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Article ; Online: General Anesthesia Type and Cancer Prognosis: Comment.

Iwasaki, Masae / Ma, Daqing

2021 Volume 135, Issue 1, Page(s) 191

MeSH term(s)	Anesthesia, Epidural ; Anesthesia, General/adverse effects ; Humans ; Neoplasms
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000003804
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Article ; Online: Dexmedetomidine Might Exacerbate Acute Kidney Injury, While Midazolam Might Have a Postconditioning Effect: A Rat Model of Lipopolysaccharide-Induced Acute Kidney Injury.

Hata, Akiko / Yamamoto, Makiko / Iwasaki, Masae / Morita, Tomonori / Ishikawa, Masashi / Sakamoto, Atsuhiro

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2023 Volume 90, Issue 5, Page(s) 387–397

Abstract: Background: The preconditioning effects of dexmedetomidine and propofol on septic acute kidney injury (AKI) have been reported, but the postconditioning effects remain unknown. This study investigated the postconditioning effects of dexmedetomidine, ... ...

Abstract	Background: The preconditioning effects of dexmedetomidine and propofol on septic acute kidney injury (AKI) have been reported, but the postconditioning effects remain unknown. This study investigated the postconditioning effects of dexmedetomidine, midazolam, and propofol on septic AKI. Methods: Forty-eight male Wistar rats were intraperitoneally administered lipopolysaccharide (LPS; 8.3 mg kg Results: Among LPS-treated groups, D group showed worsened renal dysfunction (L-C vs L-D: Cr, P=0.002, effect size (η Conclusions: Dexmedetomidine administration might worsen septic AKI, while midazolam might preserve kidney function via the NFκΒ pathway.
MeSH term(s)	Rats ; Male ; Animals ; Dexmedetomidine/pharmacology ; Midazolam/adverse effects ; Lipopolysaccharides/adverse effects ; Rats, Wistar ; Propofol/adverse effects ; I-kappa B Kinase/adverse effects ; Acute Kidney Injury/chemically induced ; Kidney ; NF-kappa B
Chemical Substances	Dexmedetomidine (67VB76HONO) ; Midazolam (R60L0SM5BC) ; Lipopolysaccharides ; Propofol (YI7VU623SF) ; I-kappa B Kinase (EC 2.7.11.10) ; NF-kappa B
Language	English
Publishing date	2023-09-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.JNMS.2023_90-406
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Article ; Online: Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation.

Ishikawa, Masashi / Iwasaki, Masae / Sakamoto, Atsuhiro / Ma, Daqing

BMC anesthesiology

2021 Volume 21, Issue 1, Page(s) 71

Abstract: Background: microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell ... ...

Abstract	Background: microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell communication, and anti-cancer immunity. Main body: Anesthetics can affect cell biology through miRNA-mediated regulation of messenger RNA (mRNA). Indeed, sevoflurane was reported to upregulate miR-203 and suppresses breast cancer cell proliferation. Propofol reduces matrix metalloproteinase expression through its impact on miRNAs, leading to anti-cancer microenvironmental changes. Propofol also modifies miRNA expression profile in circulating extracellular vesicles with their subsequent anti-cancer effects via modulating cell-to-cell communication. Conclusion: Inhalational and intravenous anesthetics can alter cancer cell biology through various cellular signaling pathways induced by miRNAs' modification. However, this area of research is insufficient and further study is needed to figure out optimal anesthesia regimens for cancer patients.
MeSH term(s)	Anesthesia/methods ; Anesthetics/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; MicroRNAs/drug effects ; Neoplasms/surgery ; RNA, Messenger/drug effects
Chemical Substances	Anesthetics ; MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2021-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1471-2253
ISSN (online)	1471-2253
DOI	10.1186/s12871-021-01294-w
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Article ; Online: Worse ECOG-PS Is Associated with Increased 30-Day Mortality among Adults Older than 90 Years Undergoing Non-Cardiac Surgery: A Single-Center Retrospective Study.

Iwasaki, Masae / Ishikawa, Masashi / Namizato, Dai / Sakamoto, Atsuhiro

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2021 Volume 89, Issue 3, Page(s) 295–300

Abstract: Background: A growing number of older patients are undergoing surgeries. However, reliable preoperative predictors of surgical mortality among older patients have not been identified. This study compared predictive factors for 30-day survival in ... ...

