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Article: Saccades predict and synchronize to visual rhythms irrespective of musical beats.

Batten, Jonathan P / Smith, Tim J

2018 Volume 26, Issue 9, Page(s) 695–718

Abstract: Music has been shown to entrain movement. One of the body's most frequent movements, saccades, are arguably subject to a timer that may also be susceptible to musical entrainment. We developed a continuous and highly-controlled visual search task and ... ...

Abstract	Music has been shown to entrain movement. One of the body's most frequent movements, saccades, are arguably subject to a timer that may also be susceptible to musical entrainment. We developed a continuous and highly-controlled visual search task and varied the timing of the search target presentation, it was either gaze-contingent, tap-contingent, or visually-timed. We found: (1) explicit control of saccadic timing is limited to gross duration variations and imprecisely synchronized; (2) saccadic timing does not implicitly entrain to musical beats, even when closely aligned in phase; (3) eye movements predict visual onsets produced by motor-movements (finger-taps) and externally-timed sequences, beginning fixation prior to visual onset; (4) eye movement timing can be rhythmic, synchronizing to both motor-produced and externally timed visual sequences; each unaffected by musical beats. These results provide evidence that saccadic timing is sensitive to the temporal demands of visual tasks and impervious to influence from musical beats.
Language	English
Publishing date	2018-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2029586-8
ISSN	1350-6285 ; 1464-0716 ; 1350-6285
ISSN (online)	1350-6285 ; 1464-0716
ISSN	1350-6285
DOI	10.1080/13506285.2018.1544181
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Article ; Online: Reverse total shoulder arthroplasty.

Burden, Eleanor G / Batten, Timothy J / Smith, Christopher D / Evans, Jonathan P

The bone & joint journal

2021 Volume 103-B, Issue 5, Page(s) 813–821

Abstract: Aims: This systematic review asked which patterns of complications are associated with the three reverse total shoulder arthroplasty (RTSA) prosthetic designs, as classified by Routman et al, in patients undergoing RTSA for the management of cuff tear ... ...

Abstract	Aims: This systematic review asked which patterns of complications are associated with the three reverse total shoulder arthroplasty (RTSA) prosthetic designs, as classified by Routman et al, in patients undergoing RTSA for the management of cuff tear arthropathy, massive cuff tear, osteoarthritis, and rheumatoid arthritis. The three implant design philosophies investigated were medial glenoid/medial humerus (MGMH), medial glenoid/lateral humerus (MGLH), and lateral glenoid/medial humerus (LGMH). Methods: A systematic review of the literature was performed via a search of MEDLINE and Embase. Two reviewers extracted data on complication occurrence and patient-reported outcome measures (PROMs). Meta-analysis was conducted on the reported proportion of complications, weighted by sample size, and PROMs were pooled using the reported standardized mean difference (SMD). Quality of methodology was assessed using Wylde's non-summative four-point system. The study was registered with PROSPERO (CRD42020193041). Results: A total of 42 studies met the inclusion and exclusion criteria. Rates of scapular notching were found to be significantly higher in MGMH implants (52% (95% confidence interval (CI) 40 to 63)) compared with MGLH ((18% (95% CI 6 to 34)) and LGMH (12% (95% CI 3 to 26)). Higher rates of glenoid loosening were seen in MGMH implants (6% (95% CI 3 to 10)) than in MGLH implants (0% (95% CI 0 to 2)). However, strength of evidence for this finding was low. No significant differences were identified in any other complication, and there were no significant differences observed in PROMs between implant philosophies. Conclusion: This systematic review has found significant improvement in PROMS and low complication rates across the implant philosophies studied. Scapular notching was the only complication found definitely to have significantly higher prevalence with the MGMH implant design. Cite this article:
MeSH term(s)	Arthroplasty, Replacement, Shoulder/methods ; Humans ; Patient Reported Outcome Measures ; Postoperative Complications ; Prosthesis Design ; Shoulder Prosthesis
Language	English
Publishing date	2021-02-22
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.103B.BJJ-2020-2101
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Book ; Online: Zero-Shot Anomaly Detection with Pre-trained Segmentation Models

Baugh, Matthew / Batten, James / Müller, Johanna P. / Kainz, Bernhard

2023

Abstract: This technical report outlines our submission to the zero-shot track of the Visual Anomaly and Novelty Detection (VAND) 2023 Challenge. Building on the performance of the WINCLIP framework, we aim to enhance the system's localization capabilities by ... ...

