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  1. Article ; Online: Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid.

    Tsiailanis, Antonis D / Renziehausen, Alexander / Kiriakidi, Sofia / Vrettos, Eirinaios I / Markopoulos, Georgios S / Sayyad, Nisar / Hirmiz, Baydaa / Aguilar, Marie-Isabel / Del Borgo, Mark P / Kolettas, Evangelos / Widdop, Robert E / Mavromoustakos, Thomas / Crook, Tim / Syed, Nelofer / Tzakos, Andreas G

    Free radical biology & medicine

    2020  Volume 160, Page(s) 391–402

    Abstract: Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Maximal surgical resection followed by radiotherapy and concomitant chemotherapy with temozolomide remains the first-line therapy, prolonging the survival of ... ...

    Abstract Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Maximal surgical resection followed by radiotherapy and concomitant chemotherapy with temozolomide remains the first-line therapy, prolonging the survival of patients by an average of only 2.5 months. There is therefore an urgent need for novel therapeutic strategies to improve clinical outcomes. Reactive oxygen species (ROS) are an important contributor to GBM development. Here, we describe the rational design and synthesis of a stable hybrid molecule tethering two ROS regulating moieties, with the aim of constructing a chemopreventive and anticancer chemical entity that retains the properties of the parent compounds. We utilized the selective AT
    MeSH term(s) Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Humans ; Losartan ; Quercetin/pharmacology ; Temozolomide/pharmacology
    Chemical Substances Quercetin (9IKM0I5T1E) ; Losartan (JMS50MPO89) ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2020.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.

    Chavdoula, Evangelia / Habiel, David M / Roupakia, Eugenia / Markopoulos, Georgios S / Vasilaki, Eleni / Kokkalis, Antonis / Polyzos, Alexander P / Boleti, Haralabia / Thanos, Dimitris / Klinakis, Apostolos / Kolettas, Evangelos / Marcu, Kenneth B

    Life science alliance

    2019  Volume 2, Issue 6

    Abstract: Through the progressive accumulation of genetic and epigenetic alterations in cellular physiology, non-small-cell lung cancer (NSCLC) evolves in distinct steps involving mutually exclusive oncogenic mutations in K-Ras or EGFR along with inactivating ... ...

    Abstract Through the progressive accumulation of genetic and epigenetic alterations in cellular physiology, non-small-cell lung cancer (NSCLC) evolves in distinct steps involving mutually exclusive oncogenic mutations in K-Ras or EGFR along with inactivating mutations in the p53 tumor suppressor. Herein, we show two independent in vivo lung cancer models in which CHUK/IKK-α acts as a major NSCLC tumor suppressor. In a novel transgenic mouse strain, wherein IKKα ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, IKKα loss increases the number and size of lung adenomas in response to the chemical carcinogen urethane, whereas IKK-β instead acts as a tumor promoter in this same context. IKKα knockdown in three independent human NSCLC lines (independent of K-Ras or p53 status) enhances their growth as tumor xenografts in immune-compromised mice. Bioinformatics analysis of whole transcriptome profiling followed by quantitative protein and targeted gene expression validation experiments reveals that IKKα loss can result in the up-regulation of activated HIF-1-α protein to enhance NSCLC tumor growth under hypoxic conditions in vivo.
    MeSH term(s) Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Animals ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; ErbB Receptors/genetics ; Female ; Gene Expression Profiling ; Heterografts ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; I-kappa B Kinase/deficiency ; I-kappa B Kinase/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Up-Regulation ; ras Proteins/genetics
    Chemical Substances HIF1A protein, human ; Hif1a protein, mouse ; Hypoxia-Inducible Factor 1, alpha Subunit ; ErbB Receptors (EC 2.7.10.1) ; CHUK protein, human (EC 2.7.11.10) ; Chuk protein, mouse (EC 2.7.11.10) ; I-kappa B Kinase (EC 2.7.11.10) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.201900460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Influence of apnoeic oxygenation in respiratory and circulatory system under general anaesthesia.

    Kolettas, Alexander / Grosomanidis, Vasilis / Kolettas, Vasilis / Zarogoulidis, Paul / Tsakiridis, Kosmas / Katsikogiannis, Nikolaos / Tsiouda, Theodora / Kiougioumtzi, Ioanna / Machairiotis, Nikolaos / Drylis, Georgios / Kesisis, Georgios / Beleveslis, Thomas / Zarogoulidis, Konstantinos

    Journal of thoracic disease

    2012  Volume 6 Suppl 1, Page(s) S116–45

    Abstract: Apnoeic oxygenation is an alternative technique of oxygenation which is recommended in the consecutive oxygen administration with varying flows (2-10 lt/min) through a catheter which is positioned over the keel of the trachea. Apnoeic oxygenation ... ...

