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  1. Book: Infection prevention and control guideline for cystic fibrosis

    Saiman, Lisa

    2013 update ; Cystic Fibrosis Foundation guideline

    (Infection control and hospital epidemiology ; 35, Suppl. 1)

    2014  

    Institution Cystic Fibrosis Foundation
    Author's details Lisa Saiman
    Series title Infection control and hospital epidemiology ; 35, Suppl. 1
    Infection control & hospital epidemiology
    Collection Infection control & hospital epidemiology
    Language English
    Size S67 S.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, IL
    Publishing country United States
    Document type Book
    HBZ-ID HT018405646
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  2. Article ; Online: Improving outcomes of infections in cystic fibrosis in the era of CFTR modulator therapy.

    Saiman, Lisa

    Pediatric pulmonology

    2019  Volume 54 Suppl 3, Page(s) S18–S26

    Abstract: Currently, available single and dual-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies have favorably altered the life course of individuals with cystic fibrosis (CF) by decreasing morbidities and increasing ... ...

    Abstract Currently, available single and dual-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies have favorably altered the life course of individuals with cystic fibrosis (CF) by decreasing morbidities and increasing survival. However, even with CFTR modulator use, questions and challenges remain to optimize the management of lung infections. This review (a) identifies these ongoing challenges and discusses the current understanding of the potential impact of CFTR modulator therapy on infections; (b) describes ongoing research to optimize detection, diagnosis, and treatment of CF microorganisms; and (c) discusses strategies to develop new anti-infective therapies. The CF Foundation has launched the Infection Research Initiative to fund research that will improve our understanding of the complex microbial ecology within the CF lung, improve detection of CF pathogens, optimize current treatment, including long-term chronic therapies, and develop new anti-infective therapies. Ongoing clinical trials to determine the optimal duration of treatment of pulmonary exacerbations and to diagnose and treat nontuberculous mycobacteria represent clinical research paradigms that could be used to answer other complex treatment questions. The anti-infective pipeline includes both existing anti-infective and non-anti-infective agents, many of which are proposed to have unique mechanisms of action in CF. Future studies plan to evaluate short- and long-term clinical effectiveness and impact on infections, of the next generation of CFTR modulator therapy, the highly effective triple-combination therapy, for individuals with CF, homozygous or heterozygous for F508del.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Chloride Channel Agonists/therapeutic use ; Combined Modality Therapy ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/microbiology ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Humans ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Chloride Channel Agonists ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2019-11-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Targeted tuberculin skin testing and treatment of latent tuberculosis infection in children and adolescents

    Saiman, Lisa

    June 6 - 7, 2002, Columbia University, New York, New York

    (Pediatrics ; 114,4, Pt. 3 = Suppl.)

    2004  

    Author's details Lisa Saiman, suppl. ed
    Series title Pediatrics ; 114,4, Pt. 3 = Suppl.
    Collection
    Language English
    Size S.1175 - 1201 : graph. Darst.
    Publisher American Academy of Pediatrics
    Publishing place Springfield, Ill.
    Publishing country United States
    Document type Book
    HBZ-ID HT014184911
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  4. Article ; Online: Potential opportunities and challenges for infection prevention and control for cystic fibrosis in the modern era.

    Murray, Laurie / Saiman, Lisa

    Current opinion in infectious diseases

    2022  Volume 35, Issue 4, Page(s) 346–352

    Abstract: Purpose of review: We describe recent changes in care for people with cystic fibrosis (PwCF) that could impact infection prevention and control (IP&C) practices.: Recent findings: Current IP&C guidelines primarily aim to prevent acquisition and ... ...

    Abstract Purpose of review: We describe recent changes in care for people with cystic fibrosis (PwCF) that could impact infection prevention and control (IP&C) practices.
    Recent findings: Current IP&C guidelines primarily aim to prevent acquisition and transmission of pathogens in PwCF utilizing evidence-based recommendations for healthcare settings. Currently, highly effective modulator therapy (HEMT) is dramatically improving the clinical manifestations of cystic fibrosis and reducing pulmonary exacerbations and hospitalizations. Thus, it is feasible that long-term, sustained improvements in pulmonary manifestations of cystic fibrosis could favorably alter cystic fibrosis microbiology. The COVID-19 pandemic increased the use of virtual care, enabling PwCF to spend less time in healthcare settings and potentially reduce the risk of acquiring cystic fibrosis pathogens. The increasing use of whole genome sequencing (WGS) shows great promise in elucidating sources of cystic fibrosis pathogens, shared strains, and epidemic strains and ultimately could allow the cystic fibrosis community to monitor the safety of changed IP&C practices, if deemed appropriate. Finally, given the nonhealthcare environmental reservoirs for cystic fibrosis pathogens, practical guidance can inform PwCF and their families about potential risks and mitigation strategies.
    Summary: New developments in the treatment of PwCF, a shift toward virtual care delivery of care, and use of WGS could change future IP&C practices.
    MeSH term(s) COVID-19/prevention & control ; Cystic Fibrosis/drug therapy ; Humans ; Pandemics
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Antimicrobial use and opportunities for antimicrobial stewardship in pediatric postacute and long-term care settings.

