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  1. Article ; Online: Synthesis of a Hexachloro Sulfate(IV) Dianion Enabled by Polychloride Chemistry.

    Voßnacker, Patrick / Wüst, Alisa / Müller, Carsten / Kleoff, Merlin / Riedel, Sebastian

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 43, Page(s) e202209684

    Abstract: The preparation and structural characterization of [ ... ...

    Abstract The preparation and structural characterization of [NEt
    Language English
    Publishing date 2022-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202209684
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  2. Article: Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine.

    Butz, Frederike / Dukaczewska, Agata / Kunze, Catarina Alisa / Krömer, Janina Maren / Reinhard, Lisa / Jann, Henning / Fehrenbach, Uli / Müller-Debus, Charlotte Friederieke / Skachko, Tatiana / Pratschke, Johann / Goretzki, Peter E / Mogl, Martina T / Dobrindt, Eva Maria

    Cancers

    2024  Volume 16, Issue 2

    Abstract: For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already ... ...

    Abstract For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, the influence of LI, VI and PnI in siNET has not been sufficiently described yet. A retrospective analysis of all patients treated for siNET at the ENETS Center of Excellence Charité-Universitätsmedizin Berlin, from 2010 to 2020 was performed (
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020305
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  3. Article ; Online: Susceptibility to infections and adaptive immunity in adults with heart failure.

    Salzer, Ulrich / Müller, Alisa / Zhou, Qian / Nieters, Alexandra / Grundmann, Sebastian / Wehr, Claudia

    ESC heart failure

    2022  Volume 9, Issue 2, Page(s) 1195–1205

    Abstract: Aims: Heart failure (HF) is a systemic inflammatory disorder with infections being an important cause of morbidity and mortality. We asked if HF patients have a higher susceptibility to infections compared with the general population and if a subtle ... ...

    Abstract Aims: Heart failure (HF) is a systemic inflammatory disorder with infections being an important cause of morbidity and mortality. We asked if HF patients have a higher susceptibility to infections compared with the general population and if a subtle secondary immunodeficiency facilitates infectious complications.
    Methods and results: In a cohort of 92 patients with HF with reduced ejection fraction, we analysed recirculating lymphocyte subpopulations, serum immunoglobulin levels, and specific antibody titres against pneumococcal antigens. We quantified susceptibility to infections of the respiratory tract with a validated questionnaire and compared it to the general population. Susceptibility to infections of the respiratory tract was comparable in HF patients and the general population. Hypogammaglobulinaemia was present in 16% of HF patients, but anti-pneumococcal titres showed no evidence of specific secondary antibody deficiency. Relative lymphopaenia in our HF cohort was due to B lymphocytopenia with a relative reduction in naive B-cells and expansion of memory B-cells while CD4+ and CD8+ T-lymphocytes as well as NK-cell counts were comparable between HF and healthy donors. The intake of the angiotensin receptor neprilysin (CD10) inhibitor (ARNI) sacubitril/valsartan was associated with increased B-lymphocyte counts, possibly by an increased output of CD10+ transitional B lymphocytes from the bone marrow.
    Conclusion: Despite a reduction of B lymphocytes in HF and mild hypogammaglobulinaemia, patients showed no evidence of secondary immunodeficiency or increased susceptibility to infections. The relevance of B-cell lymphopenia in HF patients and modulation of B-cell counts under ARNI treatment remains to be investigated.
    MeSH term(s) Adaptive Immunity ; Adult ; Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; Heart Failure ; Humans ; Stroke Volume ; Tetrazoles
    Chemical Substances Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; Tetrazoles ; sacubitril (17ERJ0MKGI)
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13793
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  4. Article ; Online: Reasons for non-participation of children and adolescents in a large-scale school-based mental health project.

    Baldofski, Sabrina / Klemm, Sarah-Lena / Kohls, Elisabeth / Mueller, Sophia M E / Bauer, Stephanie / Becker, Katja / Diestelkamp, Silke / Eschenbeck, Heike / Hiery, Alisa / Kaess, Michael / Koenig, Julian / Lehner, Laya / Moessner, Markus / Thomasius, Rainer / Rummel-Kluge, Christine

    Frontiers in public health

    2024  Volume 11, Page(s) 1294862

    Abstract: Background: Non-participation in mental health studies is an under-explored but very important topic. Investigating reasons for non-participation holds promise for the planning of future study designs and recruitment strategies. This study aimed at ... ...

    Abstract Background: Non-participation in mental health studies is an under-explored but very important topic. Investigating reasons for non-participation holds promise for the planning of future study designs and recruitment strategies. This study aimed at investigating reasons for children and adolescents (C&A) not participating in a school-based mental health research project.
    Methods: Data collection took place within the school-based recruitment of a large-scale multi-site project ("ProHEAD-Promoting Help-seeking using E-technology for Adolescents") in Germany. Participants were
    Results: Students indicated an average of
    Conclusion: The study provides unique insights into reasons for C&A and their caregivers not participating in a large federally funded mental health research project. The results suggest that in order to increase participation rates, stigma should be reduced, parents as well as teachers should be involved where possible, and the use of incentives might be helpful. The study highlights the importance of assessing reasons for non-participation, especially in online intervention studies on mental health.
    MeSH term(s) Child ; Humans ; Adolescent ; Mental Health ; Cross-Sectional Studies ; Schools ; Germany ; Parents
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1294862
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  5. Article ; Online: Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.

