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  1. Article ; Online: Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.

    Fratangelo, Luigia / Nguyen, Sylvain / D'Amelio, Patrizia

    Systematic reviews

    2023  Volume 12, Issue 1, Page(s) 84

    Abstract: Background: Hyponatremia is frequent in older age; whether it is a key player, a surrogate marker, or an innocent bystander in age-related diseases is still unclear.: Objective: To understand the role of hyponatremia in falls, osteoporosis, fractures, ...

    Abstract Background: Hyponatremia is frequent in older age; whether it is a key player, a surrogate marker, or an innocent bystander in age-related diseases is still unclear.
    Objective: To understand the role of hyponatremia in falls, osteoporosis, fractures, and cognitive impairment in old patients.
    Method: Eligibility criteria for study inclusions were: written in English, peer-reviewed observational and intervention studies, clinical trial, prospective and retrospective controlled cohort studies, and case-controlled studies without limitations regarding the date of publication.
    Information sources: Protocol available on the International Prospective Register of Systematic Reviews (PROSPERO, CRD42021218389). MEDLINE, Embase, and PsycINFO were searched. Final search done on August 8, 2021. Risk-of-bias assessment: Risk-of-Bias Assessment tool for Non-randomized Studies (RoBANS) and the Bradford Hill's criteria for causality.
    Results: Includes studies: One-hundred thirty-five articles retained for the revision. Synthesis of results - Falls: Eleven studies were included. Strong association between hyponatremia and falls in all the studies was found. Osteoporosis and fractures: nineteen articles were included. The association between hyponatremia and osteoporosis is unclear. Cognitive impairment: Five articles were included. No association between hyponatremia and cognitive impairment was found.
    Discussion: Interpretation: Falls, osteoporosis, and fractures are multifactorial. Hyponatremia is not temporally related with the outcomes; we suggest that hyponatremia may be regarded as a marker of unhealthy aging and a confounder instead of a causal factor or an innocent bystander for falls and fractures. Concerning cognitive impairment, there are no evidence supporting a real role of hyponatremia to be regarded as an innocent bystander in neurodegeneration.
    MeSH term(s) Humans ; Aging ; Fractures, Bone ; Hyponatremia/complications ; Osteoporosis ; Retrospective Studies
    Language English
    Publishing date 2023-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-023-02246-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bone Deformities through the Prism of the International Classification of Functioning, Disability and Health in Ambulant Children with Cerebral Palsy: A Systematic Review.

    Bailly, Rodolphe / Pons, Christelle / Haes, Anne-Charlotte / Nguyen, Lisa / Thepaut, Matthias / Houx, Laëtitia / Lempereur, Mathieu / Brochard, Sylvain

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: 1) Aim: The aim of this study was to determine the relationship between lower limb bone deformities and body functions, activity, and participation in ambulant children with CP and whether changing bone morphology affects outcomes in these domains. (2) ... ...

    Abstract (1) Aim: The aim of this study was to determine the relationship between lower limb bone deformities and body functions, activity, and participation in ambulant children with CP and whether changing bone morphology affects outcomes in these domains. (2) Methods: A systematic literature search (PROSPERO CRD42020208416) of studies reporting correlations between measures of lower limb bone deformities and measures of body function, activity or participation, or post-surgical outcomes in these domains was conducted from 1990 to 2023 in Medline, Scopus, and Cochrane Library. We assessed study quality with the Checklist for Case Series (CCS) and a quality assessment developed by Quebec University Hospital. Meta-analysis was not possible; therefore, descriptive synthesis was performed. (3) Results: A total of 12 of 3373 screened articles were included. No studies evaluated the relationships between bone deformities and activity or participation, or the effect of isolated bone surgery on these domains. Correlations between bone deformities and body functions were poor-to-moderate. Internal hip rotation during gait improved after femoral derotation osteotomy. (4) Conclusions: A shift in paradigm is urgently required for the research and management of bone deformities in children with CP to include the activity and participation domains of the ICF, as well as consider more psychological aspects such as self-image.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11020257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy of eculizumab in transplantation-associated thrombotic microangiopathy: results of the French nationwide study on behalf of the SFGM-TC and the CNR-MAT.

