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  1. Book ; Online ; Thesis: Structure and Function of the Ca2+ dependent K+ channel AKT1 from A.thaliana

    Bork, Alexandra [Verfasser] / Schmitt, Lutz [Gutachter] / Groth, Georg [Gutachter]

    2023  

    Author's details Alexandra Bork ; Gutachter: Lutz Schmitt, Georg Groth
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4

    Guy, Thomas V / Terry, Alexandra M / McGuire, Helen M / Shklovskaya, Elena / Fazekas de St Groth, Barbara

    Oncoimmunology

    2023  Volume 13, Issue 1, Page(s) 2290799

    Abstract: There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited. The intrinsic capacity of B cells to specifically activate tumour-specific ... ...

    Abstract There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited. The intrinsic capacity of B cells to specifically activate tumour-specific CD4+ T cells
    MeSH term(s) Mice ; Animals ; Antigen-Presenting Cells/physiology ; CD4-Positive T-Lymphocytes ; Lymphocyte Activation ; B-Lymphocytes ; Neoplasms
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-402X
    ISSN (online) 2162-402X
    ISSN 2162-402X
    DOI 10.1080/2162402X.2023.2290799
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  3. Article ; Online: Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice.

    Fischer, Alexandra A M / Robertson, Hanah B / Kong, Deqiang / Grimm, Merlin M / Grether, Jakob / Groth, Johanna / Baltes, Carsten / Fliegauf, Manfred / Lautenschläger, Franziska / Grimbacher, Bodo / Ye, Haifeng / Helms, Volkhard / Weber, Wilfried

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2311834

    Abstract: Phase separation of biomolecules into condensates is a key mechanism in the spatiotemporal organization of biochemical processes in cells. However, the impact of the material properties of biomolecular condensates on important processes, such as the ... ...

    Abstract Phase separation of biomolecules into condensates is a key mechanism in the spatiotemporal organization of biochemical processes in cells. However, the impact of the material properties of biomolecular condensates on important processes, such as the control of gene expression, remains largely elusive. Here, the material properties of optogenetically induced transcription factor condensates are systematically tuned, and probed for their impact on the activation of target promoters. It is demonstrated that transcription factors in rather liquid condensates correlate with increased gene expression levels, whereas stiffer transcription factor condensates correlate with the opposite effect, reduced activation of gene expression. The broad nature of these findings is demonstrated in mammalian cells and mice, as well as by using different synthetic and natural transcription factors. These effects are observed for both transgenic and cell-endogenous promoters. The findings provide a novel materials-based layer in the control of gene expression, which opens novel opportunities in optogenetic engineering and synthetic biology.
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202311834
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  4. Article ; Online: Grave and Pernicious Anemia Presenting as Pancytopenia.

    Groth, Alexandra / Rudiger, Alain / Herren, Thomas

    The American journal of medicine

    2019  Volume 133, Issue 6, Page(s) e302–e303

    MeSH term(s) Aged ; Anemia, Pernicious/blood ; Anemia, Pernicious/complications ; Anemia, Pernicious/diagnosis ; Anemia, Pernicious/therapy ; Bilirubin/blood ; Blood Transfusion ; Female ; Ferritins/blood ; Folic Acid/blood ; Folic Acid/therapeutic use ; Gastritis, Atrophic/complications ; Gastritis, Atrophic/diagnosis ; Humans ; L-Lactate Dehydrogenase/blood ; Pancytopenia/blood ; Pancytopenia/diagnosis ; Pancytopenia/etiology ; Pancytopenia/therapy ; Parietal Cells, Gastric ; Severity of Illness Index ; Vitamin B 12/blood ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/blood ; Vitamin B 12 Deficiency/diagnosis ; Vitamin B 12 Deficiency/therapy ; Vitamin B Complex/therapeutic use
    Chemical Substances Vitamin B Complex (12001-76-2) ; Ferritins (9007-73-2) ; Folic Acid (935E97BOY8) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Vitamin B 12 (P6YC3EG204) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.11.013
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
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  5. Article: SAP-basiertes Lieferengpassmanagement für eine sichere Patientenversorgung

    Groth-Tonberge, Christiane / Strub, Maximilian / Stetz, Ute / Schwehr, Alexandra / Voekt, Nathalie / Heni, Josef / Aigeldinger, Harald / Hug, Martin J.

    Krankenhauspharmazie

    2022  Volume 43, Issue 5, Page(s) 159

    Language German
    Document type Article
    ZDB-ID 138842-3
    ISSN 0173-7597
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2067: Show issues Location:
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  6. Article ; Online: Operationalization of a multidimensional sex/gender concept for quantitative environmental health research and implementation in the KORA study: Results of the collaborative research project INGER.

