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Book: C. elegans

Haspel, Gal / Hart, Anne C.

methods and applications

(Methods in molecular biology ; 2468 ; Springer protocols)

2022

Author's details	edited by Gal Haspel (Department of Biological Sciences, New Jersey Institute of Technology, Newark, NJ, USA), Anne C. Hart (Department of Neuroscience, Brown University, Providence, RI, USA)
Series title	Methods in molecular biology ; 2468 Springer protocols
Collection
Keywords	Caenorhabditis elegans ; Caenorhabditis elegans/Genetics ; Molecular biology
Subject code	572.81257
Language	English
Size	xi, 388 Seiten, Illustrationen, 26 cm
Edition	Third edition
Publisher	Humana Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT021305743
ISBN	978-1-0716-2180-6 ; 9781071621813 ; 1-0716-2180-7 ; 1071621815
Database	Catalogue ZB MED Medicine, Health

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Zs A 7042 -2468-	not available for loan	Lesesaal EG

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Article: Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C).

Dick, Jenna K / Sangala, Jules A / Krishna, Venkatramana D / Khaimraj, Aaron / Hamel, Lydia / Erickson, Spencer M / Hicks, Dustin / Soigner, Yvette / Covill, Laura E / Johnson, Alexander / Ehrhardt, Michael J / Ernste, Keenan / Brodin, Petter / Koup, Richard A / Khaitan, Alka / Baehr, Carly / Thielen, Beth K / Henzler, Christine M / Skipper, Caleb /

Miller, Jeffrey S / Bryceson, Yenan T / Wu, Jianming / John, Chandy C / Panoskaltsis-Mortari, Angela / Orioles, Alberto / Steiner, Marie E / Cheeran, Maxim C-J / Pravetoni, Marco / Hart, Geoffrey T

bioRxiv : the preprint server for biology

2024

Abstract: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of SARS-CoV-2 ... to understand the aberrant immune response in MIS-C is limited. Despite strong antibody production in MIS-C ... responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional ...

Abstract	Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multi-organ involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong antibody production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 weeks after infection. Therefore, we hypothesized that dysfunctional cell-mediated antibody responses downstream of antibody production may be responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional for phagocytosis and cytokine production, while natural killer (NK) cells were hypofunctional for both killing and cytokine production. The decreased NK cell cytotoxicity correlated with an NK exhaustion marker signature and systemic IL-6 levels. Potentially providing a therapeutic option, cellular engagers of CD16 and SARS-CoV-2 proteins were found to rescue NK cell function in vitro. Together, our results reveal dysregulation in antibody-mediated cellular responses unique to MIS-C that likely contribute to the immune pathology of this disease.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.16.589585
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Article ; Online: Observation of New Ξ_{c}^{0} Baryons Decaying to Λ_{c}^{+}K^{-}.

Aaij, R / Abellán Beteta, C / Ackernley, T / Adeva, B / Adinolfi, M / Afsharnia, H / Aidala, C A / Aiola, S / Ajaltouni, Z / Akar, S / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Alkhazov, G / Alvarez Cartelle, P / Alves, A A / Amato, S / Amhis, Y /

