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Article ; Online: Comparison of Placebos and Propensity Score Adjustment in Multiple Sclerosis Nonrandomized Studies.

Signori, Alessio / Pellegrini, Fabio / Bovis, Francesca / Carmisciano, Luca / de Moor, Carl / Sormani, Maria Pia

2020 Volume 77, Issue 7, Page(s) 902–903

MeSH term(s)	Humans ; Immunologic Factors/pharmacology ; Multiple Sclerosis/drug therapy ; Observational Studies as Topic/methods ; Placebos/pharmacology ; Propensity Score
Chemical Substances	Immunologic Factors ; Placebos
Language	English
Publishing date	2020-04-20
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2020.0678
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Article ; Online: Cost-effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease: a European economic evaluation of the THEMIS trial.

Steg, Philippe Gabriel / Bhatt, Deepak L / James, Stefan K / Darlington, Oliver / Hoskin, Louise / Simon, Tabassome / Fox, Kim M / Leiter, Lawrence A / Mehta, Shamir R / Harrington, Robert A / Himmelmann, Anders / Ridderstråle, Wilhelm / Andersson, Marielle / Bueno, Héctor / De Luca, Leonardo / Tank, Amarjeet / Mellström, Carl / McEwan, Phil

European heart journal. Cardiovascular pharmacotherapy

2022 Volume 8, Issue 8, Page(s) 777–785

Abstract: Aims: To conduct a health economic evaluation of ticagrelor in patients with type 2 diabetes and coronary artery disease (CAD) from a multinational payer perspective. Cost-effectiveness and cost-utility of ticagrelor were evaluated in the overall effect ...

Abstract	Aims: To conduct a health economic evaluation of ticagrelor in patients with type 2 diabetes and coronary artery disease (CAD) from a multinational payer perspective. Cost-effectiveness and cost-utility of ticagrelor were evaluated in the overall effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study (THEMIS) trial population and in the predefined patient group with prior percutaneous coronary intervention. Methods and results: A Markov model was developed to extrapolate patient outcomes over a lifetime horizon. The primary outcome was incremental cost-effectiveness ratios (ICERs), which were compared with conventional willingness-to-pay thresholds [€47 000/quality-adjusted life-year (QALY) in Sweden and €30 000/QALY in other countries].Treatment with ticagrelor resulted in QALY gains of up to 0.045 in the overall population and 0.099 in patients with percutaneous coronary intervention (PCI). Increased costs and benefits translated to ICERs ranged between €27 894 and €42 252/QALY across Sweden, Germany, Italy, and Spain in the overall population. In patients with prior PCI, estimated ICERs improved to €18 449, €20 632, €20 233, and €13 228/QALY in Sweden, Germany, Italy, and Spain, respectively, driven by higher event rates and treatment benefit. Conclusion: Based on THEMIS results, ticagrelor plus aspirin compared with aspirin alone may be cost-effective in some European countries in patients with T2DM and CAD and no prior myocardial infarction (MI) or stroke. Additionally, ticagrelor is likely to be cost-effective across European countries in patients with a history of PCI.
MeSH term(s)	Humans ; Aspirin ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/epidemiology ; Cost-Benefit Analysis ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Percutaneous Coronary Intervention ; Ticagrelor/therapeutic use
Chemical Substances	Aspirin (R16CO5Y76E) ; Ticagrelor (GLH0314RVC)
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2808613-2
ISSN	2055-6845 ; 2055-6837
ISSN (online)	2055-6845
ISSN	2055-6837
DOI	10.1093/ehjcvp/pvac032
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Article ; Online: The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice.

Ciaramelli, Elisa / De Luca, Flavia / Kwan, Donna / Mok, Jenkin / Bianconi, Francesca / Knyagnytska, Violetta / Craver, Carl / Green, Leonard / Myerson, Joel / Rosenbaum, R Shayna

eLife

2021 Volume 10

Abstract: Intertemporal choices require trade-offs between short-term and long-term outcomes. Ventromedial prefrontal cortex (vmPFC) damage causes steep discounting of future rewards (delay discounting [DD]) and impoverished episodic future thinking (EFT). The ... ...