Abstract	Background: A growing number of older patients are undergoing surgeries. However, reliable preoperative predictors of surgical mortality among older patients have not been identified. This study compared predictive factors for 30-day survival in patients older than 90 years after non-cardiac surgery. Methods: This retrospective study at Nippon Medical School Hospital investigated the records of patients aged >90 years who underwent non-cardiac surgeries between 2010 and 2020. The data collected included age, gender, American Society of Anesthesiologists physical status (ASA-PS), preoperative Charlson score, preoperative fall risk assessment, Eastern Cooperative Oncology Group performance status (ECOG-PS), modified 5-item frailty index (mFI-5), need for intraoperative transfusion, postoperative complications, and 30-day survival after surgery. Results: A total of 327 cases of elective surgery and 149 cases of emergency surgery were examined. Nonsurvivors (n=20, 4.2%) had significantly worse preoperative ASA-PS (for emergency cases) (nonsurvivors vs. survivors, 2.8 [2-3] vs. 2.3 [1-4], p=0.045), ECOG-PS (3.0 [2-4] vs. 1.0 [0-4], p<0.001), and mFI-5 values (3.0 [1-4] vs. 1.0 [0-3], p<0.001), more emergency cases (75.0% vs. 36.2%, p=0.004), and a greater need for intraoperative transfusion (55.0% vs. 13.4%, p<0.001). Among frailty assessment methods, ECOG-PS was the most strongly associated with 30-day mortality (area under the curve, ECOG-PS: 0.98, p<0.001; mFI-5: 0.86, p<0.001; Charlson score: 0.53, p=0.71; fall risk assessment: 0.55, p=0.44). Kaplan-Maier curves and multivariate logistic regression analysis demonstrated that an ECOG-PS of >3 was significantly associated with 30-day mortality (ECOG-PS: Kaplan-Maier curve, p<0.001, Log-rank test; odds ratio 1.71, 95% confidence interval: 1.35-2.16, p<0.001). Conclusions: An ECOG-PS of >3 was significantly correlated with 30-day mortality after non-cardiac surgery in patients older than 90 years.
MeSH term(s)	Adult ; Elective Surgical Procedures/adverse effects ; Frailty/complications ; Humans ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2021-11-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.JNMS.2022_89-304
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Article ; Online: The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting.

Ishikawa, Masashi / Iwasaki, Masae / Namizato, Dai / Yamamoto, Makiko / Morita, Tomonori / Ishii, Yosuke / Sakamoto, Atsuhiro

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15438

Abstract: Postoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB) ...

Abstract	Postoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB). A total of 329 adult patients, who underwent isolated OPCAB between December 2008 and February 2021, were retrospectively analyzed. The patients were divided into three groups: non-AKI, early AKI and late AKI groups. The early AKI group or the late AKI group were defined as 'having AKI that occurred before or after 48 h postoperatively', respectively. Multivariate logistic regression analysis was performed to identify the predictors of AKI. Receiver operating characteristic (ROC) curve analysis was used to evaluate the cutoff value, the sensitivity, and the specificity of the predictors. On the multivariate analysis, the emergency surgery, the preoperative serum albumin, and the postoperative day 1 neutrophil to lymphocyte ratio (NL ratio) were identified as the independent predictors of AKI. However, neither albumin nor the NL ratio predicted late AKI. The present study showed the preoperative albumin and the postoperative day 1 NL ratio were the robust and independent predictors of postoperative early AKI in isolated OPCAB.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Adult ; Coronary Artery Bypass/adverse effects ; Humans ; Lymphocytes ; Neutrophils ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors ; Serum Albumin
Chemical Substances	Serum Albumin
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-19772-7
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Article ; Online: Metronomic Chemotherapy for Pediatric Refractory Solid Tumors: A Retrospective Single-Center Study.

Sakurai, Yukari / Iwasaki, Fuminori / Hirose, Ayana / Matsumoto, Naoya / Miyagawa, Naoyuki / Keino, Dai / Yokosuka, Tomoko / Hamanoue, Satoshi / Yanagimachi, Masakatsu / Shiomi, Masae / Goto, Shoko / Tanaka, Mio / Tanaka, Yukichi / Nozawa, Kumiko / Goto, Hiroaki

Journal of pediatric hematology/oncology

2024

Abstract: Metronomic chemotherapy (MC) is based on chronic administration of chemotherapeutic agents at minimally toxic doses without prolonged drug-free breaks, that inhibits tumor angiogenesis and induces tumor dormancy. This study aimed to determine the ... ...