An, L / Anderlini, L / Andreassi, G / Andreotti, M / Archilli, F / Artamonov, A / Artuso, M / Arzymatov, K / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Back, J J / Baker, S / Balagura, V / Baldini, W / Baptista Leite, J / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batozskaya, V / Batsukh, B / Battig, A / Bay, A / Becker, M / Bedeschi, F / Bediaga, I / Beiter, A / Belavin, V / Belin, S / Bellee, V / Belous, K / Belyaev, I / Bencivenni, G / Ben-Haim, E / Benson, S / Berezhnoy, A / Bernet, R / Berninghoff, D / Bernstein, H C / Bertella, C / Bertholet, E / Bertolin, A / Betancourt, C / Betti, F / Bettler, M O / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bieker, M S / Bifani, S / Billoir, P / Bizzeti, A / Bjørn, M / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Bocci, V / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bondar, A / Bondar, N / Borghi, S / Borisyak, M / Borsato, M / Borsuk, J T / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodski, M / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buchanan, E / Büchler-Germann, A / Buonaura, A / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calero Diaz, L / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camargo Magalhaes, P / Camboni, A / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carli, I / Carniti, P / Carvalho Akiba, K / Casais Vidal, A / Casse, G / Cattaneo, M / Cavallero, G / Celani, S / Cenci, R / Cerasoli, J / Chapman, M G / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chefdeville, M / Chekalina, V / Chen, C / Chen, S / Chernov, A / Chitic, S-G / Chobanova, V / Cholak, S / Chrzaszcz, M / Chubykin, A / Chulikov, V / Ciambrone, P / Cicala, M F / Cid Vidal, X / Ciezarek, G / Cindolo, F / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Cobbledick, J L / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Contu, A / Cooke, N / Coombs, G / Coquereau, S / Corti, G / Costa Sobral, C M / Couturier, B / Craik, D C / Crkovská, J / Crocombe, A / Cruz Torres, M / Currie, R / Da Silva, C L / Dall'Occo, E / Dalseno, J / D'Ambrosio, C / Danilina, A / d'Argent, P / Davis, A / De Aguiar Francisco, O / De Bruyn, K / De Capua, S / De Cian, M / De Miranda, J M / De Paula, L / De Serio, M / De Simone, P / de Vries, J A / Dean, C T / Dean, W / Decamp, D / Del Buono, L / Delaney, B / Dembinski, H-P / Dendek, A / Denysenko, V / Derkach, D / Deschamps, O / Desse, F / Dettori, F / Dey, B / Di Canto, A / Di Nezza, P / Didenko, S / Dijkstra, H / Dobishuk, V / Dordei, F / Dorigo, M / Dos Reis, A C / Douglas, L / Dovbnya, A / Dreimanis, K / Dudek, M W / Dufour, L / Durante, P / Durham, J M / Dutta, D / Dziewiecki, M / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eidelman, S / Eisenhardt, S / Ek-In, S / Eklund, L / Ely, S / Ene, A / Epple, E / Escher, S / Eschle, J / Esen, S / Evans, T / Falabella, A / Fan, J / Fan, Y / Farley, N / Farry, S / Fazzini, D / Fedin, P / Féo, M / Fernandez Declara, P / Fernandez Prieto, A / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferrillo, M / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fischer, K M / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Franco Lima, V / Franco Sevilla, M / Frank, M / Frei, C / Friday, D A / Fu, J / Fuehring, Q / Funk, W / Gabriel, E / Gaintseva, T / Gallas Torreira, A / Galli, D / Gallorini, S / Gambetta, S / Gan, Y / Gandelman, M / Gandini, P / Gao, Y / Garcia Martin, L M / García Pardiñas, J / Garcia Plana, B / Garcia Rosales, F A / Garrido, L / Gascon, D / Gaspar, C / Gerick, D / Gersabeck, E / Gersabeck, M / Gershon, T / Gerstel, D / Ghez, Ph / Gibson, V / Gioventù, A / Gironella Gironell, P / Giubega, L / Giugliano, C / Gizdov, K / Gligorov, V V / Göbel, C / Golobardes, E / Golubkov, D / Golutvin, A / Gomes, A / Gorbounov, P / Gorelov, I V / Gotti, C / Govorkova, E / Grabowski, J P / Graciani Diaz, R / Grammatico, T / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A / Greim, R / Griffith, P / Grillo, L / Gruber, L / Gruberg Cazon, B R / Gu, C / Guarise, M / Gushchin, E / Guth, A / Guz, Yu / Gys, T / Günther, P A / Hadavizadeh, T / Haefeli, G / Haen, C / Haines, S C / Hamilton, P M / Han, Q / Han, X / Hancock, T H / Hansmann-Menzemer, S / Harnew, N / Harrison, T / Hart, R / Hasse, C / Hatch, M / He, J / Hecker, M / Heijhoff, K / Heinicke, K / Hennequin, A M / Hennessy, K / Henry, L / Heuel, J / Hicheur, A / Hill, D / Hilton, M / Hopchev, P H / Hu, J / Hu, W / Huang, W / Hulsbergen, W / Humair, T / Hunter, R J / Hushchyn, M / Hutchcroft, D / Hynds, D / Ibis, P / Idzik, M / Ilten, P / Inglessi, A / Ivshin, K / Jacobsson, R / Jakobsen, S / Jans, E / Jashal, B K / Jawahery, A / Jevtic, V / Jiang, F / John, M / Johnson, D / Jones, C R / Jost, B / Jurik, N / Kandybei, S / Karacson, M / Kariuki, J M / Kazeev, N / Kecke, M / Keizer, F / Kelsey, M / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Kim, K E / Kirn, T / Kirsebom, V S / Klaver, S / Klimaszewski, K / Koliiev, S / Kondybayeva, A / Konoplyannikov, A / Kopciewicz, P / Kopecna, R / Koppenburg, P / Korolev, M / Kostiuk, I / Kot, O / Kotriakhova, S / Kravchuk, L / Krawczyk, R D / Kreps, M / Kress, F / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kuindersma, H S / Kunde, G J / Kvaratskheliya, T / Lacarrere, D / Lafferty, G / Lai, A / Lancierini, D / Lane, J J / Lanfranchi, G / Langenbruch, C / Lantwin, O / Latham, T / Lazzari, F / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Leroy, O / Lesiak, T / Leverington, B / Li, H / Li, L / Li, X / Li, Y / Li, Z / Liang, X / Lin, T / Lindner, R / Lisovskyi, V / Liu, G / Liu, X / Loh, D / Loi, A / Lomba Castro, J / Longstaff, I / Lopes, J H / Loustau, G / Lovell, G H / Lu, Y / Lucchesi, D / Lucio Martinez, M / Luo, Y / Lupato, A / Luppi, E / Lupton, O / Lusiani, A / Lyu, X / Maccolini, S / Machefert, F / Maciuc, F / Macko, V / Mackowiak, P / Maddrell-Mander, S / Madhan Mohan, L R / Maev, O / Maevskiy, A / Maisuzenko, D / Majewski, M W / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Malygina, H / Manca, G / Mancinelli, G / Manera Escalero, R / Manuzzi, D / Marangotto, D / Maratas, J / Marchand, J F / Marconi, U / Mariani, S / Marin Benito, C / Marinangeli, M / Marino, P / Marks, J / Marshall, P J / Martellotti, G / Martinazzoli, L / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Massafferri, A / Materok, M / Matev, R / Mathad, A / Mathe, Z / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / McCann, M / Mcconnell, L / McNab, A / McNulty, R / Mead, J V / Meadows, B / Meaux, C / Meier, G / Meinert, N / Melnychuk, D / Meloni, S / Merk, M / Merli, A / Meyer Garcia, L / Mikhasenko, M / Milanes, D A / Millard, E / Minard, M-N / Mineev, O / Minzoni, L / Mitchell, S E / Mitreska, B / Mitzel, D S / Mödden, A / Mogini, A / Moise, R D / Mombächer, T / Monroy, I A / Monteil, S / Morandin, M / Morello, G / Morello, M J / Moron, J / Morris, A B / Morris, A G / Mountain, R / Mu, H / Muheim, F / Mukherjee, M / Mulder, M / Müller, D / Müller, K / Murphy, C H / Murray, D / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, I / Neri, N / Neubert, S / Neufeld, N / Newcombe, R / Nguyen, T D / Nguyen-Mau, C / Niel, E M / Nieswand, S / Nikitin, N / Nolte, N S / Nunez, C / Oblakowska-Mucha, A / Obraztsov, V / Ogilvy, S / O'Hanlon, D P / Oldeman, R / Onderwater, C J G / Osborn, J D / Ossowska, A / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Pais, P R / Pajero, T / Palano, A / Palutan, M / Panshin, G / Papanestis, A / Pappagallo, M / Pappalardo, L L / Pappenheimer, C / Parker, W / Parkes, C / Parkinson, C J / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pearce, A / Pellegrino, A / Pepe Altarelli, M / Perazzini, S / Pereima, D / Perret, P / Petridis, K / Petrolini, A / Petrov, A / Petrucci, S / Petruzzo, M / Pietrzyk, B / Pietrzyk, G / Pili, M / Pinci, D / Pinzino, J / Pisani, F / Piucci, A / Placinta, V / Playfer, S / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poliakova, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Pomery, G J / Ponce, S / Popov, A / Popov, D / Poslavskii, S / Prasanth, K / Promberger, L / Prouve, C / Pugatch, V / Puig Navarro, A / Pullen, H / Punzi, G / Qian, W / Qin, J / Quagliani, R / Quintana, B / Raab, N V / Rabadan Trejo, R I / Rachwal, B / Rademacker, J H / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Reboud, M / Redi, F / Reiss, F / Remon Alepuz, C / Ren, Z / Renaudin, V / Ricciardi, S / Richards, D S / Richards, S / Rinnert, K / Robbe, P / Robert, A / Rodrigues, A B / Rodrigues, E / Rodriguez Lopez, J A / Roehrken, M / Rollings, A / Romanovskiy, V / Romero Lamas, M / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Vidal, J / Ryzhikov, A / Ryzka, J / Saborido Silva, J J / Sagidova, N / Sahoo, N / Saitta, B / Sanchez Gras, C / Sanchez Mayordomo, C / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Sarpis, G / Sarpis, M / Sarti, A / Satriano, C / Satta, A / Saur, M / Savrina, D / Scantlebury Smead, L G / Schael, S / Schellenberg, M / Schiller, M / Schindler, H / Schmelling, M / Schmelzer, T / Schmidt, B / Schneider, O / Schopper, A / Schreiner, H F / Schubiger, M / Schulte, S / Schune, M H / Schwemmer, R / Sciascia, B / Sciubba, A / Sellam, S / Semennikov, A / Sergi, A / Serra, N / Serrano, J / Sestini, L / Seuthe, A / Seyfert, P / Shangase, D M / Shapkin, M / Shchutska, L / Shears, T / Shekhtman, L / Shevchenko, V / Shmanin, E / Shupperd, J D / Siddi, B G / Silva Coutinho, R / Silva de Oliveira, L / Simi, G / Simone, S / Skiba, I / Skidmore, N / Skwarnicki, T / Slater, M W / Smeaton, J G / Smetkina, A / Smith, E / Smith, I T / Smith, M / Snoch, A / Soares, M / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Souza De Paula, B / Spaan, B / Spadaro Norella, E / Spradlin, P / Stagni, F / Stahl, M / Stahl, S / Stefko, P / Steinkamp, O / Stemmle, S / Stenyakin, O / Stepanova, M / Stevens, H / Stone, S / Stracka, S / Stramaglia, M E / Straticiuc, M / Strokov, S / Sun, J / Sun, L / Sun, Y / Svihra, P / Swientek, K / Szabelski, A / Szumlak, T / Szymanski, M / Taneja, S / Tang, Z / Tekampe, T / Teubert, F / Thomas, E / Thomson, K A / Tilley, M J / Tisserand, V / T'Jampens, S / Tobin, M / Tolk, S / Tomassetti, L / Torres Machado, D / Tou, D Y / Tournefier, E / Traill, M / Tran, M T / Trifonova, E / Trippl, C / Tsaregorodtsev, A / Tuci, G / Tully, A / Tuning, N / Ukleja, A / Usachov, A / Ustyuzhanin, A / Uwer, U / Vagner, A / Vagnoni, V / Valassi, A / Valenti, G / van Beuzekom, M / Van Hecke, H / van Herwijnen, E / Van Hulse, C B / van Veghel, M / Vazquez Gomez, R / Vazquez Regueiro, P / Vázquez Sierra, C / Vecchi, S / Velthuis, J J / Veltri, M / Venkateswaran, A / Veronesi, M / Vesterinen, M / Viana Barbosa, J V / Vieira, D / Vieites Diaz, M / Viemann, H / Vilasis-Cardona, X / Vitali, G / Vitkovskiy, A / Vollhardt, A / Vom Bruch, D / Vorobyev, A / Vorobyev, V / Voropaev, N / Waldi, R / Walsh, J / Wang, J / Wang, M / Wang, Y / Wang, Z / Ward, D R / Wark, H M / Watson, N K / Websdale, D / Weiden, A / Weisser, C / Westhenry, B D C / White, D J / Whitehead, M / Wiedner, D / Wilkinson, G / Wilkinson, M / Williams, I / Williams, M / Williams, M R J / Williams, T / Wilson, F F / Wislicki, W / Witek, M / Witola, L / Wormser, G / Wotton, S A / Wu, H / Wyllie, K / Xiang, Z / Xiao, D / Xie, Y / Xing, H / Xu, A / Xu, J / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, Z / Yao, Y / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zarebski, K A / Zavertyaev, M / Zdybal, M / Zeng, M / Zhang, D / Zhang, L / Zhang, S / Zhang, W C / Zhang, Y / Zhelezov, A / Zheng, Y / Zhou, X / Zhou, Y / Zhu, X / Zhukov, V / Zonneveld, J B / Zucchelli, S

