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  1. Article: Heartland Virus Disease-An Underreported Emerging Infection.

    Dembek, Zygmunt F / Mothershead, Jerry L / Cirimotich, Christopher M / Wu, Aiguo

    Microorganisms

    2024  Volume 12, Issue 2

    Abstract: First recognized 15 years ago, Heartland virus disease (Heartland) is a tickborne infection contracted from the transmission of Heartland virus (HRTV) through tick bites from the lone star tick ( ...

    Abstract First recognized 15 years ago, Heartland virus disease (Heartland) is a tickborne infection contracted from the transmission of Heartland virus (HRTV) through tick bites from the lone star tick (
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Influence of Perfluoroalkyl Substances on Occurrence of Coronavirus Disease 2019.

    Dembek, Zygmunt F / Lordo, Robert A

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: Epidemiologic evidence indicates exposure to polyfluoroalkyl substances (PFAS) influences immunosuppression, with diminished vaccination response. The relationship between PFAS blood levels and coronavirus disease 2019 (COVID-19) occurrence by age ... ...

    Abstract Epidemiologic evidence indicates exposure to polyfluoroalkyl substances (PFAS) influences immunosuppression, with diminished vaccination response. The relationship between PFAS blood levels and coronavirus disease 2019 (COVID-19) occurrence by age warrants further examination. This assessment identified blood PFAS exposure levels in discrete populations. Recent PFAS population studies summarizing age and gender results were identified and included. Geographically corresponding COVID-19 incidence data were determined for selected counties in North Carolina (NC) and Ohio (OH), and the state of New Jersey (NJ). Centers for Disease Control and Prevention COVID-19 databases were accessed for national incidence data by age groupings. We assessed associations between blood PFAS concentrations, COVID-19 incidence rates, and key demographic characteristics, within subpopulations. COVID-19 incidence counts and blood PFAS concentration were obtained for each age group, along with estimated U.S. Census total population. A general trend observed is higher PFAS levels in older age groups. Younger age groups contained fewer COVID-19 cases. Global COVID-19 mortality is highest in elderly populations with hospitalization and death greatly increasing from age 50. PFAS exposures occurring early in life may cause deleterious health effects later in life, including decreased antibody response and reduced disease resistance. Highest levels of both PFAS exposure and COVID-19 were found in the oldest populations. While this does not determine causality, such associations should help promote further study.
    MeSH term(s) Aged ; Alkanesulfonic Acids ; COVID-19/epidemiology ; Environmental Pollutants ; Fluorocarbons ; Humans ; Middle Aged ; New Jersey ; North Carolina
    Chemical Substances Alkanesulfonic Acids ; Environmental Pollutants ; Fluorocarbons
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19095375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Psittacosis: An Underappreciated and Often Undiagnosed Disease.

    Dembek, Zygmunt F / Mothershead, Jerry L / Owens, Akeisha N / Chekol, Tesema / Wu, Aiguo

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: The bacterial ... ...

    Abstract The bacterial agent
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12091165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Influence of Perfluoroalkyl Substances on Occurrence of Coronavirus Disease 2019

    Zygmunt F. Dembek / Robert A. Lordo

    International Journal of Environmental Research and Public Health, Vol 19, Iss 5375, p

    2022  Volume 5375

    Abstract: Epidemiologic evidence indicates exposure to polyfluoroalkyl substances (PFAS) influences immunosuppression, with diminished vaccination response. The relationship between PFAS blood levels and coronavirus disease 2019 (COVID-19) occurrence by age ... ...

