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  1. Article: Illicit Drugs and Reversible Cerebral Vasoconstriction Syndrome.

    Short, Katherine / Emsley, Hedley C A

    The Neurohospitalist

    2020  Volume 11, Issue 1, Page(s) 40–44

    Abstract: Reversible cerebral vasoconstriction syndrome (RCVS) is a condition characterized by thunderclap headache and associated vasospasm of the cerebral vasculature. A multitude of factors are considered to potentially predispose to the development of RCVS. ... ...

    Abstract Reversible cerebral vasoconstriction syndrome (RCVS) is a condition characterized by thunderclap headache and associated vasospasm of the cerebral vasculature. A multitude of factors are considered to potentially predispose to the development of RCVS. These potential precipitants include numerous illicit drugs. In this study, we investigated the role of illicit drugs as a precipitating factor for RCVS, through systematic review of the relevant literature. We found the strongest evidence for cannabis, but a relative lack of evidence to support other illicit drugs, particularly as individual precipitating factors. We also identified a lack of the consistent application of diagnostic criteria for RCVS, which undoubtedly hampers advancement of knowledge in this field. Consistent adherence to diagnostic criteria will be important for future studies. Ultimately, a prospective registry of RCVS cases would be advantageous to advance understanding of the condition and its underlying causes.
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/1941874420953051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease.

    Kyrtata, Natalia / Emsley, Hedley C A / Sparasci, Oli / Parkes, Laura M / Dickie, Ben R

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 626636

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-05-20
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.626636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimising rehabilitation and recovery after a stroke.

    Bonifacio, Guendalina B / Ward, Nick S / Emsley, Hedley C A / Cooper, Jon / Bernhardt, Julie

    Practical neurology

    2022  Volume 22, Issue 6, Page(s) 478–485

    Abstract: Stroke can cause significant disability and impact quality of life. Multidisciplinary neurorehabilitation that meets individual needs can help to optimise recovery. Rehabilitation is essential for best quality care but should start early, be ongoing and ... ...

    Abstract Stroke can cause significant disability and impact quality of life. Multidisciplinary neurorehabilitation that meets individual needs can help to optimise recovery. Rehabilitation is essential for best quality care but should start early, be ongoing and involve effective teamwork. We describe current stroke rehabilitation processes, from the hyperacute setting through to inpatient and community rehabilitation, to long-term care and report on which UK quality care standards are (or are not) being met. We also examine the gap between what stroke rehabilitation is recommended and what is being delivered, and suggest areas for further improvement.
    MeSH term(s) Humans ; Quality of Life ; Stroke Rehabilitation ; Stroke ; Inpatients
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/practneurol-2021-003004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Uncommon causes of ischaemic stroke: how to approach the diagnosis.

    Hurford, Robert / Siripurapu, Rekha / Emsley, Hedley C A / Lovett, Joanna / Werring, David / Punter, Martin Nicholas Michael

    Practical neurology

    2022  Volume 23, Issue 1, Page(s) 35–45

    Abstract: Stroke is a common neurological emergency and although most cases are associated with traditional vascular risk factors leading to cerebral ischaemia by well-recognised pathophysiological mechanisms, around 4% of ischaemic strokes are due to rare ... ...

    Abstract Stroke is a common neurological emergency and although most cases are associated with traditional vascular risk factors leading to cerebral ischaemia by well-recognised pathophysiological mechanisms, around 4% of ischaemic strokes are due to rare conditions. These are important to recognise due to their different management, which is often specific and effective, and due to their different prognosis from otherwise cryptogenic ischaemic strokes. We outline a practical approach to identifying uncommon causes of ischaemic stroke by highlighting diagnostic 'red flags' and propose a structured approach to investigating them.
    MeSH term(s) Humans ; Stroke/diagnosis ; Stroke/diagnostic imaging ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Ischemic Stroke/complications ; Risk Factors ; Prognosis
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2022-003449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 exposes the urgent need for coding of outpatient neurology episodes.

    Kemp, Mike / Biggin, Fran / Dayanandan, Rejith / Knight, Jo / Emsley, Hedley C A

    BMJ neurology open

    2020  Volume 2, Issue 2, Page(s) e000080

    Language English
    Publishing date 2020-08-11
    Document type Editorial
    ISSN 2632-6140
    ISSN (online) 2632-6140
    DOI 10.1136/bmjno-2020-000080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Late-onset epilepsy predicts stroke: Systematic review and meta-analysis.

    Wall, Jasmine / Knight, Jo / Emsley, Hedley C A

    Epilepsy & behavior : E&B

    2020  Volume 115, Page(s) 107634

    Abstract: Objective: Late-onset epilepsy (LOE) is closely associated with cerebrovascular disease, acting as both a marker of cerebrovascular disease (CVD) and occurring as a direct consequence. Despite this, our understanding of LOE as a cerebrovascular ... ...

