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  1. Article ; Online: Le déficit en interférons de type I n’affecte pas la réponse immunitaire humorale au vaccin contre le SARS-CoV-2.

    Sokal, Aurélien / Bastard, Paul / Casanova, Jean-Laurent / Weill, Jean-Claude / Chappert, Pascal / Mahévas, Matthieu

    Medecine sciences : M/S

    2024  Volume 40, Issue 1, Page(s) 99–101

    Title translation Type I interferon deficiency does not impair humoral immune response to SARS-CoV-2 vaccination.
    MeSH term(s) Humans ; Immunity, Humoral ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccination ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language French
    Publishing date 2024-02-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2023182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of SFB in autoimmune arthritis: an example of regulation of autoreactive T cell sensitivity in the gut.

    Chappert, Pascal

    Gut microbes

    2014  Volume 5, Issue 2, Page(s) 259–264

    Abstract: A key role for segmented filamentous bacteria (SFB) has recently been demonstrated in several mouse models of autoimmune diseases, including autoimmune arthritis and multiple sclerosis. The mechanism governing the activation of systemic autoreactive T ... ...

    Abstract A key role for segmented filamentous bacteria (SFB) has recently been demonstrated in several mouse models of autoimmune diseases, including autoimmune arthritis and multiple sclerosis. The mechanism governing the activation of systemic autoreactive T cell responses by such commensals in the gut, however, remained elusive. In this addendum, we discuss recent results addressing the local regulation of autoreactive T cell sensitivity by these unique bacteria. We found that the presence of SFB in the gut microbiota was sufficient to promote a local inflammatory microenvironment altering the T cell-intrinsic desensitization process normally occurring in response to chronic self-antigen stimulation. In the absence of this key tolerance checkpoint, sustained chronic T cell proliferation, IFNγ production, and B cell activation eventually led to the development of enhanced pathologies in a Th1-driven T cell-transfer model of autoimmune arthritis.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/immunology ; Bacteria/immunology ; Gastrointestinal Tract/microbiology ; Mice ; T-Lymphocytes/immunology
    Language English
    Publishing date 2014-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ISSN 1949-0984
    ISSN (online) 1949-0984
    DOI 10.4161/gmic.28134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mémoire immunitaire contre le SARS-CoV-2 - Des anticorps contre l’infection initiale et des lymphocytes B à mémoire contre les infections futures.

    Reynaud, Claude-Agnès / Weill, Jean-Claude / Chappert, Pascal / Mahévas, Matthieu

    Medecine sciences : M/S

    2021  Volume 37, Issue 8-9, Page(s) 722–725

    Title translation Immune memory against SARS-CoV-2: Antibodies against the initial infection and memory B cells for the future ones.
    MeSH term(s) Antibodies, Neutralizing/metabolism ; Antibodies, Viral/metabolism ; Antigenic Variation/genetics ; B-Lymphocytes/immunology ; B-Lymphocytes/physiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Humans ; Immune Evasion/genetics ; Immunologic Memory/physiology ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Vaccination
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language French
    Publishing date 2021-08-04
    Publishing country France
    Document type News ; Research Support, Non-U.S. Gov't
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The whole-cell pertussis vaccine imposes a broad effector B cell response in mouse heterologous prime-boost settings.

    Valeri, Viviana / Sochon, Akhésa / Cousu, Clara / Chappert, Pascal / Lecoeuche, Damiana / Blanc, Pascal / Weill, Jean-Claude / Reynaud, Claude-Agnès

    JCI insight

    2022  Volume 7, Issue 21

    Abstract: ÍSince the introduction of new generation pertussis vaccines, resurgence of pertussis has been observed in many developed countries. Former whole-cell pertussis (wP) vaccines are able to protect against disease and transmission but have been replaced in ... ...