    Kraus, Ute / Jacke, Katharina / Dandolo, Lisa / Debiak, Malgorzata / Fichter, Sophie / Groth, Katrin / Kolossa-Gehring, Marike / Hartig, Christina / Horstmann, Sophie / Schneider, Alexandra / Palm, Kerstin / Bolte, Gabriele

    Frontiers in public health

    2023  Volume 11, Page(s) 1128918

    Abstract: Background: In environmental health research, sex and gender are not yet adequately considered. There is a need to improve data collection in population-based environmental health studies by comprehensively surveying sex/gender-related aspects according ...

    Abstract Background: In environmental health research, sex and gender are not yet adequately considered. There is a need to improve data collection in population-based environmental health studies by comprehensively surveying sex/gender-related aspects according to gender theoretical concepts. Thus, within the joint project INGER we developed a multidimensional sex/gender concept which we aimed to operationalize and to test the operationalization for feasibility.
    Methods: In an iterative process, we created questionnaire modules which quantitatively captured the requirements of the INGER sex/gender concept. We deployed it in the KORA cohort (Cooperative Health Research in the Region of Augsburg, Germany) in 2019 and evaluated response and missing rates.
    Results: The individual sex/gender self-concept was surveyed
    Conclusion: We have shown how the multidimensional INGER sex/gender concept can be operationalized according to an European and North American understanding of sex/gender for use in quantitative research. The questionnaire modules proved feasible in an epidemiologic cohort study. Being a balancing act between theoretical concepts and its quantitative implementation our operationalization paves the way for an adequate consideration of sex/gender in environmental health research.
    MeSH term(s) Infant, Newborn ; Humans ; Male ; Female ; Gender Identity ; Cohort Studies ; Self Concept ; Research Design ; Surveys and Questionnaires
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1128918
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  7. Article ; Online: Circulant preconditioning in the volume integral equation method for silicon photonics.

    Groth, Samuel P / Polimeridis, Athanasios G / Tambova, Alexandra / White, Jacob K

    Journal of the Optical Society of America. A, Optics, image science, and vision

    2019  Volume 36, Issue 6, Page(s) 1079–1088

    Abstract: Recently, the volume integral equation (VIE) approach has been proposed as an efficient simulation tool for silicon photonics applications [J. Lightw. Technol.36, 3765 (2018)JLTEDG0733-872410.1109/JLT.2018.2842054]. However, for the high-frequency and ... ...

    Abstract Recently, the volume integral equation (VIE) approach has been proposed as an efficient simulation tool for silicon photonics applications [J. Lightw. Technol.36, 3765 (2018)JLTEDG0733-872410.1109/JLT.2018.2842054]. However, for the high-frequency and strong-contrast problems arising in photonics, the convergence of iterative solvers for the solution of the linear system can be extremely slow. The uniform discretization of the volume integral operator leads to a three-level Toeplitz matrix, which is well suited to preconditioning via its circulant approximation. In this paper, we describe an effective circulant preconditioning strategy based on the multilevel circulant preconditioner of Chan and Olkin [Numer. Algorithms6, 89 (1994)NUALEG1017-139810.1007/BF02149764]. We show that this approach proves ideal in the canonical photonics problem of propagation within a uniform waveguide, in which the flow is unidirectional. For more complex photonics structures, such as Bragg gratings, directional couplers, and disk resonators, we generalize our preconditioning strategy via geometrical partitioning (leading to a block-diagonal circulant preconditioner) and homogenization (for inhomogeneous structures). Finally, we introduce a novel memory reduction technique enabling the preconditioner's memory footprint to remain manageable, even for extremely long structures. The range of numerical results we present demonstrates that the preconditioned VIE is fast and has great utility for the numerical exploration of prototype photonics devices.
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283633-6
    ISSN 1520-8532 ; 1084-7529 ; 0740-3232
    ISSN (online) 1520-8532
    ISSN 1084-7529 ; 0740-3232
    DOI 10.1364/JOSAA.36.001079
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2689: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Model-based segmentation using neural network-based boundary detectors

    Tom Brosch / Jochen Peters / Alexandra Groth / Frank Michael Weber / Jürgen Weese

    Machine Learning with Applications, Vol 6, Iss , Pp 100078- (2021)

    Application to prostate and heart segmentation in MR images

    2021  

    Abstract: Model-based segmentation (MBS) is a variant of active surfaces and active shape models that has successfully been used to segment anatomical structures such as the heart or the brain. We propose to integrate neural networks (NNs) into MBS for boundary ... ...

