Article ; Online: Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress.
2021 Volume 11, Issue 1, Page(s) 20866
Abstract: A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging ...
| Abstract | A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, can be a valuable tool for measuring effects of therapies on COVID-19 respiratory distress patients. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/complications ; Ceramides/blood ; Chromatography, Liquid ; Drug Design ; Female ; Humans ; Ions ; Lipids/chemistry ; Male ; Metabolomics ; Middle Aged ; Principal Component Analysis ; Respiratory Distress Syndrome/blood ; Respiratory Distress Syndrome/complications ; Software ; Tandem Mass Spectrometry ; Translational Research, Biomedical/methods ; Virus Diseases ; Young Adult |
| Chemical Substances | Ceramides ; Ions ; Lipids |
| Language | English |
| Publishing date | 2021-10-21 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-00286-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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