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  1. Article: Complimentary address to Mr Koichi Tanaka, the winner of Nobel Prize in Chemistry 2002.

    Shimizu, Akira

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2003  Volume 792, Issue 1, Page(s) 3–4

    MeSH term(s) Chemical Phenomena ; Chemistry ; Nobel Prize
    Language English
    Publishing date 2003-07-14
    Publishing country Netherlands
    Document type Address
    ISSN 1570-0232
    ISSN 1570-0232
    DOI 10.1016/s1570-0232(03)00313-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Fluorescein angiography; proceedings... edited by Koichi Shimizu

    Shimizu, Kōichi

    1974  

    Title variant Proceedings of the International Symposium on Fluorescein Angiography
    Event/congress International Symposium on Fluorescein Angiography (1972, Tokyo)
    MeSH term(s) Eye/diagnostic imaging ; Fluorescein Angiography ; Radiography
    Language English
    Size xix, 449 p., ill.
    Publisher Igaku Shoin
    Publishing place Tokyo
    Document type Book ; Conference proceedings
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: Near-Infrared Transillumination for Macroscopic Functional Imaging of Animal Bodies.

    Shimizu, Koichi

    Biology

    2023  Volume 12, Issue 11

    Abstract: The classical transillumination technique has been revitalized through recent advancements in optical technology, enhancing its applicability in the realm of biomedical research. With a new perspective on near-axis scattered light, we have harnessed near- ...

    Abstract The classical transillumination technique has been revitalized through recent advancements in optical technology, enhancing its applicability in the realm of biomedical research. With a new perspective on near-axis scattered light, we have harnessed near-infrared (NIR) light to visualize intricate internal light-absorbing structures within animal bodies. By leveraging the principle of differentiation, we have extended the applicability of the Beer-Lambert law even in cases of scattering-dominant media, such as animal body tissues. This approach facilitates the visualization of dynamic physiological changes occurring within animal bodies, thereby enabling noninvasive, real-time imaging of macroscopic functionality in vivo. An important challenge inherent to transillumination imaging lies in the image blur caused by pronounced light scattering within body tissues. By extracting near-axis scattered components from the predominant diffusely scattered light, we have achieved cross-sectional imaging of animal bodies. Furthermore, we have introduced software-based techniques encompassing deconvolution using the point spread function and the application of deep learning principles to counteract the scattering effect. Finally, transillumination imaging has been elevated from two-dimensional to three-dimensional imaging. The effectiveness and applicability of these proposed techniques have been validated through comprehensive simulations and experiments involving human and animal subjects. As demonstrated through these studies, transillumination imaging coupled with emerging technologies offers a promising avenue for future biomedical applications.
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12111362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Erratum: Optical parameters estimation in inhomogeneous turbid media using backscattered light: for transcutaneous scattering measurement of intravascular blood: erratum.

    Liang, Shiyang / Miyake, Takeo / Shimizu, Koichi

    Biomedical optics express

    2024  Volume 15, Issue 2, Page(s) 910

    Abstract: This corrects the article on p. 237 in vol. 15, PMID: 38223194.]. ...

    Abstract [This corrects the article on p. 237 in vol. 15, PMID: 38223194.].
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.517856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Optical parameters estimation in inhomogeneous turbid media using backscattered light: for transcutaneous scattering measurement of intravascular blood.

    Liang, Shiyang / Miyake, Takeo / Shimizu, Koichi

    Biomedical optics express

    2023  Volume 15, Issue 1, Page(s) 237–255

    Abstract: In our earlier research, a technique was developed to estimate the effective attenuation coefficient of subcutaneous blood vessels from the skin surface using the spatial distribution of backscattered near-infrared (NIR) light. The scattering effect in ... ...

    Abstract In our earlier research, a technique was developed to estimate the effective attenuation coefficient of subcutaneous blood vessels from the skin surface using the spatial distribution of backscattered near-infrared (NIR) light. The scattering effect in surrounding tissues was suppressed through the application of a differential principle, provided that the
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.510245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Erratum to: Reoperation Rates of Microendoscopic Discectomy Compared With Conventional Open Lumbar Discectomy: A Large-database Study.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Clinical orthopaedics and related research

    2024  Volume 482, Issue 3, Page(s) 569

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Erratum to: Reoperation Rates of Microendoscopic Discectomy Compared With Conventional Open Lumbar Discectomy: A Large-database Study.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Clinical orthopaedics and related research

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pressure Dynamics on Intervertebral Disc Cages in TLIF: A Cadaver Study.

    Takaki, Yoshiyama / Tanida, Shimei / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Otsuki, Bungo

    World neurosurgery

    2024  

    Abstract: Objective: This study aimed to quantify the change in pressure on the cage during compression manipulation in lumbar interbody fusion. While the procedure involves applying compression between pedicle screws to press the cage against the endplate, the ... ...