Abstract	This technical report outlines our submission to the zero-shot track of the Visual Anomaly and Novelty Detection (VAND) 2023 Challenge. Building on the performance of the WINCLIP framework, we aim to enhance the system's localization capabilities by integrating zero-shot segmentation models. In addition, we perform foreground instance segmentation which enables the model to focus on the relevant parts of the image, thus allowing the models to better identify small or subtle deviations. Our pipeline requires no external data or information, allowing for it to be directly applied to new datasets. Our team (Variance Vigilance Vanguard) ranked third in the zero-shot track of the VAND challenge, and achieve an average F1-max score of 81.5/24.2 at a sample/pixel level on the VisA dataset. Comment: Ranked 3rd in zero-shot track of the Visual Anomaly and Novelty Detection (VAND) 2023 Challenge
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning
Subject code	006
Publishing date	2023-06-15
Publishing country	us
Document type	Book ; Online
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Article ; Online: Development of real-time RT-qPCR assays for the typing of two novel bluetongue virus genotypes derived from sheeppox vaccine.

King, Simon / Flannery, John / Batten, Carrie / Rajko-Nenow, Paulina

Journal of virological methods

2021 Volume 298, Page(s) 114288

Abstract: Previously, we reported the detection of two novel bluetongue virus (BTV) strains (SPvvvv/02 and SPvvvv/03), possibly representing new BTV genotypes, in a batch of sheeppox vaccine. We developed type-specific RT-qPCR assays (targeting genome segment 2) ... ...

Abstract	Previously, we reported the detection of two novel bluetongue virus (BTV) strains (SPvvvv/02 and SPvvvv/03), possibly representing new BTV genotypes, in a batch of sheeppox vaccine. We developed type-specific RT-qPCR assays (targeting genome segment 2) for these two new BTV strains. The limit of detection of both assays was 10 genome copies/μl and no cross-reactivity with other BTV genotypes was observed. The performance of three other BTV group-specific diagnostic assays was also tested against the putative novel genotypes. RT-qPCR assays targeting BTV segment 9 and 10 detected both strains (SPvvvv/02 and SPvvvv/03) whereas a BTV segment 1 RT-qPCR assay was unable to detect either BTV strain. The work presented here expands upon the current repertoire of RT-qPCR assays for BTV genotype determination.
MeSH term(s)	Animals ; Bluetongue/diagnosis ; Bluetongue/prevention & control ; Bluetongue virus/genetics ; Genotype ; Real-Time Polymerase Chain Reaction ; Sheep ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2021-09-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2021.114288
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Zs.A 1565: Show issues

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Article ; Online: Survival of the Aequalis total shoulder replacement at a minimum 20-year follow-up: a clinical and radiographic study.

Evans, Jonathan P / Batten, Timothy / Bird, Joshua / Thomas, William J / Kitson, Jeff B / Smith, Christopher D

Journal of shoulder and elbow surgery

2021 Volume 30, Issue 10, Page(s) 2355–2360

Abstract: Aims: Shoulder replacement is increasingly performed for end-stage arthritis. Information on the long-term survival and patient outcomes is very limited. This study aimed to quantify the survival and clinical outcome at a minimum of 20-yr follow-up.: ... ...

Abstract	Aims: Shoulder replacement is increasingly performed for end-stage arthritis. Information on the long-term survival and patient outcomes is very limited. This study aimed to quantify the survival and clinical outcome at a minimum of 20-yr follow-up. Methods: A single-center, single-surgeon, consecutive cohort study was performed. Forty-four shoulder replacements in 40 patients (age at surgery 68.5 years, 82.5% female, preoperative visual analog scale [VAS] pain score 5.1/10, standard deviation [SD] 2.7) implanted between 1996 and 2000 were assessed. All-cause construct survival, radiographic glenoid and humeral stem loosening, radiographic humeral head migration, and patient-reported outcome measures were assessed. Results: Survival with all-cause revision as an endpoint was 84.1% (95% confidence interval [CI] 60.7, 94.1) at 20 years, glenoid loosening was seen in all patients who survived to the 20-year follow-up. Survival of rotator cuff integrity was 16.8% (95% CI 3.5, 38.5) at 20 years. VAS pain scores demonstrated improvement at 10 years (mean change -4/10) but not at 20 years (effect size -0.15, mean change 0.4/10, SD 2.7). At 20 years, 72% of patients had died with the prosthesis in situ. Conclusion: Older patients undergoing total shoulder arthroplasty are unlikely to require revision in their lifetime. However, beyond 10 years, a large proportion of implants demonstrate glenoid loosening, humeral head migration, and declining patient outcomes. This information will be of use to patients and clinicians when discussing the potential outcomes of surgery.
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2021.01.038
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Zs.A 3973: Show issues

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Article ; Online: Suprascapular nerve blockage for painful shoulder pathology - a systematic review and meta-analysis of treatment techniques.