    Abstract Apnoeic oxygenation is an alternative technique of oxygenation which is recommended in the consecutive oxygen administration with varying flows (2-10 lt/min) through a catheter which is positioned over the keel of the trachea. Apnoeic oxygenation maintains for a significant period of time the oxygenation of blood in breathless conditions. This technique was first applied in 1947 by Draper, Whitehead, and Spencer and it was studied sporadically by other inventors too. However, the international literature shows few studies that have examined closely apnoeic oxygenation and its effects on Hemodynamic image and the respiratory system of the human body. Recently they have begun to arise some studies which deal with the application of this technique in several conditions such as difficult tracheal intubation, ventilation of guinea pigs in campaign conditions where the oxygen supply is limited and calculable, the application of this technique in combination with the use of extracorporeal removal of carbon dioxide (CO2). All the above indicate, the clinical use of this technique.
    Language English
    Publishing date 2012-06-13
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.3978/j.issn.2072-1439.2014.01.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): current literature review.

    Papaiwannou, Antonis / Zarogoulidis, Paul / Porpodis, Konstantinos / Spyratos, Dionysios / Kioumis, Ioannis / Pitsiou, Georgia / Pataka, Athanasia / Tsakiridis, Kosmas / Arikas, Stamatis / Mpakas, Andreas / Tsiouda, Theodora / Katsikogiannis, Nikolaos / Kougioumtzi, Ioanna / Machairiotis, Nikolaos / Siminelakis, Stavros / Kolettas, Alexander / Kessis, George / Beleveslis, Thomas / Zarogoulidis, Konstantinos

    Journal of thoracic disease

    2014  Volume 6 Suppl 1, Page(s) S146–51

    Abstract: Asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases, very common in general population. These obstructive airway illnesses are manifested with chronic inflammation affecting the whole respiratory tract. Obstruction is usually ... ...

    Abstract Asthma and chronic obstructive pulmonary disease (COPD) are chronic diseases, very common in general population. These obstructive airway illnesses are manifested with chronic inflammation affecting the whole respiratory tract. Obstruction is usually intermittent and reversible in asthma, but is progressive and irreversible in COPD. Asthma and COPD may overlap and converge, especially in older people [overlap syndrome-asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)]. Although ACOS accounts approximately 15-25% of the obstructive airway diseases, is not well recognised because of the structure of clinical trials. COPD studies exclude asthma patients and asthma studies exclude COPD patients, respectively. It is crucial to define asthma, COPD and overlap syndrome (ACOS), as notable clinical entities, which they share common pathologic and functional features, but they are characterized from differences in lung function, acute exacerbations, quality of life, hospital impact and mortality.
    Language English
    Publishing date 2014-01-15
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.3978/j.issn.2072-1439.2014.03.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Epithelial-myoepithelial carcinoma of the trachea-a rare entity case report.

    Konoglou, Maria / Cheva, Aggeliki / Zarogoulidis, Paul / Porpodis, Konstantinos / Pataka, Athanasia / Mpaliaka, Aggeliki / Papaiwannou, Antonios / Zarogoulidis, Konstantinos / Kontakiotis, Theodoros / Karaiskos, Theodoros / Kesisis, Georgios / Kolettas, Alexander / Giouleka, Alina / Madesis, Athanasios / Vretzakis, George / Sakkas, Leonidas / Tsakiridis, Kosmas

    Journal of thoracic disease

    2012  Volume 6 Suppl 1, Page(s) S194–9

    Abstract: Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. Epithelial-myoepithelial carcinoma (EMCa) is a low-grade malignant tumour. According to literature, most commonly ... ...

    Abstract Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. Epithelial-myoepithelial carcinoma (EMCa) is a low-grade malignant tumour. According to literature, most commonly occurs in salivary glands, particularly in parotic gland, but it can also occur in unusual locations such as breast, lachrymal gland, nose, paranasal sinus, lung, bronchus and, as in our case, trachea. There are no many documented case reports of a primary myoepithelial carcinoma in the trachea. We report a case of a 34-year-old man diagnosed with this unusual location of an epithelial-myoepithelial tumor. The tumour was removed by segmental tracheal resection and end-to-end anastomosis.
    Language English
    Publishing date 2012-06-13
    Publishing country China
    Document type Case Reports
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.3978/j.issn.2072-1439.2013.11.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Preoperative evaluation for lung cancer resection.