    Abstract Epidemiologic evidence indicates exposure to polyfluoroalkyl substances (PFAS) influences immunosuppression, with diminished vaccination response. The relationship between PFAS blood levels and coronavirus disease 2019 (COVID-19) occurrence by age warrants further examination. This assessment identified blood PFAS exposure levels in discrete populations. Recent PFAS population studies summarizing age and gender results were identified and included. Geographically corresponding COVID-19 incidence data were determined for selected counties in North Carolina (NC) and Ohio (OH), and the state of New Jersey (NJ). Centers for Disease Control and Prevention COVID-19 databases were accessed for national incidence data by age groupings. We assessed associations between blood PFAS concentrations, COVID-19 incidence rates, and key demographic characteristics, within subpopulations. COVID-19 incidence counts and blood PFAS concentration were obtained for each age group, along with estimated U.S. Census total population. A general trend observed is higher PFAS levels in older age groups. Younger age groups contained fewer COVID-19 cases. Global COVID-19 mortality is highest in elderly populations with hospitalization and death greatly increasing from age 50. PFAS exposures occurring early in life may cause deleterious health effects later in life, including decreased antibody response and reduced disease resistance. Highest levels of both PFAS exposure and COVID-19 were found in the oldest populations. While this does not determine causality, such associations should help promote further study.
    Keywords polyfluoroalkyl substances ; PFAS ; PFOA ; PFOS ; COVID-19 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Informing COVID-19 Response and Health Equity Agenda: Collection of

    Harada, Noelle M / Kuzmichev, Andrey / Dembek, Zygmunt F / Ising, Amy I / Dean, Hazel D

    Public health reports (Washington, D.C. : 1974)

    2023  Volume 138, Issue 2, Page(s) 208–217

    Abstract: Objective: Public Health Reports: Methods: We searched databases from 1878 through 2021 using custom search strings and conducted a manual search for articles published under previously used names for : Results: We identified 349 relevant articles ...

    Abstract Objective: Public Health Reports
    Methods: We searched databases from 1878 through 2021 using custom search strings and conducted a manual search for articles published under previously used names for
    Results: We identified 349 relevant articles including 130 commentaries/reviews/editorials, 79 epidemiologic reports, 75 research articles, and 65 case study/practice articles. The collection focused on influenza (n = 244), COVID-19 (n = 75), dengue (n = 14), and other emerging viruses, such as Zika and Ebola (n = 25). The collection included 48 articles on health disparities/health of various disadvantaged populations, highlighting such disparities as race and ethnicity (n = 22), socioeconomic status (n = 17), and age (n = 15). When we categorized articles by CDC public health emergency preparedness and response capabilities, we found that 207 addressed surveillance and epidemiologic investigation, 36 addressed community preparedness, and 28 addressed medical countermeasure dispensing and administration. The articles addressing surveillance and epidemiologic investigation, nonpharmaceutical interventions, and community preparedness had the most PubMed citations (799, 334, and 308, respectively).
    Conclusions: PHR
    MeSH term(s) Humans ; United States/epidemiology ; Public Health ; COVID-19/epidemiology ; Health Equity ; Pandemics/prevention & control ; Virus Diseases ; Zika Virus ; Zika Virus Infection
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120953-x
    ISSN 1468-2877 ; 0033-3549
    ISSN (online) 1468-2877
    ISSN 0033-3549
    DOI 10.1177/00333549221148782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Psittacosis

    Zygmunt F. Dembek / Jerry L. Mothershead / Akeisha N. Owens / Tesema Chekol / Aiguo Wu

    Pathogens, Vol 12, Iss 1165, p

    An Underappreciated and Often Undiagnosed Disease

    2023  Volume 1165

    Abstract: The bacterial agent Chlamydia psittaci , and the resulting disease of psittacosis, is a little-known and underappreciated infectious disease by healthcare practitioners and in public health in general. C. psittaci infections can cause significant ... ...

    Abstract The bacterial agent Chlamydia psittaci , and the resulting disease of psittacosis, is a little-known and underappreciated infectious disease by healthcare practitioners and in public health in general. C. psittaci infections can cause significant psittacosis outbreaks, with person-to-person transmission documented in the last decade. In this publication, we review the pathogen and its disease, as well as examine the potential for genetic manipulation in this organism to create a more deadly pathogen. Recent disease surveys indicate that currently, the highest incidences of human disease exist in Australia, Germany and the UK. We recommend the universal public health reporting of C. psittaci and psittacosis disease and increasing the promotion of public health awareness.
    Keywords psittacosis ; Chlamydia psittaci ; chlamydia ; Category B pathogen ; Medicine ; R
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A message from the editor.

