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  1. Article ; Online: COVID-19 vaccination and HIV-1 acquisition - Authors' reply.

    Buchbinder, Susan P / McElrath, M Juliana / Dieffenbach, Carl / Corey, Lawrence

    Lancet (London, England)

    2022  Volume 399, Issue 10333, Page(s) e36

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; HIV Seropositivity ; HIV-1 ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-04-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00329-4
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  2. Article ; Online: Adjuvants: tailoring humoral immune responses.

    McElrath, M Juliana

    Current opinion in HIV and AIDS

    2017  Volume 12, Issue 3, Page(s) 278–284

    Abstract: Purpose of review: The development and availability of new-generation adjuvants beyond aluminum and emulsion formulations, together with a deeper understanding of the mechanistic role of adjuvant formulations in stimulating innate immunity and offer ... ...

    Abstract Purpose of review: The development and availability of new-generation adjuvants beyond aluminum and emulsion formulations, together with a deeper understanding of the mechanistic role of adjuvant formulations in stimulating innate immunity and offer opportunities to improve candidate vaccine designs intended to protect against HIV-1 acquisition.
    Recent findings: Currently, major efforts in vaccine development focus on improving prime-boost vaccine regimens to enhance efficacy beyond 31% observed in the RV144 phase 3 study and to develop a pathway to induce broadly reactive HIV neutralizing antibodies. Advances in HIV-1 envelope (Env) immunogen design and improved adjuvant formulations are moving at a parallel pace. This review highlights steps underway to rationally pair vaccine concepts with improved adjuvant formulations in preclinical and early phase 1 clinical evaluation.
    Summary: New adjuvants with immune-potentiating properties are currently being tested in combination with recent HIV Env-containing immunogens in prime-boost and subunit protein-only regimens. Greater emphasis is being applied to formulation science, delivery, and targeted safety and immune evaluation with these adjuvants in clinical trials. The need to develop an HIV vaccine that induces more potent and long-lived protective immunity will necessitate continued efforts to optimize adjuvanted vaccine formulations.
    MeSH term(s) AIDS Vaccines/administration & dosage ; AIDS Vaccines/genetics ; AIDS Vaccines/immunology ; Adjuvants, Immunologic/administration & dosage ; Animals ; HIV Antibodies/immunology ; HIV Infections/immunology ; HIV Infections/prevention & control ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/immunology ; Humans ; Immunity, Humoral
    Chemical Substances AIDS Vaccines ; Adjuvants, Immunologic ; HIV Antibodies
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and the Path to Immunity.

    Stephens, David S / McElrath, M Juliana

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1279–1281

    MeSH term(s) Adaptive Immunity ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Seroepidemiologic Studies ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.16656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report.

    Maciel, Milton / Amara, Rama R / Bar, Katharine J / Crotty, Shane / Deeks, Steven G / Duplessis, Christopher / Gaiha, Gaurav / McElrath, M Juliana / McMichael, Andrew / Palin, Amy / Rutishauser, Rachel / Shapiro, Stuart / Smiley, Stephen T / D'Souza, M Patricia

    NPJ vaccines

    2024  Volume 9, Issue 1, Page(s) 61

    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Published Erratum
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-024-00852-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report.

    Maciel, Milton / Amara, Rama R / Bar, Katharine J / Crotty, Shane / Deeks, Steven G / Duplessis, Christopher / Gaiha, Gaurav / McElrath, M Juliana / McMichael, Andrew / Palin, Amy / Rutishauser, Rachel / Shapiro, Stuart / Smiley, Stephen T / D'Souza, M Patricia

    NPJ vaccines

    2024  Volume 9, Issue 1, Page(s) 39

    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-024-00818-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Use of adenovirus type-5 vectored vaccines: a cautionary tale.

    Buchbinder, Susan P / McElrath, M Juliana / Dieffenbach, Carl / Corey, Lawrence

    Lancet (London, England)

    2020  Volume 396, Issue 10260, Page(s) e68–e69

    MeSH term(s) Adenoviridae/genetics ; Adenovirus Vaccines ; Betacoronavirus ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/prevention & control ; Genetic Vectors ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Vaccines, Synthetic ; Viral Vaccines
    Chemical Substances Adenovirus Vaccines ; COVID-19 Vaccines ; Vaccines, Synthetic ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)32156-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 and the Path to Immunity

    Stephens, David S. / McElrath, M. Juliana

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1279

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.16656
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  9. Article ; Online: Th2-Biased Transcriptional Profile Predicts HIV Envelope-Specific Polyfunctional CD4

    Cohen, Kristen W / Tian, Yuan / Thayer, Casey / Seese, Aaron / Amezquita, Robert / McElrath, M Juliana / De Rosa, Stephen C / Gottardo, Raphael

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 3, Page(s) 526–534

    Abstract: Ag-specific T cells play a critical role in responding to viral infections. In the RV144 HIV vaccine clinical trial, a rare subset of HIV-specific polyfunctional ... ...

    Abstract Ag-specific T cells play a critical role in responding to viral infections. In the RV144 HIV vaccine clinical trial, a rare subset of HIV-specific polyfunctional CD4
    MeSH term(s) AIDS Vaccines ; CD4-Positive T-Lymphocytes ; Cytokines ; HIV Antibodies ; HIV Infections ; HIV-1 ; Humans ; T-Lymphocytes
    Chemical Substances AIDS Vaccines ; Cytokines ; HIV Antibodies
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2101211
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  10. Article ; Online: Response to Guo et al.'s Letter to the Editor.

    Fong, Youyi / Huang, Ying / Lemos, Maria P / Mcelrath, M Juliana

    Biostatistics (Oxford, England)

    2018  Volume 20, Issue 2, Page(s) 363–365

    Language English
    Publishing date 2018-12-24
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2031500-4
    ISSN 1468-4357 ; 1465-4644
    ISSN (online) 1468-4357
    ISSN 1465-4644
    DOI 10.1093/biostatistics/kxy061
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