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Article ; Online: Development and Validation of a Modeling and Calibration Method for Diesel-Like Multistage Combustion Based On a Modified Multi-Wiebe Function.

Zhu, Jingyu / Du, Pengzhu / Zhang, Genyuan / Song, Hui / Li, Bo / Long, Wuqiang / Dong, Dongsheng

ACS omega

2022 Volume 7, Issue 14, Page(s) 11756–11769

Abstract: The stringent regulations of fuel consumption and exhaust emission require further refinement of the control strategy for diesel engines. In the future, the prediction of the in-cylinder combustion process will become necessary to achieve a more ... ...

Abstract	The stringent regulations of fuel consumption and exhaust emission require further refinement of the control strategy for diesel engines. In the future, the prediction of the in-cylinder combustion process will become necessary to achieve a more dedicated control performance. Hence, a more precise model able to run in a real-time application is required to predict the nature of multiphase Diesel combustion. This paper presents a modified multi-Wiebe function with a concise parameter structure, which is governed by the center point of the combustion process
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c06858
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Article ; Online: Zinc Trifluoromethanesulfonate-Catalyzed

Lan, Weiqiao / Zhu, Jiatong / Abulaiti, Buweihailiqiemu / Chen, Genyuan / Zhang, Zhihao / Yan, Nan / Wan, Jie-Ping / Zhang, Xiaomei / Liao, Lihua

The Journal of organic chemistry

2022 Volume 87, Issue 21, Page(s) 13895–13906

Abstract: An efficient zinc-catalyzed amination of free anilines and free phenols with quinoneimides has been disclosed, which proceeds smoothly under simple and mild conditions. ... ...

Abstract	An efficient zinc-catalyzed amination of free anilines and free phenols with quinoneimides has been disclosed, which proceeds smoothly under simple and mild conditions. The
Language	English
Publishing date	2022-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c01600
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Zs.A 4473: Show issues

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Article: Non-alcoholic fatty liver disease increases the risk of cardiovascular disease in young adults and children: a systematic review and meta-analysis of cohort studies.

Liao, Yan-Lin / Zhu, Gen-Yuan / Chang, Cheng

Frontiers in cardiovascular medicine

2024 Volume 10, Page(s) 1291438

Abstract: Background and aims: It is uncertain if there is a link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) in young adults and children. To evaluate the potential link between these two conditions, we conducted a ... ...

Abstract	Background and aims: It is uncertain if there is a link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) in young adults and children. To evaluate the potential link between these two conditions, we conducted a systematic review and meta-analysis of cohort studies. Methods: A comprehensive search was conducted in PubMed, Web of Science and Embase in order to locate all relevant cohort studies published until August 2023. Random effects meta-analyses were conducted using the generic inverse variance method, with additional subgroup and sensitivity analyses. The Newcastle-Ottawa Scale was employed to evaluate the methodological quality. Results: Four cohort studies (eleven datasets) involving 10,668,189 participants were included in this meta-analysis. This meta-analysis demonstrated that NAFLD increases the risk of CVD in young adults and children (HR = 1.63, 95% CI: 1.46-1.82, Conclusion: Current evidence reveals that NAFLD is linked to an increased risk of major CVD (including CHD, MI, AF, CHF and stroke) in young adults and children. Further research is needed to strengthen this association and provide stronger evidence for primary prevention of CVD in young adults and children with NAFLD. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, PROSPERO registration number: CRD42023457817.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1291438
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Article ; Online: Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.

Zhu, Genyuan / Lee, Amy S

Journal of cellular physiology

2015 Volume 230, Issue 7, Page(s) 1413–1420

Abstract: The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane proteins, as well as lipids, are synthesized and modified. When cells are subjected to ER stress, an adaptive mechanism referred to as the Unfolded Protein Response (UPR) ...

