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Article ; Online: Response of BRAF inhibitor-associated squamous cell lung carcinoma to drug withdrawal.

Blackmon, Jonathan T / Dhawan, Ratika / Terry, Nina L / Conry, Robert M

2017 Volume 27, Issue 2, Page(s) 159–163

Abstract: Vemurafenib and dabrafenib, two Food and Drug Administration-approved selective BRAF kinase inhibitors (BRAFi), have revolutionized the targeted therapy of cutaneous melanoma. Off-target effects of these drugs paradoxically activate the MAP kinase ... ...

Abstract	Vemurafenib and dabrafenib, two Food and Drug Administration-approved selective BRAF kinase inhibitors (BRAFi), have revolutionized the targeted therapy of cutaneous melanoma. Off-target effects of these drugs paradoxically activate the MAP kinase pathway in BRAF wild-type cells, leading to secondary malignancies. Although cutaneous squamous cell carcinomas are by far the most frequent, emergence of potentially life-threatening secondary tumors from other sites following prolonged therapy is a growing concern. Herein, we provide the first case report of squamous cell lung carcinoma apparently secondary to BRAFi developing in a metastatic melanoma patient on vemurafenib for 23 months. Subsequent BRAFi with dabrafenib for 5 months was accompanied by rapid lung cancer progression with 86% increase in diameter. Withdrawal of BRAFi as the only change in therapy resulted in partial response maintained for more than 8 months. Clinicians should be atuned to the risk of noncutaneous second malignancies induced by BRAFi, particularly in the setting of progression of an isolated lesion after prolonged therapy.
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1095779-0
ISSN	1473-5636 ; 0960-8931
ISSN (online)	1473-5636
ISSN	0960-8931
DOI	10.1097/CMR.0000000000000318
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Article: Talimogene laherparepvec for regionally advanced Merkel cell carcinoma: A report of 2 cases.

Blackmon, Jonathan T / Dhawan, Ratika / Viator, Toni M / Terry, Nina L / Conry, Robert M

JAAD case reports

2017 Volume 3, Issue 3, Page(s) 185–189

Language	English
Publishing date	2017-04-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2017.02.003
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Article ; Online: Parieto-frontal gyrification and working memory in healthy adults.

Green, Sophie / Blackmon, Karen / Thesen, Thomas / DuBois, Jonathan / Wang, Xiuyuan / Halgren, Eric / Devinsky, Orrin

Brain imaging and behavior

2018 Volume 12, Issue 2, Page(s) 303–308

Abstract: ... males/24 females; ages 18-68 years) completed a high-resolution 3 T T1-weighted MRI and standardized ...

Abstract	Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This study investigates whether regional variation in gyrification is associated with domain-general and domain-specific cognition. Our hypothesis is that increased local gyrification confers a functional advantage that is independent of surface area. To quantify regional gyrification, we computed the local gyrification index (LGI) at each vertex and averaged across a bilateral parietal-frontal region associated with general intelligence and reasoning (Jung and Haier 2007). A sample of 48 healthy adults (24 males/24 females; ages 18-68 years) completed a high-resolution 3 T T1-weighted MRI and standardized administration of the Wechsler Adult Intelligence Scale (WAIS). We found a positive correlation between cortical gyrification and working memory, which remained significant after controlling for cortical surface area. Results suggest that a higher degree of local cortical folding confers a functional advantage that is independent from surface area and evident for more dynamic or "fluid" cognitive processes (i.e., working memory) rather than over-learned or "crystallized" cognitive processes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Frontal Lobe/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Memory, Short-Term ; Middle Aged ; Parietal Lobe/diagnostic imaging ; Young Adult
Language	English
Publishing date	2018-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2377165-3
ISSN	1931-7565 ; 1931-7557
ISSN (online)	1931-7565
ISSN	1931-7557
DOI	10.1007/s11682-017-9696-9
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Article ; Online: Sublobar Resection, Stereotactic Body Radiation Therapy, and Percutaneous Ablation Provide Comparable Outcomes for Lung Metastasis-Directed Therapy.

