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  1. Article ; Online: SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19.

    Serrano, Geidy E / Walker, Jessica E / Tremblay, Cécilia / Piras, Ignazio S / Huentelman, Matthew J / Belden, Christine M / Goldfarb, Danielle / Shprecher, David / Atri, Alireza / Adler, Charles H / Shill, Holly A / Driver-Dunckley, Erika / Mehta, Shyamal H / Caselli, Richard / Woodruff, Bryan K / Haarer, Chadwick F / Ruhlen, Thomas / Torres, Maria / Nguyen, Steve /
    Schmitt, Dasan / Rapscak, Steven Z / Bime, Christian / Peters, Joseph L / Alevritis, Ellie / Arce, Richard A / Glass, Michael J / Vargas, Daisy / Sue, Lucia I / Intorcia, Anthony J / Nelson, Courtney M / Oliver, Javon / Russell, Aryck / Suszczewicz, Katsuko E / Borja, Claryssa I / Cline, Madison P / Hemmingsen, Spencer J / Qiji, Sanaria / Hobgood, Holly M / Mizgerd, Joseph P / Sahoo, Malaya K / Zhang, Haiyu / Solis, Daniel / Montine, Thomas J / Berry, Gerald J / Reiman, Eric M / Röltgen, Katharina / Boyd, Scott D / Pinsky, Benjamin A / Zehnder, James L / Talbot, Pierre / Desforges, Marc / DeTure, Michael / Dickson, Dennis W / Beach, Thomas G

    Journal of neuropathology and experimental neurology

    2022  Volume 81, Issue 9, Page(s) 666–695

    Abstract: Brains of 42 COVID-19 decedents and 107 non-COVID-19 controls were studied. RT-PCR screening of 16 regions from 20 COVID-19 autopsies found SARS-CoV-2 E gene viral sequences in 7 regions (2.5% of 320 samples), concentrated in 4/20 subjects (20%). ... ...

    Abstract Brains of 42 COVID-19 decedents and 107 non-COVID-19 controls were studied. RT-PCR screening of 16 regions from 20 COVID-19 autopsies found SARS-CoV-2 E gene viral sequences in 7 regions (2.5% of 320 samples), concentrated in 4/20 subjects (20%). Additional screening of olfactory bulb (OB), amygdala (AMY) and entorhinal area for E, N1, N2, RNA-dependent RNA polymerase, and S gene sequences detected one or more of these in OB in 8/21 subjects (38%). It is uncertain whether these RNA sequences represent viable virus. Significant histopathology was limited to 2/42 cases (4.8%), one with a large acute cerebral infarct and one with hemorrhagic encephalitis. Case-control RNAseq in OB and AMY found more than 5000 and 700 differentially expressed genes, respectively, unrelated to RT-PCR results; these involved immune response, neuronal constituents, and olfactory/taste receptor genes. Olfactory marker protein-1 reduction indicated COVID-19-related loss of OB olfactory mucosa afferents. Iba-1-immunoreactive microglia had reduced area fractions in cerebellar cortex and AMY, and cytokine arrays showed generalized downregulation in AMY and upregulation in blood serum in COVID-19 cases. Although OB is a major brain portal for SARS-CoV-2, COVID-19 brain changes are more likely due to blood-borne immune mediators and trans-synaptic gene expression changes arising from OB deafferentation.
    MeSH term(s) Brain ; COVID-19 ; Gene Expression ; Humans ; Immunity ; SARS-CoV-2
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlac056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease.

    Serrano, Geidy E / Walker, Jessica E / Arce, Richard / Glass, Michael J / Vargas, Daisy / Sue, Lucia I / Intorcia, Anthony J / Nelson, Courtney M / Oliver, Javon / Papa, Jaclyn / Russell, Aryck / Suszczewicz, Katsuko E / Borja, Claryssa I / Belden, Christine / Goldfarb, Danielle / Shprecher, David / Atri, Alireza / Adler, Charles H / Shill, Holly A /
    Driver-Dunckley, Erika / Mehta, Shyamal H / Readhead, Benjamin / Huentelman, Matthew J / Peters, Joseph L / Alevritis, Ellie / Bimi, Christian / Mizgerd, Joseph P / Reiman, Eric M / Montine, Thomas J / Desforges, Marc / Zehnder, James L / Sahoo, Malaya K / Zhang, Haiyu / Solis, Daniel / Pinsky, Benjamin A / Deture, Michael / Dickson, Dennis W / Beach, Thomas G

    medRxiv : the preprint server for health sciences

    2021  

    Abstract: The coronavirus SARS-CoV-2 (SCV2) causes acute respiratory distress, termed COVID-19 disease, with substantial morbidity and mortality. As SCV2 is related to previously-studied coronaviruses that have been shown to have the capability for brain invasion, ...

