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Article ; Online: Venous Thromboembolism and Chronic Thromboembolic Pulmonary Hypertension: Novel Clinical Insights.

Sagris, Marios / Bakoyiannis, Christos

2022 Volume 28, Issue 10, Page(s) 769–770

MeSH term(s)	Chronic Disease ; Humans ; Hypertension, Pulmonary/drug therapy ; Pulmonary Embolism/drug therapy ; Venous Thromboembolism/drug therapy
Language	English
Publishing date	2022-06-27
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161282810220511124302
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Article ; Online: Reply to: assessment of pericoronary adipose tissue attenuation.

Antonopoulos, Alexios S / Sagris, Marios / Tousoulis, Dimitris

European heart journal. Cardiovascular Imaging

2023 Volume 24, Issue 4, Page(s) e58

MeSH term(s)	Humans ; Coronary Artery Disease ; Adipose Tissue/diagnostic imaging
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jead019
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Article ; Online: Contemporary Management of Deep Vein Thrombosis, Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension.

Sagris, Marios / Kokkinidis, Damianos G / Bakoyiannis, Christos

Current pharmaceutical design

2022 Volume 28, Issue 7, Page(s) 511

MeSH term(s)	Humans ; Hypertension, Pulmonary/drug therapy ; Pulmonary Embolism/drug therapy ; Venous Thrombosis/drug therapy
Language	English
Publishing date	2022-04-05
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161282807220221103233
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Article ; Online: Systematic review and meta-analysis for the value of cardiac magnetic resonance strain to predict cardiac outcomes.

Korosoglou, Grigorios / Sagris, Marios / André, Florian / Steen, Henning / Montenbruck, Moritz / Frey, Norbert / Kelle, Sebastian

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1094

Abstract: Cardiac magnetic resonance (CMR) is the gold standard for the diagnostic classification and risk stratification in most patients with cardiac disorders. The aim of the present study was to investigate the ability of Strain-encoded MR (SENC) for the ... ...

Abstract	Cardiac magnetic resonance (CMR) is the gold standard for the diagnostic classification and risk stratification in most patients with cardiac disorders. The aim of the present study was to investigate the ability of Strain-encoded MR (SENC) for the prediction of major adverse cardiovascular events (MACE). A systematic review and meta-analysis was performed according to the PRISMA Guidelines, including patients with or without cardiovascular disease and asymptomatic individuals. Myocardial strain by HARP were used as pulse sequences in 1.5 T scanners. Published literature in MEDLINE (PubMed) and Cochrane's databases were explored before February 2023 for studies assessing the clinical utility of myocardial strain by Harmonic Phase Magnetic Resonance Imaging (HARP), Strain-encoded MR (SENC) or fast-SENC. In total, 8 clinical trials (4 studies conducted in asymptomatic individuals and 4 in patients with suspected or known cardiac disease) were included in this systematic review, while 3 studies were used for our meta-analysis, based on individual patient level data. Kaplan-Meier analysis and Cox proportional hazard models were used, testing the ability of myocardial strain by HARP and SENC/fast-SENC for the prediction of MACE. Strain enabled risk stratification in asymptomatic individuals, predicting MACE and the development of incident heart failure. Of 1332 patients who underwent clinically indicated CMR, including SENC or fast-SENC acquisitions, 19 patients died, 28 experienced non-fatal infarctions, 52 underwent coronary revascularization and 86 were hospitalized due to heart failure during median 22.4 (17.2-28.5) months of follow-up. SENC/fast-SENC, predicted both all-cause mortality and MACE with high accuracy (HR = 3.0, 95% CI = 1.2-7.6, p = 0.02 and HR = 4.1, 95% CI = 3.0-5.5, respectively, p < 0.001). Using hierarchical Cox-proportional hazard regression models, SENC/fast-SENC exhibited incremental value to clinical data and conventional CMR parameters. Reduced myocardial strain predicts of all-cause mortality and cardiac outcomes in symptomatic patients with a wide range of ischemic or non-ischemic cardiac diseases, whereas in asymptomatic individuals, reduced strain was a precursor of incident heart failure.
MeSH term(s)	Humans ; Magnetic Resonance Imaging, Cine/methods ; Heart/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Heart Diseases ; Heart Failure ; Magnetic Resonance Spectroscopy ; Predictive Value of Tests ; Prognosis
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50835-5
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Article ; Online: Systematic review and meta-analysis for the value of cardiac magnetic resonance strain to predict cardiac outcomes

