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Article: [The effect of Ba Duan Jin on the balance of community-dwelling older adults: a cluster randomized control trial].

Duan, L L / Zhao, Y B / Er, Y L / Ye, P P / Wang, W / Gao, X / Deng, X / Jin, Y / Wang, Y / Ji, C R / Ma, X Y / Gao, C / Zhao, Y H / Zhu, S Q / Su, S Z / Guo, X E / Peng, J J / Yu, Y / Yang, C /

Su, Y Y / Zhao, M / Guo, L H / Wu, Y P / Luo, Y N / Meng, R L / Xu, H F / Liu, H Z / Ruan, H H / Xie, B / Zhang, H M / Liao, Y H / Chen, Y / Wang, L H

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2024 Volume 45, Issue 2, Page(s) 250–256

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Male ; Humans ; Female ; Aged ; Independent Living ; Exercise ; Health Education ; China
Language	Chinese
Publishing date	2024-02-26
Publishing country	China
Document type	Randomized Controlled Trial ; English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20230506-00283
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Article ; Online: Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease.

Zhi, Jiayi / Yin, Li / Zhang, Zhoudong / Lv, Yaozhong / Wu, Fan / Yang, Yang / Zhang, Enming / Li, Huanqiu / Lu, Ning / Zhou, Mengze / Hu, Qinghua

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 3, Page(s) 117291

Abstract: Ethnopharmacological relevance: Jin-Si-Wei (JSW), a traditional Chinese medicine (TCM) formula ...

Abstract	Ethnopharmacological relevance: Jin-Si-Wei (JSW), a traditional Chinese medicine (TCM) formula, have cognitive enhancing effect and delay the memory decline in an animal model of AD， which has been reported. However, the therapeutic mechanism of JSW in the treatment of AD remains unclear. Aim of the study: This study aimed to verify the pharmacodynamics of JSW in the treatment of AD, and to explore its potential mechanism based on network pharmacology, molecular docking and experimental validation both in vitro and in vivo. Materials and methods: In this study, the underlying mechanism of JSW against AD was investigated by the integration of network pharmacology. Then, the core pathways and biological process of JSW were verified by experiment, including behavioral test and pathological and biochemical assays with 6-month-old APP Results: A Drug-Ingredient-Target network was established, which included 363 ingredients and 116 targets related to the JSW treatment of AD. The main metabolic pathway of JSW treatment for AD is neuroactive ligand-receptor interaction pathway, and biological processes are mainly involved in Aβ metabolic process. In vivo experiments, compared with APP/PS1 mice, the cognitive and memory ability of mice was significantly improved after JSW administration. In brain tissue of APP/PS1 mice, JSW could increase the contents of low-density lipoprotein receptor-related protein 1 (LRP-1), enkephalinase (NEP) and Acetyl choline (ACh), and decrease the contents of Aβ Conclusions: JSW improves AD in APP/PS1 mice, and this therapeutic effect may be achieved in part by altering the neuroactive ligand-receptor interaction pathway.
MeSH term(s)	Humans ; Animals ; Mice ; Alzheimer Disease/drug therapy ; Ligands ; Molecular Docking Simulation ; Network Pharmacology ; Neuroblastoma ; Amyloid beta-Protein Precursor/genetics ; Amyloid Precursor Protein Secretases
Chemical Substances	Ligands ; Amyloid beta-Protein Precursor ; Amyloid Precursor Protein Secretases (EC 3.4.-)
Language	English
Publishing date	2023-11-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117291
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Article ; Online: Jin-Fu-An decoction manipulation of macrophage polarization via β-catenin (CTNNB1) synergizes with cisplatin in lung cancer.

Tang, Yang / Sun, Zhe / Wu, Siqi / Zhang, Chengyu / Zhang, Yanling / Cao, Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 168, Page(s) 115828

Abstract: ... with unfavorable outcomes in the absence of CD8+ cells. Jin-Fu-An decoction (JFAD) has been utilized as an adjunct ...