    Peyre, Marion / Sicre de Fontbrune, Flore / Berceanu, Ana / Benjemia, Lise / Castelle, Martin / D'Aveni, Maud / Marçais, Ambroise / Kaphan, Eleonore / Bulabois, Claude-Eric / Sirvent, Anne / Rohrlich, Pierre-Simon / Coiteux, Valerie / Chantepie, Sylvain / Nguyen-Quoc, Stéphanie / Peffault de Latour, Régis / Coppo, Paul

    Bone marrow transplantation

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02279-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Circulating tumor cells in Waldenström macroglobulinemia.

    Boccon-Gibod, Clémentine / Sourdeau, Elise / Morel, Pierre / Chapiro, Elise / Nguyen-Khac, Florence / Bravetti, Clotilde / Davi, Frédéric / Morel, Véronique / Gauthier, Nicolas / Grenier, Adrien / Boussen, Inès / Choquet, Sylvain / Leblond, Véronique / Le Garff-Tavernier, Magali / Baron, Marine / Roos-Weil, Damien

    Leukemia

    2024  Volume 38, Issue 4, Page(s) 903–907

    MeSH term(s) Humans ; Waldenstrom Macroglobulinemia/pathology ; Neoplastic Cells, Circulating ; Mutation ; Cell Proliferation
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02156-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Growth Performance and Disease Resistance against

    Hoa, Tran Thi Tuyet / Fagnon, Mahougnon Siméon / Thy, Dang Thuy Mai / Chabrillat, Thibaut / Trung, Nguyen Bao / Kerros, Sylvain

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 21

    Abstract: Acute Hepatopancreatic Necrosis Disease (AHPND) is a serious and emerging disease caused by a group of strains ... ...

    Abstract Acute Hepatopancreatic Necrosis Disease (AHPND) is a serious and emerging disease caused by a group of strains of
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13213320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hybrid Peptide-Alkoxyamine Drugs: A Strategy for the Development of a New Family of Antiplasmodial Drugs.

    Embo-Ibouanga, Ange W / Nguyen, Michel / Paloque, Lucie / Coustets, Mathilde / Joly, Jean-Patrick / Augereau, Jean-Michel / Vanthuyne, Nicolas / Bikanga, Raphaël / Coquin, Naomie / Robert, Anne / Audran, Gérard / Boissier, Jérôme / Mellet, Philippe / Benoit-Vical, Françoise / Marque, Sylvain R A

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 6

    Abstract: The emergence and spread of drug- ... ...

    Abstract The emergence and spread of drug-resistant
    MeSH term(s) Humans ; Antimalarials/chemistry ; Cytostatic Agents/therapeutic use ; Malaria/drug therapy ; Malaria, Falciparum/drug therapy ; Plasmodium falciparum ; Peptides/pharmacology ; Peptides/therapeutic use
    Chemical Substances Antimalarials ; Cytostatic Agents ; Peptides
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29061397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Book ; Online: A Conditional Randomization Test for Sparse Logistic Regression in High-Dimension

    Nguyen, Binh T. / Thirion, Bertrand / Arlot, Sylvain

    2022  

    Abstract: Identifying the relevant variables for a classification model with correct confidence levels is a central but difficult task in high-dimension. Despite the core role of sparse logistic regression in statistics and machine learning, it still lacks a good ... ...

    Abstract Identifying the relevant variables for a classification model with correct confidence levels is a central but difficult task in high-dimension. Despite the core role of sparse logistic regression in statistics and machine learning, it still lacks a good solution for accurate inference in the regime where the number of features $p$ is as large as or larger than the number of samples $n$. Here, we tackle this problem by improving the Conditional Randomization Test (CRT). The original CRT algorithm shows promise as a way to output p-values while making few assumptions on the distribution of the test statistics. As it comes with a prohibitive computational cost even in mildly high-dimensional problems, faster solutions based on distillation have been proposed. Yet, they rely on unrealistic hypotheses and result in low-power solutions. To improve this, we propose \emph{CRT-logit}, an algorithm that combines a variable-distillation step and a decorrelation step that takes into account the geometry of $\ell_1$-penalized logistic regression problem. We provide a theoretical analysis of this procedure, and demonstrate its effectiveness on simulations, along with experiments on large-scale brain-imaging and genomics datasets.
    Keywords Statistics - Machine Learning ; Computer Science - Machine Learning ; Mathematics - Statistics Theory
    Publishing date 2022-05-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Nkx2-5

    Choquet, Caroline / Sicard, Pierre / Vahdat, Juliette / Nguyen, Thi Hong Minh / Kober, Frank / Varlet, Isabelle / Bernard, Monique / Richard, Sylvain / Kelly, Robert G / Lalevée, Nathalie / Miquerol, Lucile

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 5

    Abstract: The ventricular conduction or His-Purkinje system (VCS) mediates the rapid propagation and precise delivery of electrical activity essential for the synchronization of heartbeats. Mutations in the transcription ... ...