Grigorios Korosoglou / Marios Sagris / Florian André / Henning Steen / Moritz Montenbruck / Norbert Frey / Sebastian Kelle

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 10

Abstract: Abstract Cardiac magnetic resonance (CMR) is the gold standard for the diagnostic classification and risk stratification in most patients with cardiac disorders. The aim of the present study was to investigate the ability of Strain-encoded MR (SENC) for ... ...

Abstract	Abstract Cardiac magnetic resonance (CMR) is the gold standard for the diagnostic classification and risk stratification in most patients with cardiac disorders. The aim of the present study was to investigate the ability of Strain-encoded MR (SENC) for the prediction of major adverse cardiovascular events (MACE). A systematic review and meta-analysis was performed according to the PRISMA Guidelines, including patients with or without cardiovascular disease and asymptomatic individuals. Myocardial strain by HARP were used as pulse sequences in 1.5 T scanners. Published literature in MEDLINE (PubMed) and Cochrane’s databases were explored before February 2023 for studies assessing the clinical utility of myocardial strain by Harmonic Phase Magnetic Resonance Imaging (HARP), Strain-encoded MR (SENC) or fast-SENC. In total, 8 clinical trials (4 studies conducted in asymptomatic individuals and 4 in patients with suspected or known cardiac disease) were included in this systematic review, while 3 studies were used for our meta-analysis, based on individual patient level data. Kaplan–Meier analysis and Cox proportional hazard models were used, testing the ability of myocardial strain by HARP and SENC/fast-SENC for the prediction of MACE. Strain enabled risk stratification in asymptomatic individuals, predicting MACE and the development of incident heart failure. Of 1332 patients who underwent clinically indicated CMR, including SENC or fast-SENC acquisitions, 19 patients died, 28 experienced non-fatal infarctions, 52 underwent coronary revascularization and 86 were hospitalized due to heart failure during median 22.4 (17.2–28.5) months of follow-up. SENC/fast-SENC, predicted both all-cause mortality and MACE with high accuracy (HR = 3.0, 95% CI = 1.2–7.6, p = 0.02 and HR = 4.1, 95% CI = 3.0–5.5, respectively, p < 0.001). Using hierarchical Cox-proportional hazard regression models, SENC/fast-SENC exhibited incremental value to clinical data and conventional CMR parameters. Reduced myocardial strain predicts of ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Silent Myocardial Ischemia: From Pathophysiology to Diagnosis and Treatment.

Theofilis, Panagiotis / Antonopoulos, Alexios S / Sagris, Marios / Papanikolaou, Aggelos / Oikonomou, Evangelos / Tsioufis, Konstantinos / Tousoulis, Dimitris

Biomedicines

2024 Volume 12, Issue 2

Abstract: Silent myocardial ischemia (SMI), characterized by a lack of overt symptoms despite an inadequate blood supply to the myocardium, remains a challenging entity in cardiovascular medicine. The pathogenesis involves intricate interactions of vascular, ... ...

