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Article ; Online: Low Prognostic Nutritional Index Predicts Adverse Outcomes in Patients With Heart Failure: A Systematic Review and Meta-analysis.

Zhang, Xiaole / Su, Yongcai

2023 Volume 75, Issue 4, Page(s) 305–313

Abstract: The association of low prognostic nutritional index (PNI) with adverse outcomes remains conflicting in heart failure patients. To address these knowledge gaps, we performed this meta-analysis to investigate the predictive value of PNI in patients with ... ...

Abstract	The association of low prognostic nutritional index (PNI) with adverse outcomes remains conflicting in heart failure patients. To address these knowledge gaps, we performed this meta-analysis to investigate the predictive value of PNI in patients with heart failure (HF). PubMed and Embase databases were comprehensively searched until January 19, 2023, to identify studies that evaluated the predictive role of PNI in HF patients. Outcomes of interest included all-cause mortality and/or combined endpoint of mortality and re-hospitalization. Twelve studies involving 9365 patients with HF were included and analyzed. Comparison of the lowest with the highest PNI, the pooled multivariate adjusted risk ratio (RR) was 1.79 (95% confidence interval [CI] 1.40-2.30) and 2.67 (95% CI 1.92-3.71) for long-term all-cause mortality and combined endpoint of mortality and re-hospitalization, respectively. Furthermore, per unit reduction in PNI was associated with 8% higher risk of all-cause mortality. However, there was no clear association of low PNI with in-hospital mortality. Low PNI may be an independent predictor of long-term all-cause mortality and re-hospitalization in patients with HF. Estimation of nutritional state using the PNI may provide an important clue for risk stratification in these patients.
MeSH term(s)	Humans ; Nutrition Assessment ; Prognosis ; Nutritional Status ; Heart Failure/diagnosis ; Heart Failure/therapy ; Hospitalization
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/00033197231159680
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Article: Microbubbles activated by low-frequency ultrasound enhance the anti-tumor effects of curcumin in glioma cells by suppressing the TGF-β1/Smad/VEGF/NCAM signaling pathway.

Mei, Lixia / Zhang, Zhen / Song, Xiaole / Zhao, Xiaodi

General physiology and biophysics

2024 Volume 43, Issue 1, Page(s) 73–84

Abstract: This study investigated whether microbubbles activated by low-frequency ultrasound enhanced the anti-tumor effects of curcumin in glioma cells. CCK8 proliferation assay, scratch migration assay, and transwell invasion assay were performed to estimate the ...

Abstract	This study investigated whether microbubbles activated by low-frequency ultrasound enhanced the anti-tumor effects of curcumin in glioma cells. CCK8 proliferation assay, scratch migration assay, and transwell invasion assay were performed to estimate the proliferation, migration, and invasion rates of the glioma cells in blank control and different treatment groups, respectively. Quantitative RT-PCR (qRT-PCR) analysis was performed to determine the relative expression levels of VEGF and NCAM mRNAs in the various experimental groups. Western blotting was performed to determine the activity status of the TGF-β1/Smad signaling pathway in various groups of glioma cells by estimating the expression levels of p-SMAD2/3, VEGF, and NCAM proteins. Combined treatment (Cur-Us-MBs) with microbubbles activated by low-frequency ultrasound and curcumin significantly reduced the in vitro proliferation, migration, and invasiveness of glioma cells compared to the control and other treatment groups. Furthermore, Cur-Us-MBs significantly reduced the expression levels of VEGF and NCAM mRNAs and proteins and p-Smad2/3 proteins , including those cells stimulated with rhTGF-β. These suggested that microbubbles activated by low-frequency ultrasound enhanced the inhibition of TGF-β1/Smad/VEGF/NCAM signaling pathway by curcumin，and enhanced the antitumor effects of curcumin by significantly reducing in vitro proliferation, migration, and invasiveness of glioma cells through this pathway.
MeSH term(s)	Humans ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Curcumin/pharmacology ; Glioma/drug therapy ; Microbubbles ; Neural Cell Adhesion Molecules/metabolism ; Signal Transduction ; Transforming Growth Factor beta1/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Smad Proteins/metabolism
Chemical Substances	Curcumin (IT942ZTH98) ; Neural Cell Adhesion Molecules ; Transforming Growth Factor beta1 ; Vascular Endothelial Growth Factor A ; Smad Proteins
Language	English
Publishing date	2024-02-01
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2023024
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Zs.A 1874: Show issues

