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Article: Vsevolod Dmitrievich Tsinzerling. (K 130-letiyu so dnya rozhdeniya).

Zinserling, V A

2021 Volume 83, Issue 6, Page(s) 71–74

Abstract: IVsevolod Dmitrievich Zinserling was born on September 20, 1891, in St. Petersburg. His father ... Dmitri Petrovich Zinserling, a descendant of immigrants from the south of Germany or Switzerland ... nature well. The elder brother Boris Zinserling, a graduate of the Academy of Fine Arts, an officer ...

Title translation	Vsevolod Dmitrievich Zinserling. (On the occasion of the 130th anniversary of his birth).
Abstract	IVsevolod Dmitrievich Zinserling was born on September 20, 1891, in St. Petersburg. His father, Dmitri Petrovich Zinserling, a descendant of immigrants from the south of Germany or Switzerland, who received hereditary nobility, worked all his life as a teacher of mathematics and, as an inspector of the famous Gurevich Gymnasium, had the rank of actual state councilor. Dmitry Petrovich was also the author of scientific research on the history of mathematics in ancient Egypt, manuals on statistics, and algebra textbook, which was republished many times. His mother, Olga Ivanovna (nee Semenova), ran the household and raised four children. There was a creative atmosphere in the family, all had artistic talents, loved and knew nature well. The elder brother Boris Zinserling, a graduate of the Academy of Fine Arts, an officer, after the Civil War, found himself in Warsaw, where he became a professor and author of projects to restore many architectural masterpieces in the postwar period. His younger brother Yuri (George) Zinserling, a doctor of biological sciences, a botanist, one of the founders of a new scientific trend - geobotany, was arrested in 1938 when he was acting director of the Botanical Institute and soon died in custody. His sister Nina was an artist who died at a young age.
MeSH term(s)	Aged ; Anniversaries and Special Events ; Child ; History, 20th Century ; Humans ; Male
Language	Russian
Publishing date	2021-12-03
Publishing country	Russia (Federation)
Document type	Historical Article ; Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol20218306171
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Book ; Online ; E-Book: Infectious lesions of the central nervous system

Zinserling, Vsevolod

2022

Author's details	Vsevolod Zinserling
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (xii, 362 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021398556
ISBN	978-3-030-96260-9 ; 9783030962593 ; 3-030-96260-1 ; 3030962598
DOI	10.1007/978-3-030-96260-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Infectious pathology of the respiratory tract

Zinserling, Vsevolod / Zyuzya, Yulia R. / Svistunov, Vladimir V. / Varyasin, Valery V.

2021

Abstract: This book discusses all aspects of pulmonary pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, ... ...

Author's details	Vsevolod Zinserling ; with contributions by Yulia R. Zyuzya, Vladimir V. Svistunov, Valery V. Varyasin
Abstract	This book discusses all aspects of pulmonary pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on pneumonias of different bacterial aetiologies, influenza, and other viral infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infections and virus-bacterial pneumonias, as well as pathological changes in modern tuberculosis, lung granuloma, and respiratory tract inflammation in different age groups.
Keywords	Respiratory organs/Diseases
Subject code	616.2
Language	English
Size	1 online resource (X, 259 p. 323 illus., 310 illus. in color.)
Edition	1st ed. 2021.
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-66325-6 ; 3-030-66324-8 ; 978-3-030-66325-4 ; 978-3-030-66324-7
DOI	10.1007/978-3-030-66325-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Lobar (croupous) pneumonia: old and new data.

Zinserling, Vsevolod A / Swistunov, Vladimir V / Botvinkin, Alexander D / Stepanenko, Lilia A / Makarova, Angelica E

Infection

2021 Volume 50, Issue 1, Page(s) 235–242

Abstract: Background and aim: Pneumonia remains one of the most frequent death causes worldwide. Among the etiological factors S. pneumoniae-causing lobar pneumonia plays a leading role. According to current textbook knowledge at least three sequential stages of ... ...

