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Article ; Online: Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats.

Hajiasgharzadeh, Khalil / Shahabi, Parviz / Karimi-Sales, Elham / Alipour, Mohammad Reza

2024 Volume 25, Issue 1, Page(s) 27

Abstract: Background: Nicotine, the main compound of smoking may exert its effects by changing the expression of microRNAs (miRNAs). This study was conducted to further investigate the molecular mechanisms of miRNA-dependent effects of nicotine in an animal model ...

Abstract	Background: Nicotine, the main compound of smoking may exert its effects by changing the expression of microRNAs (miRNAs). This study was conducted to further investigate the molecular mechanisms of miRNA-dependent effects of nicotine in an animal model of liver fibrosis. Methods: The bile duct ligation (BDL) approach was used to create a model of liver fibrosis. Twenty-four male Wistar rats were used in the study. The effects of nicotine administration on miRNA-124 expression, as well as alpha-smooth muscle actin (liver fibrosis marker) and chemokine ligand 2 (an inflammatory chemokine), were investigated using RT-qPCR. In addition, the mRNA and protein expression of signal transducer and activator of transcription 3 (STAT-3; as a potential target for miRNA-124) were investigated by RT-qPCR and immunofluorescence, respectively. Liver enzyme activity levels were measured using a colorimetric assay. In addition, the effects of nicotine on the process of liver fibrosis were investigated with histological studies. Results: The development of liver fibrosis in BDL rats and nicotine administration led to a decrease in miRNA-124 expression. The decrease in the expression is accompanied by the increase in the expression of fibrotic and proinflammatory genes. Also, an increase in STAT-3 mRNA and protein expression was observed in the fibrotic rats that received nicotine. In addition, the significant increase in bilirubin and liver enzymes in fibrotic rats worsens with nicotine administration. The results of histological studies also confirm these results. Conclusion: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.
MeSH term(s)	Rats ; Male ; Animals ; Liver ; Nicotine/pharmacology ; Rats, Wistar ; Liver Cirrhosis/metabolism ; Bile Ducts/surgery ; Bile Ducts/metabolism ; Bile Ducts/pathology ; Fibrosis ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Chemokines/metabolism ; Chemokines/pharmacology ; RNA, Messenger/metabolism ; Disease Models, Animal
Chemical Substances	Nicotine (6M3C89ZY6R) ; MicroRNAs ; Chemokines ; RNA, Messenger ; MIRN124 microRNA, rat
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-024-00749-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The role of microRNAs in nicotine signaling.

Hajiasgharzadeh, Khalil / Naghipour, Bahman / Shahabi, Parviz / Dastmalchi, Narges / Alipour, Mohammad Reza

EXCLI journal

2023 Volume 22, Page(s) 433–450

Abstract: Cigarette smoking is a harmful habit that is widespread around the world. It is among the well-known lifestyle-related risk factors for many diseases. Nicotine, as its principal constituent, has various detrimental, and beneficial functions. Nicotinic ... ...

Abstract	Cigarette smoking is a harmful habit that is widespread around the world. It is among the well-known lifestyle-related risk factors for many diseases. Nicotine, as its principal constituent, has various detrimental, and beneficial functions. Nicotinic acetylcholine receptors (nAChRs), which are present in nearly all body cells, are how nicotine works. Numerous investigations have demonstrated that nicotine causes abnormal microRNA expression (miRNAs). These short sequences of RNAs are known to regulate gene expression post-transcriptionally. A wide range of miRNAs are modulated by nicotine, and nicotine-induced miRNA changes could subsequently mediate nicotine's effect on gene expression regulation. We will focus on the reciprocal interaction between nAChRs and miRNAs and describe the essential targets of these dysregulated miRNAs after nicotine exposure and activation of nAChRs. It appears that crucial subcellular mechanisms implicated in nicotine's effects are miRNA-related pathways. It is crucial to investigate the molecular mechanism underlying the effects of nicotine as well as the dysregulation of miRNA following nAChR activation. The finding about epigenetic mechanisms of nicotine-induced effects may shed light on the establishment of new treatment strategies to prevent the harmful effects of nicotine and perhaps may augment the beneficial effects in diverse smoking-related diseases.
Language	English
Publishing date	2023-05-19
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2023-6096
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Article ; Online: Regulatory Functions of MicroRNAs in Cancer Pathogenesis

Mahafarin Maralani / Behzad Baradaran / Khalil Hajiasgharzadeh / Marc Peeters

Acta Medica Iranica, Vol 58, Iss

2021 Volume 11

Abstract: MicroRNAs (miRNAs) are a large family of evolutionary conserved small non-coding RNA molecules that firstly discovered in 1993. They regulate gene expression of about 50% of protein-coding genes at the post-transcriptional level. MiRNAs can target ... ...