Abstract	Intertemporal choices require trade-offs between short-term and long-term outcomes. Ventromedial prefrontal cortex (vmPFC) damage causes steep discounting of future rewards (delay discounting [DD]) and impoverished episodic future thinking (EFT). The role of vmPFC in reward valuation, EFT, and their interaction during intertemporal choice is still unclear. Here, 12 patients with lesions to vmPFC and 41 healthy controls chose between smaller-immediate and larger-delayed hypothetical monetary rewards while we manipulated reward magnitude and the availability of EFT cues. In the EFT condition, participants imagined personal events to occur at the delays associated with the larger-delayed rewards. We found that DD was steeper in vmPFC patients compared to controls, and not modulated by reward magnitude. However, EFT cues downregulated DD in vmPFC patients as well as controls. These findings indicate that vmPFC integrity is critical for the valuation of (future) rewards, but not to instill EFT in intertemporal choice.
MeSH term(s)	Aged ; Choice Behavior ; Delay Discounting/physiology ; Female ; Humans ; Imagination ; Male ; Middle Aged ; Prefrontal Cortex/physiology ; Reward ; Time Factors
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.67387
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Article: sv-callers: a highly portable parallel workflow for structural variant detection in whole-genome sequence data.

Kuzniar, Arnold / Maassen, Jason / Verhoeven, Stefan / Santuari, Luca / Shneider, Carl / Kloosterman, Wigard P / de Ridder, Jeroen

PeerJ

2020 Volume 8, Page(s) e8214

Abstract: Structural variants (SVs) are an important class of genetic variation implicated in a wide array of genetic diseases including cancer. Despite the advances in whole genome sequencing, comprehensive and accurate detection of SVs in short-read data still ... ...

Abstract	Structural variants (SVs) are an important class of genetic variation implicated in a wide array of genetic diseases including cancer. Despite the advances in whole genome sequencing, comprehensive and accurate detection of SVs in short-read data still poses some practical and computational challenges. We present
Language	English
Publishing date	2020-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.8214
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Article ; Online: sv-callers

Arnold Kuzniar / Jason Maassen / Stefan Verhoeven / Luca Santuari / Carl Shneider / Wigard P. Kloosterman / Jeroen de Ridder

PeerJ, Vol 8, p e

a highly portable parallel workflow for structural variant detection in whole-genome sequence data

2020 Volume 8214

Abstract	Structural variants (SVs) are an important class of genetic variation implicated in a wide array of genetic diseases including cancer. Despite the advances in whole genome sequencing, comprehensive and accurate detection of SVs in short-read data still poses some practical and computational challenges. We present sv-callers, a highly portable workflow that enables parallel execution of multiple SV detection tools, as well as provide users with example analyses of detected SV callsets in a Jupyter Notebook. This workflow supports easy deployment of software dependencies, configuration and addition of new analysis tools. Moreover, porting it to different computing systems requires minimal effort. Finally, we demonstrate the utility of the workflow by performing both somatic and germline SV analyses on different high-performance computing systems.
Keywords	Scientific workflow ; Cancer genomics ; Variant calling ; Structural variants ; High-performance computing ; Cloud computing ; Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Indocyanine green angiographic findings in presumed intraocular tuberculosis.

Abouammoh, Marwan A / De Simone, Luca / Almousa, Abdullah N / Al-Dossari, Mona / Herbort, Carl P / Abu El-Asrar, Ahmed M

Eye (London, England)

2020 Volume 35, Issue 6, Page(s) 1680–1687

Abstract: Purpose: To study features of Indocyanine green angiography (ICGA) in patients with presumed intraocular tuberculosis.: Methods: Retrospective study of 48 consecutive patients (77 eyes) who underwent ICGA. The following signs were analysed: choroidal ...

Abstract	Purpose: To study features of Indocyanine green angiography (ICGA) in patients with presumed intraocular tuberculosis. Methods: Retrospective study of 48 consecutive patients (77 eyes) who underwent ICGA. The following signs were analysed: choroidal perfusion inhomogeneity, early hyperfluorescent stromal vessels, round or oval hypofluorescent dark dots (HDDs), hypofluorescent geographic lesions (HGLs), fuzzy or lost pattern of large stromal choroidal vessels, disc hyperfluorescence and diffuse late choroidal hyperfluorescence. Results: Among 44 eyes of 29 patients with no clinical evidence of choroidal involvement, only 7 eyes of 6 patients had no ICGA evidence of choroidal involvement. On the other hand, ICGA findings suggesting choroidal involvement were noted in 37 (84.1%) eyes of 23 patients in the form of HDDs in all 37 (100%) eyes, HGLs in 7 (18.9%) eyes, disc hyperfluorescence in 20 (45.5%) eyes, fuzzy stromal vessels in 17 (38.6%) eyes, early hyperfluorescent stromal vessels in 13 (29.5%) eyes, late pinpoint hyperfluorescence in 11 (25%) eyes and late diffuse choroidal hyperfluorescence in 7 (15.9%) eyes. Among 33 eyes of 19 patients with clinically evident choroidal involvement, the following findings were identified; HDDs in 12 (36.4%) eyes, HGLs in 10 (30.3%) eyes, both HDDs and HGLs in 9 (27.3%) eyes, disc hyperfluorescence in 11 (33.3%) eyes, early hyperfluorescent stromal vessels in 7 (21.2%) eyes, fuzzy stromal vessels in 6 (18.2%) eyes and late diffuse choroidal hyperfluorescence was present in 2 (6.1%) eyes. Conclusions: ICGA is necessary in identifying and diagnosing subclinical tuberculous choroidal involvement. The most prevalent ICGA finding was persistent HDDs.
MeSH term(s)	Choroid ; Coloring Agents ; Fluorescein Angiography ; Humans ; Indocyanine Green ; Retrospective Studies ; Tuberculosis
Chemical Substances	Coloring Agents ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2020-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-020-01144-y
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Zs.B 3010: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Automated False Alarm Reduction in a Real-Life Intensive Care Setting Using Motion Detection.