    Spyratos, Dionysios / Zarogoulidis, Paul / Porpodis, Konstantinos / Angelis, Nikolaos / Papaiwannou, Antonios / Kioumis, Ioannis / Pitsiou, Georgia / Pataka, Athanasia / Tsakiridis, Kosmas / Mpakas, Andreas / Arikas, Stamatis / Katsikogiannis, Nikolaos / Kougioumtzi, Ioanna / Tsiouda, Theodora / Machairiotis, Nikolaos / Siminelakis, Stavros / Argyriou, Michael / Kotsakou, Maria / Kessis, George /
    Kolettas, Alexander / Beleveslis, Thomas / Zarogoulidis, Konstantinos

    Journal of thoracic disease

    2012  Volume 6 Suppl 1, Page(s) S162–6

    Abstract: During the last decades lung cancer is the leading cause of death worldwide for both sexes. Even though cigarette smoking has been proved to be the main causative factor, many other agents (e.g., occupational exposure to asbestos or heavy metals, indoor ... ...

    Abstract During the last decades lung cancer is the leading cause of death worldwide for both sexes. Even though cigarette smoking has been proved to be the main causative factor, many other agents (e.g., occupational exposure to asbestos or heavy metals, indoor exposure to radon gas radiation, particulate air pollution) have been associated with its development. Recently screening programs proved to reduce mortality among heavy-smokers although establishment of such strategies in everyday clinical practice is much more difficult and unknown if it is cost effective compared to other neoplasms (e.g., breast or prostate cancer). Adding severe comorbidities (coronary heart disease, COPD) to the above reasons as cigarette smoking is a common causative factor, we could explain the low surgical resection rates (approximately 20-30%) for lung cancer patients. Three clinical guidelines reports of different associations have been published (American College of Chest Physisians, British Thoracic Society and European Respiratory Society/European Society of Thoracic Surgery) providing detailed algorithms for preoperative assessment. In the current mini review, we will comment on the preoperative evaluation of lung cancer patients.
    Language English
    Publishing date 2012-06-13
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.3978/j.issn.2072-1439.2014.03.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Ageing research in Greece.

    Gonos, E S / Agrafiotis, D / Dontas, A S / Efthimiopoulos, S / Galaris, D / Karamanos, N K / Kletsas, D / Kolettas, E / Panayotou, G / Pratsinis, H / Sekeri-Pataryas, K E / Simoes, D / Sourlingas, T G / Stathakos, D / Stratigos, A J / Tavernarakis, N / Trougakos, I P / Tsiganos, C P / Vynios, D H

    Experimental gerontology

    2002  Volume 37, Issue 6, Page(s) 735–747

    Abstract: ... at the University of Patras; (f) proteomic studies at the Biomedical Sciences Research Center Alexander Fleming; (g ...

    Abstract Ageing research in Greece is well established. Research groups located in universities, research institutes or public hospitals are studying various and complementary aspects of ageing. These research activities include (a) functional analysis of Clusterin/Apolipoprotein J, studies in healthy centenarians and work on protein degradation and the role of proteasome during senescence at the National Hellenic Research Foundation; (b) regulation of cell proliferation and tissue formation, a nationwide study of determinants and markers of successful ageing in Greek centenarians and studies of histone gene expression and acetylation at the National Center for Scientific Research, Demokritos; (c) work on amyloid precursor protein and Presenilin 1 at the University of Athens; (d) oxidative stress-induced DNA damage and the role of oncogenes in senescence at the University of Ioannina; (e) studies in the connective tissue at the University of Patras; (f) proteomic studies at the Biomedical Sciences Research Center Alexander Fleming; (g) work on Caenorhabditis elegans at the Foundation for Research and Technology; (h) the role of ultraviolet radiation in skin ageing at Andreas Sygros Hospital; (i) follow-up studies in healthy elderly at the Athens Home for the Aged; and (j) socio-cultural aspects of ageing at the National School of Public Health. These research activities are well recognized by the international scientific community as it is evident by the group's very good publication records as well as by their direct funding from both European Union and USA. This article summarizes these research activities and discuss future directions and efforts towards the further development of the ageing field in Greece.
    MeSH term(s) Aging ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Caenorhabditis elegans ; DNA Damage ; Greece ; Histones/genetics ; Histones/metabolism ; Humans ; Membrane Proteins/metabolism ; Oxidative Stress ; Presenilin-1 ; Research/organization & administration
    Chemical Substances Amyloid beta-Protein Precursor ; Histones ; Membrane Proteins ; PSEN1 protein, human ; Presenilin-1
    Language English
    Publishing date 2002-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 390992-x
    ISSN 0531-5565
    ISSN 0531-5565
    DOI 10.1016/s0531-5565(02)00017-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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