    Abstract ÍSince the introduction of new generation pertussis vaccines, resurgence of pertussis has been observed in many developed countries. Former whole-cell pertussis (wP) vaccines are able to protect against disease and transmission but have been replaced in several industrialized countries because of their reactogenicity and adverse effects. Current acellular pertussis (aP) vaccines, made of purified proteins of Bordetella pertussis, are efficient at preventing disease but fail to induce long-term protection from infection. While the systemic and mucosal T cell immunity induced by the 2 types of vaccines has been well described, much less is known concerning B cell responses. Taking advantage of an inducible activation-induced cytidine deaminase fate-mapping mouse model, we compared effector and memory B cells induced by the 2 classes of vaccines and showed that a stronger and broader memory B cell and plasma cell response was achieved by a wP prime. We also observed that homologous or heterologous vaccine combinations that include at least 1 wP administration, even as a booster dose, were sufficient to induce this broad effector response, thus highlighting its dominant imprint on the B cell profile. Finally, we describe the settlement of memory B cell populations in the lung following subcutaneous wP prime vaccination.
    MeSH term(s) Mice ; Animals ; Whooping Cough/prevention & control ; B-Lymphocyte Subsets ; Immunization, Secondary ; Pertussis Vaccine ; Bordetella pertussis
    Chemical Substances Pertussis Vaccine
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.157034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: BLI-MS: Combining biolayer interferometry and mass spectrometry.

    Jung, Vincent / Roger, Kévin / Chhuon, Cerina / Pannetier, Louise / Lipecka, Joanna / Gomez, Josué Sulub / Chappert, Pascal / Charbit, Alain / Guerrera, Ida Chiara

    Proteomics

    2022  Volume 22, Issue 9, Page(s) e2100031

    Abstract: Biolayer interferometry (BLI) is a technology which allows to study the affinity between two interacting macro-molecules and to visualize their kinetic of interaction in real time. In this work, we combine BLI interaction measurement with mass ... ...

    Abstract Biolayer interferometry (BLI) is a technology which allows to study the affinity between two interacting macro-molecules and to visualize their kinetic of interaction in real time. In this work, we combine BLI interaction measurement with mass spectrometry in order to identify the proteins interacting with the bait. We provide for the first time the proof of concept of the feasibility of BLI-MS in complex biological mixtures.
    MeSH term(s) Interferometry/methods ; Kinetics ; Mass Spectrometry ; Proteins/chemistry
    Chemical Substances Proteins
    Language English
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.202100031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The whole-cell pertussis vaccine imposes a broad effector B cell response in mouse heterologous prime-boost settings

    Viviana Valeri / Akhésa Sochon / Clara Cousu / Pascal Chappert / Damiana Lecoeuche / Pascal Blanc / Jean-Claude Weill / Claude-Agnès Reynaud

    JCI Insight, Vol 7, Iss

    2022  Volume 21

    Abstract: ÍSince the introduction of new generation pertussis vaccines, resurgence of pertussis has been observed in many developed countries. Former whole-cell pertussis (wP) vaccines are able to protect against disease and transmission but have been replaced in ... ...

    Abstract ÍSince the introduction of new generation pertussis vaccines, resurgence of pertussis has been observed in many developed countries. Former whole-cell pertussis (wP) vaccines are able to protect against disease and transmission but have been replaced in several industrialized countries because of their reactogenicity and adverse effects. Current acellular pertussis (aP) vaccines, made of purified proteins of Bordetella pertussis, are efficient at preventing disease but fail to induce long-term protection from infection. While the systemic and mucosal T cell immunity induced by the 2 types of vaccines has been well described, much less is known concerning B cell responses. Taking advantage of an inducible activation-induced cytidine deaminase fate-mapping mouse model, we compared effector and memory B cells induced by the 2 classes of vaccines and showed that a stronger and broader memory B cell and plasma cell response was achieved by a wP prime. We also observed that homologous or heterologous vaccine combinations that include at least 1 wP administration, even as a booster dose, were sufficient to induce this broad effector response, thus highlighting its dominant imprint on the B cell profile. Finally, we describe the settlement of memory B cell populations in the lung following subcutaneous wP prime vaccination.
    Keywords Immunology ; Vaccines ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Foxp3

    Lalfer, Mélanie / Chappert, Pascal / Carpentier, Maxime / Urbain, Dominique / Davoust, Jean M / Gross, David-Alexandre

    Frontiers in immunology

    2019  Volume 10, Page(s) 521

    Abstract: ... ...

