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Article: Development and characterization of magnetic iron oxide nanoparticles using microwave for the combustion reaction ignition, as possible candidates for biomedical applications

Căpraru, Aylin / Moacă, Elena-Alina / Păcurariu, Cornelia / Ianoş, Robert / Lazău, Radu / Barbu-Tudoran, Lucian

Powder technology. 2021 Dec., v. 394

2021

Abstract: Magnetic iron oxide nanoparticles were prepared by solution combustion synthesis, using iron nitrate as oxidizer and citric acid as fuel. The influence of the combustion reaction ignition procedure, conventional heating and microwave heating, on ... ...

Abstract	Magnetic iron oxide nanoparticles were prepared by solution combustion synthesis, using iron nitrate as oxidizer and citric acid as fuel. The influence of the combustion reaction ignition procedure, conventional heating and microwave heating, on nanoparticles characteristics was investigated. The synthesized nanoparticles were characterized by scanning and transmission electron microscopy, X-ray powder diffraction, thermogravimetric and differential scanning calorimetry, magnetic measurements, specific surface area and adsorption-desorption isotherms. The magnetic nanoparticles prepared by microwave heating exhibit larger specific surface area (70.7 m²/g), lower particle medium size (10.7 ± 3.09 nm) and lower saturation magnetization (41.8 emu/g) as compared to the sample prepared by conventional heating. Magnetic nanoparticles prepared by microwave heating were coated with oleic acid and Tween 80, and dispersed in phosphate buffered saline and distilled water. The colloidal suspensions demonstrated good stability, small polydispersity and small values of the hydrodynamic diameter, characteristics which recommend them to be tested for biomedical applications.
Keywords	X-ray diffraction ; citric acid ; combustion ; heat ; hydrodynamics ; iron oxides ; magnetism ; microwave treatment ; nitrates ; oleic acid ; oxidants ; phosphates ; polysorbates ; surface area ; thermogravimetry ; transmission electron microscopy
Language	English
Dates of publication	2021-12
Size	p. 1026-1038.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0032-5910
DOI	10.1016/j.powtec.2021.08.093
Database	NAL-Catalogue (AGRICOLA)

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Article: Biologic Impact of Green Synthetized Magnetic Iron Oxide Nanoparticles on Two Different Lung Tumorigenic Monolayers and a 3D Normal Bronchial Model-EpiAirway

Moacă, Elena-Alina / Watz, Claudia / Faur, Alexandra-Corina / Lazăr, Daniela / Socoliuc, Vlad / Păcurariu, Cornelia / Ianoș, Robert / Rus, Cristiana-Iulia / Minda, Daliana / Barbu-Tudoran, Lucian / Dehelean, Cristina Adriana

Pharmaceutics

2022 Volume 15, Issue 1

Abstract: The present study reports the successful synthesis of biocompatible magnetic iron oxide nanoparticles (MNPs) by an ecofriendly single step method, using two ethanolic extracts based on leaves ... ...

Abstract	The present study reports the successful synthesis of biocompatible magnetic iron oxide nanoparticles (MNPs) by an ecofriendly single step method, using two ethanolic extracts based on leaves of
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15010002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of dermatologic adverse reactions on QOL in oncologic patients: results from a single-center prospective study.

Barbu, Maria Alexandra / Niţipir, Cornelia / Voiosu, Theodor / Giurcăneanu, Călin

Romanian journal of internal medicine = Revue roumaine de medecine interne

2018 Volume 56, Issue 2, Page(s) 96–101

Abstract: Introduction: Skin toxicity in patients receiving novel therapeutic cancer agents has become a very important marker in determining drug activity, but it can also severely impact their quality of life. About half of the patients receiving this type of ... ...

