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  1. Article ; Online: Aktive kardiale Implantate in der Rechtsmedizin : Übersicht aus rechtsmedizinischer und kardiologischer Perspektive.

    Fischer, Florian / Lafleur, Laurent / Lackermair, Korbinian

    Herzschrittmachertherapie & Elektrophysiologie

    2023  Volume 34, Issue 3, Page(s) 212–217

    Abstract: In 2021, about 75,000 persons in Germany died unnaturally or due to unexplained reasons. As a consequence, there are difficulties in more precisely identifying the time, cause and circumstances of death. Nevertheless, clarification is crucial not only ... ...

    Title translation Cardiac implantable electric devices in forensic medicine : Overview from the forensic and cardiology perspective.
    Abstract In 2021, about 75,000 persons in Germany died unnaturally or due to unexplained reasons. As a consequence, there are difficulties in more precisely identifying the time, cause and circumstances of death. Nevertheless, clarification is crucial not only from the clinical perspective, but these data are of considerable importance in the context of investigative procedures as they can be used to answer numerous legally relevant questions. Cardiac implantable devices (CIED) are of vital importance in the treatment of cardiac arrhythmias. In 2020 about 100,000 patients underwent CIED implantation in Germany. Therefore, CIED are present in a relevant proportion of the deceased mentioned above. The valuable source of information represented by postmortal CIED interrogation has been shown in numerous studies. Nevertheless, postmortal CIED interrogation is not routinely performed in the context of forensic medical examinations for reasons of practicability. This article summarizes benefits and limitations of postmortal CIED interrogation from the perspective of forensic medicine and cardiology and gives a recommendation for realization.
    MeSH term(s) Humans ; Pacemaker, Artificial ; Defibrillators, Implantable ; Heart ; Forensic Medicine ; Cardiology ; Retrospective Studies
    Language German
    Publishing date 2023-07-04
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-023-00952-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of Acute Altitude Exposure on Anaerobic Threshold Assessed by a Novel Electrocardiogram-Based Method.

    Weis, Georges / Schlichtiger, Jenny / Lackermair, Korbinian / Hamm, Wolfgang / Schüttler, Dominik / Brunner, Stefan / Strüven, Anna

    High altitude medicine & biology

    2024  Volume 25, Issue 1, Page(s) 94–99

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Anaerobic Threshold/physiology ; Altitude ; Cross-Sectional Studies ; Electrocardiography ; Exercise Test/methods
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2076262-8
    ISSN 1557-8682 ; 1527-0297
    ISSN (online) 1557-8682
    ISSN 1527-0297
    DOI 10.1089/ham.2023.0073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Review: Sex-related differences in the treatment of cardiac arrhythmia.

    Haum, Magda / Kellnar, Antonia / Thienel, Manuela / Lackermair, Korbinian

    Pharmacology & therapeutics

    2023  Volume 244, Page(s) 108388

    Abstract: Cardiac arrhythmias are a common and potentially serious cardiovascular disorders that affect both men and women. However, there is evidence to suggest that there may be sex-related differences in the prevalence, clinical presentation, and management of ... ...

    Abstract Cardiac arrhythmias are a common and potentially serious cardiovascular disorders that affect both men and women. However, there is evidence to suggest that there may be sex-related differences in the prevalence, clinical presentation, and management of cardiac arrhythmias. Hormonal and cellular factors may play a role in these sex-specific differences. In addition, there are differences in the types of arrhythmias that men and women experience, with men more likely to experience ventricular arrhythmias and women more likely to experience supraventricular arrhythmias. The management of cardiac arrhythmias also differs between men and women. For example, some studies have found that women are less likely to receive appropriate treatment for arrhythmias and are more likely to have adverse outcomes following treatment. Despite these sex-related differences, the majority of research on cardiac arrhythmias has been conducted in men, and there is a need for more research to specifically examine the differences between men and women. This is especially important given that the prevalence of cardiac arrhythmia is increasing, and it is essential to understand how to effectively diagnose and treat these conditions in both men and women. In this review, we examine the current understanding of sex-related differences in cardiac arrhythmias. We also review the available data on sex-specific management strategies for cardiac arrhythmias and highlight areas of future research.
    MeSH term(s) Male ; Humans ; Female ; Sex Factors ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/therapy ; Cardiovascular Diseases/epidemiology ; Prevalence
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Präklinische und klinische Ansätze zur Verbesserung von Diagnose und Therapie Stress-assoziierter kardialer Erkrankungen

    Lackermair, Korbinian [Verfasser]

    2019  

    Author's details Korbinian Lackermair
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: [No title information]

    Estner, Heidi / Lackermair, Korbinian

    MMW Fortschritte der Medizin

    2018  Volume 160, Issue 10, Page(s) 67

    Title translation Erratum zu: Häufige Rhythmusstörungen in der Hausarztpraxis.
    Language German
    Publishing date 2018-05-31
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-018-0019-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of Preparticipating Hypohydration on Cardiopulmonary Exercise Capacity in Ambitious Recreational Athletes.