Abstract	MicroRNAs (miRNAs) are a large family of evolutionary conserved small non-coding RNA molecules that firstly discovered in 1993. They regulate gene expression of about 50% of protein-coding genes at the post-transcriptional level. MiRNAs can target numerous messenger RNAs and subsequent misexpression of them can affect many different signaling pathways. They are playing a pivotal role in cancer development by regulation of the genes expression which involved in the proliferation, survival, differentiation, apoptosis or metastasis of the cancer cells. Several treatment approaches such as inhibition of oncomiRs and restoration of tumor suppressor miRNAs have been established in certain types of cancers and some other miRNA-based strategies are in development for cancer prevention and treatment. Nowadays, cancer is the most important target of miRNA therapeutics and the specific mechanisms by which miRNA mediates cancer pathways needs more research and study.
Keywords	MicroRNA ; Cancer ; Proliferation ; Metastasis ; Therapeutic molecule ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Cross-talk between myeloid-derived suppressor cells and Mucin1 in breast cancer vaccination: On the verge of a breakthrough.

Abdoli Shadbad, Mahdi / Hajiasgharzadeh, Khalil / Baradaran, Behzad

Life sciences

2020 Volume 258, Page(s) 118128

Abstract: Although breast cancer is one of the leading troublesome cancers, the available therapeutic options have not fulfilled the desired outcomes. Immune-based therapy has gained special attention for breast cancer treatment. Although this approach is highly ... ...

Abstract	Although breast cancer is one of the leading troublesome cancers, the available therapeutic options have not fulfilled the desired outcomes. Immune-based therapy has gained special attention for breast cancer treatment. Although this approach is highly tolerable, its low response rate has rendered it as an undesirable approach. This review aims to describe the essential oncogenic pathways involved in breast cancer, elucidate the immunosuppression and oncogenic effect of Mucin1, and introduce myeloid-derived suppressor cells, which are the main culprits of anti-tumoral immune response attenuation. The various auto-inductive loops between Mucin1 and myeloid-derived suppressor cells are focal in the suppression of anti-tumoral immune responses in patients with breast cancer. These cross-talks between the Mucin1 and myeloid-derived suppressor cells can be the underlying causes of immunotherapy's impotence for patients with breast cancer. This approach can pave the road for the development of a potent vaccine for patients with breast cancer and is translated into clinical settings.
MeSH term(s)	Animals ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Clinical Trials as Topic ; Female ; Humans ; Mucin-1/metabolism ; Myeloid-Derived Suppressor Cells/metabolism ; Vaccination
Chemical Substances	Mucin-1
Language	English
Publishing date	2020-07-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118128
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Article: Inflammatory reflex disruption in COVID-19.

Hajiasgharzadeh, Khalil / Jafarlou, Mahdi / Mansoori, Behzad / Dastmalchi, Narges / Baradaran, Behzad / Khabbazi, Alireza