Abstract	Previous studies have demonstrated that tumor-associated macrophages (TAMs) exhibiting an M2 phenotype contribute significantly to the pathogenesis of various cancer types, including lung cancer. Therapeutic approaches targeting TAMs have the potential to complement and synergize with conventional chemotherapy and immunotherapy. Through database analysis, it has become evident that the expression of CTNNB1 (β-catenin) is predominantly localized in macrophages, and its presence is associated with unfavorable outcomes in the absence of CD8+ cells. Jin-Fu-An decoction (JFAD) has been utilized as an adjunct to augment current clinical interventions. By conducting a network pharmacological analysis, we discovered that CTNNB1 is a significant target of JFAD. Experiments were conducted to examine the impact of JFAD on macrophage polarization both in vitro and in vivo. Furthermore, the study investigated the combined effect of JFAD and cisplatin (CDDP) on mitigating adverse reactions and prolonging survival in subcutaneously transplanted tumor models and orthotopic lung cancer models. The percentage of M1 and M2 macrophages in the tumor and spleen were measured using flow cytometry. Additionally, the levels of β-catenin, M1, and M2 macrophage markers were measured by Western blotting and qPCR, while CD8 and iNOS protein expression was analyzed via immunohistochemistry. Our research findings indicate that JFAD has the ability to modulate the transformation of M2 macrophages into M1 macrophages, augment the anticancer efficacy of CDDP, and diminish the expression of cell-related markers in M2 cells. This regulatory effect may potentially be associated with the downregulation of β-catenin expression.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Cisplatin/metabolism ; beta Catenin/metabolism ; Cell Line, Tumor ; Macrophages/metabolism ; Fluorouracil/pharmacology ; Tumor Microenvironment
Chemical Substances	Cisplatin (Q20Q21Q62J) ; beta Catenin ; Fluorouracil (U3P01618RT) ; CTNNB1 protein, human
Language	English
Publishing date	2023-11-03
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115828
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Article ; Online: Effects of tai chi, ba duan jin, and walking on the mental health status of urban older people living alone: the mediating role of social participation and the moderating role of the exercise environment.

Wu, Baoyuan / Xiong, Guoyan / Zhang, Peng / Ma, Xiujie

Frontiers in public health

2024 Volume 12, Page(s) 1294019

Abstract: ... the multifaceted impacts of engaging in tai chi, ba duan jin, and walking on the mental wellbeing of older people ... ba duan jin, and walking, and the mental health status of urban older people living alone ... duan jin, and walking and mental health status; among these, tai chi had the greatest impact ...

Abstract	With the global trend of aging, lacking of interpersonal communication and spiritual support and companionship have had a great impact on the mental health of older people living alone. This study examines the multifaceted impacts of engaging in tai chi, ba duan jin, and walking on the mental wellbeing of older people residing alone in urban areas. Additionally, this research aims to explore the association between tai chi, ba duan jin, and walking, and the mental health status of urban older people living alone, by considering the mediating influence of social participation and the moderating influence of the exercise environment. To do so, 1,027 older people living alone in six Chinese cities were investigated using the Physical Activity Rating Scale (PARS-3), the Geriatric Health Questionnaire (GHQ-12), the Social Participation Indicator System Scale, and the Exercise Environment Scale. SPSS 25.0 was utilized for conducting mathematical statistical analysis, specifically for doing linear regression analysis. Additionally, AMOS was employed to develop the study model. We found that a significant negative correlation between tai chi, ba duan jin, and walking and mental health status; among these, tai chi had the greatest impact on the mental health status of urban older people living alone. Social participation mediated the relationship between tai chi, ba duan jin, walking, and mental health status, and the exercise environment had a moderating effect on this relationship. The findings of this study indicate that tai chi, ba duan jin, and walking have a positive impact on the mental health of urban older people living alone, which can be influenced by the mediating efficacy of social participation and the moderating effect of the exercise environment.
MeSH term(s)	Aged ; Humans ; Exercise ; Health Status ; Home Environment ; Social Participation ; Tai Ji/psychology ; Walking ; Exercise Movement Techniques/methods ; Mental Health
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1294019
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Article: Suppressing inflammatory signals and apoptosis-linked sphingolipid metabolism underlies therapeutic potential of Qing-Jin-Hua-Tan decoction against chronic obstructive pulmonary disease.

Yang, Jing / Shen, Xin / Qin, Mi / Zhou, Ping / Huang, Fei-Hong / You, Yun / Wang, Long / Wu, Jian-Ming

Heliyon

2024 Volume 10, Issue 3, Page(s) e24336

Abstract: Background: Qing-Jin-Hua-Tan decoction (QJHTD) is a classic traditional Chinese medicine (TCM ...

Abstract	Background: Qing-Jin-Hua-Tan decoction (QJHTD) is a classic traditional Chinese medicine (TCM) prescription that first appeared in the ancient book Yi-Xue-Tong-Zhi. QJHTD has shown effectiveness for treating chronic obstructive pulmonary disease (COPD), although its mechanisms of action are still perplexing. The molecular mechanisms underlying the curative effects of QJHTD on COPD is worth exploring. Methods: In vitro Results: Increased cell viability and proliferation with decreased apoptosis rate and proinflammatory cytokine expression were noted after QJHTD intervention. QJHTD administration elevated PEFb and PIFb values, reduced MLI, and inhibited IL-1β, TNF-α, and c-Casp3 expression Conclusion: The therapeutic effect of QJHTD on COPD is dependent on regulating inflammatory signals and apoptosis-directed SL metabolism. These findings provide deeper insights into the molecular mechanism of action of QJHTD against COPD and justify its theoretical promise in novel pharmacotherapy for this multifactorial disease.
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24336
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Article: Exploring the impact of mass migration in Jin Dynasty by psycholinguistic analysis on Classical Chinese legacy text.