    Dembek, Zygmunt F

    Public health reports (Washington, D.C. : 1974)

    2013  Volume 128, Issue 6, Page(s) 433

    MeSH term(s) Accidents, Traffic/mortality ; Attention ; Automobile Driving/psychology ; Child ; Child, Preschool ; Female ; Food Assistance ; Healthcare Disparities ; Humans ; Infant ; Infant, Newborn ; Lead Poisoning/prevention & control ; Male
    Language English
    Publishing date 2013-10-31
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 120953-x
    ISSN 1468-2877 ; 0033-3549
    ISSN (online) 1468-2877
    ISSN 0033-3549
    DOI 10.1177/003335491312800601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Preclinical Evidence for the Role of Botulinum Neurotoxin A (BoNT/A) in the Treatment of Peripheral Nerve Injury.

    Adler, Michael / Pellett, Sabine / Sharma, Shashi K / Lebeda, Frank J / Dembek, Zygmunt F / Mahan, Mark A

    Microorganisms

    2022  Volume 10, Issue 5

    Abstract: Traumatic peripheral nerve injuries tend to be more common in younger, working age populations and can lead to long-lasting disability. Peripheral nerves have an impressive capacity to regenerate; however, successful recovery after injury depends on a ... ...

    Abstract Traumatic peripheral nerve injuries tend to be more common in younger, working age populations and can lead to long-lasting disability. Peripheral nerves have an impressive capacity to regenerate; however, successful recovery after injury depends on a number of factors including the mechanism and severity of the trauma, the distance from injury to the reinnervation target, connective tissue sheath integrity, and delay between injury and treatment. Even though modern surgical procedures have greatly improved the success rate, many peripheral nerve injuries still culminate in persistent neuropathic pain and incomplete functional recovery. Recent studies in animals suggest that botulinum neurotoxin A (BoNT/A) can accelerate nerve regeneration and improve functional recovery after injury to peripheral nerves. Possible mechanisms of BoNT/A action include activation or proliferation of support cells (Schwann cells, mast cells, and macrophages), increased angiogenesis, and improvement of blood flow to regenerating nerves.
    Language English
    Publishing date 2022-04-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10050886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Systems Perspective of DoD Global Health Engagement.

    Lebeda, Frank J / Scheerer, Julia B / Dembek, Zygmunt F

    Military medicine

    2020  Volume 185, Issue 7-8, Page(s) e1024–e1031

    Abstract: Introduction: A systems perspective was used to describe U.S. Department of Defense (DoD) Global Health Engagement (GHE). This description was based on DoD instructions and higher-level documents related to DoD GHE. A complex system of systems such as ... ...

    Abstract Introduction: A systems perspective was used to describe U.S. Department of Defense (DoD) Global Health Engagement (GHE). This description was based on DoD instructions and higher-level documents related to DoD GHE. A complex system of systems such as health care can benefit from using modeling approaches to help understand the interactions among major components. Models (conceptual, computer-based programs, realistic simulations, or training exercises) can be used to help stakeholders prioritize options and to identify important components and gaps for making performance improvements. Based on the cited documents, we identified major DoD GHE components to create a conceptual model.
    Materials and methods: Components were selected from DoDI 2000.30 for DoD GHE. Definitions of these interacting components are given and assigned to our network model that consists of three levels: strategic, operational, and tactical. These levels are linked by critical nodes (decision points) that allow feedback to previous levels for modifying appropriate components. A network that is reminiscent of this structure is Boyd's observe-orient-decision-act diagram. Acceptable strategic and operational plans are linked to the tactical level. Acceptable tactical components lead to the desired outcome of accomplishing the DoD GHE goals. Complex systems also have feedback loops to allow for component evaluations and modifications. Accomplishing DoD GHE goals need to have adaptable components in dynamic permissive environments.
    Results: The network that we considered is multicomponent and interdisciplinary. The network uses DoD GHE goals as the input (observing in the observe-orient-decide-act loop) to provide relevant information. It consists of three levels of adaptable, interacting (orienting) components that are linked by critical nodes (decision points) involving the evaluation of plans and desired outcomes. Strategic components (eg, sharing, personal interactions, agreements, planning, readiness, etc.) are required to develop strategic plans, the first critical node. If these plans are acceptable, the information is passed on (feed forward, action) to the operational components (define problems, understand strategic direction and guidance, understand the operational environment, etc.). At the second critical node, the decision is made about moving the operational plans to the tactical components (eg, evaluation, data, training, etc.). Tactical components are essential to provide further information to the third critical node, desired outcomes, in accomplishing DoD GHE goals. Feedback from all critical nodes is essential to allow modifications of various components and to attain health-related interoperability in supporting security policies and military strategies.
    Conclusions: Examining the composition of DoD GHE and creating a defined model can help identify interacting features of this complex system. All of the identified components have been associated with gaps, such as the need for monitoring and measuring tools, and standards. The current state of this system is dynamic and is evolving when confronting gaps. DoD GHE represents an intersection of global health and security in supporting U.S. national security objectives by establishing access and influence with partner nations and among health care-related government and non-government organizations, and as a result, improves the readiness, health, and safety of our military personnel.
    MeSH term(s) Global Health ; Humans ; Military Personnel ; Security Measures
    Language English
    Publishing date 2020-05-12
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usz461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Opioid Epidemic: Challenge to Military Medicine and National Security.