Abstract	Metronomic chemotherapy (MC) is based on chronic administration of chemotherapeutic agents at minimally toxic doses without prolonged drug-free breaks, that inhibits tumor angiogenesis and induces tumor dormancy. This study aimed to determine the efficacy of MC for pediatric refractory solid tumors. We retrospectively analyzed the data of pediatric patients with relapsed/refractory solid tumors who received treatment, including low-dose continuous administration of anticancer drugs, at our institute. Of the 18 patients, the disease statuses at the initiation of MC were complete remission (n=2), partial remission/stable disease (n=5), and progressive disease (n=11). The overall survival rate was 61% at 12 months and 34% at 24 months, and the progression-free survival rate was 21% at 12 and 24 months. Although only 5 of the 18 patients showed certain tumor regression or maintained remission, tumors that stabilized, maintained remission/stable disease, and showed certain advantages in terms of overall survival rate, even if limited to progressive disease. Approximately half of the patients demonstrated temporal tumor stabilization and improved survival time. Overall, previous reports and the present study support the conclusion that MC has the potential to play an important role in pediatric cancer treatment during the advanced stage.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002870
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Article ; Online: "Anti-cancer" effect of ketamine in comparison with MK801 on neuroglioma and lung cancer cells.

Saito, Junichi / Zao, Hailin / Wu, Lingzhi / Iwasaki, Masae / Sun, Qizhe / Hu, Cong / Ishikawa, Masashi / Hirota, Kazuyoshi / Ma, Daqing

European journal of pharmacology

2023 Volume 945, Page(s) 175580

Abstract: Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used to induce anaesthesia during cancer surgery and relieve neuropathic and cancer pain. This study was conducted to assess whether ketamine has any inhibiting effects on ... ...

Abstract	Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used to induce anaesthesia during cancer surgery and relieve neuropathic and cancer pain. This study was conducted to assess whether ketamine has any inhibiting effects on neuroglioma (H4) and lung cancer cells (A549) in vitro. The cultured H4 and A549 cells were treated with ketamine and MK801 (0.1, 1, 10, 100, or 1000 μM) for 24 h. The expressions of glutamate receptors on both types of cancer cells were assessed with qRT-PCR. In addition, cell proliferation and migration were assessed with cell counting Kit-8 and wound healing assays. Cyclin D1, matrix metalloproteinase 9 (MMP9), phosphorylation of extracellular signal-regulated kinase (pERK), and cleaved-caspase-3 expression together with reactive oxygen species (ROS) were also assessed with Western blot, immunostaining, and/or flowcytometry. NMDA and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors were expressed on both H4 and A549 cells. Ketamine inhibited cancer cell proliferation and migration in a dose-dependent manner by suppressing the cell cycle and inducing apoptosis. Ketamine decreased cyclin D1, pERK, and MMP9 expression. In addition, ketamine increased ROS and cleaved caspase-3 expression and induced apoptosis. The anti-cancer effect of ketamine was more pronounced in A549 cells when compared with H4 cells. MK801 showed similar effects to those of ketamine. Ketamine suppressed cell proliferation and migration in both neuroglioma and lung cancer cells, likely through the antagonization of NMDA receptors.
MeSH term(s)	Humans ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Dizocilpine Maleate/pharmacology ; Caspase 3/metabolism ; Cyclin D1/metabolism ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; N-Methylaspartate/pharmacology ; Reactive Oxygen Species/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Apoptosis ; Receptors, N-Methyl-D-Aspartate/metabolism
Chemical Substances	Ketamine (690G0D6V8H) ; Dizocilpine Maleate (6LR8C1B66Q) ; Caspase 3 (EC 3.4.22.-) ; Cyclin D1 (136601-57-5) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; N-Methylaspartate (6384-92-5) ; Reactive Oxygen Species ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2023-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2023.175580
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Article ; Online: The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence.

Iwasaki, Masae / Zhao, Hailin / Hu, Cong / Saito, Junichi / Wu, Lingzhi / Sherwin, Aislinn / Ishikawa, Masashi / Sakamoto, Atsuhiro / Buggy, Donal / Ma, Daqing

Cell biology and toxicology

2022 Volume 39, Issue 4, Page(s) 1561–1575

Abstract: Anaesthetics may modify colorectal cancer cell biology which potentially affects long-term survival. This study aims to compare propofol and sevoflurane regarding with the direct anaesthetic effects on cancer malignancy and the indirect effects on host ... ...