Physical review letters

2020 Volume 124, Issue 22, Page(s) 222001

Abstract: The Λ_{c}^{+}K^{-} mass spectrum is studied with a data sample of pp collisions at a center-of-mass ... experiment. Three Ξ_{c}^{0} states are observed with a large significance and their masses and natural widths ... are measured to be m[Ξ_{c}(2923)^{0}]=2923.04±0.25±0.20±0.14 MeV, Γ[Ξ_{c}(2923)^{0}]=7.1±0.8±1.8 MeV ...

Abstract	The Λ_{c}^{+}K^{-} mass spectrum is studied with a data sample of pp collisions at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 5.6 fb^{-1} collected by the LHCb experiment. Three Ξ_{c}^{0} states are observed with a large significance and their masses and natural widths are measured to be m[Ξ_{c}(2923)^{0}]=2923.04±0.25±0.20±0.14 MeV, Γ[Ξ_{c}(2923)^{0}]=7.1±0.8±1.8 MeV, m[Ξ_{c}(2939)^{0}]=2938.55±0.21±0.17±0.14 MeV, Γ[Ξ_{c}(2939)^{0}]=10.2±0.8±1.1 MeV, m[Ξ_{c}(2965)^{0}]=2964.88±0.26±0.14±0.14 MeV, Γ[Ξ_{c}(2965)^{0}]=14.1±0.9±1.3 MeV, where the uncertainties are statistical, systematic, and due to the limited knowledge of the Λ_{c}^{+} mass. The Ξ_{c}(2923)^{0} and Ξ_{c}(2939)^{0} baryons are new states. The Ξ_{c}(2965)^{0} state is in the vicinity of the known Ξ_{c}(2970)^{0} baryon; however, their masses and natural widths differ significantly.
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.222001
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Article ; Online: Effects of intravenous administration of ascorbic acid (vitamin C) on oxidative status in healthy adult horses.

Taylor, Sandra D / Hart, Kelsey A / Vaughn, Sarah / Giancola, Shyla C / Serpa, Priscila B S / Santos, Andrea P

Journal of veterinary internal medicine

2023 Volume 38, Issue 1, Page(s) 460–468

Abstract: Background: Ascorbic acid (AA) is an antioxidant that might be beneficial for adjunctive treatment of sepsis in horses. The optimal dose and effects on oxidative status are unknown.: Hypothesis: Ascorbic acid administration will increase plasma AA ... ...

Abstract	Background: Ascorbic acid (AA) is an antioxidant that might be beneficial for adjunctive treatment of sepsis in horses. The optimal dose and effects on oxidative status are unknown. Hypothesis: Ascorbic acid administration will increase plasma AA concentrations and decrease determinants of reactive oxygen metabolites (dROM), basal and stimulant-induced intraerythrocytic reactive oxygen species (ROS) concentrations, and stimulant-induced neutrophil ROS production, and increase plasma antioxidant capacity (PAC) in a dose-dependent manner. Animals: Eight healthy horses. Methods: Randomized placebo-controlled crossover study. Each horse received 4 single-dose IV treatments including AA at 25, 50, and 100 mg/kg and saline (placebo) with each treatment separated by ≥1 week. Blood was collected at baseline, 2 and 6 hours for assessment of plasma dROM and PAC via photometer, intraerythrocytic ROS by flow cytometry, and stimulant-induced neutrophil ROS by a fluorometric assay. Plasma AA concentrations were measured by high-performance liquid chromatography/electrochemical detection. Results: Ascorbic acid at 100 mg/kg resulted in decreased dROM 2 hours after treatment (P = .03, 95% CI 5.51-121.2, point estimate 63.3). There was no effect of AA on basal or stimulant-induced intraerythrocytic ROS (P = .88, 95% CI -0.156 to 0.081, point estimate -0.037; P = .93, 95% CI -0.123 to 0.112, point estimate -0.006, respectively), basal or stimulant-induced neutrophil ROS (P ≥ .12, 95% CI -644.9 to 56.2, point estimate -294.4), or PAC (P ≥ .64, 95% CI -1567 to 463.4, point estimate -552.0) at any dose or timepoint. Plasma AA concentrations increased in a dose-dependent manner. Conclusions and clinical importance: High-dose administration of AA might provide antioxidant benefits in horses.
MeSH term(s)	Horses ; Animals ; Ascorbic Acid/pharmacology ; Antioxidants ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/pharmacology ; Cross-Over Studies ; Oxidative Stress ; Vitamins ; Oxygen ; Administration, Intravenous/veterinary
Chemical Substances	Ascorbic Acid (PQ6CK8PD0R) ; Antioxidants ; Reactive Oxygen Species ; Vitamins ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16934
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Article ; Online: Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain.