Batten, T J / Evans, J P / Burden, E G / Mak, W K / White, W / Smith, C D

Annals of the Royal College of Surgeons of England

2022 Volume 105, Issue 7, Page(s) 589–598

Abstract: Background: Suprascapular nerve blockade (SSNB) through injection (SSNBi) and/or pulsed radiofrequency (PRF) provide options for the management of painful shoulder pathology. Multiple techniques for delivery of SSNB are described but no consensus on ... ...

Abstract	Background: Suprascapular nerve blockade (SSNB) through injection (SSNBi) and/or pulsed radiofrequency (PRF) provide options for the management of painful shoulder pathology. Multiple techniques for delivery of SSNB are described but no consensus on optimal symptom control is available. This systematic review and meta-analysis aims to assess patient-focussed outcomes in SSNB and explore the impact of variation in the technical application of this treatment modality. Methods: MEDLINE, Embase and CINAHL were searched for case series, cohort studies and randomised control trials published from database inception until 28 January 2021. Articles reporting use of SSNBi or PRF for treatment of shoulder pain with a minimum 3 months follow-up were included. Patient-reported outcome measures (PROMs) were extracted and the pooled standardised mean difference (SMD), weighted by study size, was reported. Quality of methodology was assessed using Wylde's nonsummative four-point system. Findings: Of 758 references, 18 studies were included, totalling 704 SSNB. Average pain improvement at 3 months was 52.3%, with meta-analysis demonstrating a SMD of 2.37. Whereas SSNBi combined with PRF shows the greatest SMD of 2.75, this did not differ significantly from SSNBi or PRF when used as monotherapy. Location of treatment and the guidance technique used did not influence outcome. Conclusion: SSNBi and PRF provide safe and effective treatment for shoulder pain, as judged by PROMs. This may be of particular value in aging or comorbid patients and with surgical restrictions during the COVID-19 pandemic. Regardless of technique, patients experience a marked improvement in pain that is maintained beyond 3 months.
MeSH term(s)	Humans ; Shoulder Pain/therapy ; Pandemics ; Nerve Block/methods ; COVID-19 ; Treatment Outcome
Language	English
Publishing date	2022-08-17
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2022.0026
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Book ; Online: NSF Integrated Circuit Research, Education and Workforce Development Workshop Final Report

Guthaus, M. / Batten, C. / Brunvand, E. / Gaillardon, P. E. / harris, D. / Manohar, R. / Mazumder, P. / Pileggi, L. / Stine, J.

2023

Abstract: As the pace of progress that has followed Moore's law continues to diminish, it is critical that the US support Integrated Circuit (IC or chip) education and research to maintain technological innovation. Furthermore, US economic independence, security, ... ...

Abstract	As the pace of progress that has followed Moore's law continues to diminish, it is critical that the US support Integrated Circuit (IC or chip) education and research to maintain technological innovation. Furthermore, US economic independence, security, and future international standing rely on having on-shore IC design capabilities. New devices with disparate technologies, improved design software toolchains and methodologies, and technologies to integrate heterogeneous systems will be needed to advance IC design capabilities. This will require rethinking both how we teach design to address the new complexity and how we inspire student interest in a hardware systems career path. The main recommendation of this workshop is that accessibility is the key issue. To this end, a National Chip Design Center (NCDC) should be established to further research and education by partnering academics and industry to train our future workforce. This should not be limited to R1 universities, but should also include R2, community college, minority serving institutions (MSI), and K-12 institutions to have the broadest effect. The NCDC should support the access, development, and maintenance of open design tools, tool flows, design kits, design components, and educational materials. Open-source options should be emphasized wherever possible to maximize accessibility. The NCDC should also provide access and support for chip fabrication, packaging and testing for both research and educational purposes. Comment: This material is based upon work supported by the NSF under Grant No. 2137629
Keywords	Computer Science - Hardware Architecture
Subject code	020
Publishing date	2023-11-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: C.acnes in the joint, is it all just a false positive?

Batten, Timothy J / Gallacher, Sian / Thomas, William J / Kitson, Jeffrey / Smith, Christopher D

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

2022 Volume 33, Issue 2, Page(s) 315–320

Abstract: ... presence in both (p = 0.0001). 15% with previous surgery had C.acnes. 53% with previous injection had C ...