Abstract	The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane proteins, as well as lipids, are synthesized and modified. When cells are subjected to ER stress, an adaptive mechanism referred to as the Unfolded Protein Response (UPR) is triggered to allow the cells to restore homeostasis. Evidence has accumulated that the UPR pathways provide specialized and unique roles in diverse development and metabolic processes. The glucose regulated proteins (GRPs) are traditionally regarded as ER proteins with chaperone and calcium binding properties. The GRPs are constitutively expressed at basal levels in all organs, and as stress-inducible ER chaperones, they are major players in protein folding, assembly and degradation. This conventional concept is augmented by recent discoveries that GRPs can be actively translocated to other cellular locations such as the cell surface, where they assume novel functions that regulate signaling, proliferation, apoptosis and immunity. Recent construction and characterization of mouse models where the gene encoding for the UPR components and the GRPs is genetically altered provide new insights on the physiological contribution of these proteins in vivo. This review highlights recent progress towards the understanding of the role of the UPR and two major GRPs (GRP78 and GRP94) in regulating homeostasis of organs arising from the endoderm, mesoderm and ectoderm. GRP78 and GRP94 exhibit shared and unique functions, and in specific organs their depletion elicits adaptive responses with physiological consequences.
MeSH term(s)	Animals ; Gene Expression Regulation/physiology ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Homeostasis/physiology ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Unfolded Protein Response/physiology
Chemical Substances	Heat-Shock Proteins ; Membrane Glycoproteins ; endoplasmin ; molecular chaperone GRP78
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.24923
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Uc I Zs.212: Show issues

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Article ; Online: OMIP-049: Analysis of Human Myelopoiesis and Myeloid Neoplasms.

Zhu, Genyuan / Brayer, Jason / Padron, Eric / Mulé, James J / Mailloux, Adam W

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2018 Volume 93, Issue 10, Page(s) 982–986

MeSH term(s)	Cell Differentiation/physiology ; Flow Cytometry/methods ; Hematopoiesis/physiology ; Humans ; Myeloid Cells/physiology ; Myelopoiesis/physiology ; Neoplasms/pathology
Language	English
Publishing date	2018-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.23598
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Zs.A 1688: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 68: Show issues

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Article: Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering.

Zhu, Genyuan / Falahat, Rana / Wang, Kui / Mailloux, Adam / Artzi, Natalie / Mulé, James J

Frontiers in immunology

2017 Volume 8, Page(s) 767

Abstract: Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a ... ...

Abstract	Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a direct correlation of the presence of human tumor-localized TLS and better patient outcome (e.g., increase in overall survival) in certain solid tumor histologies, but not all. We had identified a tumor-derived immune gene-expression signature, encoding 12 distinct chemokines, which could reliably identify the presence of TLSs, of different degrees, in various human solid tumors. We are focused on understanding the influence of TLSs on the tumor microenvironment and leveraging this understanding to both manipulate the antitumor immune response and potentially enhance immunotherapy applications. Moreover, as not all human solid tumors show the presence of these lymphoid structures, we are embarking on bioengineering approaches to design and build "designer" TLSs to address, and potentially overcome, an unmet medical need in cancer patients whose tumors lack such lymphoid structures.
Language	English
Publishing date	2017-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.00767
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Article ; Online: STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity.

Falahat, Rana / Perez-Villarroel, Patricio / Mailloux, Adam W / Zhu, Genyuan / Pilon-Thomas, Shari / Barber, Glen N / Mulé, James J

Cancer immunology research

2019 Volume 7, Issue 11, Page(s) 1837–1848

Abstract: STING (stimulator of IFN genes) signaling is an innate immune pathway for induction of a spontaneous antitumor T-cell response against certain immunogenic tumors. Although antigen-presenting cells are known to be involved in this process, insight into ... ...

Abstract	STING (stimulator of IFN genes) signaling is an innate immune pathway for induction of a spontaneous antitumor T-cell response against certain immunogenic tumors. Although antigen-presenting cells are known to be involved in this process, insight into the participation of tumor cell-intrinsic STING signaling remains weak. In this study, we find diversity in the regulation of STING signaling across a panel of human melanoma cell lines. We show that intact activation of STING signaling in a subset of human melanoma cell lines enhances both their antigenicity and susceptibility to lysis by human melanoma tumor-infiltrating lymphocytes (TIL) through the augmentation of MHC class I expression. Conversely, defects in the STING signaling pathway protect melanoma cells from increased immune recognition by TILs and limit their sensitivity to TIL lysis. Based on these findings, we propose that defects in tumor cell-intrinsic STING signaling can mediate not only tumor immune evasion but also resistance to TIL-based immunotherapies.
MeSH term(s)	Cytotoxicity, Immunologic ; Histocompatibility Antigens Class I/metabolism ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Melanoma/immunology ; Melanoma/metabolism ; Membrane Proteins/agonists ; Membrane Proteins/metabolism ; Nucleotidyltransferases/metabolism ; Signal Transduction/immunology ; Tumor Cells, Cultured ; Tumor Escape/immunology ; Up-Regulation
Chemical Substances	Histocompatibility Antigens Class I ; Membrane Proteins ; STING1 protein, human ; Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-)
Language	English
Publishing date	2019-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-19-0229
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Zs.A 7022: Show issues

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Article: Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line.

