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Article ; Online: Effect of Xiao-Ai-Ping injection on paclitaxel pharmacokinetics in rats by LC-MS/MS method.

Shi, Mei-Zhi / Xing, Ting-Yu / Chen, Jun-Jun / Jiang, Bo / Xiao, Xiao / Yang, Jiao / Zhu, Jiang / Guo, Cheng / Hu, Jiu-Dong / Han, Yong-Long

Journal of pharmaceutical and biomedical analysis

2019 Volume 174, Page(s) 728–733

Abstract: Xiao-Ai-Ping injection (XAP) has been shown to be clinically effective in treatment of gastric ...

Abstract	Xiao-Ai-Ping injection (XAP) has been shown to be clinically effective in treatment of gastric carcinoma, liver cancer and lung cancer, when it was combined with anticancer drug paclitaxel (PTX). To analyze the effect of XAP on the pharmacokinetics of PTX, a liquid chromatography-tandem mass spectroscopy (LCMS/MS) assay method was developed and validated to quantify PTX simultaneously and its main metabolite 3'-p-hydroxypaclitaxel (C3'-OHP) in rat plasma. PTX and C3'-OHP were quantified using positive MRM mode. The analysis method was validated for specificity, recovery, carry-over, accuracy, precision, sample stability and dilution integrity under various storage conditions. The pharmacokinetic parameters were determined in rats after tail intravenous administration of 6 mg/mL PTX in the absence (control group) or presence of intraperitoneal administration of 10 mL/kg、20 mL/kg XAP (study groups). Compared to control group, the area under the plasma concentration-time curve (AUC) of PTX and C3'-OHP in study groups increased significantly following consecutive administration with XAP for 10 days. In conclusion, pretreatment with XAP enhanced the exposure of PTX and C3'-OHP. There would be herb-drug interaction happening between XAP and PTX in rats.
MeSH term(s)	Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/blood ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Calibration ; Chromatography, Liquid ; Drugs, Chinese Herbal/administration & dosage ; Female ; Herb-Drug Interactions ; Linear Models ; Paclitaxel/administration & dosage ; Paclitaxel/blood ; Paclitaxel/pharmacokinetics ; Quality Control ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry
Chemical Substances	Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2019.07.003
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Article ; Online: Xiao-Ai-Ping Injection Enhances Effect of Paclitaxel to Suppress Breast Cancer Proliferation and Metastasis via Activating Transcription Factor 3.

Chen, Junjun / Zhang, Xiangqi / Xiao, Xiao / Ding, Yawei / Zhang, Wei / Shi, Meizhi / Yang, Jiao / Liu, Ying / Han, Yonglong

Integrative cancer therapies

2020 Volume 19, Page(s) 1534735420906463

Abstract: ... effects in the progress of treating breast cancer. Xiao-Ai-Ping (XAP) injection, composed of a traditional ...

Abstract	Chemotherapy is an effective treatment for invasive breast cancer. Paradoxically, many recently published findings showed that the first-line chemotherapeutic agent paclitaxel (PTX) showed pro-metastatic effects in the progress of treating breast cancer. Xiao-Ai-Ping (XAP) injection, composed of a traditional herbal medicine,
MeSH term(s)	Activating Transcription Factor 3/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/pharmacology ; Female ; Humans ; Mice ; Neoplasm Invasiveness/prevention & control ; Paclitaxel/pharmacology ; Xenograft Model Antitumor Assays
Chemical Substances	Activating Transcription Factor 3 ; Antineoplastic Agents ; Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2020-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/1534735420906463
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Article: [Effects and mechanisms of Xiao-Ai-Ping injection on angiogenesis].

Wang, Mei-jian / Du, Dan-yu / Fan, Wei / Zhang, Cang / Liu, Yang / Fan, Jia-hong / Yuan, Sheng-tao / Lin, Sen-sen

Yao xue xue bao = Acta pharmaceutica Sinica

2016 Volume 51, Issue 2, Page(s) 309–315

Abstract: This study was designed to investigate the effect of Xiao-Ai-Ping injection on cancer angiogenesis ... the effect of Xiao-Ai-Ping injection on HUVECs migration. The anti-angiogenic effect of Xiao-Ai-Ping ... signaling pathways were examined by Western blot. Our data demonstrated that Xiao-Ai-Ping injection inhibited HUVECs ...