Abstract	Background: Cutibacterium Acnes (C.acnes) has been linked to several shoulder pathologies. An alternative hypothesis suggests it only occurs in the joint secondary to previous instrumentation. Our hypothesis was patients with previous instrumentation would have C.acnes in their joint if it was in skin. Materials and methods: Sixty-six patients undergoing arthroscopic shoulder surgery had biopsies taken from the affected joint at the time of surgery, along with control biopsies of subdermal fat. The extended culture results were assessed and correlated to previous intervention. Results: 35% tested positive for C.acnes in their joint. 78% were male. 53% had absence of C.acnes in both skin and joint and 29% had presence in both (p = 0.0001). 15% with previous surgery had C.acnes. 53% with previous injection had C.acnes. 25% of patients with virgin joints had C.acnes. There was no statistical difference in the presence of C.acnes in the joint between those with previous instrumentation and without. Conclusion: The significant factors for joint C.acnes were male sex and the presence of the bacteria in the fat. Previous instrumentation was not correlated with C.acnes in the joint. This raises the question of whether the process of biopsy itself may lead to inoculation of the joint.
MeSH term(s)	Humans ; Male ; Female ; Shoulder Joint/surgery ; Gram-Positive Bacterial Infections/microbiology ; Shoulder ; Skin/microbiology ; Propionibacterium acnes
Language	English
Publishing date	2022-01-15
Publishing country	France
Document type	Journal Article
ZDB-ID	1231084-0
ISSN	1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
ISSN (online)	1432-1068
ISSN	1633-8065 ; 0948-4817 ; 0940-3264
DOI	10.1007/s00590-021-03186-8
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Zs.A 3479: Show issues

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Book ; Online: Many tasks make light work

Baugh, Matthew / Tan, Jeremy / Müller, Johanna P. / Dombrowski, Mischa / Batten, James / Kainz, Bernhard

Learning to localise medical anomalies from multiple synthetic tasks

2023

Abstract: There is a growing interest in single-class modelling and out-of-distribution detection as fully supervised machine learning models cannot reliably identify classes not included in their training. The long tail of infinitely many out-of-distribution ... ...

Abstract	There is a growing interest in single-class modelling and out-of-distribution detection as fully supervised machine learning models cannot reliably identify classes not included in their training. The long tail of infinitely many out-of-distribution classes in real-world scenarios, e.g., for screening, triage, and quality control, means that it is often necessary to train single-class models that represent an expected feature distribution, e.g., from only strictly healthy volunteer data. Conventional supervised machine learning would require the collection of datasets that contain enough samples of all possible diseases in every imaging modality, which is not realistic. Self-supervised learning methods with synthetic anomalies are currently amongst the most promising approaches, alongside generative auto-encoders that analyse the residual reconstruction error. However, all methods suffer from a lack of structured validation, which makes calibration for deployment difficult and dataset-dependant. Our method alleviates this by making use of multiple visually-distinct synthetic anomaly learning tasks for both training and validation. This enables more robust training and generalisation. With our approach we can readily outperform state-of-the-art methods, which we demonstrate on exemplars in brain MRI and chest X-rays. Code is available at https://github.com/matt-baugh/many-tasks-make-light-work . Comment: Early accepted to MICCAI 2023
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2023-07-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Simultaneous Detection of Bluetongue Virus Serotypes Using xMAP Technology.

Ashby, Martin / Rajko-Nenow, Paulina / Batten, Carrie / Flannery, John

Microorganisms

2020 Volume 8, Issue 10

Abstract: Bluetongue is an economically important disease of ruminants caused by the bluetongue virus (BTV). BTV is serologically diverse, which complicates vaccination strategies. Rapid identification of the causative BTV serotypes is critical, however, real-time ...

Abstract	Bluetongue is an economically important disease of ruminants caused by the bluetongue virus (BTV). BTV is serologically diverse, which complicates vaccination strategies. Rapid identification of the causative BTV serotypes is critical, however, real-time PCR (RT-qPCR) can be costly and time consuming to perform when the circulating serotypes are unknown. The Luminex xMAP technology is a high-throughput platform that uses fluorescent beads to detect multiple targets simultaneously. We utilized existing BTV serotyping RT-qPCR assays for BTV-1 to BTV-24 and adapted them for use with the xMAP platform. The xMAP assay specifically detected all 24 BTV serotypes when testing reference strains. In all BTV-positive samples, the sensitivity of the BTV xMAP was 87.55% whereas the sensitivity of the serotype-specific RT-qPCR was 79.85%. The BTV xMAP assay allowed for the specific detection of BTV serotypes 1-24 at a lower cost than current RT-qPCR assays. Overall, the assay provides a useful novel diagnostic tool, particularly when analyzing large sample sets. The use of the BTV xMAP assay will allow for the rapid assessment of BTV epidemiology and may inform decision-making related to control and prevention measures.
Language	English
Publishing date	2020-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8101564
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