Xiong, Huan / Wu, Gengxuan / Li, Sijia / Xue, Shujie / Li, Hua / Zhu, Tingshao

Frontiers in psychology

2022 Volume 13, Page(s) 993141

Abstract: The first mass migration in China took place at the end of the Western Jin, which resulted ... exerted significant impacts on the gentry of the Jin Dynasty. This paper used a huge volume of Classical ... Chinese legacy text of Jin gentry members. We used CC-LIWC to calculate frequencies of different word ...

Abstract	The first mass migration in China took place at the end of the Western Jin, which resulted in the southward transfer of the Central Plains Culture and brought about huge social changes. Such social changes exerted significant impacts on the gentry of the Jin Dynasty. This paper used a huge volume of Classical Chinese legacy text of Jin gentry members. We used CC-LIWC to calculate frequencies of different word categories used in these text contents and conducted an analysis of variance to measure significant differences between the three groups. We found 16 categories of words with significant differences and calculated their effect sizes, such as tense markers (tensem),
Language	English
Publishing date	2022-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.993141
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Article ; Online: Pharmaceuticals in multi-media environment from the Jin River to adjacent marine embayment in Southeast China.

Wu, Lin / Shi, Guowei / Liu, Yaci / Li, Yasong / Liu, Chunlei / Hao, Qichen / Cao, Wenzhi / Li, Qingsheng

Environmental science and pollution research international

2022 Volume 30, Issue 11, Page(s) 29909–29920

Abstract: ... groundwater and sediments from the Jin River to adjacent marine embayment, Southeast China, was reported ...

Abstract	Multi-media environmental distribution of 21 pharmaceuticals in river water, coastal water, groundwater and sediments from the Jin River to adjacent marine embayment, Southeast China, was reported for the first time. All the detected 10 pharmaceuticals were antibiotics. Oxytetracycline (OTC), ciprofloxacin (CFC) and enrofloxacin (EFC) were the most ubiquitous antibiotics and could be detected in all water samples. EFC also showed the highest detection frequency (100%) in both riverine and coastal sediments. The detected antibiotics were more widely distributed in coastal environment of Asia, especially China, rather than Europe, USA and Australia. Sulfamethoxazole (SMX) showed stronger sorption onto sediments compared with other antibiotics due to its higher pseudo-partitioning coefficients (846-10,786 L kg
MeSH term(s)	Rivers ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Anti-Bacterial Agents/analysis ; China ; Sulfamethoxazole ; Ciprofloxacin ; Enrofloxacin ; Pharmaceutical Preparations ; Water ; Risk Assessment
Chemical Substances	Water Pollutants, Chemical ; Anti-Bacterial Agents ; Sulfamethoxazole (JE42381TNV) ; Ciprofloxacin (5E8K9I0O4U) ; Enrofloxacin (3DX3XEK1BN) ; Pharmaceutical Preparations ; Water (059QF0KO0R)
Language	English
Publishing date	2022-11-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-24173-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Jin-Tian-Ge ameliorates ovariectomy-induced bone loss in rats and modulates osteoblastogenesis and osteoclastogenesis in vitro.

Shen, Yi / Wang, Na / Zhang, Qi / Liu, Yuling / Wu, Qudi / He, Yuqiong / Wang, Yang / Wang, Xiaoyan / Zhao, Qiming / Zhang, Quanlong / Qin, Luping / Zhang, Qiaoyan

Chinese medicine

2022 Volume 17, Issue 1, Page(s) 78

Abstract: ... for the treatment of osteoporosis and rheumatoid arthritis. Jin-Tian-Ge (JTG), the artificial tiger bone powder ...