Clark, Nathaniel E / Katolik, Adam / Gallant, Pascal / Welch, Anastasia / Murphy, Eileen / Buerer, Luke / Schorl, Christoph / Naik, Nandita / Naik, Mandar T / Holloway, Stephen P / Cano, Kristin / Weintraub, Susan T / Howard, Katherine M / Hart, P John / Jogl, Gerwald / Damha, Masad J / Fairbrother, William G

The Journal of biological chemistry

2023 Volume 299, Issue 9, Page(s) 105100

Abstract: ... missing. Here we show that human Dbr1 contains a disordered C-terminal domain through sequence analysis ...

Abstract	In eukaryotic cells, the introns are excised from pre-mRNA by the spliceosome. These introns typically have a lariat configuration due to the 2'-5' phosphodiester bond between an internal branched residue and the 5' terminus of the RNA. The only enzyme known to selectively hydrolyze the 2'-5' linkage of these lariats is the RNA lariat debranching enzyme Dbr1. In humans, Dbr1 is involved in processes such as class-switch recombination of immunoglobulin genes, and its dysfunction is implicated in viral encephalitis, HIV, ALS, and cancer. However, mechanistic details of precisely how Dbr1 affects these processes are missing. Here we show that human Dbr1 contains a disordered C-terminal domain through sequence analysis and nuclear magnetic resonance. This domain stabilizes Dbr1 in vitro by reducing aggregation but is dispensable for debranching activity. We establish that Dbr1 requires Fe
MeSH term(s)	Humans ; Introns ; RNA Nucleotidyltransferases/genetics ; RNA Nucleotidyltransferases/metabolism ; RNA Splicing ; Adaptor Proteins, Signal Transducing/metabolism ; Enzyme Activation/genetics ; Protein Domains ; Protein Binding ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Entamoeba histolytica/enzymology ; Entamoeba histolytica/genetics ; Metals, Heavy/metabolism
Chemical Substances	Dbr1 protein, human (EC 2.7.7.-) ; RNA Nucleotidyltransferases (EC 2.7.7.-) ; MPLKIP protein, human ; Adaptor Proteins, Signal Transducing ; Intrinsically Disordered Proteins ; Metals, Heavy
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.105100
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Article ; Online: Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)

Miller, Jeffrey S / Bryceson, Yenan T / Wu, Jianming / John, Chandy C / Panoskaltsis-Mortari, Angela / Orioles, Alberto / Steiner, Marie E / Cheeran, Maxim C-J / Pravetoni, Marco / Hart, Geoffrey T

bioRxiv

Abstract	Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multi-organ involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong antibody production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 weeks after infection. Therefore, we hypothesized that dysfunctional cell-mediated antibody responses downstream of antibody production may be responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional for phagocytosis and cytokine production, while natural killer (NK) cells were hypofunctional for both killing and cytokine production. The decreased NK cell cytotoxicity correlated with an NK exhaustion marker signature and systemic IL-6 levels. Potentially providing a therapeutic option, cellular engagers of CD16 and SARS-CoV-2 proteins were found to rescue NK cell function in vitro. Together, our results reveal dysregulation in antibody-mediated cellular responses unique to MIS-C that likely contribute to the immune pathology of this disease.
Keywords	covid19
Language	English
Publishing date	2024-04-18
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2024.04.16.589585
Database	COVID19

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Article ; Online: Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)

Dick, Jenna K / Sangala, Jules A / Krishna, Venkatramana D / Khaimraj, Aaron / Hamel, Lydia / Erickson, Spencer M / Hicks, Dustin / Soigner, Yvette / Covill, Laura E / Johnson, Alexander / Ehrhardt, Michael J / Ernst, Keenan / Brodin, Petter / Koup, Richard A / Khaitan, Alka / Baehr, Carly / Thielen, Beth K / Henzler, Christine M / Skipper, Caleb /

