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  1. Article: Facing ethical concerns in the age of precise gene therapy: Outlook on inherited arrhythmias.

    Carbone, Federico / Montecucco, Fabrizio

    World journal of cardiology

    2024  Volume 16, Issue 2, Page(s) 64–66

    Abstract: This editorial, comments on the article by ... ...

    Abstract This editorial, comments on the article by Spartalis
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573665-6
    ISSN 1949-8462
    ISSN 1949-8462
    DOI 10.4330/wjc.v16.i2.64
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A journey through clinic and research.

    Montecucco, Fabrizio

    European heart journal

    2021  Volume 42, Issue 18, Page(s) 1721–1723

    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab184
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    Zs.A 1563: Show issues Location:
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  3. Article ; Online: Future research with advanced imaging technology and biomarkers.

    Montecucco, Fabrizio / Schindler, Thomas H

    European heart journal

    2023  Volume 44, Issue 48, Page(s) 5021–5023

    MeSH term(s) Humans ; Biomarkers ; Technology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad530
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  4. Article ; Online: Hot topics for the European Journal of Clinical Investigation in 2023.

    Montecucco, Fabrizio / Nathoe, Hendrik

    European journal of clinical investigation

    2022  Volume 53, Issue 2, Page(s) e13938

    Language English
    Publishing date 2022-12-24
    Publishing country England
    Document type Editorial
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13938
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    Zs.A 677: Show issues Location:
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  5. Article ; Online: Sepsis in elderly patients: the role of neutrophils in pathophysiology and therapy.

    Ramoni, Davide / Tirandi, Amedeo / Montecucco, Fabrizio / Liberale, Luca

    Internal and emergency medicine

    2024  

    Abstract: Sepsis is among the most important causes of mortality, particularly within the elderly population. Sepsis prevalence is on the rise due to different factors, including increasing average population age and the concomitant rise in the prevalence of ... ...

    Abstract Sepsis is among the most important causes of mortality, particularly within the elderly population. Sepsis prevalence is on the rise due to different factors, including increasing average population age and the concomitant rise in the prevalence of frailty and chronic morbidities. Recent investigations have unveiled a "trimodal" trajectory for sepsis-related mortality, with the ultimate zenith occurring from 60 to 90 days until several years after the original insult. This prolonged temporal course ostensibly emanates from the sustained perturbation of immune responses, persevering beyond the phase of clinical convalescence. This phenomenon is particularly associated with the aging immune system, characterized by a broad dysregulation commonly known as "inflammaging." Inflammaging associates with a chronic low-grade activation of the innate immune system preventing an appropriate response to infective agents. Notably, during the initial phases of sepsis, neutrophils-essential in combating pathogens-may exhibit compromised activity. Paradoxically, an overly zealous neutrophilic reaction has been observed to underlie multi-organ dysfunction during the later stages of sepsis. Given this scenario, discovering treatments that can enhance neutrophil activity during the early phases of sepsis while curbing their overactivity in the later phases could prove beneficial in fighting pathogens and reducing the detrimental effects caused by an overactive immune system. This narrative review delves into the potential key role of neutrophils in the pathological process of sepsis, focusing on how the aging process impacts their functions, and highlighting possible targets for developing immune-modulatory therapies. Additionally, the review includes tables that outline the principal potential targets for immunomodulating agents.
    Language English
    Publishing date 2024-01-31
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03515-1
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  6. Article ; Online: CAR T therapy from haematological malignancies to aging-related diseases: An ever-expanding universe.

    Ramoni, Davide / Montecucco, Fabrizio / Carbone, Federico

    European journal of clinical investigation

    2024  , Page(s) e14203

    Abstract: Background: Short but impactful, the two-decade story of gene editing allowed a significant breakthrough in the treatment of haematological malignancies. However, despite different generations of chimeric antigen receptor T (CAR T), such a successful ... ...