Zhu, Genyuan / Nemoto, Satoshi / Mailloux, Adam W / Perez-Villarroel, Patricio / Nakagawa, Ryosuke / Falahat, Rana / Berglund, Anders E / Mulé, James J

Frontiers in immunology

2018 Volume 9, Page(s) 1609

Abstract: Tertiary lymphoid structures (TLSs) associate with better prognosis in certain cancer types, but their underlying formation and immunological benefit remain to be determined. We established a mouse model of TLSs to study their contribution to antitumor ... ...

Abstract	Tertiary lymphoid structures (TLSs) associate with better prognosis in certain cancer types, but their underlying formation and immunological benefit remain to be determined. We established a mouse model of TLSs to study their contribution to antitumor immunity. Because the stroma in lymph nodes (sLN) participates in architectural support, lymphogenesis, and lymphocyte recruitment, we hypothesized that TLSs can be created by sLN. We selected a sLN line with fibroblast morphology that expressed sLN surface markers and lymphoid chemokines. The subcutaneous injection of the sLN line successfully induced TLSs that attracted infiltration of host immune cell subsets. Injection of MC38 tumor lysate-pulsed dendritic cells activated TLS-residing lymphocytes to demonstrate specific cytotoxicity. The presence of TLSs suppressed MC38 tumor growth
Language	English
Publishing date	2018
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.01609
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Article ; Online: GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant

Shen, Jieli / Ha, Dat P / Zhu, Genyuan / Rangel, Daisy F / Kobielak, Agnieszka / Gill, Parkash S / Groshen, Susan / Dubeau, Louis / Lee, Amy S

Proceedings of the National Academy of Sciences of the United States of America

2017 Volume 114, Issue 20, Page(s) E4020–E4029

Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strategies. Here, we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78/HSPA5), a key regulator of endoplasmic reticulum ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strategies. Here, we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78/HSPA5), a key regulator of endoplasmic reticulum homeostasis and PI3K/AKT signaling, is overexpressed in the acini and PDAC of
MeSH term(s)	Acinar Cells/metabolism ; Animals ; Carcinogenesis ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Transdifferentiation ; Female ; Haploinsufficiency ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Male ; Metaplasia ; Mice ; Pancreas/pathology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Transforming Growth Factor alpha/metabolism
Chemical Substances	Heat-Shock Proteins ; Transforming Growth Factor alpha ; molecular chaperone GRP78 (YCYIS6GADR)
Language	English
Publishing date	2017-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1616060114
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Zs.A 1148: Show issues

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Article: The effect of copper species in copper-ceria catalysts: structure evolution and enhanced performance in CO oxidation

Zhu, Wenshuang / Tang, Ke / Li, Jing / Liu, Wei / Niu, Xiaoran / Zhao, Genyuan / Ma, Xueqin / Liu, Zhaohui / Wei, Huiying / Yang, Yanzhao

RSC advances. 2016 May 12, v. 6, no. 52

2016

Abstract: In this paper, copper doped ceria porous nanospheres were synthesized using carbon nanospheres as a hard template via a homogenous precipitation method at low temperature. The results showed that the copper-doped ceria has undergone a morphology ... ...

Abstract	In this paper, copper doped ceria porous nanospheres were synthesized using carbon nanospheres as a hard template via a homogenous precipitation method at low temperature. The results showed that the copper-doped ceria has undergone a morphology transformation from the initial double-shell spheres to hollow spheres as the copper doping concentration increased from 0 to 7.5%mol. Notably, the Cu/Ce + Cu atomic ratio in the final products was approximately five times the initial design ratio, which confirmed an efficient utilization of copper in this system. Furthermore, the copper-ceria catalysts exhibited enhanced catalytic performance towards CO conversion when compared with pure ceria catalysts (e.g., for the optimal catalysts, the complete conversion temperature was 160 °C, for the pure catalysts, complete conversion temperature was 300 °C). Through the analysis of the catalysts structure, we proved that the superior catalytic performance was derived from a combination of CuOx clusters and copper ions in the Cu–[Ox]–Ce bulk phase.
Keywords	carbon ; carbon monoxide ; catalysts ; catalytic activity ; copper ; copper nanoparticles ; nanospheres ; oxidation ; temperature
Language	English
Dates of publication	2016-0512
Size	p. 46966-46971.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra08204a
Database	NAL-Catalogue (AGRICOLA)

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