Abstract	This study was designed to investigate the effect of Xiao-Ai-Ping injection on cancer angiogenesis. CCK8 assay and Brd U incorporation immunofluorescence assay were used to detect the effect of Xiao-Ai-Ping injection on HUVECs proliferation; wound healing assay and transwell assay were employed to test the effect of Xiao-Ai-Ping injection on HUVECs migration. The anti-angiogenic effect of Xiao-Ai-Ping injection was examined by tube formation assay, rat aortic ring assay and chicken chorioallantoic membrane(CAM) assay. ELISA assay was used to measure the secretion of vascular endothelial growth factor(VEGF); and the activation of vascular endothelial growth factor receptor 2(VEGFR2) protein and its downstream signaling pathways were examined by Western blot. Our data demonstrated that Xiao-Ai-Ping injection inhibited HUVECs proliferation in a time- and dose-dependent manner, and the IC(50) (mg·m L(-1)) values for 24, 48 and 72 h were 48.7 ± 7.14, 29.1 ±2.25 and 22.0 ± 4.53, individually. Xiao-Ai-Ping injection inhibited HUVECs DNA synthesis and migration. Xiao-Ai-Ping injection suppressed HUVECs tube formation, and reduced microvessel sprouting from rat aortic rings and vessel growth in CAMs. Furthermore, Xiao-Ai-Ping injection attenuated the secretion of VEGF, and inhibited the expression of p-VEGFR2 and phosphorylation of protein kinase B(p-AKT). We conclude that Xiao-Ai-Ping injection inhibits angiogenesis by down-regulation of VEGF signaling and AKT pathway.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Cell Movement ; Chickens ; Chorioallantoic Membrane ; Drugs, Chinese Herbal/pharmacology ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Neovascularization, Pathologic/drug therapy ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Wound Healing
Chemical Substances	Angiogenesis Inhibitors ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Vascular Endothelial Growth Factor A ; KDR protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	Chinese
Publishing date	2016
Publishing country	China
Document type	Journal Article
ZDB-ID	788758-9
ISSN	0513-4870
ISSN	0513-4870
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Article: Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8(+) T Lymphocytes.

Li, Wanshuai / Yang, Yang / Ouyang, Zijun / Zhang, Qi / Wang, Lu / Tao, Feifei / Shu, Yongqian / Gu, Yanhong / Xu, Qiang / Sun, Yang

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 879512

Abstract: Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and ... Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured ... every three days. Results. Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth ...

Abstract	Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and an ancillary drug in tumor treatment, enhances the antitumor effects of cisplatin on Lewis lung cancer (LLC) cells. Methods. LLC-bearing mice were daily intraperitoneally injected with various doses of cisplatin, Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured every three days. Results. Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth and proapoptotic effects on LLC xenografts than sole drug treatment did. In addition, we found that Xiao-Ai-Ping triggered the infiltration of CD8(+) T cells, a group of cytotoxic T cells, to LLC xenografts. Furthermore, the mRNA levels of interferon- γ (ifn- γ ), perforin-1 (prf-1), and granzyme B (gzmb) in CD8(+) T cells were significantly increased after combination treatment of Xiao-Ai-Ping and cisplatin. In vitro studies showed that Xiao-Ai-Ping markedly upregulated the mRNA levels of ifn- γ , prf-1, and gzmb in CD8(+) T cells in a concentration-dependent manner, suggesting that Xiao-Ai-Ping augments the function of CD8(+) T cells. Conclusions. Xiao-Ai-Ping promotes the infiltration and function of CD8(+) T cells and thus enhances the antigrowth effects of cisplatin on LLC xenografts, which provides new evidence for the combination of Xiao-Ai-Ping and cisplatin in clinic in China.
Language	English
Publishing date	2013-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/879512
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Article ; Online: Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8+ T Lymphocytes

Wanshuai Li / Yang Yang / Zijun Ouyang / Qi Zhang / Lu Wang / Feifei Tao / Yongqian Shu / Yanhong Gu / Qiang Xu / Yang Sun

Evidence-Based Complementary and Alternative Medicine, Vol

2013 Volume 2013

Abstract	Objectives. To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and an ancillary drug in tumor treatment, enhances the antitumor effects of cisplatin on Lewis lung cancer (LLC) cells. Methods. LLC-bearing mice were daily intraperitoneally injected with various doses of cisplatin, Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured every three days. Results. Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth and proapoptotic effects on LLC xenografts than sole drug treatment did. In addition, we found that Xiao-Ai-Ping triggered the infiltration of CD8+ T cells, a group of cytotoxic T cells, to LLC xenografts. Furthermore, the mRNA levels of interferon-γ (ifn-γ), perforin-1 (prf-1), and granzyme B (gzmb) in CD8+ T cells were significantly increased after combination treatment of Xiao-Ai-Ping and cisplatin. In vitro studies showed that Xiao-Ai-Ping markedly upregulated the mRNA levels of ifn-γ, prf-1, and gzmb in CD8+ T cells in a concentration-dependent manner, suggesting that Xiao-Ai-Ping augments the function of CD8+ T cells. Conclusions. Xiao-Ai-Ping promotes the infiltration and function of CD8+ T cells and thus enhances the antigrowth effects of cisplatin on LLC xenografts, which provides new evidence for the combination of Xiao-Ai-Ping and cisplatin in clinic in China.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prevalence and clinical characteristics of T2DM patients with OTUD3 gene rs78466831 SNP at a single academic center in China.

