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  1. Article ; Online: Bilobed tongue base associated with multiple branchial anomalies.

    Konstantinidou, Sevasti / Wyatt, Michelle / Butler, Colin / Frauenfelder, Claire

    BMJ case reports

    2021  Volume 14, Issue 3

    Abstract: A bilobed tongue base was identified in an infant with multiple other head, neck and cardiac congenital anomalies. This anatomical variation of the posterior tongue is rare, with only two other cases identified in the literature. We report a case of a 5- ... ...

    Abstract A bilobed tongue base was identified in an infant with multiple other head, neck and cardiac congenital anomalies. This anatomical variation of the posterior tongue is rare, with only two other cases identified in the literature. We report a case of a 5-month-old boy with a bilobed posterior tongue incidentally identified during workup for cardiac surgery.
    MeSH term(s) Humans ; Infant ; Larynx ; Male ; Neck/diagnostic imaging ; Tongue/surgery
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-241081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Paediatric olfactory dysfunction: a chance to detect COVID-19?

    Hall, Andrew / Frauenfelder, Claire / Butler, Colin / Coyle, Paula / Hopkins, Claire

    Archives of disease in childhood

    2020  Volume 106, Issue 3, Page(s) e17

    MeSH term(s) Anosmia/diagnosis ; Anosmia/etiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/prevention & control ; Child ; Communicable Disease Control/methods ; Diagnosis, Differential ; Disease Transmission, Infectious/prevention & control ; Female ; Humans ; Male ; Respiratory Tract Infections/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Letter
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-319971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Subglottic ectopic thymus mimicking airway haemangioma.

    Konstantinidou, Sevasti / Butler, Colin R / Hartley, Benjamin / Frauenfelder, Claire

    BMJ case reports

    2021  Volume 14, Issue 5

    Abstract: Subglottic haemangioma presents as progressive obstruction in the neonatal and infantile airway, with a soft lesion seen during endoscopy. Diagnosis is based on macroscopic findings, biopsy is not usually performed and propranolol is first-line treatment. ...

    Abstract Subglottic haemangioma presents as progressive obstruction in the neonatal and infantile airway, with a soft lesion seen during endoscopy. Diagnosis is based on macroscopic findings, biopsy is not usually performed and propranolol is first-line treatment. In contrast, ectopic thymus is a rare differential diagnosis for subglottic mass made by histopathological examination after excision or autopsy. In this article, we present a case of an infant with a subglottic lesion with endoscopic features consistent with haemangioma. After initial clinical response to propranolol, the patient represented with progressive stridor no longer responding to therapy. Open excision of the lesion was performed, and histopathology revealed ectopic thymus tissue. In this case, ectopic thymus tissue mimicked the presentation of subglottic haemangioma, and confirmation bias persisted due to an apparent initial clinical response to treatment with propranolol. In cases of subglottic mass refractory to medical treatment, excision of the lesion should be considered.
    MeSH term(s) Hemangioma/diagnostic imaging ; Humans ; Infant ; Infant, Newborn ; Laryngeal Neoplasms/diagnostic imaging ; Lymphatic Diseases ; Propranolol/therapeutic use ; Respiratory Sounds/etiology
    Chemical Substances Propranolol (9Y8NXQ24VQ)
    Language English
    Publishing date 2021-05-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-241074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Laryngeal reinnervation for paediatric vocal cord palsy: a systematic review.

    Hoey, Andrew W / Hall, Andrew / Butler, Colin / Frauenfelder, Claire / Wyatt, Michelle

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 12, Page(s) 5771–5781

    Abstract: Objective: This systematic review aims to provide an overview of the current evidence-base for paediatric surgical reinnervation in unilateral and bilateral vocal fold palsies in clinical practice. We aim to assess patient demographics, surgical ... ...

