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Article ; Online: Reply to M. Koehler et al.

Efficace, Fabio / Cottone, Francesco / Lo-Coco, Francesco

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2015 Volume 33, Issue 9, Page(s) 1091–1092

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Arsenicals/therapeutic use ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Oxides/therapeutic use ; Quality of Life ; Tretinoin/therapeutic use
Chemical Substances	Antineoplastic Agents ; Arsenicals ; Oxides ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2015-03-20
Publishing country	United States
Document type	Comment ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2014.60.3597
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Navigating Care for Patients With Terminal Illnesses as First-Year Medical Students.

Cottone, Michael C / Shah, Mohammed M

Academic medicine : journal of the Association of American Medical Colleges

2023

Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000005534
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Zs.A 112: Show issues

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Article ; Online: Harnessing the open access version of ChatGPT for enhanced clinical opinions.

Tenner, Zachary M / Cottone, Michael C / Chavez, Martin R

PLOS digital health

2024 Volume 3, Issue 2, Page(s) e0000355

Abstract: With the advent of Large Language Models (LLMs) like ChatGPT, the integration of Generative Artificial Intelligence (GAI) into clinical medicine is becoming increasingly feasible. This study aimed to evaluate the ability of the freely available ChatGPT-3. ...

Abstract	With the advent of Large Language Models (LLMs) like ChatGPT, the integration of Generative Artificial Intelligence (GAI) into clinical medicine is becoming increasingly feasible. This study aimed to evaluate the ability of the freely available ChatGPT-3.5 to generate complex differential diagnoses, comparing its output to case records of the Massachusetts General Hospital published in the New England Journal of Medicine (NEJM). Forty case records were presented to ChatGPT-3.5, prompting it to provide a differential diagnosis and then narrow it down to the most likely diagnosis. The results indicated that the final diagnosis was included in ChatGPT-3.5's original differential list in 42.5% of the cases. After narrowing, ChatGPT correctly determined the final diagnosis in 27.5% of the cases, demonstrating a decrease in accuracy compared to previous studies using common chief complaints. These findings emphasize the necessity for further investigation into the capabilities and limitations of LLMs in clinical scenarios while highlighting the potential role of GAI as an augmented clinical opinion. Anticipating the growth and enhancement of GAI tools like ChatGPT, physicians and other healthcare workers will likely find increasing support in generating differential diagnoses. However, continued exploration and regulation are essential to ensure the safe and effective integration of GAI into healthcare practice. Future studies may seek to compare newer versions of ChatGPT or investigate patient outcomes with physicians integrating this GAI technology. Understanding and expanding GAI's capabilities, particularly in differential diagnosis, may foster innovation and provide additional resources, especially in underserved areas in the medical field.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2767-3170
ISSN (online)	2767-3170
DOI	10.1371/journal.pdig.0000355
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Article ; Online: A controlled trial assessing the acceptability and efficacy of a yoga-based eating disorder prevention program among division I athletes: Eat Breathe Thrive (EBT).

Cook-Cottone, Catherine / Rovig, Stephanie / Cottone, Maya / Evelyn Estey, Esther Ellyn / Guyker, Wendy / Roff, Chelsea

Eating disorders

2024 , Page(s) 1–19

Abstract: Objective: This study evaluated the acceptability and effectiveness of the Eat Breathe Thrive (EBT) program as an eating disorder prevention intervention among women collegiate athletes.: Method: Change over time in eating disorder risk and ... ...

Abstract	Objective: This study evaluated the acceptability and effectiveness of the Eat Breathe Thrive (EBT) program as an eating disorder prevention intervention among women collegiate athletes. Method: Change over time in eating disorder risk and competencies of positive embodiment were examined in 94 women ( Results: Repeated measures ANOVAS revealed EBT participants reported experiencing significantly less state anxiety and greater interoceptive body trusting over time relative to matched-controls. No other significant interactions were found. Respondents found the EBT program acceptable. Discussion: Acceptability and partial support for integrative, yoga-based, interventions targeting Division I student-athletes is indicated.
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1209799-8
ISSN	1532-530X ; 1064-0266 ; 1067-1633
ISSN (online)	1532-530X
ISSN	1064-0266 ; 1067-1633
DOI	10.1080/10640266.2024.2313296
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Zs.A 4394: Show issues

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Article ; Online: (B)On(e)-cohistones and the epigenetic alterations at the root of bone cancer.

Salomoni, Paolo / Flanagan, Adrienne M / Cottone, Lucia

Cell death and differentiation

2023

Abstract: Identification of mutations in histones in a number of human neoplasms and developmental syndromes represents the most compelling evidence to date for a causal role of epigenetic perturbations in human disease. In most cases, these mutations have gain of ...