Abstract	Introduction: Skin toxicity in patients receiving novel therapeutic cancer agents has become a very important marker in determining drug activity, but it can also severely impact their quality of life. About half of the patients receiving this type of oncologic treatment will develop cutaneous reactions, that is why adequate understanding and management of these side effects is very important for drug adherence and patients' quality of life. Materials and methods: We conducted a prospective study of consecutive patients who received oncologic treatment in our institution and presented with dermatologic side effects. The severity of skin toxicity was assessed using the DLQI score and patients were prospectively followed to evaluate response to therapy. Univariate analysis of factors influencing the impact of skin toxicity on patient QOL was conducted. Results: 52 patients were enrolled in the study. Patients who developed grade 3 and 4 skin toxicity had a higher DLQI score, with a greater impact on quality of life, but with better clinical outcome at 3 months follow-up, based on RECIST. Patients with moderate or severe cutaneous AE were more likely to achieve complete or partial response to therapy than those with mild AE (16/33 vs. 3/19, p = 0.035). Interestingly, female patients had a significantly poorer quality of life than male patients as assessed by the DLQI score (7.28 ± 7 vs. 3.7 ± 3.6, p = 0.038). Conclusion: Cutaneous side effects are often encountered in cancer patients and their severity can be a surrogate marker for a positive clinical tumor response to therapy.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antineoplastic Agents/adverse effects ; Drug Eruptions/drug therapy ; Drug Eruptions/etiology ; ErbB Receptors/antagonists & inhibitors ; Exanthema/chemically induced ; Exanthema/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/drug therapy ; Prospective Studies ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Quality of Life ; Severity of Illness Index ; TOR Serine-Threonine Kinases/adverse effects ; Vitamin K 1/therapeutic use ; Vitamins/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Antineoplastic Agents ; Vitamins ; Vitamin K 1 (84-80-0) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; ErbB Receptors (EC 2.7.10.1) ; Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2018-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2015966-3
ISSN	1220-4749 ; 0035-3973 ; 1582-3296
ISSN	1220-4749 ; 0035-3973 ; 1582-3296
DOI	10.2478/rjim-2018-0002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of dermatologic adverse reactions on QOL in oncologic patients

Barbu Maria Alexandra / Niţipir Cornelia / Voiosu Theodor / Giurcăneanu Călin

Romanian Journal of Internal Medicine, Vol 56, Iss 2, Pp 96-

results from a single-center prospective study

2018 Volume 101

Abstract: Introduction. Skin toxicity in patients receiving novel therapeutic cancer agents has become a very important marker in determining drug activity, but it can also severely impact their quality of life. About half of the patients receiving this type of ... ...

Abstract	Introduction. Skin toxicity in patients receiving novel therapeutic cancer agents has become a very important marker in determining drug activity, but it can also severely impact their quality of life. About half of the patients receiving this type of oncologic treatment will develop cutaneous reactions, that is why adequate understanding and management of these side effects is very important for drug adherence and patients’ quality of life.
Keywords	exanthema ; toxicity ; egfr tyrosine kinase inhibitor ; quality of life ; chemotherapy ; Internal medicine ; RC31-1245
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Biosynthesis of Iron Oxide Nanoparticles: Physico-Chemical Characterization and Their In Vitro Cytotoxicity on Healthy and Tumorigenic Cell Lines.

Moacă, Elena-Alina / Watz, Claudia Geanina / Flondor Ionescu, Daniela / Păcurariu, Cornelia / Tudoran, Lucian Barbu / Ianoș, Robert / Socoliuc, Vlad / Drăghici, George-Andrei / Iftode, Andrada / Liga, Sergio / Dragoș, Dan / Dehelean, Cristina Adriana

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: Iron oxide nanoparticles were synthesized starting from two aqueous extracts based ... ...

Abstract	Iron oxide nanoparticles were synthesized starting from two aqueous extracts based on
Language	English
Publishing date	2022-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12122012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unmet needs in the diagnosis and treatment of Romanian patients with bilio-pancreatic tumors: results of a prospective observational multicentric study.