    Abstract The coronavirus SARS-CoV-2 (SCV2) causes acute respiratory distress, termed COVID-19 disease, with substantial morbidity and mortality. As SCV2 is related to previously-studied coronaviruses that have been shown to have the capability for brain invasion, it seems likely that SCV2 may be able to do so as well. To date, although there have been many clinical and autopsy-based reports that describe a broad range of SCV2-associated neurological conditions, it is unclear what fraction of these have been due to direct CNS invasion versus indirect effects caused by systemic reactions to critical illness. Still critically lacking is a comprehensive tissue-based survey of the CNS presence and specific neuropathology of SCV2 in humans. We conducted an extensive neuroanatomical survey of RT-PCR-detected SCV2 in 16 brain regions from 20 subjects who died of COVID-19 disease. Targeted areas were those with cranial nerve nuclei, including the olfactory bulb, medullary dorsal motor nucleus of the vagus nerve and the pontine trigeminal nerve nuclei, as well as areas possibly exposed to hematogenous entry, including the choroid plexus, leptomeninges, median eminence of the hypothalamus and area postrema of the medulla. Subjects ranged in age from 38 to 97 (mean 77) with 9 females and 11 males. Most subjects had typical age-related neuropathological findings. Two subjects had severe neuropathology, one with a large acute cerebral infarction and one with hemorrhagic encephalitis, that was unequivocally related to their COVID-19 disease while most of the 18 other subjects had non-specific histopathology including focal β-amyloid precursor protein white matter immunoreactivity and sparse perivascular mononuclear cell cuffing. Four subjects (20%) had SCV2 RNA in one or more brain regions including the olfactory bulb, amygdala, entorhinal area, temporal and frontal neocortex, dorsal medulla and leptomeninges. The subject with encephalitis was SCV2-positive in a histopathologically-affected area, the entorhinal cortex, while the subject with the large acute cerebral infarct was SCV2-negative in all brain regions. Like other human coronaviruses, SCV2 can inflict acute neuropathology in susceptible patients. Much remains to be understood, including what viral and host factors influence SCV2 brain invasion and whether it is cleared from the brain subsequent to the acute illness.
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.02.15.21251511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Infectious causes of adrenal insufficiency.

    Alevritis, Ellie M / Sarubbi, Felix A / Jordan, Richard M / Peiris, Alan N

    Southern medical journal

    2003  Volume 96, Issue 9, Page(s) 888–890

    Abstract: More than 150 years ago, Thomas Addison first described the clinical features and pathogenesis of adrenal insufficiency. At that time, tuberculosis was the most common cause of this disease. The pathway to diagnosis and treatment of Addison's disease has ...

    Abstract More than 150 years ago, Thomas Addison first described the clinical features and pathogenesis of adrenal insufficiency. At that time, tuberculosis was the most common cause of this disease. The pathway to diagnosis and treatment of Addison's disease has been well described. However, determining the cause of the disorder remains a challenge. It is important to consider recently described infectious agents in the pathogenesis of Addison's disease. Mycobacterial, bacterial, viral, and fungal infections may lead to the development of adrenal insufficiency. Skin, pulmonary, and imaging findings can aid the clinician in making a prompt diagnosis of specific infections, which is crucial because early identification of infectious causes of Addison's disease may enable recovery of adrenal function. This review describes the clinical presentations of the multiple infectious causes of adrenal insufficiency.
    MeSH term(s) Adrenal Insufficiency/etiology ; Adrenal Insufficiency/microbiology ; Adrenal Insufficiency/virology ; Communicable Diseases/complications ; Communicable Diseases/microbiology ; Communicable Diseases/virology ; Humans
    Language English
    Publishing date 2003-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/01.SMJ.0000073269.49575.DF
    Database MEDical Literature Analysis and Retrieval System OnLINE

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