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  1. Article: Targeted Therapy in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (LA-R/M HNSCC).

    Echarri, María José / Lopez-Martin, Ana / Hitt, Ricardo

    Cancers

    2016  Volume 8, Issue 3

    Abstract: Surgery and radiotherapy are the standard treatment options for patients with squamous cell carcinoma of the head and neck (SCCHN). Chemoradiotherapy is an alternative for patients with locally advanced disease. In recurrent/metastatic disease and after ... ...

    Abstract Surgery and radiotherapy are the standard treatment options for patients with squamous cell carcinoma of the head and neck (SCCHN). Chemoradiotherapy is an alternative for patients with locally advanced disease. In recurrent/metastatic disease and after progression to platin-based regimens, no standard treatments other than best supportive care are currently available. Most SCCHN tumours overexpress the epidermal growth factor receptor (EGFR). This receptor is a tyrosine-kinase membrane receptor that has been implicated in angiogenesis, tumour progression and resistance to different cancer treatments. In this review, we analysed the different drugs and pathways under development to treat SCCHN, especially recurrent/metastatic disease. Until now, the EGFR signalling pathway has been considered the most important target with respect to new drugs; however, new drugs, such as immunotherapies, are currently under study. As new treatments for SCCHN are developed, the influence of therapies with respect to overall survival, progression free survival and quality of life in patients with this disease is changing.
    Language English
    Publishing date 2016-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers8030027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Biography of Todd R. Klaenhammer.

    Hitt, Emma

    Proceedings of the National Academy of Sciences of the United States of America

    2005  Volume 102, Issue 11, Page(s) 3903–3905

    MeSH term(s) Bacteriophages/pathogenicity ; Genome, Bacterial ; History, 20th Century ; History, 21st Century ; Lactobacillus acidophilus/genetics ; Lactobacillus acidophilus/metabolism ; Oligosaccharides/metabolism
    Chemical Substances Oligosaccharides ; fructooligosaccharide
    Language English
    Publishing date 2005-03-15
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0500351102
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  3. Article: The effects of location and MNC attributes on MNCs' establishment of foreign R&D centers

    Holmes, R. Michael / DeGhetto, Kaitlyn / Hitt, Michael A / Li, Haiyang / Sutton, Trey

    Long range planning : LRP : international journal of strategic management Vol. 49, No. 5 , p. 594-513

    evidence from China

    2016  Volume 49, Issue 5, Page(s) 594–513

    Author's details R. Michael Holmes Jr., Haiyang Li, Michael A. Hitt, Kaitlyn DeGhetto, Trey Sutton
    Language English
    Publisher Elsevier
    Publishing place Oxford
    Document type Article
    ZDB-ID 160984-1
    ISSN 0024-6301
    Database ECONomics Information System

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  4. Article: R&D intensity and international joint venture performance in an emerging market

    Cui, Geng / Hitt, Michael A / Li, Haiyang / Zhang, Yan

    Journal of international business studies : JIBS ; a publication of the Academy of International Business and the Western Business School Vol. 38, No. 6 , p. 944-960

    moderating effects of market focus and ownership structure

    2007  Volume 38, Issue 6, Page(s) 944–960

    Author's details Yan Zhang, Haiyang Li, Michael A. Hitt and Geng Cui
    Keywords Industrieforschung ; Joint Venture ; Schwellenländer ; Eigentümerstruktur ; Wissenstransfer
    Language English
    Size graph. Darst.
    Publisher Palgrave Macmillan
    Publishing place Basingstoke, Hampshire
    Document type Article
    ZDB-ID 410609x
    Database ECONomics Information System

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  5. Article ; Online: Pain severity scale: A methodology for classifying postoperative pain severity by surgical procedure.

    Hitt, James / Lee, Robert / Elkin, Peter

    Surgery open science

    2023  Volume 12, Page(s) 29–34

    Abstract: Background: Acute postoperative pain is common following many types of surgery, and a significant subset of patients experience severe pain, which can be difficult to manage and result in postoperative complications. Opioid agonists are commonly used to ...