Abstract	Background and aim: Pneumonia remains one of the most frequent death causes worldwide. Among the etiological factors S. pneumoniae-causing lobar pneumonia plays a leading role. According to current textbook knowledge at least three sequential stages of lobar pneumonia are distinguished: congestion, red hepatization and gray hepatization. However, there are no detailed data supporting this stage concept. There are also controversial views on its etiology. In this study, the lung changes in lobar pneumonia were related to the cause and duration of the disease. In addition, the complications of the disease were evaluated. PCR studies verified the etiology of pneumonia. Material and methods: Lobar pneumonia was analyzed in 252 post mortem cases examined in a large hospital in Irkutsk. The pathology, etiology of pneumonia, course of disease and cause of death were recorded and correlated to its clinical course and duration. In the second part of the study, the results in 95 patients were analyzed in detail and related to PCR findings. Results: Most patients were adult men of low social status who showed signs of severe alcoholism. Lobar pneumonia was observed in 85% of the patients, while the remaining patients showed sublobar ("lobular", focal) lung involvement. Histologically, three patterns of inflammation were observed, which in most patients occurred concurrently in different parts of the involved lobe: "congestion", characterized by serous exudation with multiple cocci (41% of cases), "red hepatization" (41% of cases) and "gray hepatization" (100% of cases). The latter pattern was subdivided into three subgroups according to the ratio of fibrin-neutrophils and the presence of macrophages. The mean number of different histological patterns observed per patient was 3.8. There was no correlation between the inflammatory patterns and the duration of the disease. In 23% of the patients, the cause of death was of pulmonary origin, while the remaining patients died of extrapulmonary complications (i.e. acute heart failure 26%, acute vascular insufficiency 15% purulent meningitis 11-24.3%. In 29/95 patients (20 with lobar and 9 with focal pneumonia) pneumococcal etiology of pneumonia was established by PCR. Conclusion: Lobar pneumonia is a distinct clinico-pathological entity caused by S. pneumoniae, demonstrated by PCR testing and/or cytological examinations. Bacteriologic studies frequently give falsenegative results. Lobar pneumonia is characterized by three main histopathological patterns (congestion or microbeous edema, and red and gray hepatization) which usually occur side by side and not in chronological order. Early death is often related to heart failure and septic shock, while meningitis is a frequent complication later in the course.
MeSH term(s)	Humans ; Leukocyte Count ; Lung/diagnostic imaging ; Male ; Pneumonia/epidemiology ; Pneumonia, Pneumococcal ; Streptococcus pneumoniae ; Thorax
Language	English
Publishing date	2021-09-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-021-01689-4
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: SARS-CoV-2-Induced Pathology-Relevance to COVID-19 Pathophysiology.

Zinserling, Vsevolod A / Semenova, Natalia Yu / Bikmurzina, Anastasia E / Kruglova, Natalia M / Rybalchenko, Oksana V / Markov, Alexander G

Pathophysiology : the official journal of the International Society for Pathophysiology

2022 Volume 29, Issue 2, Page(s) 281–297

Abstract: In spite of intensive studies of different aspects of a new coronavirus infection, many issues still remain unclear. In a screening analysis of histopathology in l200 lethal cases, authors succeeded in performing a wide spectrum of immune histochemical ... ...

Abstract	In spite of intensive studies of different aspects of a new coronavirus infection, many issues still remain unclear. In a screening analysis of histopathology in l200 lethal cases, authors succeeded in performing a wide spectrum of immune histochemical reactions (CD2, CD 3, CD 4, CD 5, CD 7, CD 8, CD14, CD 20, CD 31, CD 34, CD 56, CD 57, CD 68, CD 163, collagen 1,3, spike protein SARS-CoV-2, caspase-3, MLCM; ACE2 receptor, occludin, and claudin-1 and -3) and electron microscopy. The results of the histological and IHC studies of deceased people with varying degrees of severity of coronavirus infection confirmed the ability of these pathogens to cause cytoproliferative changes, primarily in epithelial and endothelial cells. Lesions of various organs are possible, while the reasons for significant differences in organotropy remain unclear. Severe respiratory failure in COVID-19 in humans is associated with a very peculiar viral pneumonia. In the pathogenesis of COVID-19, the most important role is played by lesions of the microcirculatory bed, the genesis of which requires further study, but direct viral damage is most likely. Endothelial damage can be associated with both thrombosis in vessels of various calibers, leading to characteristic complications, and the development of DIC syndrome with maximal kidney damage. Such lesions can be the basis of clinically diagnosed septic shock, while usually there are no morphological data in favor of classical sepsis caused by bacteria or fungi. A massive infiltration of the lung tissue and other organs, mainly by T lymphocytes, including those with suppressor properties, makes it necessary to conduct a differential diagnosis between the morphological manifestation of the protective cellular immune response and direct viral lesions but does not exclude the hypothesis of an immunopathological component of pathogenesis. In many of the deceased, even in the absence of clear clinical symptoms, a variety of extrapulmonary lesions were also detected. The mechanism of their development probably has a complex nature: direct lesions associated with the generalization of viral infection and vascular disorders associated with endothelial damage and having an autoimmune nature. Many aspects of the pathogenesis of coronavirus infection require further comprehensive study.
Language	English
Publishing date	2022-06-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1212740-1
ISSN	1873-149X ; 0928-4680
ISSN (online)	1873-149X
ISSN	0928-4680
DOI	10.3390/pathophysiology29020021
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Article: Stillborn child with diffuse SARS-CoV-2 viral infection of multiple organs.

Zinserling, Vsevolod A / Bornstein, Stefan R / Narkevich, Tatyana A / Sukhanova, Yulia V / Semenova, Natalia Yu / Vashukova, Maria A / Steenblock, Charlotte

IDCases

2021 Volume 26, Page(s) e01328

Abstract: In May 2020, a pregnant woman in her 37th pregnancy week was diagnosed with COVID-19 in St. Petersburg in Russia. All treatments failed and the patient died after 11 days due to acute respiratory distress syndrome. A stillborn child was removed by ... ...