    Abstract Objective: This study aimed to quantify the change in pressure on the cage during compression manipulation in lumbar interbody fusion. While the procedure involves applying compression between pedicle screws to press the cage against the endplate, the exact compression force remains elusive. We hypothesize that an intact facet joint might serve as a fulcrum, potentially reducing cage pressure.
    Methods: Pressure on the intervertebral disc cage was measured during compression manipulation in four donor cadavers undergoing lumbar interbody fusion. Unilateral facetectomy models with both normal and parallel compression and bilateral facetectomy models were included. A transforaminal lumbar interbody fusion (TLIF) cage with a built-in load cell measured the compression force.
    Results: Pressure data from 14 discs indicated a consistent pre-compression pressure average of 68.16N. Following compression, pressures increased to 125.99N and 140.84N for normal and parallel compression post-unilateral facetectomy, respectively, and to 154.58N and 150.46N for bilateral models. A strong linear correlation (correlation coefficient: 0.967, P < 0.0001) between pre- and post-compression pressures emphasized the necessity of sufficient pre-compression pressure for achieving desired post-compression outcomes. None of the data showed a decrease in compression force to the cage with the compression maneuver.
    Conclusion: Both normal and parallel compression maneuvers effectively increased the pressure on the cage, irrespective of the facet joint resection status. Compression manipulation consistently enhanced compressive force on the cage. However, when baseline pressure is low, the manipulation might not yield significant increases in compression force. This underlines the essential role of meticulous pre-compression preparation in enhancing surgical outcomes.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.03.080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Differences in joint angles during pole vaulting between male pole vaulters with and without chronic low back pain

    Enoki Shota / Kuramochi Rieko / Nakayama Koichi / Takigawa Hiroko / Shimizu Takuya

    Biomedical Human Kinetics, Vol 15, Iss 1, Pp 131-

    2023  Volume 138

    Abstract: Study aim: To determine the difference in joint angles of the shoulder, hip, and trunk (angle of the upper torso and lower torso) during vaulting between male pole vaulters with and without chronic low back pain (LBP) and to examine the relationship ... ...

    Abstract Study aim: To determine the difference in joint angles of the shoulder, hip, and trunk (angle of the upper torso and lower torso) during vaulting between male pole vaulters with and without chronic low back pain (LBP) and to examine the relationship between the range of motion (ROM) and maximum angle of the same joint during vaulting in all participants.
    Keywords back pain ; lumbago ; track and field ; 3d-dlt ; Sports medicine ; RC1200-1245 ; Physiology ; QP1-981
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Linagliptin exacerbates heart failure due to energy deficiency via downregulation of glucose utilization and absorption in a mouse model.

    Shiraki, Aya / Oyama, Jun-Ichi / Shimizu, Takahiko / Node, Koichi

    European journal of pharmacology

    2023  Volume 948, Page(s) 175673

    Abstract: Use of dipeptidyl peptidase-4 (DPP4) inhibitor in some clinical trials might have caused heart failure (HF), leading to increased hospitalizations. The aim of the present study was to determine whether linagliptin has any effect on chronic dilated HF, ... ...

    Abstract Use of dipeptidyl peptidase-4 (DPP4) inhibitor in some clinical trials might have caused heart failure (HF), leading to increased hospitalizations. The aim of the present study was to determine whether linagliptin has any effect on chronic dilated HF, and its underlying mechanisms. Physiologic and pathologic studies were conducted on heart/muscle-specific manganese superoxide dismutase-deficient mice, which exhibited dilated cardiomyopathy, and were randomized to receive a low dose (1 mg/kg, HF-L group) or high dose (10 mg/kg, HF-H group) mixed with food, or normal food (HF group), for 8 weeks. Linagliptin increased mortality and heart/body weight ratio in mice with HF. Cardiac contractility and fibrosis worsened, whereas hepatic glycogen content and individual carbohydrate consumption decreased significantly in the HF-H group, when compared with the HF control group. Therefore, we performed a complementary experiment by supplementing glucose to the mice treated with high-dose linagliptin (HF-HG group). Adequate glucose supplementation reduced heart/body weight ratio and cardiac fibrosis, and improved cardiac contractility, without changing mortality. Following oral administration of
    MeSH term(s) Animals ; Mice ; Body Weight ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Disease Models, Animal ; Down-Regulation ; Fibrosis ; Glucose ; Heart Failure/drug therapy ; Hypoglycemic Agents/pharmacology ; Linagliptin/pharmacology ; Linagliptin/therapeutic use
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Glucose (IY9XDZ35W2) ; Hypoglycemic Agents ; Linagliptin (3X29ZEJ4R2)
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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