Abstract	Anaesthetics may modify colorectal cancer cell biology which potentially affects long-term survival. This study aims to compare propofol and sevoflurane regarding with the direct anaesthetic effects on cancer malignancy and the indirect effects on host immunity in a cancer xenograft mode of mice. Cultured colon cancer cell (Caco-2) was injected subcutaneously to nude mice (day 1). Mice were exposed to either 1.5% sevoflurane for 1.5 h or propofol (20 μg g
MeSH term(s)	Humans ; Mice ; Animals ; Propofol/pharmacology ; Propofol/therapeutic use ; Sevoflurane/pharmacology ; Anesthetics, Intravenous/pharmacology ; Tissue Inhibitor of Metalloproteinase-2 ; Anesthetics, Inhalation/pharmacology ; Methyl Ethers/pharmacology ; Heterografts ; Lipopolysaccharides/pharmacology ; Caco-2 Cells ; Mice, Nude ; Neoplasms/drug therapy
Chemical Substances	Propofol (YI7VU623SF) ; Sevoflurane (38LVP0K73A) ; Anesthetics, Intravenous ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Anesthetics, Inhalation ; Methyl Ethers ; Lipopolysaccharides
Language	English
Publishing date	2022-08-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	48824-0
ISSN	1573-6822 ; 0742-2091
ISSN (online)	1573-6822
ISSN	0742-2091
DOI	10.1007/s10565-022-09747-9
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Article: [Molecular basis for the multiplication of negative-strand RNA viruses: basic research and potential applications in vaccine development].

Iwasaki, Masaharu

Uirusu

2023 Volume 72, Issue 1, Page(s) 67–78

Abstract: Viruses achieve their efficient reproduction by utilizing their limited components (nucleic acids, lipids, and proteins) and host cell machineries. A detailed understanding of virus-virus and virus-host interactions will lead to the elucidation of ... ...

Abstract	Viruses achieve their efficient reproduction by utilizing their limited components (nucleic acids, lipids, and proteins) and host cell machineries. A detailed understanding of virus-virus and virus-host interactions will lead to the elucidation of mechanisms underlying viral pathogenesis and the development of novel medical countermeasures. We elucidated the details of several such interactions and their roles in the multiplication of negative-strand RNA viruses, measles virus, and Lassa virus. These discoveries were harnessed to develop a novel genetic approach for the generation of live-attenuated vaccine candidates with a well-defined molecular mechanism of attenuation. This article describes our findings.
Language	Japanese
Publishing date	2023-10-24
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	603272-2
ISSN	0042-6857
ISSN	0042-6857
DOI	10.2222/jsv.72.67
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Article: Elderly-onset calcinosis of hyperphosphataemic familial tumoural calcinosis/hyperostosis-hyperphosphataemia syndrome: the role of comorbid scleroderma.

Iwasaki, Hiroaki

Endocrinology, diabetes & metabolism case reports

2023 Volume 2023, Issue 4

Abstract: ... for glycaemic control. Physical examination revealed two subcutaneous hard masses around the left shoulder and ...

Abstract	Summary: A 73-year-old woman with type 2 diabetes mellitus was referred to our department for glycaemic control. Physical examination revealed two subcutaneous hard masses around the left shoulder and the right hip joint. The patient could not fully extend her fingers because of skin sclerosis in both hands. Laboratory studies showed hyperphosphataemia and a high ratio of renal tubular maximum reabsorption of phosphate to glomerular filtration rate. There were no abnormalities in serum calcium, creatinine, alkaline phosphatase, and intact parathyroid hormone levels, whereas serum fibroblast growth factor 23 was low. Hyperphosphataemic familial tumoural calcinosis/hyperostosis-hyperphosphataemia syndrome (HFTC/HHS) was diagnosed using whole genome sequencing that revealed a novel frameshift beyond the 584th threonine located in the lectin domain of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 associated with a duplication of the 1748th thymine in the coding region of the corresponding gene. Furthermore, anti-nuclear, anti-centromere, and anti-cardiolipin antibodies were positive, implying that comorbid limited type scleroderma might play a role in tumoural calcinosis (TC) development. A low phosphate diet was prescribed with phosphate-lowering medications, including aluminium hydroxide, acetazolamide, and sevelamer hydrochloride. The patient displayed a decrease in serum phosphate levels from 6.5 to 5.5 mg/dL 10 months after the initiation of treatment, but her TC had not improved during treatment for more than 1 year. This case was interesting because the patient with HFTC/HHS exhibited TC despite being over her 60s, and subsequent scleroderma might contribute to the specific clinical course. When HFTC/HHS presents with elderly-onset TC, the involvement of comorbidities in exacerbating TC should be considered. Learning points: HFTC/HHS occurs on an autosomal recessive basis, but its clinical course and manifestations differ significantly throughout the cases. HFTC/HHS may be undiagnosed until later in life because of its rarity, unfamiliarity, and phenotype diversity; therefore, HFTC/HHS should be included in the differential diagnosis of elderly patients with unexplained hyperphosphataemia or ectopic calcinosis. Comorbidities, including rheumatologic disorders, may contribute to developing HFTC/HHS-associated calcinosis.
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2785530-2
ISSN	2052-0573
ISSN	2052-0573
DOI	10.1530/EDM-23-0071
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