Liu, Jian-Ping / Yang, Ai-Ping / Lei, Gang / Yu, Man / Peng, Yu / Le, Ai-Ping

Frontiers in endocrinology

2022 Volume 13, Page(s) 1059641

Abstract: Background: A novel, rare OTUD3 c.863G>A (rs78466831) in humans has been reported associated with diabetes, but the prevalence and clinical characteristics of T2DM patients with rs78466831 have not been reported before.: Objective: To investigate the ...

Abstract	Background: A novel, rare OTUD3 c.863G>A (rs78466831) in humans has been reported associated with diabetes, but the prevalence and clinical characteristics of T2DM patients with rs78466831 have not been reported before. Objective: To investigate the prevalence and clinical characteristics of T2DM patients with rs78466831 and provide a basis for clinical diagnosis and treatment. Methods: OTUD3 gene rs78466831 SNP was detected by Sanger sequencing in all the collected specimens of laboratory-confirmed T2DM patients and healthy people. Clinical characteristics indexes inconsisting of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and a body mass index (BMI), T2DM-associated chronic complications (myocardial infarction, cerebrovascular disease, retinopathy, arterial plaque, peripheral neuropathy and nephropathy) were obtained from the clinical laboratory information systems and electronic medical record system. Clinical characteristic indicators were compared between the wild-type and variant (rs78466831) patients with T2DM. Results: The prevalence of rs78466831 in the T2DM patients group was significantly higher than the healthy control in our academic center. The general characteristic indicators were not significantly different between the wild-type and rs78466831 patients with T2DM, except the family history of diabetes. Clinical laboratory indicators including HbA1c, FBG, OGTT, TC, HDL-C, LDL-C and CP had no significant difference between the two groups. The therapeutic drug and target achievement rates were not significantly different between the two groups. The incidence of diabetic retinopathy in the variant group was significantly higher than the wild-type group. Conclusions: The OTUD3 gene rs78466831 was associated with T2DM and may be a biological risk factor of diabetes retinopathy.
MeSH term(s)	Humans ; Glycated Hemoglobin ; Blood Glucose ; Cholesterol, LDL ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Prevalence ; Cholesterol, HDL ; Diabetic Retinopathy/complications ; China/epidemiology ; Ubiquitin-Specific Proteases
Chemical Substances	Glycated Hemoglobin ; Blood Glucose ; Cholesterol, LDL ; Cholesterol, HDL ; OTUD3 protein, human (EC 3.4.19.12) ; Ubiquitin-Specific Proteases (EC 3.4.19.12)
Language	English
Publishing date	2022-12-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1059641
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Article ; Online: High Expression of Cancer-derived Immunoglobulin G is Associated with Poor Survival in Metastatic Clear Cell Renal Cell Carcinoma.

Cui, Hong-Lei / Wu, Jie / Xie, Rui-Yang / Xu, Wei-Yan / Shi, Hong-Zhe / Zhou, Ai-Ping / Qiu, Xiao-Yan / Shou, Jian-Zhong

European urology open science

2024 Volume 61, Page(s) 56–58

Language	English
Publishing date	2024-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2024.01.001
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Article: [Effect of sulfur fumigation on quality and safety of Lilii Bulbus].

Zhang, Rong / Yang, Ya-Ling / Deng, Ai-Ping / Kang, Li-Ping / Cheng, Ming-En / Kang, Chuan-Zhi / Guo, Lan-Ping

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 3, Page(s) 660–671

Abstract: Lilii Bulbus is a commonly used Chinese herbal medicine with both medicinal and edible values, while the market products usually has the problem of sulfur fumigation. Therefore, the quality and safety of Lilii Bulbus products deserve attention. In this ... ...