Abstract	Identification of mutations in histones in a number of human neoplasms and developmental syndromes represents the most compelling evidence to date for a causal role of epigenetic perturbations in human disease. In most cases, these mutations have gain of function properties that cause deviation from normal developmental processes leading to embryo defects and/or neoplastic transformation. These exciting discoveries represent a step-change in our understanding of the role of chromatin (dys)regulation in development and disease. However, the mechanisms of action of oncogenic histone mutations (oncohistones) remain only partially understood. Here, we critically assess existing literature on oncohistones focussing mainly on bone neoplasms. We show how it is possible to draw parallels with some of the cell-autonomous mechanisms of action described in paediatric brain cancer, although the functions of oncohistones in bone tumours remain under-investigated. In this respect, it is becoming clear that histone mutations targeting the same residues display, at least in part, tissue-specific oncogenic mechanisms. Furthermore, it is emerging that cancer cells carrying oncohistones can modify the surrounding microenvironment to support growth and/or alter differentiation trajectories. A better understanding of oncohistone function in different neoplasms provide potential for identification of signalling that could be targeted therapeutically. Finally, we discuss some of the main concepts and future directions in this research area, while also drawing possible connections and parallels with other cancer epigenetic mechanisms.
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-023-01227-9
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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 80: Show issues

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Article ; Online: Otolaryngologic sequelae of Ehlers Danlos Syndrome in pediatric patients.

Cottone, Chloe / Nanu, Douglas / Gawel, Erin M / Corbin, Alexandra F / Clausen, Sean / Carr, Michele

International journal of pediatric otorhinolaryngology

2024 Volume 180, Page(s) 111959

Abstract: Objective: As outlined by the NIH, Ehlers Danlos Syndrome (EDS) is a group of hereditary connective tissue disorders characterized by skin hyperelasticity, joint hypermobility, atrophic scarring, and blood vessel fragility, with no otolaryngological ... ...

Abstract	Objective: As outlined by the NIH, Ehlers Danlos Syndrome (EDS) is a group of hereditary connective tissue disorders characterized by skin hyperelasticity, joint hypermobility, atrophic scarring, and blood vessel fragility, with no otolaryngological criteria for diagnosis. We aimed to compare otolaryngological disorders between children with EDS and those not affected by EDS. Methods: A retrospective chart review was conducted using the US collaborative network within TriNetX. The EDS group was defined by ICD-10 code G47.33, while the non-EDS group excluded any patients with an EDS diagnosis. Cohorts were matched by age, sex, and race using propensity score matching. Pathologies analyzed included hearing loss (ICD-10H90, H91), otitis media (ICD-10H66, H65), allergic rhinitis, acute tonsillitis (ICD-10 J03), sinusitis (ICD-10 J32, J01), and obstructive sleep apnea (OSA) (ICD-10 G47.33). Chi-square and relative risk within a 95 % confidence interval were calculated. Results: Propensity score matching yielded 6440 patients (male: N = 2,523, 39.2 %; female: N = 3,893, 60.5 %; unknown: N = 24, 0.37 %) with a mean age of 9.28 years (SD = 4.38). Children with EDS were 2.04 times more likely to be diagnosed with hearing loss, occurring in 286 (4.4 %) EDS children versus 140 (2.1 %) controls (P < 0.001). Children with EDS were 1.6 times more likely to be diagnosed with allergic rhinitis, occurring in 436 (6.8 %) EDS children versus 274 (4.2 %) controls (P < 0.001). Children with EDS were also 1.52 times (EDS: N = 350, 5.4 %; control: N = 231, 3.6 %) and 4.24 times (EDS: N = 335, 5.2 %; control: N = 79, 1.2 %) more likely to develop sinusitis and be diagnosed with OSA, respectively, compared to children without EDS (P < 0.001). However, children with EDS were only 0.71 times as likely to develop acute tonsillitis, with 101 (1.6 %) of EDS children compared to 142 (2.2 %) of control children being diagnosed (P = 0.009). No statistical difference was found in risk of developing otitis media. Conclusions: Children with EDS are at higher risk of developing hearing loss, allergic rhinitis, acute sinusitis, and OSA, possibly due to underlying immune dysfunction. Pediatric otolaryngologists should be vigilant about these otolaryngologic sequela in EDS patients.
Language	English
Publishing date	2024-04-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2024.111959
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 134: Show issues

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Article ; Online: Working with older adults impacts training preferences of counselors.

Schmidt, Nicholas E / Cottone, R Rocco / Steffen, Ann M

Gerontology & geriatrics education

2022 Volume 45, Issue 1, Page(s) 86–91

Abstract: Clinicians specializing in working with older adults make up a very small portion of providers, and the majority of the service provision falls on general practitioners. Licensed Professional Counselors (LPCs) have heavily focused on Multicultural ... ...

Abstract	Clinicians specializing in working with older adults make up a very small portion of providers, and the majority of the service provision falls on general practitioners. Licensed Professional Counselors (LPCs) have heavily focused on Multicultural Competency in training and practice, but the profession has not specified standards of competence for work with older adults. Efforts to increase competency for generalists providing care for older adults are needed. A random sampling of LPCs was surveyed regarding demographic variables, work characteristics, perceived competence for working with older adults, and interest in aging-specific continuing education (CE). About half of the sample reported engaging in practice with older adults over the previous year. Counselors who reported practicing with older adults over the last year were more interested in aging-specific CE and reported higher perceived competence for working with older adults.
MeSH term(s)	Humans ; Aged ; Counselors ; Geriatrics/education ; Education, Continuing ; Clinical Competence ; Surveys and Questionnaires
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	605726-3
ISSN	1545-3847 ; 0270-1960
ISSN (online)	1545-3847
ISSN	0270-1960
DOI	10.1080/02701960.2022.2139693
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Zs.A 1944: Show issues

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Article ; Online: Increases in preventable diseases due to antivaccination beliefs: Implications for schools.

