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  1. Book ; Online ; E-Book: Neurological complications of infectious diseases

    Hasbun, Rodrigo / Bloch, Karen C. / Bhimraj, Adarsh

    (Current clinical neurology)

    2021  

    Author's details Rodrigo Hasbun, MD MPH, Karen C. Bloch, MD MPH, Adarsh Bhimraj, MD. editors
    Series title Current clinical neurology
    Keywords Neurology  ; Infectious diseases
    Subject code 616.8
    Language English
    Size 1 Online-Ressource (XIV, 387 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020839708
    ISBN 978-3-030-56084-3 ; 9783030560836 ; 3-030-56084-8 ; 303056083X
    DOI 10.1007/978-3-030-56084-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial: What's hot in neurologic infections?

    Bhimraj, Adarsh

    Current opinion in infectious diseases

    2021  Volume 34, Issue 3, Page(s) 206

    MeSH term(s) COVID-19/cerebrospinal fluid ; COVID-19/epidemiology ; COVID-19/pathology ; Central Nervous System Infections/microbiology ; Central Nervous System Infections/pathology ; Humans ; Inflammation/pathology ; SARS-CoV-2
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lack of Benefit of Fluvoxamine for COVID-19.

    Bhimraj, Adarsh / Gallagher, Jason C

    JAMA

    2023  Volume 329, Issue 4, Page(s) 291–292

    MeSH term(s) Humans ; COVID-19/therapy ; COVID-19 Drug Treatment ; Fluvoxamine/therapeutic use
    Chemical Substances Fluvoxamine (O4L1XPO44W)
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.23954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: Foreword.

    Bhimraj, Adarsh

    Current opinion in infectious diseases

    2019  Volume 32, Issue 3, Page(s) 231–232

    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pharmacologic Treatment and Management of Coronavirus Disease 2019.

    Shumaker, Amy Hirsch / Bhimraj, Adarsh

    Infectious disease clinics of North America

    2022  Volume 36, Issue 2, Page(s) 349–364

    Abstract: Over the last 2 years, there has been gradual and sustained progress toward our understanding of pharmacotherapy for coronavirus disease 2019 (COVID-19) as a result of large- and small-scale randomized controlled trials. Numerous new and repurposed ... ...

    Abstract Over the last 2 years, there has been gradual and sustained progress toward our understanding of pharmacotherapy for coronavirus disease 2019 (COVID-19) as a result of large- and small-scale randomized controlled trials. Numerous new and repurposed treatments have been evaluated; some have demonstrated benefit in clinically important outcomes like mortality and hospitalization, and optimism for oral antiviral treatments is growing. Given the rapidly evolving landscape of COVID-19 treatments, frontline clinicians should use treatment and management guidelines to guide their approach to each patient, with the individual's severity and location of illness in mind to appreciate the nuances in clinical evidence.
    MeSH term(s) COVID-19/drug therapy ; Hospitalization ; Humans
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2022.02.001
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  6. Article ; Online: Diagnostic approach and update on encephalitis.

    Bhimraj, Adarsh / Hasbun, Rodrigo

    Current opinion in infectious diseases

    2022  Volume 35, Issue 3, Page(s) 231–237

    Abstract: Purpose of review: The present article gives an update and outlines the fundamental principles of clinical reasoning and a diagnostic approach to a patient suspected to have acute encephalitis.: Recent findings: Encephalitis remains to be associated ... ...

    Abstract Purpose of review: The present article gives an update and outlines the fundamental principles of clinical reasoning and a diagnostic approach to a patient suspected to have acute encephalitis.
    Recent findings: Encephalitis remains to be associated with significant mortality and neurological morbidity. Unfortunately, the etiologic diagnosis remains elusive for the majority of the patients with encephalitis preventing targeted therapies. Clinicians could utilize clues such as duration of symptoms, exposure history, cerebrospinal fluid profile, neuroimaging findings and locations, and entertain certain opportunistic infections in immunosuppressed individuals. A comprehensive diagnostic for the most common viral and autoimmune etiologies should be systematically done and prompt empiric antiviral therapy should be started. Evaluation and therapy for autoimmune etiologies should be done for patients with a negative viral work up. Brain biopsy and metagenomic sequencing should be considered for patients with unknown etiologies that are clinically worsening.
    Summary: Encephalitis remains with unacceptable mortality and morbidity with the most common etiologies being idiopathic. A comprehensive diagnostic work up and prompt antiviral and autoimmune therapies are of paramount importance to improve the outcomes of this devastating disease.
    MeSH term(s) Antiviral Agents/therapeutic use ; Encephalitis/diagnosis ; Humans ; Metagenomics/methods ; Neuroimaging
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reader Response: Acute Necrotizing Encephalopathy With SARS-CoV-2 RNA Confirmed in Cerebrospinal Fluid.