    Abstract Background: Acute postoperative pain is common following many types of surgery, and a significant subset of patients experience severe pain, which can be difficult to manage and result in postoperative complications. Opioid agonists are commonly used to treat severe postoperative pain, but their use has been associated with adverse outcomes. This retrospective study uses data from the Veterans Administration Surgical Quality Improvement Project (VASQIP) database to develop a postoperative Pain Severity Scale (PSS) based on subjective pain reports and postoperative opioid requirements.
    Methods: Postoperative pain scores and opioid prescription data were extracted from the VASQIP database for surgeries occurring between 2010 and 2020. Procedures were grouped by surgical Common Procedural Terminology (CPT) codes, and a total of 165,321 surgical procedures were examined, representing 1141 distinct CPT codes.
    Results: K
    Conclusions: K
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-8450
    ISSN (online) 2589-8450
    DOI 10.1016/j.sopen.2023.02.003
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  6. Article ; Online: A Collaborative Simulation: Navigating Care and Advocacy for Diverse Patients in Crisis.

    Hitt, Amanda R / Harrington, Lisa / Hunt, Amanda / Winston, Rachel / Glover, Ashton

    The Journal of nursing education

    2024  , Page(s) 1–3

    Abstract: Background: Collaboration and cultural competence are essential to nursing practice. Simulation-based training allows students to explore sensitive topics safely while surveying their own biases.: Method: Faculty created a collaborative simulation ... ...

    Abstract Background: Collaboration and cultural competence are essential to nursing practice. Simulation-based training allows students to explore sensitive topics safely while surveying their own biases.
    Method: Faculty created a collaborative simulation involving baccalaureate nursing students based on a transgender adolescent with suicidal ideations and a controlling parent.
    Results: Three themes emerged during debriefings: empathy, communication, and safety. The faculty found this experience was ideal for students to process their perceptions while fine tuning soft skills needed to create a safe and inclusive environment.
    Conclusion: Nurse educators should tailor simulation-based experiences to incorporate didactic concepts such as collaboration, ethics, diversity, and conflict management to afford students an opportunity to learn skills needed to provide safe and inclusive care.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410686-6
    ISSN 1938-2421 ; 0148-4834
    ISSN (online) 1938-2421
    ISSN 0148-4834
    DOI 10.3928/01484834-20240130-02
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 616: Show issues Location:
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  7. Article ; Online: The association of self-perceived changes due to COVID-19 with mental and physical health among adult primary care patients with multiple chronic conditions: A US-based longitudinal study.

    Bonnell, Levi N / Clifton, Jessica / Natkin, Lisa W / Hitt, Juvena R / Littenberg, Benjamin

    Journal of multimorbidity and comorbidity

    2024  Volume 14, Page(s) 26335565231222148

    Abstract: Introduction: This study explores the association between self-perceived personal and community changes due to COVID-19 and health among vulnerable primary care patients experiencing multiple chronic conditions.: Methods: Between September 2017 and ... ...

    Abstract Introduction: This study explores the association between self-perceived personal and community changes due to COVID-19 and health among vulnerable primary care patients experiencing multiple chronic conditions.
    Methods: Between September 2017 and February 2021, we obtained data from 2,426 primary care patients managing multiple chronic conditions from across the United States. We assessed the relationship between self-perceived personal and community changes due to COVID-19 and change in health measured by the PROMIS-29 mental and physical health summary scores, GAD-7 (anxiety), andPHQ-9 (depression), and DASI (functional capacity) adjusting for relevant demographic, neighborhood characteristics, and county covariates.
    Results: After adjustment, self-perceived personal and community changes due to COVID-19 were associated with significantly worse mental health summary scores (ß = -0.55; 95% Confidence Interval (CI) = -0.72, -0.37), anxiety (ß = 0.28; 95% CI = 0.16, 0.39), depression (ß = 0.35; 95% CI = 0.22, 0.47), and physical health summary scores (ß = -0.44; 95% CI = 0.88, 0.00). There was no association with functional capacity (ß = - 0.05; 95% CI = -0.16, 0.05).
    Discussion: Among adults managing multiple chronic conditions, self-perceived personal and community changes due to COVID-19 were associated with health. This vulnerable population may be particularly susceptible to the negative effects of COVID-19. As we do not know the long-term health effects of COVID, this paper establishes a baseline of epidemiological data on COVID-19 burden and health among primary care patients with multiple chronic conditions.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ISSN 2633-5565
    ISSN (online) 2633-5565
    DOI 10.1177/26335565231222148
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  8. Article: Sex-Specific Differences in Nutrient Intake in Late Preterm Infants.

    Alur, Pradeep / Ramarao, Sumana / Hitt, Addie / Vig, Simmy / Alur, Radha / Hussain, Naveed

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 3

    Abstract: Challenging the assumption of uniform nutritional needs in preterm feeding, this study identifies crucial sex-specific disparities in formula milk intake and growth among late preterm infants. Premature infants have difficulty regulating their oral ... ...