Miller, Jeffrey S / Bryceson, Yenan T / Wu, Jianming / John, Chandy C / Panoskaltsis-Mortari, Angela / Orioles, Alberto / Steiner, Marie E / Cheeran, Maxim C-J / Pravetoni, Marco / Hart, Geoffrey T

bioRxiv

Abstract	Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multi-organ involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong antibody production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 weeks after infection. Therefore, we hypothesized that dysfunctional cell-mediated antibody responses downstream of antibody production may be responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional for phagocytosis and cytokine production, while natural killer (NK) cells were hypofunctional for both killing and cytokine production. The decreased NK cell cytotoxicity correlated with an NK exhaustion marker signature and systemic IL-6 levels. Potentially providing a therapeutic option, cellular engagers of CD16 and SARS-CoV-2 proteins were found to rescue NK cell function in vitro. Together, our results reveal dysregulation in antibody-mediated cellular responses unique to MIS-C that likely contribute to the immune pathology of this disease.
Keywords	covid19
Language	English
Publishing date	2024-04-18
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2024.04.16.589585
Database	COVID19

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Book ; Online: On Tsirelson pairs of C*-algebras

Goldbring, Isaac / Hart, Bradd

2022

Abstract: We introduce the notion of a Tsirelson pair of C*-algebras, which is a pair of C*-algebras ... containing a C*-algebra with Kirchberg's QWEP property is a Tsirelson pair. We then introduce the notion ... of a C*-algebra with the Tsirelson property (TP) and establish a number of closure properties ...

Abstract	We introduce the notion of a Tsirelson pair of C-algebras, which is a pair of C-algebras for which the space of quantum strategies obtained by using states on the minimal tensor product of the pair and the space of quantum strategies obtained by using states on the maximal tensor product of the pair coincide. We exhibit a number of examples of such pairs that are ``nontrivial'' in the sense that the minimal tensor product and the maximal tensor product of the pair are not isomorphic. For example, we prove that any pair containing a C-algebra with Kirchberg's QWEP property is a Tsirelson pair. We then introduce the notion of a C-algebra with the Tsirelson property (TP) and establish a number of closure properties for this class. We also show that the class of C*-algebras with the TP form an axiomatizable class (in the sense of model theory), but that this class admits no ``effective'' axiomatization. Comment: 13 pages; version 2; some errors from the Preliminaries section corrected
Keywords	Mathematics - Operator Algebras ; Computer Science - Computational Complexity ; Mathematics - Logic ; Quantum Physics
Subject code	512
Publishing date	2022-10-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Room-Temperature Cu(II) Radical-Triggered Alkyne C-H Activation.

Devonport, Jack / Sully, Lauren / Boudalis, Athanassios K / Hassell-Hart, Storm / Leech, Matthew C / Lam, Kevin / Abdul-Sada, Alaa / Tizzard, Graham J / Coles, Simon J / Spencer, John / Vargas, Alfredo / Kostakis, George E

JACS Au

2021 Volume 1, Issue 11, Page(s) 1937–1948

Abstract: A dimeric Cu(II) complex [Cu(II) ...

Abstract	A dimeric Cu(II) complex [Cu(II)
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Journal Article
ISSN	2691-3704
ISSN (online)	2691-3704
DOI	10.1021/jacsau.1c00310
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Article ; Online: A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects.

Olson, Margaret E / Hornick, Mary G / Stefanski, Ashley / Albanna, Haya R / Gjoni, Alesia / Hall, Griffin D / Hart, Peter C / Rajab, Ibraheem M / Potempa, Lawrence A

Frontiers in immunology

2023 Volume 14, Page(s) 1264383

Abstract: C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted ...

Abstract	C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically, CRP has been classified as a mediator of the innate immune system, acting as a pattern recognition receptor for phosphocholine-containing ligands. For decades, CRP was envisioned as a single, non-glycosylated, multi-subunit protein arranged non-covalently in cyclic symmetry around a central void. Over the past few years, however, CRP has been shown to exist in at least three distinct isoforms: 1.) a pentamer of five identical globular subunits (pCRP), 2.) a modified monomer (mCRP) resulting from a conformational change when subunits are dissociated from the pentamer, and 3.) a transitional isoform where the pentamer remains intact but is partially changed to express mCRP structural characteristics (referred to as pCRP* or mCRP
MeSH term(s)	Humans ; C-Reactive Protein/metabolism ; Endothelial Cells/metabolism ; Inflammation ; Protein Isoforms/metabolism ; Immunity
Chemical Substances	C-Reactive Protein (9007-41-4) ; Protein Isoforms
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1264383
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