Muroi, Carl / Meier, Sando / De Luca, Valeria / Mack, David J / Strässle, Christian / Schwab, Patrick / Karlen, Walter / Keller, Emanuela

Neurocritical care

2019 Volume 32, Issue 2, Page(s) 419–426

Abstract: Background: Contemporary monitoring systems are sensitive to motion artifacts and cause an excess of false alarms. This results in alarm fatigue and hazardous alarm desensitization. To reduce the number of false alarms, we developed and validated a ... ...

Abstract	Background: Contemporary monitoring systems are sensitive to motion artifacts and cause an excess of false alarms. This results in alarm fatigue and hazardous alarm desensitization. To reduce the number of false alarms, we developed and validated a novel algorithm to classify alarms, based on automatic motion detection in videos. Methods: We considered alarms generated by the following continuously measured parameters: arterial oxygen saturation, systolic blood pressure, mean blood pressure, heart rate, and mean intracranial pressure. The movements of the patient and in his/her surroundings were monitored by a camera situated at the ceiling. Using the algorithm, alarms were classified into RED (true), ORANGE (possibly false), and GREEN alarms (false, i.e., artifact). Alarms were reclassified by blinded clinicians. The performance was evaluated using confusion matrices. Results: A total of 2349 alarms from 45 patients were reclassified. For RED alarms, sensitivity was high (87.0%) and specificity was low (29.6%) for all parameters. As the sensitivities and specificities for RED and GREEN alarms are interrelated, the opposite was observed for GREEN alarms, i.e., low sensitivity (30.2%) and high specificity (87.2%). As RED alarms should not be missed, even at the expense of false positives, the performance was acceptable. The low sensitivity for GREEN alarms is acceptable, as it is not harmful to tag a GREEN alarm as RED/ORANGE. It still contributes to alarm reduction. However, a 12.8% false-positive rate for GREEN alarms is critical. Conclusions: The proposed system is a step forward toward alarm reduction; however, implementation of additional layers, such as signal curve analysis, multiple parameter correlation analysis and/or more sophisticated video-based analytics are needed for improvement.
MeSH term(s)	Alert Fatigue, Health Personnel/prevention & control ; Automation ; Blood Pressure ; Clinical Alarms/classification ; Heart Rate ; Humans ; Intensive Care Units ; Intracranial Pressure ; Monitoring, Physiologic/methods ; Motion
Language	English
Publishing date	2019-07-09
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2381896-7
ISSN	1556-0961 ; 1541-6933
ISSN (online)	1556-0961
ISSN	1541-6933
DOI	10.1007/s12028-019-00711-w
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Article ; Online: Cardiac arrest in the perioperative period: a consensus guideline for identification, treatment, and prevention from the European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2023 Volume 49, Issue 5, Page(s) 2031–2046

Abstract: Introduction: Cardiac arrest in the operating room is a rare but potentially life-threatening event with mortality rates of more than 50%. Contributing factors are often known, and the event is recognised rapidly as patients are usually under full ... ...