Gits, Hunter C / Khosravi Flanigan, Mitra A / Kapplinger, Jamie D / Reisenauer, Janani S / Eiken, Patrick W / Breen, William G / Vu, Linh H / Welch, Brian T / Harmsen, William S / Day, Courtney N / Olivier, Kenneth R / Park, Sean S / Garces, Yolanda I / Hallemeier, Christopher L / Merrell, Kenneth W / Ashman, Jonathan B / Schild, Steven E / Grams, Michael P / Lucido, J John /

Shen, K Robert / Cassivi, Stephen D / Wigle, Dennis / Nichols, Francis C / Blackmon, Shanda / Tapias, Luis F / Callstrom, Matthew R / Owen, Dawn

Chest

2023 Volume 165, Issue 5, Page(s) 1247–1259

Abstract: Background: Prolonged survival of patients with metastatic disease has furthered interest in metastasis-directed therapy (MDT).: Research question: There is a paucity of data comparing lung MDT modalities. Do outcomes among sublobar resection (SLR), ... ...

Abstract	Background: Prolonged survival of patients with metastatic disease has furthered interest in metastasis-directed therapy (MDT). Research question: There is a paucity of data comparing lung MDT modalities. Do outcomes among sublobar resection (SLR), stereotactic body radiation therapy (SBRT), and percutaneous ablation (PA) for lung metastases vary in terms of local control and survival? Study design and methods: Medical records of patients undergoing lung MDT at a single cancer center between January 2015 and December 2020 were reviewed. Overall survival, local progression, and toxicity outcomes were collected. Patient and lesion characteristics were used to generate multivariable models with propensity weighted analysis. Results: Lung MDT courses (644 total: 243 SLR, 274 SBRT, 127 PA) delivered to 511 patients were included with a median follow-up of 22 months. There were 47 local progression events in 45 patients, and 159 patients died. Two-year overall survival and local progression were 80.3% and 63.3%, 83.8% and 9.6%, and 4.1% and 11.7% for SLR, SBRT, and PA, respectively. Lesion size per 1 cm was associated with worse overall survival (hazard ratio, 1.24; P = .003) and LP (hazard ratio, 1.50; P < .001). There was no difference in overall survival by modality. Relative to SLR, there was no difference in risk of local progression with PA; however, SBRT was associated with a decreased risk (hazard ratio, 0.26; P = .023). Rates of severe toxicity were low (2.1%-2.6%) and not different among groups. Interpretation: This study performs a propensity weighted analysis of SLR, SBRT, and PA and shows no impact of lung MDT modality on overall survival. Given excellent local control across MDT options, a multidisciplinary approach is beneficial for patient triage and longitudinal management.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/mortality ; Lung Neoplasms/radiotherapy ; Radiosurgery/methods ; Male ; Female ; Middle Aged ; Aged ; Retrospective Studies ; Pneumonectomy/methods ; Treatment Outcome ; Survival Rate ; Propensity Score
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article ; Comparative Study
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.12.013
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Article: Inflammatory melanoma in transit metastases with complete response to talimogene laherparepvec.

Blackmon, Jonathan T / Stratton, Michael S / Kwak, Young / Pavlidakey, Peter G / Slominski, Andrzej T / McKee, Svetlana B / Viator, Toni M / Kim, Ju Young / Huang, Conway C / Conry, Robert M

JAAD case reports

2017 Volume 3, Issue 4, Page(s) 280–283

Language	English
Publishing date	2017-06-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2017.02.011
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Article ; Online: Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma.

Freeman, Samuel S / Sade-Feldman, Moshe / Kim, Jaegil / Stewart, Chip / Gonye, Anna L K / Ravi, Arvind / Arniella, Monica B / Gushterova, Irena / LaSalle, Thomas J / Blaum, Emily M / Yizhak, Keren / Frederick, Dennie T / Sharova, Tatyana / Leshchiner, Ignaty / Elagina, Liudmila / Spiro, Oliver G / Livitz, Dimitri / Rosebrock, Daniel / Aguet, François /

Cell reports. Medicine

2022 Volume 3, Issue 2, Page(s) 100500

Abstract: ... Tumor mutational burden (TMB) and tumor-infiltrating T cells are associated with response, and ... respectively. Using DNA, we calculate T cell and B cell burdens (TCB/BCB) from rearranged TCR/Ig sequences and ...

