser Ablation in Liquid (PLAL), Silver Oxide nanoparticles (AgO) were prepared by using this technique, where silver target was submerged in ultra-pure water (UPW) at room temperature after ... ...

Abstract	One technique used to prepare nanoparticles material is Pulsed Laser Ablation in Liquid (PLAL), Silver Oxide nanoparticles (AgO) were prepared by using this technique, where silver target was submerged in ultra-pure water (UPW) at room temperature after that Nd:Yag laser which characteristics by 1064 nm wavelength, Q-switched, and 6ns pulse duration was used to irradiated silver target. This preparation method was used to study the effects of laser irradiation on Nanoparticles synthesized by used varying laser pulse energy 1000 mJ, 500 mJ, and 100 mJ, with 500 pulses each time on the particle size. Nanoparticles are characterized using XRD, SEM, AFM, and UV-Visible spectroscopy. All the structural peaks determined by the XRD test can be indexed as face-centered cubic (FCC) type, the stronger crystalline orientation is located in the (111) plane. The nanoscale particles have an almost spherical shape as inferred from the SEM images. In (1000) mJ laser pulse energy the best smallest particle size was produced. According to AFM results of all films, the particle size 32.45nm, 64.3nm, and 67.86nm respectively for 1000 mJ, 500 mJ, and 100 mJ , the surface roughness affected and increased as increase the laser energy because the increase particle size and aggregation of partials. UV-Visible spectroscopy measured the absorbance of the silver nanoparticle prepared which is increased as increase pulsed laser ablation energy at wavelength 440 nm.
Keywords	AgO Nanoparticles ; Nd:Yag Laser ; Particle size ; Pulsed Laser Ablation Technique ; UV-Visible spectroscopy ; Science ; Q
Subject code	620
Language	Arabic
Publishing date	2024-01-01T00:00:00Z
Publisher	College of Science for Women, University of Baghdad
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Attenuation properties of poly methyl methacrylate reinforced with micro/nano ZrO2 as gamma-ray shields

Mahmoud T. Alabsy / Mahmoud I. Abbas / Alaa Y. El-khatib / Ahmed M. El-Khatib

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 18

Abstract: Abstract This research aimed to examine the radiation shielding properties of unique polymer composites for medical and non-medical applications. For this purpose, polymer composites, based on poly methyl methacrylate (PMMA) as a matrix, were prepared ... ...

Abstract	Abstract This research aimed to examine the radiation shielding properties of unique polymer composites for medical and non-medical applications. For this purpose, polymer composites, based on poly methyl methacrylate (PMMA) as a matrix, were prepared and reinforced with micro- and nanoparticles of ZrO2 fillers at a loading of 15%, 30%, and 45% by weight. Using the high purity germanium (HPGe) detector, the suggested polymer composites’ shielding characteristics were assessed for various radioactive sources. The experimental values of the mass attenuation coefficients (MAC) of the produced composites agreed closely with those obtained theoretically from the XCOM database. Different shielding parameters were estimated at a broad range of photon energies, including the linear attenuation coefficient (μ), tenth value layer (TVL), half value layer (HVL), mean free path (MFP), effective electron density (Neff), effective atomic number (Zeff), and equivalent atomic number (Zeq), as well as exposure buildup factor (EBF) and energy absorption buildup factor (EABF) to provide more shielding information about the penetration of γ-rays into the chosen composites. The results showed that increasing the content of micro and nano ZrO2 particles in the PMMA matrix increases μ values and decreases HVL, TVL, and MFP values. P-45nZ sample with 45 wt% of ZrO2 nanoparticles had the highest μ values, which varied between 2.6546 and 0.0991 cm−1 as γ-ray photon energy increased from 0.0595 to 1.408 MeV, respectively. Furthermore, the highest relative increase rate in μ values between nano and micro composites was 17.84%, achieved for the P-45nZ sample at 59.53 keV. These findings demonstrated that ZrO2 nanoparticles shield radiation more effectively than micro ZrO2 even at the same photon energy and filler wt%. Thus, the proposed nano ZrO2/PMMA composites can be used as effective shielding materials to lessen the transmitted radiation dose in radiation facilities.
Keywords	Medicine ; R ; Science ; Q
Subject code	620
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparison of infection severity of vaccinated and unvaccinated health workers with Corona Virus: A cohort study.

Ayed, Alaa Y / Younis, Nasir M / Ahmed, Mahmoud M

Journal of education and health promotion

2023 Volume 12, Page(s) 336

Abstract: Background: Hospital staff members are most susceptible to the COVID-19 illness, which is currently prevented through vaccination. Hospital staff members also refuse vaccinations, albeit the underlying causes have not been identified. The study aimed to ...