Abstract	Background: Tiger bone, which had been one of the most famous traditional Chinese medicine for 2000 years, was originate from the skeleton of Panthera tigris L., and had the actions of anti-inflammatory, analgesic, immune-regulatory and promoting healing of bone fracture, and was used for the treatment of osteoporosis and rheumatoid arthritis. Jin-Tian-Ge (JTG), the artificial tiger bone powder, were prepared from skeletons of several farmed animals to substitute the natural tiger bone, and has been used for the treatment of osteoporosis in clinical practice. However, the characteristic and mechanism of action of JTG for the therapy of osteoporosis need to be further evidenced by using modern pharmacological methods. The aim of this work is to investigate the bone-protective effects of JTG, and explore the possible underlying mechanism. Methods: Ovariectomy (OVX) rats were orally administrated JTG or estradiol valerate (EV) for 12 weeks. We investigated the pharmacodynamic effects of JTG on anti-bone loss in OVX rats, and also investigated the role of JTG in promoting osteogenesis and inhibiting osteoclast differentiation. Results: JTG increased the bone mineral density (BMD), improved the bone microarchitecture and biomechanical properties in ovariectomized rast, whereas reversed the bone high turnover in OVX rats as evidenced by serum biochemical markers in OVX rats. JTG increased osteogenic differentiation of BMSCs in vitro, and up-regulated the expression of the key proteins of BMP and Wnt/β-catenin pathways. JTG also inhibited the osteoclastogenesis of BMM as evidenced by the alteration of the TRAP activity, F-actin construction and the expression of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), c-Fos, Cathepsin K (Ctsk) and matrix metallopeptidase 9 (MMP9) of OCs induced with RANKL and LPS, reduced the expression and phosphorylation of NF-κB in OCs. Conclusions: JTG prevented bone loss in OVX rats and increased osteogenic differentiation of BMSCs through regulation of the BMP and Wnt/β-catenin pathway, inhibited osteoclastogenesis by suppressing the NF-κB pathway, suggesting that JTG had the potentials for prevention and treatment of osteoporosis by modulating formation and differentiation of osteoblast and osteoclast.
Language	English
Publishing date	2022-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-022-00627-2
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Article: Yu Jin Pulvis inhibits carbon tetrachloride-induced liver fibrosis by blocking the MAPK and PI3K/Akt signaling pathways.

Wu, Wei / Piao, Haiyu / Wu, Fushun / Han, Yong / An, Dongzhu / Wu, Yanling / Lin, Zhenhua / Piao, Yingshi / Jin, Jingchun

American journal of translational research

2019 Volume 11, Issue 9, Page(s) 5998–6006

Abstract: Traditional Chinese medicine theory indicates that Yu Jin Pulvis (YJP) could prevent liver fibrosis ...

Abstract	Traditional Chinese medicine theory indicates that Yu Jin Pulvis (YJP) could prevent liver fibrosis progression and this has been verified in liver fibrosis patients. However, the mechanism underlying the protective effects of YJP against liver fibrosis remains unclear. While different signaling pathways are involved in liver fibrosis progression, mitogen-activated protein kinase (MAPK) and phosphoinositide-3-kinase-protein kinase B/Akt (PI3K/Akt) are the most crucial. To determine whether YJP regulates these signaling pathways to prevent liver fibrosis, we used a mouse model of liver fibrosis induced by intraperitoneal injection of carbon tetrachloride (CCl
Language	English
Publishing date	2019-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Pharmaceuticals in multi-media environment from the Jin River to adjacent marine embayment in Southeast China

Wu, Lin / Shi, Guowei / Liu, Yaci / Li, Yasong / Liu, Chunlei / Hao, Qichen / Cao, Wenzhi / Li, Qingsheng

Environ Sci Pollut Res. 2023 Mar., v. 30, no. 11 p.29909-29920

2023

Abstract: ... groundwater and sediments from the Jin River to adjacent marine embayment, Southeast China, was reported ...

Abstract	Multi-media environmental distribution of 21 pharmaceuticals in river water, coastal water, groundwater and sediments from the Jin River to adjacent marine embayment, Southeast China, was reported for the first time. All the detected 10 pharmaceuticals were antibiotics. Oxytetracycline (OTC), ciprofloxacin (CFC) and enrofloxacin (EFC) were the most ubiquitous antibiotics and could be detected in all water samples. EFC also showed the highest detection frequency (100%) in both riverine and coastal sediments. The detected antibiotics were more widely distributed in coastal environment of Asia, especially China, rather than Europe, USA and Australia. Sulfamethoxazole (SMX) showed stronger sorption onto sediments compared with other antibiotics due to its higher pseudo-partitioning coefficients (846–10,786 L kg⁻¹). The discharged wastewater and aquaculture were the main sources of antibiotics in the multi-media environment. Risk assessment indicated that CFC and SMX posed high risks to Microcystis aeruginosa and Synechococcus leopolensis in river water, coastal water and groundwater.
Keywords	Microcystis aeruginosa ; Synechococcus ; aquaculture ; ciprofloxacin ; coastal water ; enrofloxacin ; groundwater ; oxytetracycline ; riparian areas ; risk assessment ; river water ; rivers ; sorption ; sulfamethoxazole ; wastewater ; Australia ; China ; Europe
Language	English
Dates of publication	2023-03
Size	p. 29909-29920.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-24173-4
Database	NAL-Catalogue (AGRICOLA)

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