Abstract	Immune checkpoint blockade (CPB) improves melanoma outcomes, but many patients still do not respond. Tumor mutational burden (TMB) and tumor-infiltrating T cells are associated with response, and integrative models improve survival prediction. However, integrating immune/tumor-intrinsic features using data from a single assay (DNA/RNA) remains underexplored. Here, we analyze whole-exome and bulk RNA sequencing of tumors from new and published cohorts of 189 and 178 patients with melanoma receiving CPB, respectively. Using DNA, we calculate T cell and B cell burdens (TCB/BCB) from rearranged TCR/Ig sequences and find that patients with TMB
MeSH term(s)	Humans ; Melanoma/drug therapy ; RNA ; Sequence Analysis, RNA ; Transcriptome/genetics ; Exome Sequencing
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2021.100500
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Article ; Online: A Comparison of Patient-Reported Health-Related Quality of Life During Proton Versus Photon Chemoradiation Therapy for Esophageal Cancer.

Garant, Aurelie / Whitaker, Thomas J / Spears, Grant M / Routman, David M / Harmsen, William S / Wilhite, Tyler J / Ashman, Jonathan B / Sio, Terence T / Rule, William G / Neben Wittich, Michelle A / Martenson, James A / Tryggestad, Erik J / Yoon, Harry H / Blackmon, Shanda / Merrell, Kenneth W / Haddock, Michael G / Hallemeier, Christopher L

Practical radiation oncology

2019 Volume 9, Issue 6, Page(s) 410–417

Abstract: Purpose: The purpose of this study was to compare Functional Assessment of Cancer Therapy-Esophagus (FACT-E) questionnaire changes during proton (PRT) or photon (XRT) chemoradiation therapy (CRT) for esophageal cancer (EC).: Methods and materials: We ...

Abstract	Purpose: The purpose of this study was to compare Functional Assessment of Cancer Therapy-Esophagus (FACT-E) questionnaire changes during proton (PRT) or photon (XRT) chemoradiation therapy (CRT) for esophageal cancer (EC). Methods and materials: We reviewed patients enrolled in a prospective registry who received preoperative or definitive CRT for EC. Patients completed the FACT-E before CRT and during the last week of CRT. Analysis of variance testing was used to assess associations between patient and treatment characteristics and FACT-E score changes. Results: One hundred twenty-five patients completed a baseline and posttreatment FACT-E; 63 received XRT and 62 received PRT. The mean age was 65 years; the PRT group was older (68 vs 64 years, P = .0063). The following characteristics were similar between cohorts: 83% male, 78% adenocarcinoma, and 89% stage II-III. The radiation therapy prescription dose was higher in the PRT group (≥50 Gy in 94% vs 67%, P < .0001), whereas the median clinical target volume was smaller in the PRT group (553 vs 668 cm Conclusions: For patients receiving CRT for EC, PRT was associated with less decline in FACT-E scores compared with XRT.
MeSH term(s)	Aged ; Chemoradiotherapy/methods ; Female ; Humans ; Male ; Patient Reported Outcome Measures ; Photons/therapeutic use ; Prospective Studies ; Protons ; Quality of Life/psychology
Chemical Substances	Protons
Language	English
Publishing date	2019-07-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2655748-4
ISSN	1879-8519 ; 1879-8500
ISSN (online)	1879-8519
ISSN	1879-8500
DOI	10.1016/j.prro.2019.07.003
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Article ; Online: Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.

Sade-Feldman, Moshe / Yizhak, Keren / Bjorgaard, Stacey L / Ray, John P / de Boer, Carl G / Jenkins, Russell W / Lieb, David J / Chen, Jonathan H / Frederick, Dennie T / Barzily-Rokni, Michal / Freeman, Samuel S / Reuben, Alexandre / Hoover, Paul J / Villani, Alexandra-Chloé / Ivanova, Elena / Portell, Andrew / Lizotte, Patrick H / Aref, Amir R / Eliane, Jean-Pierre /

Hammond, Marc R / Vitzthum, Hans / Blackmon, Shauna M / Li, Bo / Gopalakrishnan, Vancheswaran / Reddy, Sangeetha M / Cooper, Zachary A / Paweletz, Cloud P / Barbie, David A / Stemmer-Rachamimov, Anat / Flaherty, Keith T / Wargo, Jennifer A / Boland, Genevieve M / Sullivan, Ryan J / Getz, Gad / Hacohen, Nir

Cell

2019 Volume 176, Issue 1-2, Page(s) 404

Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Published Erratum
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2018.12.034
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Article ; Online: Septal nuclei enlargement in human temporal lobe epilepsy without mesial temporal sclerosis.