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Article ; Online: The "crosstalk" between microbiota and metabolomic profile in high-fat-diet-induced obese mice supplemented with Bletilla striata polysaccharides and composite polysaccharides.

Zhang, Qian / Zeng, Rui / Tang, Junni / Jiang, Xiaole / Zhu, Chenglin

International journal of biological macromolecules

2024 Volume 262, Issue Pt 1, Page(s) 130018

Abstract: The potential prebiotic feature of Bletilla striata polysaccharides (BSP) has been widely accepted, while the beneficial effect of BSP on high-fat-diet-induced obesity is unclear. Moreover, the "crosstalk" between microbiota and metabolomic profile in ... ...

Abstract	The potential prebiotic feature of Bletilla striata polysaccharides (BSP) has been widely accepted, while the beneficial effect of BSP on high-fat-diet-induced obesity is unclear. Moreover, the "crosstalk" between microbiota and metabolomic profile in high-fat-diet-induced obese mice supplemented with BSP still need to be further explored. The present study attempted to illustrate the effect of BSP and/or composite polysaccharides on high-fat-diet-induced obese mice by combining multi-matrix (feces, urine, liver) metabolomics and gut microbiome. The results showed that BSP and/or composite polysaccharides were able to reduce the abnormal weight gain induced by high-fat diet. A total of 175 molecules were characterized by proton nuclear magnetic resonance (
MeSH term(s)	Animals ; Mice ; Diet, High-Fat/adverse effects ; Mice, Obese ; Obesity/etiology ; Obesity/chemically induced ; Polysaccharides/chemistry ; Gastrointestinal Microbiome ; Dietary Supplements ; Mice, Inbred C57BL
Chemical Substances	Polysaccharides
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130018
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Zs.B 2374: Show issues

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Article ; Online: Advances on adaptive immune responses affected by infectious bursal disease virus in chicken.

Zhang, Tao / Wang, Suyan / Liu, Yongzhen / Qi, Xiaole / Gao, Yulong

Frontiers in immunology

2024 Volume 14, Page(s) 1330576

Abstract: Infectious bursal disease (IBD) is an acute, highly infectious, and immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which interferes with the immune system, causes hypoimmunity and seriously threatens the healthy ... ...

Abstract	Infectious bursal disease (IBD) is an acute, highly infectious, and immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which interferes with the immune system, causes hypoimmunity and seriously threatens the healthy development of the poultry industry. Adaptive immune response, an important defense line of host resistance to pathogen infection, is the host-specific immune response mainly mediated by T and B lymphocytes. As an important immunosuppressive pathogen in poultry, IBDV infection is closely related to the injury of the adaptive immune system. In this review, we focus on recent advances in adaptive immune response influenced by IBDV infection, especially the damage on immune organs, as well as the effect on humoral immune response and cellular immune response, hoping to provide a theoretical basis for further exploration of the molecular mechanism of immunosuppression induced by IBDV infection and the establishment of novel prevention and control measures for IBD.
MeSH term(s)	Animals ; Immunity, Humoral ; Chickens ; Infectious bursal disease virus ; B-Lymphocytes ; Health Status ; Immunosuppressive Agents
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1330576
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Article ; Online: Facile Synthesis of Hierarchically Porous Ni-N-C for Efficient CO

Zhou, Chong / Zhang, Rui / Rong, Youwen / Yang, Yaoyue / Jiang, Xiaole

ACS applied materials & interfaces

2023 Volume 15, Issue 36, Page(s) 42585–42593

Abstract: The reasonable design of atomically dispersed Ni- ... ...