Abstract	Background: Hospital staff members are most susceptible to the COVID-19 illness, which is currently prevented through vaccination. Hospital staff members also refuse vaccinations, albeit the underlying causes have not been identified. The study aimed to compare the severity of the symptoms of the disease on the body for health workers who took the coronavirus vaccine and those who did not take the vaccine. Materials and methods: This cohort study aimed to estimate the of infection severity of vaccinated and unvaccinated health workers with Corona Virus in Mosul Hospital, Iraq. Data were obtained from the General Mosul Hospital, Nineveh, Iraq. The first of the three components of this questionnaire outlined the demographic characteristics. Second part: First group of unvaccinated Health care workers included those who had not received the COVID-19 immunization or had only gotten one dose of the vaccine; the second group included those who had received their first dose of Corona vaccine and the third group included those who had received two doses of Corona Vaccine. HCWs who got corona vaccine were included in the three-dose final group. Results: The study's findings indicate that as compared to the corona vaccination, the vaccinated experienced less severe infection symptoms and fewer dosage stays. The high share of healthcare workers among the 20- to 30-year-olds who received vaccinations accounts for the gender gap between the vaccinated and unvaccinated groups. Conclusion: This study concluded that the results of the corona vaccine are not consistent among the various groups of HCWs. The acceptability of vaccinations is practically unanimous among nurses, but less so among doctors and other healthcare professionals.
Language	English
Publishing date	2023-09-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2715449-X
ISSN	2319-6440 ; 2277-9531
ISSN (online)	2319-6440
ISSN	2277-9531
DOI	10.4103/jehp.jehp_440_23
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Article ; Online: Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways.

Sayed, Alaa H / Mahmoud, Nadia S / Mohawed, Ola A M / Ahmed, Hanaa H

Inflammopharmacology

2024

Abstract: Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people worldwide. This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and ... ...

Abstract	Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people worldwide. This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and adipose tissue-derived mesenchymal stem cells (ADSCs) in comparison with each treatment alone on the healing process of the experimentally induced GU in rats, and to uncover the involved pathways. Rats were divided into five groups: (1) Control, (2) GU, (3) PANTO, (4) ADSCs and (5) ADSCs + PANTO. Markers of oxidative stress, inflammation and apoptosis were assessed. The current data indicated that PANTO-, ADSCs- and ADSCs + PANTO-treated groups showed significant drop (p < 0.05) in serum advanced oxidation protein products (AOPPs) and advanced glycation end products (AGEPs) along with significant elevation (p < 0.05) in serum TAC versus the untreated GU group. Moreover, the treated groups (PANTO, ADSCs and ADSCs + PANTO) displayed significant down-regulation (p < 0.05) in gastric nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor alpha (TNF-α), cyclooxygenase-2 (COX-2), intercellular adhesion molecule-1 (ICAM-1), matrix metallopeptidase 9 (MMP-9) and caspase-3 along with significant up-regulation (p < 0.05) in vascular endothelial growth factor (VEGF) and peroxisome proliferator-activated receptor gamma (PPARγ) genes expression compared to the untreated GU group. Immunohistochemical examination of gastric tissue for transforming growth factor β1 (TGF-β1), epidermal growth factor (EGF) and proliferating cell nuclear antigen (PCNA) showed moderate to mild and weak immune reactions, respectively in the PANTO-, ADSCs- and ADSCs + PANTO-treated rat. Histopathological investigation of gastric tissue revealed moderate to slight histopathological alterations and almost normal histological features of the epithelial cells, gastric mucosal layer, muscularis mucosa and submucosa in PANTO-, ADSCs- and ADSCs + PANTO-treated rats, respectively. Conclusively, the co-treatment with ADSCs and PANTO evidenced sententious physiological protection against GU by suppressing oxidative stress, inhibiting inflammation and reducing apoptosis with consequent acceleration of gastric tissue healing process.
Language	English
Publishing date	2024-04-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01469-0
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Article ; Online: Impact of intravenous/intranasal polyinosinic-polycytidylic acid administration on the mediastinal fat-associated lymphoid clusters and lung tissue in healthy mice.

Elewa, Yaser Hosny Ali / Khalifa, Alaa M / Zahran, Mahmoud Hosny

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2023 Volume 250, Page(s) 152158

Abstract: Background: Polyinosinic-polycytidylic acid (pIC) is a synthetic analog of double-stranded RNA. It is used as a synthetic adjuvant to induce an adaptive immune response. However, the effect of pIC on the development of mediastinal fat-associated ... ...