Abstract	In May 2020, a pregnant woman in her 37th pregnancy week was diagnosed with COVID-19 in St. Petersburg in Russia. All treatments failed and the patient died after 11 days due to acute respiratory distress syndrome. A stillborn child was removed by caesarian section. Pathological investigations showed that the child died due to antenatal asphyxia with aspiration pneumonia. The child was positive for SARS-CoV-2 and immunohistochemical investigations showed viral infection and cellular changes in several organs such as pancreas, brain, spleen, and adrenals. These results emphasize the importance of vaccinating pregnant women against SARS-CoV-2.
Language	English
Publishing date	2021-11-05
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2021.e01328
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Article: Noncanonical Adult Human Neurogenesis and Axonal Growth as Possible Structural Basis of Recovery From Traumatic Vegetative State.

Vainshenker, Yulia / Zinserling, Vsevolod / Korotkov, Alexander / Medvedev, Svyatoslav

Clinical medicine insights. Case reports

2017 Volume 10, Page(s) 1179547617732040

Abstract: Patient recovering from traumatic vegetative state has suddenly died from cardiac arrest. In-life improvement of consciousness appeared after reduction of generalized spasticity due to botulinum toxin administration. Neuropathologic examination revealed ... ...

Abstract	Patient recovering from traumatic vegetative state has suddenly died from cardiac arrest. In-life improvement of consciousness appeared after reduction of generalized spasticity due to botulinum toxin administration. Neuropathologic examination revealed Musashi1+, Nestin+, PCNA+, and Ki67+ cells in the hippocampus, frontal, parietal and occipital cortex, caudate, thalamus, mammillary bodies, brainstem, cerebellum, and near the posterior horn of the lateral ventricle. New neurons with neurite growth (TUC4+) appeared in corpus callosum. At the same time, axonal growth was detected in all areas of interest. New cells whose functional state was continuously improving, as revealed by in-life neurologic and positron emission tomography monitoring, have mainly been found in brain areas without neuropathologic signs of damage. We suggest that the possible role of neurogenesis consists in improvement of the microenvironment and interneuron interactions, whereas the activation of neurogenesis and the induction of neurite growth may be associated with reduction of spasticity.
Language	English
Publishing date	2017-09-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2580498-4
ISSN	1179-5476
ISSN	1179-5476
DOI	10.1177/1179547617732040
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Article ; Online: Neutrophils Mediate Pulmonary Artery Thrombosis In Situ.

Porembskaya, Olga / Zinserling, Vsevolod / Tomson, Vladimir / Toropova, Yana / Starikova, Eleonora A / Maslei, Vitaliy V / Bulavinova, Nika I / Kirik, Olga V / Syrtsova, Marina A / Laberko, Leonid / Galchenko, Maxim I / Kravchuk, Vyacheslav / Saiganov, Sergey / Brill, Alexander

International journal of molecular sciences

2022 Volume 23, Issue 10

Abstract: Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs) ...

Abstract	Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs). However, growing evidence suggests that occlusion of the vessels in the lungs can develop without preceding deep vein thrombosis (DVT). In this work, we used an inferior vena cava (IVC) complete ligation model of DVT in Wistar rats to explore the possibility and mechanisms of PA thrombosis under the conditions where all routes of thrombotic mass migration from peripheral veins are blocked. We demonstrate that rats both with normal and reduced neutrophil counts developed thrombi in the IVC, although, neutropenia caused a substantial decrease in thrombus size and a shift from fresh fibrin toward mature fibrin and connective tissue inside the thrombus. Massive fibrin deposition was found in the PA branches in the majority of DVT rats with normal neutrophil counts, but in none of the neutropenic animals. Neutrophil ablation also abolished macroscopic signs of lung damage. Altogether, the results demonstrate that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the DVT setting.
MeSH term(s)	Animals ; Fibrin ; Lung ; Neutrophils ; Pulmonary Artery ; Rats ; Rats, Wistar ; Venous Thrombosis/etiology
Chemical Substances	Fibrin (9001-31-4)
Language	English
Publishing date	2022-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23105829
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Article ; Online: Inflammatory Cell Infiltration of Adrenals in COVID-19.

Zinserling, Vsevolod A / Semenova, Natalya Yu / Markov, Alexander G / Rybalchenko, Oksana V / Wang, Jun / Rodionov, Roman N / Bornstein, Stefan R

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

2020 Volume 52, Issue 9, Page(s) 639–641

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions.
MeSH term(s)	Adrenal Glands/immunology ; Adrenal Glands/pathology ; Adrenal Glands/virology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; T-Lymphocytes/immunology
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/a-1191-8094
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Article ; Online: Covid-19 and autoimmunity.

Ehrenfeld, Michael / Tincani, Angela / Andreoli, Laura / Cattalini, Marco / Greenbaum, Assaf / Kanduc, Darja / Alijotas-Reig, Jaume / Zinserling, Vsevolod / Semenova, Natalia / Amital, Howard / Shoenfeld, Yehuda

Autoimmunity reviews

2020 Volume 19, Issue 8, Page(s) 102597

MeSH term(s)	Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/virology ; Autoimmunity ; Betacoronavirus/chemistry ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2
Chemical Substances	Autoantibodies
Keywords	covid19
Language	English
Publishing date	2020-06-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2020.102597
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