Abstract	The reasonable design of atomically dispersed Ni-N
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c08187
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Article ; Online: 1

Yang, Li / Zhang, Xiaole / Zhang, Jiahai / Tu, Xiaoming

Biomolecular NMR assignments

2022 Volume 16, Issue 2, Page(s) 253–255

Abstract: ... ...

Abstract	1
MeSH term(s)	Histones/chemistry ; Magnetic Resonance Spectroscopy ; Nuclear Magnetic Resonance, Biomolecular ; Protozoan Proteins/chemistry ; Trypanosoma brucei brucei/metabolism
Chemical Substances	Histones ; Protozoan Proteins
Language	English
Publishing date	2022-06-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2388861-1
ISSN	1874-270X ; 1874-2718
ISSN (online)	1874-270X
ISSN	1874-2718
DOI	10.1007/s12104-022-10088-1
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Article ; Online: Association of Metabolic Syndrome with Adverse Outcomes in Patients with Stable Coronary Artery Disease: A Meta-Analysis.

Su, Yongcai / Zhang, Xiaole

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

2022 Volume 55, Issue 2, Page(s) 96–102

Abstract: A consensus has not been reached on the association of metabolic syndrome (MetS) with adverse outcomes in patients with stable coronary artery disease (CAD). The purpose of this systematic review and meta-analysis was to summarize the prognostic ... ...

Abstract	A consensus has not been reached on the association of metabolic syndrome (MetS) with adverse outcomes in patients with stable coronary artery disease (CAD). The purpose of this systematic review and meta-analysis was to summarize the prognostic implication of MetS in patients with stable CAD. We comprehensively searched articles indexing in PubMed and Embase databases until August 14, 2022. Original studies investigating the association of MetS with adverse outcomes in patients with stable CAD were included. Seven studies including 32 736 patients with stable CAD were identified. Depending on the definition of MetS, the reported prevalence of MetS ranged from 23.4% to 63%. Meta-analysis showed that patients with MetS conferred an increased risk of all-cause mortality [risk ratio (RR) 1.22; 95% confidence intervals (CI) 1.15-1.19], cardiovascular mortality (RR 1.49; 95% CI 1.16-1.92), and MACEs defined by death, myocardial infarction, revascularization, cardiac arrest, or angina admission (RR 1.47; 95% CI 1.20-1.79), respectively. Leave-one-out sensitivity analysis indicated the robustness of the value of MetS in prediction of all-cause mortality. MetS may be an independently predictor of adverse outcomes in patients with stable CAD. However, future studies are required to consolidate the current evidence due to the small number of studies included.
MeSH term(s)	Humans ; Coronary Artery Disease/complications ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Risk Factors ; Myocardial Infarction ; Prognosis
Language	English
Publishing date	2022-09-16
Publishing country	Germany
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/a-1946-4823
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Zs.A 681: Show issues

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Article ; Online: Polycyclic aromatic hydrocarbon (PAH) biodegradation capacity revealed by a genome-function relationship approach

Yue Huang / Liguan Li / Xiaole Yin / Tong Zhang

Environmental Microbiome, Vol 18, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background Polycyclic aromatic hydrocarbon (PAH) contamination has been a worldwide environmental issue because of its impact on ecosystems and human health. Biodegradation plays an important role in PAH removal in natural environments. To date, ...