    Amrhein, Jennifer Alisa / Berger, Lena Marie / Balourdas, Dimitrios-Ilias / Joerger, Andreas C / Menge, Amelie / Krämer, Andreas / Frischkorn, Julia Marie / Berger, Benedict-Tilman / Elson, Lewis / Kaiser, Astrid / Schubert-Zsilavecz, Manfred / Müller, Susanne / Knapp, Stefan / Hanke, Thomas

    Journal of medicinal chemistry

    2023  Volume 67, Issue 1, Page(s) 674–690

    Abstract: MST1, MST2, MST3, MST4, and YSK1 are conserved members of the mammalian sterile 20-like serine/threonine (MST) family that regulate cellular functions such as proliferation and migration. The MST3 isozyme plays a role in regulating cell growth and ... ...

    Abstract MST1, MST2, MST3, MST4, and YSK1 are conserved members of the mammalian sterile 20-like serine/threonine (MST) family that regulate cellular functions such as proliferation and migration. The MST3 isozyme plays a role in regulating cell growth and apoptosis, and its dysregulation has been linked to high-grade tumors. To date, there are no isoform-selective inhibitors that could be used for validating the role of MST3 in tumorigenesis. We designed a series of 3-aminopyrazole-based macrocycles based on the structure of a promiscuous inhibitor. By varying the moieties targeting the solvent-exposed region and optimizing the linker, macrocycle JA310 (
    MeSH term(s) Animals ; Protein Serine-Threonine Kinases/metabolism ; Phosphorylation ; Apoptosis ; Mammals/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01980
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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  6. Article ; Online: Mehrere livid-erythematöse Maculae und Plaques mit leichter Abschuppung bei einem jungen Mann.

    Müller, Alisa / Wolfsperger, Frederik / Kofler, Lukas / Yazdi, Amir S

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2018  Volume 16, Issue 10, Page(s) 1282–1285

    Language English
    Publishing date 2018-10-06
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.13655_g
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  7. Conference proceedings: Forschungsprojekt ‚ReduSys‘: Kontaktreduzierte Pflege im klinischen Umfeld durch multimodale Systeme und Robotik

    Buetikofer, Alisa / Bloemeke, Svenja / Müller, Friedemann / Schneider, Carolin / Ohneberg, Christoph / Eberl, Ingeborg / Schmailzl, Marc / Linner, Thomas / Grabig, Sylvia / Hostettler, Rafael / Eichhorn, Christian / Klinker, Gudrun

    2023  , Page(s) 23ebmPSI–3–07

    Event/congress 24. Jahrestagung des Netzwerks Evidenzbasierte Medizin; Gesundheit und Klima – EbM für die Zukunft; Potsdam; Netzwerk Evidenzbasierte Medizin e.V.; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-03-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23ebm048
    Database German Medical Science

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  8. Article ; Online: [No title information]

    Kofler, Lukas / Berg, Christoph / Kofler, Katrin / Geipel, Andrea / Lipp, Hans-Peter / Müller, Alisa / Eigentler, Thomas / Forschner, Andrea

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2020  Volume 18, Issue 1, Page(s) 42–43

    Title translation Simultane zielgerichtete Therapie bei metastasiertem Melanom und Hepatitis C.
    Language German
    Publishing date 2020-01-27
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.13952_g
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  9. Article ; Online: Caught in a Flare.

    Mueller, Alisa A / Vaidya, Anand / Tarter, Laura L / Klein, Joshua P / Barkoudah, Ebrahim

    The New England journal of medicine

    2020  Volume 383, Issue 7, Page(s) e48

    MeSH term(s) Arthralgia/etiology ; Aspirin/therapeutic use ; Atorvastatin/therapeutic use ; Brain/diagnostic imaging ; Diagnosis, Differential ; Exanthema/etiology ; Fatigue/etiology ; Female ; Hematologic Tests ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Lupus Erythematosus, Systemic/complications ; Magnetic Resonance Imaging ; Nervous System Diseases/diagnostic imaging ; Nervous System Diseases/etiology ; Platelet Aggregation Inhibitors/therapeutic use ; Secondary Prevention ; Stroke/diagnosis ; Stroke/drug therapy ; Stroke/etiology ; Stroke/surgery ; Young Adult
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Platelet Aggregation Inhibitors ; Atorvastatin (A0JWA85V8F) ; Aspirin (R16CO5Y76E)
    Keywords covid19
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMimc2003325
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  10. Article ; Online: Discovery of 3-Amino-1

    Amrhein, Jennifer Alisa / Berger, Lena Marie / Tjaden, Amelie / Krämer, Andreas / Elson, Lewis / Tolvanen, Tuomas / Martinez-Molina, Daniel / Kaiser, Astrid / Schubert-Zsilavecz, Manfred / Müller, Susanne / Knapp, Stefan / Hanke, Thomas

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: The PCTAIRE subfamily belongs to the CDK (cyclin-dependent kinase) family and represents an understudied class of kinases of the dark kinome. They exhibit a highly conserved binding pocket and are activated by cyclin Y binding. CDK16 is targeted to the ... ...

    Abstract The PCTAIRE subfamily belongs to the CDK (cyclin-dependent kinase) family and represents an understudied class of kinases of the dark kinome. They exhibit a highly conserved binding pocket and are activated by cyclin Y binding. CDK16 is targeted to the plasma membrane after binding to
    Language English
    Publishing date 2022-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314834
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