    Abstract Model-based segmentation (MBS) is a variant of active surfaces and active shape models that has successfully been used to segment anatomical structures such as the heart or the brain. We propose to integrate neural networks (NNs) into MBS for boundary detection. We formulate boundary detection as a regression task and use a NN to predict the distances between a surface mesh and the corresponding boundary points. The proposed approach has been applied to two tasks — prostate segmentation in MR images and the segmentation of the left and right ventricle in MR images. For the first task, data from the Prostate MR Image Segmentation 2012 (PROMISE12) challenge has been used. For the second task, a diverse database with cardiac MR images from six clinical sites has been used. We compare the results to the popular U-net approaches using the nnU-net implementation that is among the top performing segmentation algorithms in various challenges. In cross-validation experiments, the mean Dice scores are very similar and no statistically significant difference is observed. On the PROMISE12 test set, nnU-net Dice scores are significantly better. This is achieved by using an ensemble of 2D and 3D U-nets to generate the final segmentation, a concept that may also be adapted to NN-based boundary detection in the future. While the U-net provides a voxel labeling, our approach provides a 3D surface mesh with pre-defined mesh topology, establishes correspondences with respect to the reference mesh, avoids isolated falsely segmented regions and ensures proper connectivity of different regions.
    Keywords Model-based segmentation ; Boundary detection ; Neural networks ; Prostate ; Heart ; MRI ; Cybernetics ; Q300-390 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 004 ; 006
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  9. Article: Favorable Pregnancy Outcomes in Women With Well-Controlled Pulmonary Arterial Hypertension.

    Corbach, Nadine / Berlier, Charlotte / Lichtblau, Mona / Schwarz, Esther I / Gautschi, Fiorenza / Groth, Alexandra / Schüpbach, Rolf / Krähenmann, Franziska / Saxer, Stéphanie / Ulrich, Silvia

    Frontiers in medicine

    2021  Volume 8, Page(s) 689764

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.689764
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  10. Article ; Online: Operationalization of a multidimensional sex/gender concept for quantitative environmental health research and implementation in the KORA study

    Ute Kraus / Katharina Jacke / Lisa Dandolo / Malgorzata Debiak / Sophie Fichter / Katrin Groth / Marike Kolossa-Gehring / Christina Hartig / Sophie Horstmann / Alexandra Schneider / Kerstin Palm / Gabriele Bolte

    Frontiers in Public Health, Vol

    Results of the collaborative research project INGER

    2023  Volume 11

    Abstract: BackgroundIn environmental health research, sex and gender are not yet adequately considered. There is a need to improve data collection in population-based environmental health studies by comprehensively surveying sex/gender-related aspects according to ...

    Abstract BackgroundIn environmental health research, sex and gender are not yet adequately considered. There is a need to improve data collection in population-based environmental health studies by comprehensively surveying sex/gender-related aspects according to gender theoretical concepts. Thus, within the joint project INGER we developed a multidimensional sex/gender concept which we aimed to operationalize and to test the operationalization for feasibility.MethodsIn an iterative process, we created questionnaire modules which quantitatively captured the requirements of the INGER sex/gender concept. We deployed it in the KORA cohort (Cooperative Health Research in the Region of Augsburg, Germany) in 2019 and evaluated response and missing rates.ResultsThe individual sex/gender self-concept was surveyed via a two-step approach that asked for sex assigned at birth and the current sex/gender identity. Additionally, we used existing tools to query internalized sex/gender roles and externalized sex/gender expressions. Adapted to the KORA population, we asked for discrimination experiences and care and household activities contributing to explain structural sex/gender relations. Further intersectionality-related social categories (e.g., socio-economic position), lifestyle and psychosocial factors were covered through data available in KORA. We could not identify appropriate tools to assess the true biological sex, sexual orientation and ethnic/cultural identity, which have yet to be developed or improved. The response-rate was 71%, the evaluation of 3,743 questionnaires showed a low missing rate. Prevalence of marginalized groups regarding sex/gender identity and definable by experiences of discrimination was very low.ConclusionWe have shown how the multidimensional INGER sex/gender concept can be operationalized according to an European and North American understanding of sex/gender for use in quantitative research. The questionnaire modules proved feasible in an epidemiologic cohort study. Being a balancing act between ...
    Keywords sex/gender ; sex ; gender ; operationalization ; intersectionality ; environmental health research ; Public aspects of medicine ; RA1-1270
    Subject code 390 ; 150
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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