Voiosu, Theodor / Voiosu, Andrei / Danielescu, Cella / Popescu, Daniela / Puscasu, Claudia / State, Monica / Chiricuţă, Aurelia / Mardare, Mara / Spanu, Andrada / Bengus, Andreea / Busuioc, Bogdan / Zamfir, Marius / Ginghina, Octav / Barbu, Maria / Nitipir, Cornelia / Mateescu, Bogdan

Romanian journal of internal medicine = Revue roumaine de medecine interne

2021 Volume 59, Issue 3, Page(s) 286–295

Abstract: Background. ...

Abstract	Background.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/epidemiology ; Bile Duct Neoplasms/therapy ; Cholangiocarcinoma ; Drainage ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/therapy ; Prospective Studies ; Romania/epidemiology
Language	English
Publishing date	2021-08-26
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2015966-3
ISSN	2501-062X ; 0035-3973 ; 1582-3296
ISSN (online)	2501-062X
ISSN	0035-3973 ; 1582-3296
DOI	10.2478/rjim-2021-0009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Location:
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Synthesis and Characterization of Bioactive Magnetic Nanoparticles from the Perspective of Hyperthermia Applications

Elena-Alina Moacă / Vlad Socoliuc / Dana Stoian / Claudia Watz / Daniela Flondor / Cornelia Păcurariu / Robert Ianoș / Cristiana Iulia Rus / Lucian Barbu-Tudoran / Alexandra Semenescu / Cristian Sarău / Adelina Chevereșan / Cristina Adriana Dehelean

Magnetochemistry, Vol 8, Iss 145, p

2022 Volume 145

Abstract: Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood ( Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic nanoparticles suitable for ... ...

Abstract	Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood ( Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic nanoparticles suitable for medical purposes, more precisely with hyperthermia inducing features, a synthesis reaction was conducted, both at room temperature (25 °C) and at 80 °C, and with two formulations of the precipitation agent. Both the quality and stability of the synthesized magnetic iron oxide nanoparticles were physiochemically characterized: phase composition (X-ray powder diffraction (XRD)), thermal behavior (thermogravimetry (TG) and differential scanning calorimetry (DSC)), electron microscopy (scanning (SEM) and transmission (TEM)), and magnetic properties (DC and HF-AC). The magnetic investigation of the as-obtained magnetic iron oxide nanoparticles revealed that the synthesis at 80 °C using a mixture of NaOH and NH 3 (aq) increases their diameter and implicitly enhances their specific absorption rate (SAR), a mandatory parameter for practical applications in hyperthermia.
Keywords	specific absorption rate ; magnetic nanoparticles ; green synthesis ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unmet needs in the diagnosis and treatment of Romanian patients with bilio-pancreatic tumors

Voiosu Theodor / Voiosu Andrei / Danielescu Cella / Popescu Daniela / Puscasu Claudia / State Monica / Chiricuţă Aurelia / Mardare Mara / Spanu Andrada / Bengus Andreea / Busuioc Bogdan / Zamfir Marius / Ginghina Octav / Barbu Maria / Nitipir Cornelia / Mateescu Bogdan

Romanian Journal of Internal Medicine, Vol 59, Iss 3, Pp 286-

results of a prospective observational multicentric study

2021 Volume 295

Abstract: Background. Biliopancreatic tumors (BPT) are among the most aggressive solid malignancies, and their incidence is rising. Good patient outcome relies heavily on a multidisciplinary approach to therapy, including timely access to endoscopy, surgery and ... ...

Abstract	Background. Biliopancreatic tumors (BPT) are among the most aggressive solid malignancies, and their incidence is rising. Good patient outcome relies heavily on a multidisciplinary approach to therapy, including timely access to endoscopy, surgery and chemo/radiotherapy. We aimed to evaluate current practices as reflected in the management and outcome of patients diagnosed with BPT in the setting of a low-resource medical system in order to identify areas suitable for improvement.
Keywords	pancreatic neoplasms ; cholangiocarcinoma ; multidisciplinary team ; oncology ; endoscopy ; patient outcome ; survival ; Internal medicine ; RC31-1245
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biocompatible Magnetic Colloidal Suspension Used as a Tool for Localized Hyperthermia in Human Breast Adenocarcinoma Cells