Clinical & experimental neuroimmunology

2022

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, in late 2019 and caused coronavirus disease 2019 (COVID-19), which is still a global pandemic. In most infected people, SARS-CoV-2 can only cause moderate ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China, in late 2019 and caused coronavirus disease 2019 (COVID-19), which is still a global pandemic. In most infected people, SARS-CoV-2 can only cause moderate symptoms, while in other patients, it leads to severe illness and eventually death. Although the main clinical manifestation of COVID-19 is often seen in the lungs, this disease affects almost all body organs. The excessive and prolonged release of inflammatory cytokines that may occur in COVID-19 patients, known as cytokine storms, stimulates undesired immune responses and can cause various tissues damage. In the current review article, we focus on the potential advantages of the intrinsic cholinergic anti-inflammatory pathway (CAP) as the efferent arm of inflammatory reflex in COVID-19 management. Considering this endogenous protective mechanism against chronic inflammation, we focused on the effects of SARS-CoV-2 in the destruction of this anti-inflammatory system. Several studies indicated the interaction of SARS-CoV-2 with the alpha7 subtype of the nicotinic acetylcholine receptor as the effector molecule of the inflammatory reflex. On the other hand, neurological manifestations have increasingly been identified as significant extrapulmonary manifestations of COVID-19. The rational connection between these findings and COVID-19 pathogenesis may be an important issue in both our understanding and dealing with this disease. COVID-19 is deeply rooted in our daily life and requires an urgent need for the establishment of effective therapeutic options, and all the possible treatments must be considered for the control of such inflammatory conditions.
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1759-1961
ISSN	1759-1961
DOI	10.1111/cen3.12703
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Article: Downregulation of HMGA2 by Small Interfering RNA Affects the Survival, Migration, and Apoptosis of Prostate Cancer Cell Line.

Khajouee, Shima / Baghbani, Elham / Mohammadi, Ali / Mansoori, Behzad / Shanehbandi, Dariush / Hajiasgharzadeh, Khalil / Baradaran, Behzad

Advanced pharmaceutical bulletin

2021 Volume 12, Issue 2, Page(s) 398–403

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2021-04-03
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2022.039
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Article: Cholinergic Anti-Inflammatory Pathway and the Liver.

Hajiasgharzadeh, Khalil / Baradaran, Behzad

Advanced pharmaceutical bulletin

2017 Volume 7, Issue 4, Page(s) 507–513

Abstract: The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers. This activation and subsequent acetylcholine releases ... ...

Abstract	The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers. This activation and subsequent acetylcholine releases from vagus nerve terminals leads to inhibition of inflammatory cytokines through α7 nicotinic acetylcholine receptors (α7nAChRs) which located on the surface of different cell types such as liver Kupffer cells. This protective role of vagus-α7nAChR axis in liver diseases has been shown in several experimental studies. On the other hand, accumulated evidence clearly demonstrate that, autonomic dysfunction which is reduced functioning of both vagal and sympathetic nervous system, occurs during chronic liver disease and is well-known complication of patients suffering from cirrhosis. This review describes the impact and significance of cholinergic anti-inflammatory pathway in the liver and discusses about its disease-related dysfunction on the progression of cirrhosis. Considering the fact that sepsis is major cause of death in cirrhotic patients, convergence of these findings, may lead to designing novel therapeutic strategies in the field of chronic liver diseases management involving selective drug targeting and electrical nerve stimulation.
Language	English
Publishing date	2017-12-31
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.15171/apb.2017.063
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Article ; Online: Nicotinic acetylcholine receptors in chemotherapeutic drugs resistance: An emerging targeting candidate.

Afrashteh Nour, Mina / Hajiasgharzadeh, Khalil / Kheradmand, Fatemeh / Asadzadeh, Zahra / Bolandi, Nadia / Baradaran, Behzad

Life sciences

2021 Volume 278, Page(s) 119557

Abstract: There is no definitive cure for cancer, and most of the current chemotherapy drugs have limited effects due to the development of drug resistance and toxicity at high doses. Therefore, there is an ongoing need for identifying the causes of ... ...