    Johnson, Candace L / Neu, Natalie / Saiman, Lisa

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 9, Page(s) 1515–1517

    Abstract: We performed a point-prevalence study of antimicrobial prescriptions in 9 pediatric postacute and long-term care (pPALTC) settings. Antimicrobials were prescribed for 5%-7% of residents including infectious (41%), noninfectious (24%), prophylaxis (24%), ... ...

    Abstract We performed a point-prevalence study of antimicrobial prescriptions in 9 pediatric postacute and long-term care (pPALTC) settings. Antimicrobials were prescribed for 5%-7% of residents including infectious (41%), noninfectious (24%), prophylaxis (24%), and unknown (11%) indications. Macrolides were often prescribed for noninfectious indications. Developing treatment guidelines are antimicrobial stewardship opportunities for pPALTC.
    MeSH term(s) Humans ; Child ; Long-Term Care ; Antimicrobial Stewardship ; Anti-Infective Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Prescriptions
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2022.287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Next Steps for Health Care-Associated Infections in the Neonatal Intensive Care Unit.

    Brachio, Sandhya S / Gu, Wendi / Saiman, Lisa

    Clinics in perinatology

    2023  Volume 50, Issue 2, Page(s) 381–397

    Abstract: We discuss the burden of health care-associated infections (HAIs) in the neonatal ICU and the role of quality improvement (QI) in infection prevention and control. We examine specific QI opportunities and approaches to prevent HAIs caused by ... ...

    Abstract We discuss the burden of health care-associated infections (HAIs) in the neonatal ICU and the role of quality improvement (QI) in infection prevention and control. We examine specific QI opportunities and approaches to prevent HAIs caused by Staphylococcus aureus , multidrug-resistant gram-negative pathogens, Candida species, and respiratory viruses, and to prevent central line-associated bloodstream infections (CLABSIs) and surgical site infections. We explore the emerging recognition that many hospital-onset bacteremia episodes are not CLABSIs. Finally, we describe the core tenets of QI, including engagement with multidisciplinary teams and families, data transparency, accountability, and the impact of larger collaborative efforts to reduce HAIs.
    MeSH term(s) Infant, Newborn ; Humans ; Intensive Care Units, Neonatal ; Catheter-Related Infections ; Cross Infection/prevention & control ; Hospitals ; Delivery of Health Care
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 193116-7
    ISSN 1557-9840 ; 0095-5108
    ISSN (online) 1557-9840
    ISSN 0095-5108
    DOI 10.1016/j.clp.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Approach to intrapartum fever during the COVID-19 pandemic: A New York City Hospital experience.

    Parow, Aimee / Cron, Julia / Nagy, Szilvia / Saiman, Lisa / Singh, Harjot K

    American journal of infection control

    2024  

    Abstract: The yield of repeat severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) testing for intrapartum fever in patients admitted to labor and delivery negative for SARS-CoV-2 on admission testing is unknown. From October 2020 to June 2022, we ... ...

    Abstract The yield of repeat severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) testing for intrapartum fever in patients admitted to labor and delivery negative for SARS-CoV-2 on admission testing is unknown. From October 2020 to June 2022, we performed a retrospective study of 151/3,168 (4.8%) patients who had repeat testing for intrapartum fever. One (0.7%) patient was SARS-CoV-2-positive suggesting repeat SARS-CoV-2 testing for intrapartum fever is generally not warranted nor is separating birthing dyads while awaiting test results.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2024.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Success of Targeted Strategies to Reduce Methicillin-Susceptible Staphylococcus aureus Infections in the Neonatal Intensive Care Unit.

    Saiman, Lisa

    Infection control and hospital epidemiology

    2016  Volume 37, Issue 4, Page(s) 388–389

    MeSH term(s) Cross Infection ; Humans ; Intensive Care Units, Neonatal ; Methicillin ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections ; Staphylococcus aureus
    Chemical Substances Methicillin (Q91FH1328A)
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2016.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Infection control recommendations for patients with cystic fibrosis

    Saiman, Lisa / Siegel, Jane

    microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission

    (American journal of infection control ; 31,3, Suppl.)

    2003  

    Author's details Lisa Saiman, Jane Siegel, and the Cystic Fibrosis Foundation Consensus Conference on Infection Control participants
    Series title American journal of infection control ; 31,3, Suppl.
    Collection
    Language English
    Size S62 S.
    Publisher Mosby
    Publishing place St. Louis, MO
    Publishing country United States
    Document type Book
    HBZ-ID HT013712002
    Database Catalogue ZB MED Medicine, Health

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  10. Book: Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission

    Saiman, Lisa / Siegel, Jane

    (Infection control and hospital epidemiology ; 24,5, Suppl.)

    2003  

    Author's details Lisa Saiman, Jane Siegel, and the Cystic Fibrosis Foundation Consensus Conference on Infection Control participants
    Series title Infection control and hospital epidemiology ; 24,5, Suppl.
    Infection control & hospital epidemiology
    Collection Infection control & hospital epidemiology
    Language English
    Size S52 S.
    Publisher SLACK
    Publishing place Thorofare, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013717240
    Database Catalogue ZB MED Medicine, Health

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