Cottone, Dina M / McCabe, Paul C

School psychology (Washington, D.C.)

2022 Volume 37, Issue 4, Page(s) 319–329

Abstract: Human history is replete with pandemics caused by virulent diseases that have produced overwhelming suffering and death. Our future will require swift, sensible, and near-universal vaccine response as viruses evolve and thrive. When viruses like COVID-19, ...

Abstract	Human history is replete with pandemics caused by virulent diseases that have produced overwhelming suffering and death. Our future will require swift, sensible, and near-universal vaccine response as viruses evolve and thrive. When viruses like COVID-19, SARS-CoV-2 emerge and mutate, vaccine researchers must be nimble and responsive to quickly develop effective vaccines. However, averting a preventable disease and consequent pandemic also requires the participation of all members of society, and there remain a considerable number of individuals who refuse to accept vaccination as a safe and effective prophylaxis. This refusal stems from deeply rooted fears and values and is further reinforced by antivaccination propaganda circulating the internet and media. By considering the psychological underpinnings of antivaccination attitudes, vaccination advocates, scientists, and policy makers can adapt and target their vaccination campaigns to appeal to those with doubts and concerns about vaccines. Schools serve an important role in promoting and mandating vaccinations to help prevent disease, and vaccinations are vital in school settings where densely populated classrooms facilitate the propagation of disease. School administrators and school nurses have important roles in establishing vaccination requirements and ensuring compliance, and school psychologists and mental health staff can help address vaccination concerns, doubts, and fears among school staff, parents, and students. It is vital that scientists, health care providers, and school staff work collaboratively to communicate with families and children about vaccination and counter antivaccination narratives with emotionally compelling stories that promote vaccine uptake and prevent disease outbreaks. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
MeSH term(s)	COVID-19 ; Child ; Humans ; Pandemics ; SARS-CoV-2 ; Vaccination/psychology ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article
ISSN	2578-4226
ISSN (online)	2578-4226
DOI	10.1037/spq0000504
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Article: Improving the Design of Undergraduate Biology Courses toward the Goal of Retention: The Case of Real-World Inquiry and Active Learning through Metagenomics.

Cottone, Amanda M / Yoon, Susan

Journal of microbiology & biology education

2020 Volume 21, Issue 1

Abstract: Retention in science is low in undergraduate populations, especially for under-represented minority (URM) and first generation (FG) college students. Thus, educators have been called upon to design curricula to counteract this trend. This study examined ... ...

Abstract	Retention in science is low in undergraduate populations, especially for under-represented minority (URM) and first generation (FG) college students. Thus, educators have been called upon to design curricula to counteract this trend. This study examined variables most likely to lead to retention, such as increased achievement, improved attitudes, and self-efficacy beliefs, through participation in active learning and real-world research experiences in an introductory biology course. The research experience was embedded in metagenomics content and processes that have increasingly gained focus in microbiology. This study also investigated differences in learning outcomes when the curriculum was infused with more active learning. The active learning components included integrating interactive technology into the pre-lab lectures, providing students with authentic protocols to conduct lab work, and allowing students to rerun problematic samples. Results showed increased achievement for URM/FG students, although this was not strongly tied to the active learning elements incorporated into the three-week metagenomics research experience. However, students participating in research with more active learning did report higher frequencies of engaging in mastery experiences (an important source of self-efficacy) when compared with students engaged in research with less active learning. This analysis can aid in identifying specific curricular design features associated with promoting retention in undergraduate biology and science programs in general.
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.v21i1.1965
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Article: Weight Loss Effects of Glucagon-Like Peptide-One Receptor Analog Treatment in a Severely Obese Patient During Hospital Admission.

Figueredo, Yaiseli / Cottone, Claudia / Ferreira, Tanira / Gonzalez, Jesus / Iacobellis, Gianluca

Cureus

2023 Volume 15, Issue 1, Page(s) e34331

Abstract: ... 314 kg) with a body mass index (BMI) of 108 kg/m ...

Abstract	Obesity is considered an independent risk factor for increased hospital length of stay and can be an obstacle to a safe discharge. Although typically prescribed in the outpatient setting, initiating glucagon-like peptide-one receptor agonists (GLP-1RAs) in the inpatient setting can be efficacious in reducing weight and increasing functional status. We report the use of GLP-1RA therapy with liraglutide and subsequent transition to subcutaneous semaglutide weekly in a 37-year-old female with severe obesity, weighing 694 lbs (314 kg) with a body mass index (BMI) of 108 kg/m
Language	English
Publishing date	2023-01-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34331
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