Abstract	There is no definitive cure for cancer, and most of the current chemotherapy drugs have limited effects due to the development of drug resistance and toxicity at high doses. Therefore, there is an ongoing need for identifying the causes of chemotherapeutic resistance, and it will be possible to develop innovative treatment approaches based on these novel targeting candidates. Cigarette smoking is known to be one of the main causes of resistance to chemotherapeutic agents. Nicotine as a component of cigarette smoke is an exogenous activator of nicotinic acetylcholine receptors (nAChRs). It can inhibit apoptosis, increase cell proliferation and cell survival, reducing the cytotoxic effects of chemotherapy drugs and cause a reduced therapeutic response. Recent studies have demonstrated that nAChRs and their downstream signaling pathways have considerable implications in different cancer's initiation, progression, and chemoresistance. In some previous studies, nAChRs have been targeted to obtain better efficacies for chemotherapeutics. Besides, nAChRs-based therapies have been used in combination with chemotherapy drugs to reduce the side effects. This strategy requires lower doses of chemotherapy drugs compared to the conditions that must be used alone. Here, we discussed the experimental and clinical studies that show the nAChRs involvement in response to chemotherapy agents. Also, controversies relating to the effects of nAChR on chemotherapy-induced apoptosis are in our focus in this review article. Delineating the complex influences of nAChRs would be of great interest in establishing new effective chemotherapy regimens.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Humans ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Receptors, Nicotinic/metabolism ; Signal Transduction/drug effects
Chemical Substances	Antineoplastic Agents ; Receptors, Nicotinic
Language	English
Publishing date	2021-04-27
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119557
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Article: Restoring of miR-193a-5p Sensitizes Breast Cancer Cells to Paclitaxel through P53 Pathway.

Khordadmehr, Monireh / Shahbazi, Roya / Baradaran, Behzad / Sadreddini, Sanam / Shanebandi, Dariush / Hajiasgharzadeh, Khalil

Advanced pharmaceutical bulletin

2020 Volume 10, Issue 4, Page(s) 595–601

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2020-08-09
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2020.071
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Article ; Online: Cholinergic anti-inflammatory pathway and connective tissue diseases.

Hajiasgharzadeh, Khalil / Khabbazi, Alireza / Mokhtarzadeh, Ahad / Baghbanzadeh, Amir / Asadzadeh, Zahra / Adlravan, Elham / Baradaran, Behzad

Inflammopharmacology

2021 Volume 29, Issue 4, Page(s) 975–986

Abstract: Connective tissue diseases (CTDs) consist of an extensive range of heterogeneous medical conditions, which are caused by immune-mediated chronic inflammation and influences the various connective tissues of the body. They include rheumatoid arthritis, ... ...

Abstract	Connective tissue diseases (CTDs) consist of an extensive range of heterogeneous medical conditions, which are caused by immune-mediated chronic inflammation and influences the various connective tissues of the body. They include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, vasculitis, Sjögren's syndrome, Behcet's disease, and many other autoimmune CTDs. To date, several anti-inflammatory approaches have been developed to reduce the severity of inflammation or its subsequent organ manifestations. As a logical mechanism to harnesses the undesired inflammation, some studies investigated the role of the intrinsic cholinergic anti-inflammatory pathway (CAP) in the modulation of chronic inflammation. Many different experimental and clinical models have been developed to evaluate the therapeutic significance of the CAP in CTDs. On the other hand, an issue that is less emphasized in this regard is the presence of autonomic neuropathy in CTDs, which influences the efficiency of CAP in such clinical settings. This condition occurs during CTDs and is a well-known complication of patients suffering from them. The advantages and limitations of CAP in the control of inflammatory responses and its possible therapeutic benefits in the treatment of CTDs are the main subjects of the current study. Therefore, this narrative review article is provided based on the recent findings of the complicated role of CAP in CTDs which were retrieved by searching Science Direct, PubMed, Google Scholar, and Web of Science. It seems that delineating the complex influences of CAP would be of great interest in designing novel surgical or pharmacological therapeutic strategies for CTDs therapy.
MeSH term(s)	Animals ; Cholinergic Agents/pharmacology ; Cholinergic Agents/therapeutic use ; Connective Tissue Diseases/immunology ; Connective Tissue Diseases/metabolism ; Connective Tissue Diseases/therapy ; Humans ; Implantable Neurostimulators ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Neuroimmunomodulation/drug effects ; Neuroimmunomodulation/physiology ; Receptors, Nicotinic/immunology ; Receptors, Nicotinic/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; alpha7 Nicotinic Acetylcholine Receptor/antagonists & inhibitors ; alpha7 Nicotinic Acetylcholine Receptor/immunology ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
Chemical Substances	Cholinergic Agents ; Inflammation Mediators ; Receptors, Nicotinic ; alpha7 Nicotinic Acetylcholine Receptor
Language	English
Publishing date	2021-06-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-021-00812-z
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