Article: Infección diseminada por vacuna con bacilo de Calmette-Guérin y coinfección por SARS-CoV-2 en paciente con deficiencia de la subunidad β1 del receptor de IL-12.
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
2021 Volume 67, Issue 4, Page(s) 401–407
Abstract: Background: Inborn errors of immunity manifest with a greater susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, or malignancies. One of these is the mendelian susceptibility to mycobacterial disease. The most frequent ... ...
| Title translation | Disseminated infection caused by the bacillus Calmette-Guérin vaccine and SARS-CoV-2 coinfection in a patient with IL-12 receptor β1 subunit deficiency. | |||||
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| Abstract | Background: Inborn errors of immunity manifest with a greater susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, or malignancies. One of these is the mendelian susceptibility to mycobacterial disease. The most frequent etiology is the complete autosomal recessive deficiency of the β1 subunit of the interleukin 12 receptor. Case report: A female patient who, by the age of six months, started with a nodular lesion in the right shoulder and ipsilateral axillary adenitis after the bacillus Calmette-Guérin vaccine was applied. Later, she developed a cutaneous fistula in the anterior thorax, the inframammary region, and chronic recidivant suppurative lymphadenitis. A disseminated infection caused by Mycobacterium bovis was diagnosed, therefore, individualized pharmacological treatment was required due to failure with the primary treatment. The patient was diagnosed with deficiency in the β1 subunit of the interleukin 12 receptor at age six. During her last hospitalization, she presented fever, cough, and tachypnea, and SARS-CoV-2 was detected by quantitative polymerase chain reaction. The patient has had a favorable evolution. Conclusion: In patients with disseminated infections caused by bacillus Calmette-Guérin vaccination or by environmental mycobacteria, there should be suspicion of an inborn error of immunity and the patient should be referred to a third level hospital for an early immunological assessment. |
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| MeSH term(s) | BCG Vaccine/adverse effects ; COVID-19/complications ; Candidiasis, Oral/complications ; Child ; Coinfection ; Cutaneous Fistula/etiology ; Female ; Genetic Predisposition to Disease ; Humans ; Immunocompromised Host ; Interleukin-12 Subunit p40/deficiency ; Interleukin-12 Subunit p40/genetics ; Mycobacterium bovis/pathogenicity ; SARS-CoV-2 ; Tuberculosis/etiology ; Tuberculosis, Lymph Node/etiology ; Vasculitis, Leukocytoclastic, Cutaneous/complications | |||||
| Chemical Substances | BCG Vaccine ; Interleukin-12 Subunit p40 | |||||
| Language | Spanish | |||||
| Publishing date | 2021-02-26 | |||||
| Publishing country | Mexico | |||||
| Document type | Case Reports ; Journal Article ; Review | |||||
| ZDB-ID | 639125-4 | |||||
| ISSN | 0002-5151 | |||||
| ISSN | 0002-5151 | |||||
| DOI | 10.29262/ram.v67i4.798 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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