    Strüven, Anna / Brunner, Stefan / Weis, Georges / Stremmel, Christopher / Teupser, Daniel / Schlichtiger, Jenny / Lackermair, Korbinian

    Nutrients

    2023  Volume 15, Issue 15

    Abstract: Background: Heat induces a thermoregulatory strain that impairs cardiopulmonary exercise capacity. The aim of the current study is to elucidate the effect of isolated dehydration on cardiopulmonary exercise capacity in a model of preparticipating ... ...

    Abstract Background: Heat induces a thermoregulatory strain that impairs cardiopulmonary exercise capacity. The aim of the current study is to elucidate the effect of isolated dehydration on cardiopulmonary exercise capacity in a model of preparticipating hypohydration.
    Methods: Healthy recreational athletes underwent a standardised fluid deprivation test. Hypohydration was assessed by bioelectrical impedance analysis (BIA) and laboratory testing of electrolytes and retention parameters in the blood and urine. The participants underwent cardiopulmonary exercise testing (CPET) with a cycle ramp protocol. Each participant served as their own control undergoing CPET in a hypohydrated [HYH] and euhydrated [EUH] state.
    Results: Fluid deprivation caused a mild (2%) but significant reduction of body water (38.6 [36.6; 40.7] vs. 39.4 [37.4; 41.5] %;
    Conclusion: Isolated hypohydration causes impairment of workload as well as peak oxygen uptake in recreational athletes. Our findings might indicate an important role of hypohydration in the heat-induced reduction of exercise capacity.
    MeSH term(s) Humans ; Dehydration ; Exercise Tolerance ; Exercise ; Athletes ; Hot Temperature ; Electrolytes ; Oxygen
    Chemical Substances Electrolytes ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15153333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of Preparticipation Hypohydration on Cognitive Performance and Concussion-like Symptoms in Recreational Athletes.

    Strüven, Anna / Brunner, Stefan / Weis, Georges / Cohrdes, Yannick / Lackermair, Stephan / Schlichtiger, Jenny / Kellnar, Antonia / Lackermair, Korbinian

    Nutrients

    2023  Volume 15, Issue 20

    Abstract: Background: Sports-related concussion is a relevant risk of contact sports, with several million cases per year worldwide. Prompt identification is crucial to prevent complications and late effects but may be impeded by an overlap with dehydration- ... ...

    Abstract Background: Sports-related concussion is a relevant risk of contact sports, with several million cases per year worldwide. Prompt identification is crucial to prevent complications and late effects but may be impeded by an overlap with dehydration-associated impairment of cognitive function. Researchers have extensively studied the effects of pronounced dehydration in endurance sports, especially in the heat. However, little is known about the effects of isolated and mild dehydration.
    Methods: Healthy recreational athletes underwent a standardized fluid deprivation test. Hypohydration was assessed by bioelectrical impedance analysis (BIA) and laboratory testing of electrolytes and retention parameters. Participants underwent cardiopulmonary exercise testing (CPET) with a cycle ramp protocol. Each participant served as their own control undergoing CPET in a hypohydrated [HYH] and a euhydrated [EUH] state. Effects were assessed using a shortened version of Sport Concussion Assessment Tool 3 (SCAT3).
    Results: Fluid deprivation caused a mild (2%) reduction in body water, resulting in a calculated body mass loss of 0.8% without alterations of electrolytes, serum-osmolality, or hematocrit. Athletes reported significantly more (1.8 ± 2.2 vs. 0.4 ± 0.7;
    Conclusions: Mild dehydration caused relevant alterations of concussion-like symptoms and balance in healthy recreational athletes in the absence of endurance exercise or heat. Further research is needed to clarify the real-life relevance of these findings and to strengthen the differential diagnosis of concussion.
    MeSH term(s) Humans ; Dehydration/etiology ; Dehydration/complications ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Athletes ; Electrolytes ; Cognition
    Chemical Substances Electrolytes
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15204420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Herzen ohne Takt — das ist zu tun!

    Estner, Heidi / Lackermair, Korbinian

    MMW Fortschritte der Medizin

    2018  Volume 160, Issue 7, Page(s) 52–62

    Title translation Heart rhythm disturbances in family doctor's practice.
    Language German
    Publishing date 2018-04-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-018-0013-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pacing Using Cardiac Implantable Electric Device During TAVR: 10-Year Experience of a High-Volume Center.