    Abstract Background: Short but impactful, the two-decade story of gene editing allowed a significant breakthrough in the treatment of haematological malignancies. However, despite different generations of chimeric antigen receptor T (CAR T), such a successful therapy has not yet been replicated in solid tumours and non-oncological diseases.
    Methods: This narrative review discusses how CAR T therapy still faces challenges in overcoming the complexity of the solid tumour microenvironment and the concerns that its long-term activity raises about potential unknown and unpredictable consequences in non-oncological diseases.
    Results: In the most recent studies, the senolytic potential of CAR T is becoming an exciting field of research. Still, experimental but promising results indeed indicate the clearance of senescent cells as an effective strategy to improve exercise capacity and metabolic dysfunction in physiological ageing, with long-term therapeutic and preventive effects. However, an effective expansion of a CAR T population requires a lympho-depleting chemotherapy prior to infusion. While this procedure sounds reasonable for rescue therapy of oncological diseases, it poses genotoxic risks that may not be justified for non-malignant diseases. Those represent the leading gaps for applying CAR T therapy in non-oncological diseases.
    Conclusion: More is expected from current studies on the other classes of CAR cells now under investigation. Engineering NK cells and macrophages are candidates to improve cytotoxic and immunomodulating properties, potentially able to broaden application in solid tumours and non-oncological diseases. Finally, engineering autologous T cells in old individuals may generate biologically deteriorated CAR T clones with impaired function and unpredictable effects on cytokine release.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14203
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  7. Article ; Online: Heart and vessels 'on fire'.

    Tirandi, Amedeo / Montecucco, Fabrizio / Liberale, Luca

    European journal of clinical investigation

    2023  Volume 53, Issue 11, Page(s) e14052

    Language English
    Publishing date 2023-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14052
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  8. Article ; Online: Role of glucagon-like peptide-1 receptor agonists in the treatment of obesity, cardiovascular disease, and cerebrovascular disease.

    Tirandi, Amedeo / Montecucco, Fabrizio / Carbone, Federico / Liberale, Luca

    Polish archives of internal medicine

    2024  Volume 134, Issue 2

    Abstract: Worldwide prevalence of obesity is increasing dramatically, imposing a significant economic burden on our society. Treatment of obesity is challenging, potentially due to different disease phenotypes. Taking into consideration "obesities" rather than " ... ...

    Abstract Worldwide prevalence of obesity is increasing dramatically, imposing a significant economic burden on our society. Treatment of obesity is challenging, potentially due to different disease phenotypes. Taking into consideration "obesities" rather than "obesity," and thus aiming to understand different pathophysiologic mechanisms of individual phenotypes, might help identify more tailored treatment strategies. Glucagon‑like peptide‑1 receptor agonists (GLP‑1RAs), for example, dulaglutide and semaglutide, are routinely prescribed for the treatment of type 2 diabetes mellitus (T2DM) in patients with obesity or those at a high cardiovascular (CV) risk. Indeed, despite having been developed for T2DM, GLP‑1RAs are being increasingly often recognized as antiobesity medications due to their weight loss effects. Furthermore, recent evidence has shown that the extent of CV prevention offered by these drugs goes beyond that associated with their weight loss and pleiotropic effects. For instance, they exert anti‑inflammatory effects on vessels, enhance atherosclerotic plaque stability, reduce local advanced glycation end product receptor expression, lower monocyte‑macrophage adhesion, and antagonize the effect of angiotensin II. In the heart, GLP‑1RAs ameliorate cardiomyocyte survival and myocardial contractility, reduce cardiac hypertrophy, and are one of few drugs that can reduce epicardial fat thickness. In this review, we summarize recent evidence concerning the effects of GLP‑1RAs on obesity / dysmetabolism and on cardio- / cerebrovascular health. We further highlight the possible role of GLP‑1RAs in the treatment of obesity‑related CV diseases by describing the principal molecular mechanisms reported in the current literature.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Hypoglycemic Agents/therapeutic use ; Glucagon-Like Peptide-1 Receptor Agonists ; Obesity/complications ; Obesity/drug therapy ; Cerebrovascular Disorders/drug therapy ; Weight Loss
    Chemical Substances Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor Agonists
    Language English
    Publishing date 2024-01-09
    Publishing country Poland
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16658
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  9. Article ; Online: BIOCOVID: A lesson of systemic inflammatory response beyond pneumonia.

    Carbone, Federico / Montecucco, Fabrizio

    European journal of clinical investigation

    2022  Volume 52, Issue 8, Page(s) e13816

    MeSH term(s) Biomarkers ; Humans ; Pneumonia ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13816
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  10. Article ; Online: Hydrogen sulphide: Diabetic cardiomyopathy as the paradigm of its pleiotropic function.

    Carbone, Federico / Montecucco, Fabrizio

    European journal of clinical investigation

    2022  Volume 52, Issue 9, Page(s) e13823

    MeSH term(s) Diabetes Mellitus ; Diabetic Cardiomyopathies ; Humans ; Hydrogen Sulfide
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13823
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