Abstract	Abstract Background Polycyclic aromatic hydrocarbon (PAH) contamination has been a worldwide environmental issue because of its impact on ecosystems and human health. Biodegradation plays an important role in PAH removal in natural environments. To date, many PAH-degrading strains and degradation genes have been reported. However, a comprehensive PAH-degrading gene database is still lacking, hindering a deep understanding of PAH degraders in the era of big data. Furthermore, the relationships between the PAH-catabolic genotype and phenotype remain unclear. Results Here, we established a bacterial PAH-degrading gene database and explored PAH biodegradation capability via a genome-function relationship approach. The investigation of functional genes in the experimentally verified PAH degraders indicated that genes encoding hydratase-aldolase could serve as a biomarker for preliminarily identifying potential degraders. Additionally, a genome-centric interpretation of PAH-degrading genes was performed in the public genome database, demonstrating that they were ubiquitous in Proteobacteria and Actinobacteria. Meanwhile, the global phylogenetic distribution was generally consistent with the culture-based evidence. Notably, a few strains affiliated with the genera without any previously known PAH degraders (Hyphomonas, Hoeflea, Henriciella, Saccharomonospora, Sciscionella, Tepidiphilus, and Xenophilus) also bore a complete PAH-catabolic gene cluster, implying their potential of PAH biodegradation. Moreover, a random forest analysis was applied to predict the PAH-degrading trait in the complete genome database, revealing 28 newly predicted PAH degraders, of which nine strains encoded a complete PAH-catabolic pathway. Conclusions Our results established a comprehensive PAH-degrading gene database and a genome-function relationship approach, which revealed several potential novel PAH-degrader lineages. Importantly, this genome-centric and function-oriented approach can overcome the bottleneck of conventional ...
Keywords	PAH ; Biodegradation ; Database mining ; Functional gene ; Genome-centric analysis ; Genotype–phenotype relationship ; Environmental sciences ; GE1-350 ; Microbiology ; QR1-502
Subject code	500
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assessing the Clinical Efficacy of Stereotactic Puncture in Combination with Postoperative Rehabilitation Training for Hypertensive Cerebral Hemorrhage.

Xie, Qin / Zhang, Xiaole / Ding, Yanli / Zhang, Lixin

Alternative therapies in health and medicine

2023

Abstract: Objective: This study aims to investigate the clinical efficacy of stereotactic puncture for intracerebral hematoma removal, combined with postoperative individualized health education and rehabilitation training concerning hypertensive cerebral ... ...

Abstract	Objective: This study aims to investigate the clinical efficacy of stereotactic puncture for intracerebral hematoma removal, combined with postoperative individualized health education and rehabilitation training concerning hypertensive cerebral hemorrhage. We also assessed its impact on rebleeding prevention and neurological function recovery. Methods: A retrospective study was conducted, including 90 patients diagnosed with hypertensive cerebral hemorrhage in our hospital between March 2020 and June 2022. The inclusion criteria were patients with an episcleral hematoma volume exceeding 30 ml. The control group underwent minimally invasive removal using neuroendoscopy (45 patients), while the observation group received stereotactic puncture for intracerebral hematoma removal (45 patients). After surgery, both groups received individualized health education and rehabilitation training. The assessment included: (1) determination of clinical efficacy, (2) monitoring for rebleeding within 72 hours after surgery, (3) evaluation of daily living ability using the Barthel index, (4) assessment of motor function using the Fugl-Meyer Assessment (FMA) scale, and (5) monitoring for adverse reactions. Results: The observation group, which underwent stereotactic puncture for intracerebral hematoma removal combined with postoperative individualized health education and rehabilitation training, exhibited significantly better clinical efficacy, Barthel index scores, and FMA scores compared to the control group that underwent neuroendoscopic minimally invasive removal (P < .05). Notably, no complications were observed in either group, and there was no significant difference in the postoperative bleeding rate within 72 hours. Conclusions: The combined treatment approach of stereotactic puncture for intracerebral hematoma removal and postoperative individualized health education and rehabilitation training demonstrates promising therapeutic effects in managing hypertensive cerebral hemorrhage. This approach also contributes significantly to the rehabilitation of patients with hypertensive cerebral hemorrhage, warranting widespread clinical adoption.
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Zs.A 4504: Show issues

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Article ; Online: The "Hand as Foot" teaching method in cervical cancer.

Wang, Xiaole / Meng, Weijie / Zhang, Leilei / He, Miaolong

Asian journal of surgery

2022 Volume 45, Issue 10, Page(s) 1944–1946

MeSH term(s)	Female ; Foot/pathology ; Hand ; Humans ; Lower Extremity ; Neoplasm Staging ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery
Language	English
Publishing date	2022-04-25
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.04.027
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