    Frontera, Jennifer A / Lewis, Ariane / Yaghi, Shadi / Bhimraj, Adarsh

    Neurology

    2021  Volume 97, Issue 5, Page(s) 252

    MeSH term(s) Brain Diseases ; COVID-19 ; Humans ; RNA, Viral/genetics ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000012357
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  8. Article ; Online: Acute community-acquired bacterial meningitis in adults: an evidence-based review.

    Bhimraj, Adarsh

    Cleveland Clinic journal of medicine

    2012  Volume 79, Issue 6, Page(s) 393–400

    Abstract: Community-acquired bacterial meningitis is still a significant cause of morbidity and mortality. Clinicians should know how to quickly diagnose it, perform a lumbar puncture, order the necessary tests, and start appropriate empiric therapy promptly. ...

    Abstract Community-acquired bacterial meningitis is still a significant cause of morbidity and mortality. Clinicians should know how to quickly diagnose it, perform a lumbar puncture, order the necessary tests, and start appropriate empiric therapy promptly.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/microbiology ; Community-Acquired Infections/therapy ; Cross Infection ; Diagnosis, Differential ; Humans ; Listeria/isolation & purification ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/microbiology ; Meningitis, Bacterial/therapy ; Neisseria meningitidis/isolation & purification ; Practice Guidelines as Topic ; Spinal Puncture ; Streptococcus pneumoniae/isolation & purification ; Tomography, X-Ray Computed
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.79gr.12003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Severe covid-19 pneumonia: pathogenesis and clinical management.

    Attaway, Amy H / Scheraga, Rachel G / Bhimraj, Adarsh / Biehl, Michelle / Hatipoğlu, Umur

    BMJ (Clinical research ed.)

    2021  Volume 372, Page(s) n436

    Abstract: Severe covid-19 pneumonia has posed critical challenges for the research and medical communities. Older age, male sex, and comorbidities increase the risk for severe disease. For people hospitalized with covid-19, 15-30% will go on to develop covid-19 ... ...

    Abstract Severe covid-19 pneumonia has posed critical challenges for the research and medical communities. Older age, male sex, and comorbidities increase the risk for severe disease. For people hospitalized with covid-19, 15-30% will go on to develop covid-19 associated acute respiratory distress syndrome (CARDS). Autopsy studies of patients who died of severe SARS CoV-2 infection reveal presence of diffuse alveolar damage consistent with ARDS but with a higher thrombus burden in pulmonary capillaries. When used appropriately, high flow nasal cannula (HFNC) may allow CARDS patients to avoid intubation, and does not increase risk for disease transmission. During invasive mechanical ventilation, low tidal volume ventilation and positive end expiratory pressure (PEEP) titration to optimize oxygenation are recommended. Dexamethasone treatment improves mortality for the treatment of severe and critical covid-19, while remdesivir may have modest benefit in time to recovery in patients with severe disease but shows no statistically significant benefit in mortality or other clinical outcomes. Covid-19 survivors, especially patients with ARDS, are at high risk for long term physical and mental impairments, and an interdisciplinary approach is essential for critical illness recovery.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Utilizing Ceftazidime/Avibactam Therapeutic Drug Monitoring in the Treatment of Neurosurgical Meningitis Caused by Difficult-to-Treat Resistant

    Yasmin, Mohamad / Nutman, Amir / Wang, Lu / Marshall, Steven / Chen, Ke / Wang, Jiping / Yahav, Dafna / Lupinsky, Liad / Hujer, Andrea M / Bhimraj, Adarsh / van Duin, David / Li, Jian / Bonomo, Robert A

    Open forum infectious diseases

    2023  Volume 10, Issue 11, Page(s) ofad507

    Abstract: Background: Central nervous system (CNS) infections caused by : Methods: Therapeutic drug monitoring (TDM) was performed in 3 patients with health care-associated ventriculitis and meningitis (HAVM) using CAZ-AVI 2.5 g infused intravenously every 8 ... ...

    Abstract Background: Central nervous system (CNS) infections caused by
    Methods: Therapeutic drug monitoring (TDM) was performed in 3 patients with health care-associated ventriculitis and meningitis (HAVM) using CAZ-AVI 2.5 g infused intravenously every 8 hours as standard and extended infusion. Simultaneous CSF and plasma samples were obtained throughout the dosing interval in each patient. Concentrations of CAZ and AVI were determined by liquid chromatography/mass spectrometry.
    Results: Bacterial identification revealed KPC-producing
    Conclusions: Postinfusion concentrations of CAZ-AVI were measured in plasma and CSF samples obtained from 3 patients with complicated CNS infections caused by antimicrobial-resistant isolates. The measured concentrations revealed that standard CAZ and AVI exposures sufficiently attained values correlating to 50%
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad507
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