Abstract	Lilii Bulbus is a commonly used Chinese herbal medicine with both medicinal and edible values, while the market products usually has the problem of sulfur fumigation. Therefore, the quality and safety of Lilii Bulbus products deserve attention. In this study, ultra-high performance liquid chromatography-time of flight-tandem mass spectrometry(UPLC-Q-TOF-MS/MS) was combined with principal component analysis(PCA) and orthogonal partial least squares discriminant analysis(OPLS-DA) to analyze the differential components of Lilii Bulbus before and after sulfur fumigation. We identified ten markers generated after sulfur fumigation, summarized their mass fragmentation and transformation patterns, and verified the structures of phenylacrylic acid markers of sulfur fumigation. At the same time, the cytotoxicity of the aqueous extracts of Lilii Bulbus before and after sulfur fumigation was evaluated. The results showed that in the concentration range of 0-800 mg·L~(-1), the aqueous extract of Lilii Bulbus after sulfur fumigation had no significant effect on the viability of human liver LO2 cells, human renal proximal tubular HK-2 cells, and rat adrenal pheochromocytoma PC-12 cells. Moreover, the viability of the cells exposed to the aqueous extract of Lilii Bulbus before and after sulfur fumigation showed no significant difference. This study identified phenylacrylic acid and furostanol saponins as markers of sulfur-fumigated Lilii Bulbus for the first time, and made clear that proper sulfur fumigation of Lilii Bulbus would not produce cytotoxicity, providing a theoretical basis for the rapid identification and quality and safety control of sulfur-fumigated Lilii Bulbus.
MeSH term(s)	Humans ; Animals ; Rats ; Fumigation ; Tandem Mass Spectrometry ; Chromatography, High Pressure Liquid ; Epithelial Cells ; Sulfur
Chemical Substances	Sulfur (70FD1KFU70)
Language	Chinese
Publishing date	2023-03-02
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20221031.301
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Article ; Online: Development and optimization of sustained release triptolide microspheres.

Zeng, Hui-Lin / Qiu, Qian / Fu, Ting-Xiong / Deng, Ai-Ping / Xie, Xiang-Yang

PloS one

2023 Volume 18, Issue 10, Page(s) e0292861

Abstract: Rheumatoid arthritis is considered a chronic systemic autoimmune disorder that may cause joint destruction. Triptolide, an active component isolated from Tripterygium wilfordii Hook.f., is considered to have promising potential for clinical use in ... ...

Abstract	Rheumatoid arthritis is considered a chronic systemic autoimmune disorder that may cause joint destruction. Triptolide, an active component isolated from Tripterygium wilfordii Hook.f., is considered to have promising potential for clinical use in treating rheumatoid arthritis. However, its clinical application has been limited by the narrow therapeutic window, side effects associated with plasma drug fluctuations, low oral bioavailability, and poor patient compliance with the long and frequent dosing regimen. An extended drug release preparation may address these limitations. The aim of this work was therefore to develop, formulate and optimize sustained release triptolide microspheres with poly (lactide-co-glycolide) (PLGA). Triptolide-loaded microspheres were prepared using PLGA as the matrix polymer, dichloromethane as the oil phase, and polyvinyl alcohol (PVA) as the matrix forming emulsifier. An oil-in-water (O/W) emulsion solvent evaporation technique was utilized to prepare the microspheres. Surface response methodology (RSM) coupled with central composite design (CCD) was used to optimize the formulation and a total of twenty formulations were prepared. PVA concentration (X1), PLGA concentration (X2), and theoretical drug content (X3) were selected as independent variables; and drug content (Y1), encapsulation efficiency (Y2), mean diameter (Y3) and the initial release during the first day (Y4) were taken as the response variables. The optimized formulation showed mean diameter of 42.36 μm, drug content of 7.96%, encapsulation efficiency of 80.16% and an initial release of 14.48%. The prepared microspheres exhibited a sustained release profile of triptolide in vitro over 4 weeks, which was wellfitted with a Korsmeyer-Peppas equation. However, the initial drug release (~14%) of triptolide-loaded microspheres was very high and should be specifically investigated in future studies. The results indicate that long-term sustained release microspheres of triptolide can be considered a strategy to overcome the low bioavailability and poor patient compliance with conventional triptolide tablets. The issue of initial burst release and in vivo evaluations should be specifically investigated in the future.
MeSH term(s)	Humans ; Delayed-Action Preparations ; Microspheres ; Particle Size ; Arthritis, Rheumatoid
Chemical Substances	Delayed-Action Preparations ; triptolide (19ALD1S53J)
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0292861
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Article ; Online: Risk Factors for Infection of Sutured Maxillofacial Soft Tissue Injuries.

Guo, Hua-Qiu / Yang, Xue / Wang, Xiao-Tong / Ji, Ai-Ping / Bai, Jie

Surgical infections

2022 Volume 23, Issue 3, Page(s) 298–303

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Adult ; Facial Injuries/epidemiology ; Facial Injuries/surgery ; Female ; Humans ; Male ; Risk Factors ; Soft Tissue Injuries/epidemiology ; Soft Tissue Injuries/etiology ; Soft Tissue Injuries/surgery ; Sutures ; Wound Infection/etiology ; Young Adult
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440120-4
ISSN	1557-8674 ; 1096-2964
ISSN (online)	1557-8674
ISSN	1096-2964
DOI	10.1089/sur.2021.358
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