    Dembek, Zygmunt F / Chekol, Tesema / Wu, Aiguo

    Military medicine

    2020  Volume 185, Issue 5-6, Page(s) e662–e667

    Abstract: Introduction: We examine the current status of the military relevance of opioids, their use and misuse in military and veteran populations, the national security consequences of opioid use in our military age population, public health implications, and ... ...

    Abstract Introduction: We examine the current status of the military relevance of opioids, their use and misuse in military and veteran populations, the national security consequences of opioid use in our military age population, public health implications, and military, veteran, and government solutions for opioid addiction.
    Materials and methods: A literature search of recent published research, federal government, and related open source materials was conducted using PubMed, Google, and Google Scholar, and all materials retrieved were manually identified, screened, and evaluated for inclusion. A modified Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach was used for the selection of relevant articles. Heath policy literature and relevant demographic information published within the last 5 years was also included to provide current information and search for solutions to address the escalating national opioid crisis.
    Results: Synthetic opioids are used for pain and trauma management, not readily substituted, and have exceptionally high addiction potential. Combat wounded veterans have greater potential for opioid misuse than civilian populations. Assessment, management, and treatment of opioid use in this population are essential. Veterans receiving synthetic opioids have been noted to have multiple overdose risk factors. Opioids are readily available nationally as "street drugs" and also in the form of fentanyl-contaminated heroin. The opioid crisis affects the military age population and the top states for military enlistments. Younger age males with lower education and income are at significant risk for opioid use disorder. Recently increased drug overdose deaths contribute to an increased U.S. mortality rate with a commensurate decline in life expectancy at birth. Opioid abuse contributes to increased incidence of infectious disease. Behavioral health programs directed at military and veterans to identify risk factors for opioid misuse have been introduced. Prescription drug monitoring initiatives continue for these populations with increased information exchanged between military and civilian healthcare. Lifesaving interventions for opioid addiction include methadone maintenance and fentanyl test strip accessibility. Newly implemented federal funding healthcare initiatives to the states are now directed at opioid use prevention and enhanced surveillance.
    Conclusions: Given increasing rates of opioid addiction and death, viable solutions are universally needed. Successful intervention measures should be widely shared between military, veteran, and civilian healthcare and public health communities. Increased collaboration between these groups could inculcate successful programs to prevent and decrease opioid use. Results received from recent military and veterans' programs for prescription and electronic medical record (EMR) monitoring and data sharing may also prove useful for civilian healthcare providers and hospital systems. Future evaluations from ongoing federally funded programs to the states for addiction surveillance and intervention may help create measures to address the proliferation of opioid addiction with increased death rates. Anticipated results from these federal efforts should help inform opioid programs in military and veterans' health systems.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Drug Overdose/drug therapy ; Drug Overdose/epidemiology ; Humans ; Male ; Military Medicine ; Opioid Epidemic ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Security Measures ; United States/epidemiology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2020-02-20
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usz487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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