Abstract	Introduction: Cardiac arrest in the operating room is a rare but potentially life-threatening event with mortality rates of more than 50%. Contributing factors are often known, and the event is recognised rapidly as patients are usually under full monitoring. This guideline covers the perioperative period and is complementary to the European Resuscitation Council guidelines. Material and methods: The European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery jointly nominated a panel of experts to develop guidelines for the recognition, treatment, and prevention of cardiac arrest in the perioperative period. A literature search was conducted in MEDLINE, EMBASE, CINAHL and the Cochrane Central Register of Controlled Trials. All searches were restricted to publications from 1980 to 2019 inclusive and to the English, French, Italian and Spanish languages. The authors also contributed individual, independent literature searches. Results: This guideline contains background information and recommendation for the treatment of cardiac arrest in the operating room environment, and addresses controversial topics such as open chest cardiac massage, resuscitative endovascular balloon occlusion and resuscitative thoracotomy, pericardiocentesis, needle decompression, and thoracostomy. Conclusions: Successful prevention and management of cardiac arrest during anaesthesia and surgery requires anticipation, early recognition, and a clear treatment plan. The ready availability of expert staff and equipment must also be taken into consideration. Success not only depends on medical knowledge, technical skills and a well-organised team using crew resource management, but also on an institutional safety culture embedded in everyday practice through continuous education, training, and multidisciplinary co-operation.
MeSH term(s)	Humans ; Anesthesiology ; Critical Care ; Heart Arrest/etiology ; Heart Arrest/prevention & control ; Resuscitation ; Thoracotomy
Language	English
Publishing date	2023-07-11
Publishing country	Germany
Document type	Journal Article ; Practice Guideline
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-023-02271-3
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Article ; Online: Cardiac arrest in the perioperative period: a consensus guideline for identification, treatment, and prevention from the European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery.

European journal of anaesthesiology

2023 Volume 40, Issue 10, Page(s) 724–736

Abstract	Introduction: Cardiac arrest in the operating room is a rare but potentially life-threatening event with mortality rates of more than 50%. Contributing factors are often known, and the event is recognised rapidly as patients are usually under full monitoring. This guideline covers the perioperative period and is complementary to the European Resuscitation Council (ERC) guidelines. Material and methods: The European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery jointly nominated a panel of experts to develop guidelines for the recognition, treatment and prevention of cardiac arrest in the perioperative period. A literature search was conducted in MEDLINE, EMBASE, CINAHL and the Cochrane Central Register of Controlled Trials. All searches were restricted to publications from 1980 to 2019 inclusive and to the English, French, Italian and Spanish languages. The authors also contributed individual, independent literature searches. Results: This guideline contains background information and recommendation for the treatment of cardiac arrest in the operating room environment, and addresses controversial topics such as open chest cardiac massage (OCCM), resuscitative endovascular balloon occlusion (REBOA) and resuscitative thoracotomy, pericardiocentesis, needle decompression and thoracostomy. Conclusion: Successful prevention and management of cardiac arrest during anaesthesia and surgery requires anticipation, early recognition and a clear treatment plan. The ready availability of expert staff and equipment must also be taken into consideration. Success not only depends on medical knowledge, technical skills and a well organised team using crew resource management but also on an institutional safety culture embedded in everyday practice through continuous education, training and multidisciplinary co-operation.
MeSH term(s)	Humans ; Anesthesiology ; Balloon Occlusion ; Critical Care ; Heart Arrest/diagnosis ; Heart Arrest/etiology ; Heart Arrest/prevention & control ; Resuscitation
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article ; Practice Guideline
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000001813
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Article ; Online: The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice

Elisa Ciaramelli / Flavia De Luca / Donna Kwan / Jenkin Mok / Francesca Bianconi / Violetta Knyagnytska / Carl Craver / Leonard Green / Joel Myerson / Shayna Rosenbaum

eLife, Vol

2021 Volume 10

Abstract	Intertemporal choices require trade-offs between short-term and long-term outcomes. Ventromedial prefrontal cortex (vmPFC) damage causes steep discounting of future rewards (delay discounting [DD]) and impoverished episodic future thinking (EFT). The role of vmPFC in reward valuation, EFT, and their interaction during intertemporal choice is still unclear. Here, 12 patients with lesions to vmPFC and 41 healthy controls chose between smaller-immediate and larger-delayed hypothetical monetary rewards while we manipulated reward magnitude and the availability of EFT cues. In the EFT condition, participants imagined personal events to occur at the delays associated with the larger-delayed rewards. We found that DD was steeper in vmPFC patients compared to controls, and not modulated by reward magnitude. However, EFT cues downregulated DD in vmPFC patients as well as controls. These findings indicate that vmPFC integrity is critical for the valuation of (future) rewards, but not to instill EFT in intertemporal choice.
Keywords	delay discounting ; episodic future thinking ; ventromedial prefrontal cortex ; decision making ; reward ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	150
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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