    Abstract Challenging the assumption of uniform nutritional needs in preterm feeding, this study identifies crucial sex-specific disparities in formula milk intake and growth among late preterm infants. Premature infants have difficulty regulating their oral intake during feeds, which is why clinicians prescribe feeding volume, calories, and protein via the nasogastric route. However, premature male and female infants have different body compositions at birth, and, subsequently, there is no evidence to suggest that male and female preterm infants differ in their nutritional consumption once they begin feeding ad libitum. This study investigates whether there are any differences in the volume and nutrient intake between the sexes when fed formula ad libitum.
    Methods: The study involved a retrospective analysis of preterm infants admitted to the NICU and evaluated between 34 0/7 and 36 6/7 weeks of corrected gestation. Late preterm infants appropriate for gestational age who were spontaneously fed formula milk ad-lib and free of any respiratory support for at least two days were included. The study excluded infants with short gut syndrome, severe chromosomal anomalies, or congenital heart conditions. We included 85 male and 85 female infants in this study. The data collected included sex, gestational age, birth weight, anthropometric data at birth, maternal data, nutritional intake, and neonatal morbidity.
    Results: This study found that female infants consumed more volume, protein, and calories than male infants. The mean formula intake in female and male infants was 145.5 ± 20.8 mL/kg/d and 135.3 ± 19.3 mL/kg/d, respectively, with
    Conclusions: This study is the first to demonstrate differences in formula milk intake among late preterm infants fed ad libitum. Additional research is needed to confirm our findings and understand sex-specific differences in neonatal nutrition in extremely early preterm infants.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11030265
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  9. Article ; Online: Medical and Nursing Students' Perceptions of and Advice for Extended Breastfeeding: An Exploratory Study.

    Goldbort, Joanne / Hitt, Rose / Zhuang, Jie

    Health communication

    2022  Volume 38, Issue 9, Page(s) 1754–1761

    Abstract: Although the health benefits to both mother and child produced by breastfeeding have been documented, and numerous efforts have been made to promote breastfeeding rates in the United States, extended breastfeeding (breastfeeding beyond 12 months) ... ...

    Abstract Although the health benefits to both mother and child produced by breastfeeding have been documented, and numerous efforts have been made to promote breastfeeding rates in the United States, extended breastfeeding (breastfeeding beyond 12 months) research has been largely overlooked. Guided by the Framework of Integrative Normative Influences on Stigma, this study examined how extended breastfeeding was perceived among medical and nursing students and how perceptions of extended breastfeeding were translated into stigmatizing outcomes including attitudes, behavioral predispositions, and behavioral intention to encourage weaning. One hundred and sixteen medical and nursing students enrolled at a large mid-western University completed an online survey. Participants were asked to provide answers to questions regarding their knowledge of extended breastfeeding, attitudes toward it, perception about stigma associated with breastfeeding, and their behavioral intention to encourage future patients to wean. A lack of knowledge about extended breastfeeding was evident among the medical and nursing students; they also exhibited increasingly negative attitudes toward extended breastfeeding as the child's age increased. Medical and nursing students' behavioral intention to encourage weaning is associated with their pre-dispositional stigma of extended breastfeeding. Addressing stigma and negative attitudes toward extended breastfeeding in pre-healthcare students' curriculum may help future healthcare providers understand that while cultural norms in the United States do not tend toward extended breastfeeding, it is more common in other parts of the world, as well as help them understand health benefits to the child and to the mother.
    MeSH term(s) Female ; Child ; Humans ; Breast Feeding ; Students, Nursing ; Attitude ; Social Stigma ; Intention ; Surveys and Questionnaires ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038723-7
    ISSN 1532-7027 ; 1041-0236
    ISSN (online) 1532-7027
    ISSN 1041-0236
    DOI 10.1080/10410236.2022.2030079
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    Zs.A 2769: Show issues Location:
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  10. Article ; Online: Survey on the continued impact of COVID-19 on immunocompromised patients in rheumatology.

    Libman, Bonita / Morrison, Tessalyn / Haines, Laura / Hitt, Juvena R / Kennedy, Amanda G

    Musculoskeletal care

    2023  

    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2171452-6
    ISSN 1557-0681 ; 1478-2189
    ISSN (online) 1557-0681
    ISSN 1478-2189
    DOI 10.1002/msc.1845
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