    Abstract The ventricular conduction or His-Purkinje system (VCS) mediates the rapid propagation and precise delivery of electrical activity essential for the synchronization of heartbeats. Mutations in the transcription factor
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10050194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Treatment of cognitive and mood disorders secondary to traumatic brain injury by the association of bilateral occipital nerve stimulation and a combined protocol of multisite repetitive transcranial magnetic stimulation and cognitive training: A case report.

    Caloc'h, Tiphanie / Le Saout, Estelle / Litaneur, Séverine / Suarez, Alcira / Durand, Sylvain / Lefaucheur, Jean-Pascal / Nguyen, Jean-Paul

    Frontiers in neurology

    2023  Volume 14, Page(s) 1195513

    Abstract: Purpose: Cognitive impairment secondary to traumatic brain injury (TBI) is difficult to treat and usually results in severe disability.: Method: A 48-year-old man presented with chronic refractory headaches and persistent disabling cognitive ... ...

    Abstract Purpose: Cognitive impairment secondary to traumatic brain injury (TBI) is difficult to treat and usually results in severe disability.
    Method: A 48-year-old man presented with chronic refractory headaches and persistent disabling cognitive impairment after TBI. He was first treated with occipital nerve stimulation (ONS) implanted bilaterally to relieve headaches (8 years after the head trauma). Two years later, he was treated with a 6-week protocol combining repetitive transcranial magnetic stimulation (rTMS) delivered to multiple cortical sites (prefrontal cortex, language areas, and areas involved in visuo-spatial functions) and computerized cognitive training (CogT) (targeting memory, language, and visuo-spatial functions) to improve cognitive performance.
    Results: Executive and cognitive functions (attention, ability to perform calculations, and verbal fluency) improved in association with pain relief after ONS (33-42% improvement) and then improved even more after the rTMS-CogT protocol with an additional improvement of 36-40% on apathy, depression, and anxiety, leading to a significant reduction in caregiver burden. The functional improvement persisted and even increased at 6 months after the end of the rTMS-CogT procedure (10 years after the onset of TBI and 2 years after ONS implantation).
    Conclusion: This is the first observation describing sustained improvement in post-TBI refractory headache, depression, and cognitive impairment by the association of bilaterally implanted ONS and a combined procedure of multisite rTMS and CogT to target various brain functions.
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1195513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SPITFIR(e): a supermaneuverable algorithm for fast denoising and deconvolution of 3D fluorescence microscopy images and videos.

    Prigent, Sylvain / Nguyen, Hoai-Nam / Leconte, Ludovic / Valades-Cruz, Cesar Augusto / Hajj, Bassam / Salamero, Jean / Kervrann, Charles

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1489

    Abstract: Modern fluorescent microscopy imaging is still limited by the optical aberrations and the photon budget available in the specimen. A direct consequence is the necessity to develop flexible and "off-road" algorithms in order to recover structural details ... ...

    Abstract Modern fluorescent microscopy imaging is still limited by the optical aberrations and the photon budget available in the specimen. A direct consequence is the necessity to develop flexible and "off-road" algorithms in order to recover structural details and improve spatial resolution, which is critical when restraining the illumination to low levels in order to limit photo-damages. Here, we report SPITFIR(e) a flexible method designed to accurately and quickly restore 2D-3D fluorescence microscopy images and videos (4D images). We designed a generic sparse-promoting regularizer to subtract undesirable out-of-focus background and we developed a primal-dual algorithm for fast optimization. SPITFIR(e) is a "swiss-knife" method for practitioners as it adapts to any microscopy techniques, to various sources of signal degradation (noise, blur), to variable image contents, as well as to low signal-to-noise ratios. Our method outperforms existing state-of-the-art algorithms, and is more flexible than supervised deep-learning methods requiring ground truth datasets. The performance, the flexibility, and the ability to push the spatiotemporal resolution limit of sub-diffracted fluorescence microscopy techniques are demonstrated on experimental datasets acquired with various microscopy techniques from 3D spinning-disk confocal up to lattice light sheet microscopy.
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26178-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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