Abstract	Silent myocardial ischemia (SMI), characterized by a lack of overt symptoms despite an inadequate blood supply to the myocardium, remains a challenging entity in cardiovascular medicine. The pathogenesis involves intricate interactions of vascular, neurohormonal, and metabolic factors, contributing to perfusion deficits without the characteristic chest pain. Understanding these mechanisms is pivotal for recognizing diverse clinical presentations and designing targeted interventions. Diagnostic strategies for SMI have evolved from traditional electrocardiography to advanced imaging modalities, including stress echocardiography, single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (MRI). Treating SMI is a matter of ongoing debate, as the available evidence on the role of invasive versus medical management is controversial. This comprehensive review synthesizes current knowledge of silent myocardial ischemia, addressing its pathophysiology, diagnostic modalities, and therapeutic interventions.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020259
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Article: Diabetes mellitus and atrial fibrillation-from pathophysiology to treatment.

Leopoulou, Marianna / Theofilis, Panagiotis / Kordalis, Athanasios / Papageorgiou, Nikolaos / Sagris, Marios / Oikonomou, Evangelos / Tousoulis, Dimitris

World journal of diabetes

2023 Volume 14, Issue 5, Page(s) 512–527

Abstract: Type 2 diabetes mellitus (T2DM) is a leading risk factor for cardiovascular complications around the globe and one of the most common medical conditions. Atrial fibrillation (AF) is the most common supraventricular arrhythmia, with a rapidly increasing ... ...

Abstract	Type 2 diabetes mellitus (T2DM) is a leading risk factor for cardiovascular complications around the globe and one of the most common medical conditions. Atrial fibrillation (AF) is the most common supraventricular arrhythmia, with a rapidly increasing prevalence. T2DM has been closely associated with the risk of AF development, identified as an independent risk factor. Regarding cardio-vascular complications, both AF and T2DM have been linked with high mortality. The underlying pathophysiology has not been fully determined yet; however, it is multifactorial, including structural, electrical, and autonomic pathways. Novel therapies include pharmaceutical agents in sodium-glucose cotransporter-2 inhibitors, as well as antiarrhythmic strategies, such as cardioversion and ablation. Of interest, glucose-lowering therapies may affect the prevalence of AF. This review presents the current evidence regarding the connection between the two entities, the pathophysiological pathways that link them, and the therapeutic options that exist.
Language	English
Publishing date	2023-06-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v14.i5.512
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Article ; Online: Novel Concepts in the Management of Angina in Coronary Artery Disease.

Theofilis, Panagiotis / Oikonomou, Evangelos / Sagris, Marios / Papageorgiou, Nikolaos / Tsioufis, Konstantinos / Tousoulis, Dimitris

Current pharmaceutical design

2023 Volume 29, Issue 23, Page(s) 1825–1834

Abstract: Coronary artery disease remains a condition with high prevalence and detrimental effects on the quality of life of affected individuals. Its most frequent manifestation, stable angina pectoris, may be challenging to manage despite the available ... ...

Abstract	Coronary artery disease remains a condition with high prevalence and detrimental effects on the quality of life of affected individuals. Its most frequent manifestation, stable angina pectoris, may be challenging to manage despite the available antianginal pharmacotherapy and adequate risk factor control, especially in subjects not amenable to revascularization. In the direction of refractory angina pectoris, several approaches have been developed over the years with varying degrees of success. Among the most recognized techniques in managing angina is enhanced external counterpulsation, which utilizes mechanical compression of the lower extremities to increase blood flow to the heart. Moving to coronary sinus reduction, it leads to an increase in coronary sinus backward pressure, ultimately augmenting myocardial blood flow redistribution to ischemic regions and ameliorating chronic angina. Clinical trial results of the above-mentioned techniques have been encouraging but are based on small sample sizes to justify their widespread application. Other interventional approaches, such as transmyocardial laser revascularization, extracorporeal shockwave myocardial revascularization, and spinal cord stimulation, have been met with either controversial or negative results, and their use is not recommended. Lastly, angiogenic therapy with targeted intramyocardial vascular endothelial growth factor injection or CD34+ cell therapy may be beneficial and warrants further investigation. In this review, we summarize the current knowledge in the field of angina management, highlighting the potential and the gaps in the existing evidence that ought to be addressed in future larger-scale, randomized studies before these techniques can be safely adapted in the clinical practice of patients with refractory angina pectoris.
MeSH term(s)	Humans ; Coronary Artery Disease/therapy ; Quality of Life ; Vascular Endothelial Growth Factor A ; Angina Pectoris/drug therapy ; Myocardial Revascularization/methods
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-05-14
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612829666230512152153
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Article ; Online: Direct Oral Anticoagulants use in Patients with Stable Coronary Artery Disease, Acute Coronary Syndrome or Undergoing Percutaneous Coronary Intervention.