    Abstract Objective: Late-onset epilepsy (LOE) is closely associated with cerebrovascular disease, acting as both a marker of cerebrovascular disease (CVD) and occurring as a direct consequence. Despite this, our understanding of LOE as a cerebrovascular phenomenon is in its infancy. LOE also appears to be a harbinger of dementia.
    Methods: A systematic review was performed to identify publications relating to LOE and identified observational studies, clinical studies, and radiological studies.
    Results: A meta-analysis of observational studies demonstrated that patients presenting with LOE experience an increased risk of subsequent stroke (weighted OR 3.88 (95% CI 2.76-5.46)). The additional studies demonstrated clinical and radiological evidence to support the premise that LOE is likely to reflect underlying cerebrovascular disease.
    Significance: Cerebrovascular disease risk factors convey increased risk of LOE and LOE can precede stroke and dementia, acting as an early marker for cerebrovascular risk. This may represent a potential point for intervention. There are a number of suggested mechanisms relating LOE to stroke; however, there is limited understanding of the natural history of LOE. Current data support the need for prospective research in order to understand the natural history of LOE and modify disease, in order to reduce the apparent sequelae of stroke and dementia.
    MeSH term(s) Cerebrovascular Disorders/complications ; Cerebrovascular Disorders/diagnostic imaging ; Epilepsy/etiology ; Humans ; Prospective Studies ; Risk Factors ; Stroke/complications ; Stroke/diagnostic imaging
    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2020.107634
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    Zs.A 5289: Show issues Location:
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  7. Article ; Online: Routinely collected patient data in neurology research: a systematic mapping review.

    Biggin, Fran / Emsley, Hedley C A / Knight, Jo

    BMC neurology

    2020  Volume 20, Issue 1, Page(s) 431

    Abstract: Background: This review focuses on neurology research which uses routinely collected data. The number of such studies is growing alongside the expansion of data collection. We aim to gain a broad picture of the scope of how routine healthcare data have ... ...

    Abstract Background: This review focuses on neurology research which uses routinely collected data. The number of such studies is growing alongside the expansion of data collection. We aim to gain a broad picture of the scope of how routine healthcare data have been utilised.
    Methods: This study follows a systematic mapping review approach which does not make a judgement on the quality of the papers included in the review, thereby enabling a complete overview of the field.
    Results: Of 4481 publications retrieved, 386 met the eligibility criteria for this study. These publications covered a wide range of conditions, but the majority were based on one or only a small number of neurological conditions. In particular, publications concerned with three discrete areas of neurological practice - multiple sclerosis (MS), epilepsy/seizure and Parkinson's disease - accounted for 60% of the total. MS was the focus of the highest proportion of eligible studies (35%), yet in the recent Global Burden of Neurological Disease study it ranks only 14th out of 15 neurological disorders for DALY rates. In contrast, migraine is the neurological disorder with the highest ranking of DALYs globally (after stroke) and yet it was represented by only 4% of eligible studies.
    Conclusion: This review shows that there is a disproportionately large body of literature pertaining to relatively rare disorders, and a correspondingly small body of literature describing more common conditions. Therefore, there is potential for future research to redress this balance.
    MeSH term(s) Biomedical Research ; Data Collection ; Humans ; Nervous System Diseases ; Neurology/statistics & numerical data
    Language English
    Publishing date 2020-11-27
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-020-01993-w
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  8. Article ; Online: Postexertional harlequin syndrome with spontaneous improvement.

    Emsley, Hedley C A

    BMJ case reports

    2013  Volume 2013

    MeSH term(s) Autonomic Nervous System Diseases ; Flushing ; Humans ; Hypohidrosis ; Male ; Middle Aged ; Physical Exertion
    Language English
    Publishing date 2013-09-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-200516
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  9. Article ; Online: Outpatient neurology diagnostic coding: a proposed scheme for standardised implementation.

    Biggin, Fran / Knight, Jo / Dayanandan, Rejith / Marson, Anthony / Wilson, Martin / Nitkunan, Arani / Rog, David / Kipps, Christopher / Mummery, Catherine / Williams, Adrian / Emsley, Hedley C A

    Practical neurology

    2023  Volume 23, Issue 4, Page(s) 317–322

    Abstract: Clinical coding uses a classification system to assign standard codes to clinical terms and so facilitates good clinical practice through audit, service design and research. However, despite clinical coding being mandatory for inpatient activity, this is ...

    Abstract Clinical coding uses a classification system to assign standard codes to clinical terms and so facilitates good clinical practice through audit, service design and research. However, despite clinical coding being mandatory for inpatient activity, this is often not so for outpatient services, where most neurological care is delivered. Recent reports by the UK National Neurosciences Advisory Group and NHS England's 'Getting It Right First Time' initiative recommend implementing outpatient coding. The UK currently has no standardised system for outpatient neurology diagnostic coding. However, most new attendances at general neurology clinics appear to be classifiable with a limited number of diagnostic terms. We present the rationale for diagnostic coding and its benefits, and the need for clinical engagement to develop a system that is pragmatic, quick and easy to use. We outline a scheme developed in the UK that could be used elsewhere.
    MeSH term(s) Humans ; Outpatients ; Clinical Coding ; Neurology ; Ambulatory Care ; Neurosciences
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2021-003286
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  10. Article ; Online: COVID-19 exposes the urgent need for coding of outpatient neurology episodes

    Hedley C A Emsley / Rejith Dayanandan / Mike Kemp / Fran Biggin / Jo Knight

    BMJ Neurology Open, Vol 2, Iss

    2020  Volume 2

    Keywords Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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