Elena-Alina Moacă / Claudia-Geanina Watz / Vlad Socoliuc / Roxana Racoviceanu / Cornelia Păcurariu / Robert Ianoş / Simona Cîntă-Pînzaru / Lucian Barbu Tudoran / Fran Nekvapil / Stela Iurciuc / Codruța Șoica / Cristina-Adriana Dehelean

Nanomaterials, Vol 11, Iss 1189, p

Physicochemical Analysis and Complex In Vitro Biological Profile

2021 Volume 1189

Abstract: Magnetic iron oxide nanoparticles are the most desired nanomaterials for biomedical applications due to their unique physiochemical properties. A facile single-step process for the preparation of a highly stable and biocompatible magnetic colloidal ... ...

Abstract	Magnetic iron oxide nanoparticles are the most desired nanomaterials for biomedical applications due to their unique physiochemical properties. A facile single-step process for the preparation of a highly stable and biocompatible magnetic colloidal suspension based on citric-acid-coated magnetic iron oxide nanoparticles used as an effective heating source for the hyperthermia treatment of cancer cells is presented. The physicochemical analysis revealed that the magnetic colloidal suspension had a z-average diameter of 72.7 nm at 25 °C with a polydispersity index of 0.179 and a zeta potential of −45.0 mV, superparamagnetic features, and a heating capacity that was quantified by an intrinsic loss power analysis. Raman spectroscopy showed the presence of magnetite and confirmed the presence of citric acid on the surfaces of the magnetic iron oxide nanoparticles. The biological results showed that breast adenocarcinoma cells (MDA-MB-231) were significantly affected after exposure to the magnetic colloidal suspension with a concentration of 30 µg/mL 24 h post-treatment under hyperthermic conditions, while the nontumorigenic (MCF-10A) cells exhibited a viability above 90% under the same thermal setup. Thus, the biological data obtained in the present study clearly endorse the need for further investigations to establish the clinical biological potential of synthesized magnetic colloidal suspension for magnetically triggered hyperthermia.
Keywords	magnetic iron oxides nanoparticles ; citric acid ; Raman spectroscopy ; combustion method ; breast adenocarcinoma ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Linear and nonlinear regression analysis for heavy metals removal using Agaricus bisporus macrofungus

Boldizsar Nagy / Carmen Mânzatu / Andrada Măicăneanu / Cerasella Indolean / Lucian Barbu-Tudoran / Cornelia Majdik

Arabian Journal of Chemistry, Vol 10, Iss S2, Pp S3569-S

2017 Volume 3579

Abstract: In the present study the biosorption characteristics of Cd (II) and Zn (II) ions from monocomponent aqueous solutions by Agaricus bisporus macrofungus were investigated. The initial metal ion concentrations, contact time, initial pH and temperature were ... ...

Abstract	In the present study the biosorption characteristics of Cd (II) and Zn (II) ions from monocomponent aqueous solutions by Agaricus bisporus macrofungus were investigated. The initial metal ion concentrations, contact time, initial pH and temperature were parameters that influence the biosorption. Maximum removal efficiencies up to 76.10% and 70.09% (318 K) for Cd (II) and Zn (II), respectively and adsorption capacities up to 3.49 and 2.39 mg/g for Cd (II) and Zn (II), respectively at the highest concentration, were calculated. The experimental data were analyzed using pseudo-first- and pseudo-second-order kinetic models, various isotherm models in linear and nonlinear (CMA-ES optimization algorithm) regression and thermodynamic parameters were calculated. The results showed that the biosorption process of both studied metal ions, followed pseudo second-order kinetics, while equilibrium is best described by Sips isotherm. The changes in morphological structure after heavy metal-biomass interactions were evaluated by SEM analysis. Our results confirmed that macrofungus A. bisporus could be used as a cost effective, efficient biosorbent for the removal of Cd (II) and Zn (II) from aqueous synthetic solutions.
Keywords	Agaricus bisporus ; Cd (II) ; Zn (II) ; Biosorption ; SEM ; Regression analysis ; Chemistry ; QD1-999
Subject code	541
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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