Sagris, Marios / Theofilis, Panagiotis / Papanikolaou, Angelos / Antonopoulos, Alexios S / Tsioufis, Constantinos / Tousoulis, Dimitris

Current pharmaceutical design

2023 Volume 29, Issue 35, Page(s) 2787–2794

Abstract: The investigation for the optimal anticoagulation strategy for patients with stable coronary artery disease, acute coronary syndromes, and undergoing percutaneous coronary intervention constitutes a great challenge for physicians and is a field of ... ...

Abstract	The investigation for the optimal anticoagulation strategy for patients with stable coronary artery disease, acute coronary syndromes, and undergoing percutaneous coronary intervention constitutes a great challenge for physicians and is a field of extensive research. Although aspirin is commonly recommended as a protective measure for all patients with coronary artery disease and dual antiplatelet therapy for those undergoing procedures, such as percutaneous coronary intervention or coronary artery bypass graft surgery, the risk of recurrent cardiovascular events remains significant. In this context, the shortcomings associated with the use of vitamin K antagonists have led to the assessment of direct oral anticoagulants as promising alternatives. This review will explore and provide a comprehensive analysis of the existing data regarding the use of direct oral anticoagulants in patients with stable coronary artery disease or acute coronary syndrome, as well as their effectiveness in those undergoing percutaneous coronary intervention or coronary artery bypass graft surgery.
MeSH term(s)	Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Acute Coronary Syndrome/drug therapy ; Acute Coronary Syndrome/surgery ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/surgery ; Hemorrhage/drug therapy ; Anticoagulants/therapeutic use ; Percutaneous Coronary Intervention/adverse effects ; Drug Therapy, Combination ; Atrial Fibrillation/drug therapy
Chemical Substances	Platelet Aggregation Inhibitors ; Anticoagulants
Language	English
Publishing date	2023-11-30
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128259508231118141831
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Article ; Online: Anticoagulation Treatment in Venous Thromboembolism: Options and Optimal Duration.

Diavati, Stavrianna / Sagris, Marios / Terentes-Printzios, Dimitrios / Vlachopoulos, Charalambos

Current pharmaceutical design

2021 Volume 28, Issue 4, Page(s) 296–305

Abstract: Venous thromboembolism (VTE), clinically presented as deep-vein thrombosis (DVT) or pulmonary embolism (PE), constitutes a major global healthcare concern with severe complications, long-term morbidity, and mortality. Although several clinical, genetic, ... ...

Abstract	Venous thromboembolism (VTE), clinically presented as deep-vein thrombosis (DVT) or pulmonary embolism (PE), constitutes a major global healthcare concern with severe complications, long-term morbidity, and mortality. Although several clinical, genetic, and acquired risk factors for VTE have been identified, the molecular pathophysiology and mechanisms of disease progression remain poorly understood. Anticoagulation has been the cornerstone of therapy for decades, but data is sparse regarding primary and secondary VTE prevention, as well as optimal therapy duration. In this review, we discuss the role of factor Xa in the coagulation cascade and the different choices of anticoagulation therapy based on patients' predisposing risk factors and risk of event recurrence. Further, we compare newer agents to traditional anticoagulation treatment based on the most recent studies and guidelines.
MeSH term(s)	Anticoagulants ; Blood Coagulation ; Humans ; Pulmonary Embolism ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Venous Thrombosis
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-11-12
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612827666211111150705
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