Abstract	Background: Polyinosinic-polycytidylic acid (pIC) is a synthetic analog of double-stranded RNA. It is used as a synthetic adjuvant to induce an adaptive immune response. However, the effect of pIC on the development of mediastinal fat-associated lymphoid clusters (MFALCs) that regulate intrathoracic hemostasis has remained unidentified. Methods: We investigated the impact of intranasal (i.n.) administration (pIC i.n. group) and intravenous (i.v.) administration (pIC i.v. group) of pIC on both MFALCs and lung tissue. Results: Compared with the control phosphate-buffered saline (PBS) groups, both pIC-administered groups displayed a significant increase in the MFALC size (particularly in the pIC i.n. group), area of MFALC high endothelial venules (HEVs), area of lymphatic vessels (LVs), number of proliferating cells (particularly in the pIC i.v. group), and number of immune cells (B220 Conclusion: In all, our data indicate that local or systemic administration of pIC induces the development of MFALCs and can be used as an immunostimulant therapeutic strategy.
MeSH term(s)	Mice ; Animals ; Poly I-C/pharmacology ; Poly I-C/therapeutic use ; Lung ; T-Lymphocytes ; B-Lymphocytes ; Lymphatic Vessels
Chemical Substances	Poly I-C (O84C90HH2L)
Language	English
Publishing date	2023-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2023.152158
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Article ; Online: Comparison of infection severity of vaccinated and unvaccinated health workers with Corona Virus

Alaa Y Ayed / Nasir M Younis / Mahmoud M Ahmed

Journal of Education and Health Promotion, Vol 12, Iss 1, Pp 336-

A cohort study

2023 Volume 336

Abstract: BACKGROUND: Hospital staff members are most susceptible to the COVID-19 illness, which is currently prevented through vaccination. Hospital staff members also refuse vaccinations, albeit the underlying causes have not been identified. The study aimed to ... ...

Abstract	BACKGROUND: Hospital staff members are most susceptible to the COVID-19 illness, which is currently prevented through vaccination. Hospital staff members also refuse vaccinations, albeit the underlying causes have not been identified. The study aimed to compare the severity of the symptoms of the disease on the body for health workers who took the coronavirus vaccine and those who did not take the vaccine.MATERIALS AND METHODS: This cohort study aimed to estimate the of infection severity of vaccinated and unvaccinated health workers with Corona Virus in Mosul Hospital, Iraq. Data were obtained from the General Mosul Hospital, Nineveh, Iraq. The first of the three components of this questionnaire outlined the demographic characteristics. Second part: First group of unvaccinated Health care workers included those who had not received the COVID-19 immunization or had only gotten one dose of the vaccine; the second group included those who had received their first dose of Corona vaccine and the third group included those who had received two doses of Corona Vaccine. HCWs who got corona vaccine were included in the three-dose final group.RESULTS: The study's findings indicate that as compared to the corona vaccination, the vaccinated experienced less severe infection symptoms and fewer dosage stays. The high share of healthcare workers among the 20- to 30-year-olds who received vaccinations accounts for the gender gap between the vaccinated and unvaccinated groups.CONCLUSION: This study concluded that the results of the corona vaccine are not consistent among the various groups of HCWs. The acceptability of vaccinations is practically unanimous among nurses, but less so among doctors and other healthcare professionals.
Keywords	corona virus ; health workers ; infection severity ; unvaccinated ; vaccinated ; Special aspects of education ; LC8-6691 ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Correction: Consolidating food safety measures against COVID-19: a review.

Abolmaaty, Assem / Amin, Dina H / El-Kader, Reham M M Abd / ELsayed, Alaa F / Soliman, Basma S M / Elbahnasawy, Amr S / Sitohy, Mahmoud

The Journal of the Egyptian Public Health Association

2023 Volume 98, Issue 1, Page(s) 12

Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Published Erratum
ZDB-ID	604779-8
ISSN	2090-262X ; 0013-2446
ISSN (online)	2090-262X
ISSN	0013-2446
DOI	10.1186/s42506-023-00137-5
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Article: Bilateral Adrenal Myelolipoma and Breast Cancer in a Patient With Congenital Adrenal Hyperplasia.

M M Zeer, Zahraa / Noman, Mahmoud / Alzeer, Almotazbellah M / Mahamid, Yamama / Abu Moch, Malak / Atwaneh, Alaa

Cureus

2024 Volume 16, Issue 2, Page(s) e54784

Abstract: Adrenal myelolipoma is a rare, benign tumor of the adrenal gland, typically non-functional, asymptomatic and unilateral. With the increased use of radiological imaging, it has been discovered more frequently as incidental mass. It is common to occur ... ...

Abstract	Adrenal myelolipoma is a rare, benign tumor of the adrenal gland, typically non-functional, asymptomatic and unilateral. With the increased use of radiological imaging, it has been discovered more frequently as incidental mass. It is common to occur concurrently with hormonal dysfunction conditions like congenital adrenal hyperplasia. However, there are few previous reported cases of malignancy concomitant with adrenal myelolipoma. We present a case of a 33-year-old patient diagnosed with congenital adrenal hyperplasia since birth. She was diagnosed with giant bilateral adrenal myelolipoma incidentally during the investigation done for staging her breast cancer. To the best of our knowledge, this is the second reported case of breast cancer concomitant with adrenal myelolipoma. Although this entity is very rare, physicians should be familiar with such rare adrenal masses and their associations in order to manage them appropriately.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54784
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