    Abstract Foxp3
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; Cell Proliferation/physiology ; Forkhead Transcription Factors/immunology ; Immune Tolerance/immunology ; Isoantigens/immunology ; Mice ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes, Regulatory/immunology ; Transplantation Tolerance/immunology
    Chemical Substances Forkhead Transcription Factors ; Foxp3 protein, mouse ; Isoantigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2019-03-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The function of IRAP+ endosomes in T cells

    Evnouchidou, Irini / Chappert, Pascal / Benadda, Samira / Zucchetti, Andres / Weimershaus, Mirjana / Bens, Marcelle / van Endert, Peter / Guermonprez, Pierre / Hivroz, Claire / Gross, David / Saveanu, Loredana

    Molecular immunology. 2022 Oct., v. 150

    2022  

    Abstract: T lymphocytes form an immunological synapse with cells infected by pathogens or cancer cells, after recognition of MHC-epitope complexes by the TCR. The expression of the TCR on the T cell surface, its internalization and its recycling are essential for ... ...

    Abstract T lymphocytes form an immunological synapse with cells infected by pathogens or cancer cells, after recognition of MHC-epitope complexes by the TCR. The expression of the TCR on the T cell surface, its internalization and its recycling are essential for the TCR signaling pathway. While the proteins implicated in this pathway are well known, there is controversy on the role of TCR endocytosis and recycling in TCR signaling. We identified IRAP+ endosomes as a novel compartment in T cells, that controls TCR signaling. Using mice that are deficient for IRAP only in T cells (IRAP-lox-lox mice crossed with Lck-cre mice) we observed a decreased effector CD8+ T cell number 12 days after immunization with a tumor cell line, as well as increased tumor weight. Since IRAP+ endosomes had never been studied before in T cells, we proceeded to the characterization of this compartment by immunoprecipitations and immunofluorescence not only in mouse transgenic OTI T cells but also in the Jurkat human T cell line. We demonstrated that IRAP colocalizes and coimmunoprecipitates with Rab4, Lck and CD3ζ, the limiting TCR component for signal transduction. In addition, the absence of IRAP inhibits the polarized recruitment of signaling proteins to the synapse, alters the intracellular distribution of CD3ζ, leads to a strong reduction in TCR signaling and results in diminished IL-2 production. According to our results, we suggest that CD3ζ recycles and can signal through IRAP endosomes and that this signaling compartment is essential for the engagement of the TCR-dependent signaling pathways. Our results will help to the understanding of molecular mechanisms implicated in T cell activation, a crucial step of the adaptive immune response on which is based the organism’s defense towards pathogens and tumors.
    Keywords CD8-positive T-lymphocytes ; adaptive immunity ; cell lines ; endocytosis ; endosomes ; fluorescent antibody technique ; genetically modified organisms ; humans ; immunization ; immunological synapse ; interleukin-2 ; mice ; neoplasm cells ; neoplasms ; signal transduction ; synapse
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2022.05.051
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 166: Show issues Location:
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  9. Article ; Online: Correction: Depletion of Regulatory T Cells Induces High Numbers of Dendritic Cells and Unmasks a Subset of Anti-Tumour CD8+CD11c+ PD-1lo Effector T Cells.

    Goudin, Nicolas / Chappert, Pascal / Mégret, Jérome / Gross, David-Alexandre / Rocha, Benedita / Azogui, Orly

    PloS one

    2017  Volume 12, Issue 1, Page(s) e0171373

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0157822.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0157822.].
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0171373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cross-Presentation of Skin-Targeted Recombinant Adeno-associated Virus 2/1 Transgene Induces Potent Resident Memory CD8

    Gross, David-Alexandre / Ghenassia, Alexandre / Bartolo, Laurent / Urbain, Dominique / Benkhelifa-Ziyyat, Sofia / Lorain, Stéphanie / Davoust, Jean / Chappert, Pascal

    Journal of virology

    2019  Volume 93, Issue 5

    Abstract: A key aspect to consider for vaccinal protection is the induction of a local line of defense consisting of nonrecirculating tissue-resident memory T cells ( ... ...

    Abstract A key aspect to consider for vaccinal protection is the induction of a local line of defense consisting of nonrecirculating tissue-resident memory T cells (T
    MeSH term(s) Animals ; Antigen Presentation/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cross-Priming/immunology ; Dendritic Cells/immunology ; Immunologic Memory/immunology ; Mice ; Mice, Inbred C57BL ; Parvovirinae/genetics ; Parvovirinae/immunology ; Skin/cytology ; Skin/immunology ; Transgenes/genetics ; Transgenes/immunology ; Vaccination ; Viral Vaccines/immunology
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2019-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.01334-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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