    Abstract Objective: This systematic review aims to provide an overview of the current evidence-base for paediatric surgical reinnervation in unilateral and bilateral vocal fold palsies in clinical practice. We aim to assess patient demographics, surgical technique and pre- and post-operative outcome measures.
    Methods: A systematic literature review was performed and reported according to international PRISMA recommendations. A comprehensive search of PubMed, Embase, and Cochrane CENTRAL databases for relevant publications for all available dates with appropriate MESH search criteria was performed. Articles were categorised by four authors independently. A pooled summative analysis was carried out to allow review of demographic and outcome data.
    Results: Our systematic PRISMA approach resulted in 19 papers being selected for inclusion and analysis with 179 patients undergoing reinnervation (153 unilateral, 26 bilateral). The youngest patient was 1.9 years. Iatrogenic injury to recurrent laryngeal nerve most common aetiology (65.4% and 19.2% of unilateral and bilateral vocal fold palsies, respectively). Patent ductus arteriosus ligation was the single most common procedure resulting in unilateral vocal fold palsies (43.1% of cases). Statistically significant improvements in subjective and objective outcomes for both voice and swallowing were seen. Meta-analysis was able to be performed on the particularly evident improvements in GRBAS score and Maximum Phonation Time (MPT). GRBAS scores improved by 3.64 (p < 0.01, 95% CI 2.65 to 4.63). MPT showed a statistically significant improvement of 5.26 s (p < 0.05, 95% CI 4.28 to 6.24). No major complications were reported.
    Conclusion: The current published evidence on one-hundred and seventy-nine paediatric surgical reinnervation procedures demonstrates its role as a safe and effective treatment for both unilateral and bilateral vocal fold palsies. Anatomically it has been shown to improve vocal fold tone, bulk and position. Both post-operative voice and swallowing outcomes show improvement as well as associated quality of life measures.
    MeSH term(s) Humans ; Child ; Vocal Cord Paralysis/etiology ; Vocal Cord Paralysis/surgery ; Quality of Life ; Recurrent Laryngeal Nerve/surgery ; Vocal Cords/surgery ; Vocal Cords/innervation ; Larynx
    Language English
    Publishing date 2022-07-15
    Publishing country Germany
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07471-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Paediatric olfactory dysfunction

    Hall, Andrew / Frauenfelder, Claire / Butler, Colin / Coyle, Paula / Hopkins, Claire

    Archives of Disease in Childhood

    a chance to detect COVID-19?

    2020  , Page(s) archdischild–2020–319971

    Keywords Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-319971
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir.

    Frauenfelder, Claire / Brierley, Joe / Whittaker, Elizabeth / Perucca, Giulia / Bamford, Alasdair

    Pediatrics

    2020  Volume 146, Issue 3

    Abstract: We describe an ex-premature infant presenting with severe acute respiratory syndrome coronavirus 2 infection in the fifth week of life. In current reports, researchers indicate that acute symptomatic severe acute respiratory syndrome coronavirus 2 ... ...

    Abstract We describe an ex-premature infant presenting with severe acute respiratory syndrome coronavirus 2 infection in the fifth week of life. In current reports, researchers indicate that acute symptomatic severe acute respiratory syndrome coronavirus 2 infection is relatively rare and much less severe than in adults. This case highlights that infection can be associated with life-threatening pulmonary disease in young infants and that infection can follow a similar disease course to that described in adults. We provide first data on the use of the novel antiviral remdesivir in a young child and an innovative approach to expedited approval from a multidisciplinary clinical team and bioethics committee for compassionate access to the drug.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Female ; Humans ; Infant ; Infant, Premature ; Intensive Care Units ; Intubation, Intratracheal/methods ; Pandemics ; Patient Discharge ; Pneumonia, Viral/diagnosis ; Radiography, Thoracic/methods ; Respiration, Artificial/methods ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/drug therapy ; Treatment Outcome
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-1701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Micro-CT Imaging of Pediatric Thyroglossal Duct Cysts: A Prospective Case Series.

    Frauenfelder, Claire / Shelmerdine, Susan C / Simcock, Ian C / Hall, Andrew / Hutchinson, John Ciaran / Ashworth, Michael T / Arthurs, Owen J / Butler, Colin R

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 746010

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.746010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Otolaryngologic Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With COVID-19.

    Cheong, Ryan C T / Jephson, Christopher / Frauenfelder, Claire / Cavalli, Lesley / Moshal, Karyn / Butler, Colin R / Wyatt, Michelle E

    JAMA otolaryngology-- head & neck surgery

    2021  Volume 147, Issue 5, Page(s) 482–484

    MeSH term(s) Adolescent ; Anosmia/virology ; COVID-19/complications ; Child ; Deglutition Disorders/virology ; Dysphonia/virology ; Female ; Humans ; Male ; Otorhinolaryngologic Diseases/virology ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/complications
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2020.5698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir

    Frauenfelder, Claire / Brierley, Joe / Whittaker, Elizabeth / Perucca, Giulia / Bamford, Alasdair

    Pediatrics

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32554811
    Database COVID19

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