    Haum, Magda / Steffen, Julius / Sadoni, Sebastian / Theiss, Hans / Stark, Konstantin / Estner, Heidi / Massberg, Steffen / Deseive, Simon / Lackermair, Korbinian

    JACC. Cardiovascular interventions

    2024  Volume 17, Issue 8, Page(s) 1020–1028

    Abstract: Background: Transcatheter aortic valve replacement (TAVR) is an effective and safe therapy for severe aortic stenosis. Rapid or fast pacing is required for implantation, which can be performed via a pre-existing cardiac implantable electric device (CIED) ...

    Abstract Background: Transcatheter aortic valve replacement (TAVR) is an effective and safe therapy for severe aortic stenosis. Rapid or fast pacing is required for implantation, which can be performed via a pre-existing cardiac implantable electric device (CIED). However, safety data on CIEDs for pacing in TAVR are missing.
    Objectives: The aim of this study was to elucidate procedural safety and feasibility of internal pacing with a CIED in TAVR.
    Methods: Patients undergoing TAVR with a CIED were included in this analysis. Baseline characteristics, procedural details, and complications according to Valve Academic Research Consortium 3 (VARC-3) criteria after TAVR were compared between both groups.
    Results: A total of 486 patients were included. Pacing was performed using a CIED in 150 patients and a transient pacemaker in 336 patients. No differences in technical success according to VARC-3 criteria or procedure duration occurred between the groups. The usage of transient pacers for pacing was associated with a significantly higher bleeding rate (bleeding type ≥2 according to VARC-3-criteria; 2.0% vs 13.1%; P < 0.01). Furthermore, impairment of the CIED appeared in 2.3% of patients after TAVR only in the group in which pacing was performed by a transient pacer, leading to surgical revision of the CIED in 1.3% of all patients when transient pacemakers were used.
    Conclusions: Internal pacing using a CIED is safe and feasible without differences of procedural time and technical success and might reduce bleeding rates. Furthermore, pacing using a CIED circumvents the risk of lead dislocation. Our data provide an urgent call for the use of a CIED for pacing during a TAVR procedure in general.
    MeSH term(s) Humans ; Female ; Male ; Transcatheter Aortic Valve Replacement/adverse effects ; Transcatheter Aortic Valve Replacement/instrumentation ; Aged, 80 and over ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/diagnostic imaging ; Cardiac Pacing, Artificial ; Treatment Outcome ; Time Factors ; Aged ; Pacemaker, Artificial ; Feasibility Studies ; Risk Factors ; Hospitals, High-Volume ; Aortic Valve/surgery ; Aortic Valve/physiopathology ; Aortic Valve/diagnostic imaging ; Retrospective Studies ; Severity of Illness Index ; Risk Assessment
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A patient with Takayasu arteritis presenting with malignant hypertension: a case report.

    Sierra, Laura Villegas / Binzenhöfer, Leonhard / Schulze-Koops, Hendrik / Lackermair, Korbinian / Massberg, Steffen / Lüsebrink, Enzo

    European heart journal. Case reports

    2023  Volume 7, Issue 6, Page(s) ytad263

    Abstract: Background: Takayasu arteritis (TA) is a rare large-vessel vasculitis primarily affecting the aorta and its proximal branches. The manifestation of TA is variable, ranging from asymptomatic cases to severe organ dysfunction secondary to vascular damage, ...

    Abstract Background: Takayasu arteritis (TA) is a rare large-vessel vasculitis primarily affecting the aorta and its proximal branches. The manifestation of TA is variable, ranging from asymptomatic cases to severe organ dysfunction secondary to vascular damage, which often delays diagnosis.
    Case summary: Here, we present a 37-year-old male patient suffering from visual impairment and malignant hypertension. Emergency fundoscopy showed large left subretinal bleeding and bilateral signs of hypertensive retinopathy. Echocardiographic and magnetic resonance imaging showed mildly reduced left ventricular ejection fraction and signs of hypertensive cardiomyopathy. Evaluation for secondary causes of arterial hypertension did not reveal an underlying disease, and the patient was discharged with optimal medical therapy. He was re-admitted after 11 days with fever of unknown origin, fatigue, and elevated inflammatory markers. The diagnosis of TA was finally established using
    Discussion: This case highlights the diversity of initial symptoms, the challenges of TA diagnosis, and the importance of comprehensive evaluation for rare secondary causes of arterial hypertension. Individualized acute and long-term care necessitates multidisciplinary management of immunosuppressive therapy, secondary organ involvement, and concomitant diseases.
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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