Butler, Tracy / Zaborszky, Laszlo / Wang, Xiuyuan / McDonald, Carrie R / Blackmon, Karen / Quinn, Brian T / DuBois, Jonathan / Carlson, Chad / Barr, William B / French, Jacqueline / Kuzniecky, Ruben / Halgren, Eric / Devinsky, Orrin / Thesen, Thomas

Neurology

2013 Volume 80, Issue 5, Page(s) 487–491

Abstract: Objective: To measure the volume of basal forebrain septal nuclei in patients with temporal lobe epilepsy (TLE) as compared to patients with extratemporal epilepsy and controls. In animal models of TLE, septal lesions facilitate epileptogenesis, while ... ...

Abstract	Objective: To measure the volume of basal forebrain septal nuclei in patients with temporal lobe epilepsy (TLE) as compared to patients with extratemporal epilepsy and controls. In animal models of TLE, septal lesions facilitate epileptogenesis, while septal stimulation is antiepileptic. Method: Subjects were recruited from 2 sites and consisted of patients with pharmacoresistant focal epilepsy (20 with TLE and mesial temporal sclerosis [MTS], 24 with TLE without MTS, 23 with extratemporal epilepsy) and 114 controls. Septal volume was measured using high-resolution MRI in association with newly developed probabilistic septal nuclei maps. Septal volume was compared between subject groups while controlling for relevant factors. Results: Patients with TLE without MTS had significantly larger septal nuclei than patients with extratemporal epilepsy and controls. This was not true for patients with MTS. These results are interpreted with reference to prior studies demonstrating expansion of the septo-hippocampal cholinergic system in animal models of TLE and human TLE surgical specimens. Conclusion: Septal nuclei are enlarged in patients with TLE without MTS. Further investigation of septal nuclei and antiepileptic septo-hippocampal neurocircuitry could be relevant to development of new therapeutic interventions such as septal stimulation for refractory TLE.
MeSH term(s)	Adolescent ; Adult ; Epilepsy, Temporal Lobe/pathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Sclerosis/pathology ; Septal Nuclei/pathology ; Statistics as Topic ; Temporal Lobe/pathology ; Young Adult
Language	English
Publishing date	2013-01-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0b013e31827f0ed7
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Article ; Online: Individual differences in verbal abilities associated with regional blurring of the left gray and white matter boundary.

Blackmon, Karen / Halgren, Eric / Barr, William B / Carlson, Chad / Devinsky, Orrin / DuBois, Jonathan / Quinn, Brian T / French, Jacqueline / Kuzniecky, Ruben / Thesen, Thomas

The Journal of neuroscience : the official journal of the Society for Neuroscience

2011 Volume 31, Issue 43, Page(s) 15257–15263

Abstract: ... white matter contrast (GWC) in healthy human adults. Participants were scanned at 3 T MRI and ...

Abstract	Blurring of the cortical gray and white matter border on MRI is associated with normal aging, pathological aging, and the presence of focal cortical dysplasia. However, it remains unclear whether normal variations in signal intensity contrast at the gray and white matter junction reflect the functional integrity of subjacent tissue. This study explores the relationship between verbal abilities and gray and white matter contrast (GWC) in healthy human adults. Participants were scanned at 3 T MRI and administered standardized measures of verbal expression and verbal working memory. GWC was estimated by calculating the non-normalized T1 image intensity contrast above and below the cortical gray/white matter interface. Spherical averaging and whole-brain correlational analyses were performed. Sulcal regions exhibited higher contrast compared to gyral regions. We found a strongly lateralized and regionally specific profile with reduced verbal expression abilities associated with blurring in left hemisphere inferior frontal cortex and temporal pole. Reduced verbal working memory was associated with blurring in widespread left frontal and temporal cortices. Such lateralized and focal results provide support for GWC as a measure of regional functional integrity and highlight its potential role in probing the neuroanatomical substrates of cognition in healthy and diseased populations.
MeSH term(s)	Adult ; Aged ; Brain/anatomy & histology ; Brain/physiology ; Brain Mapping ; Cognition ; Female ; Humans ; Image Processing, Computer-Assisted ; Individuality ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Nerve Fibers, Myelinated/physiology ; Neuropsychological Tests ; Verbal Behavior/physiology ; Young Adult
Language	English
Publishing date	2011-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.3039-11.2011
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