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Article ; Online: Oral fluoroquinolones and the risk of Achilles tendon rupture.

Rasmussen, Peter Vibe / Strange, Jarl Emanuel / Holt, Anders

2024

Language	English
Publishing date	2024-04-02
Publishing country	China
Document type	Letter
ZDB-ID	2673028-5
ISSN	2213-2961 ; 2095-2546
ISSN (online)	2213-2961
ISSN	2095-2546
DOI	10.1016/j.jshs.2024.04.001
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Article ; Online: On logistic regression with right censored data, with or without competing risks, and its use for estimating treatment effects.

Blanche, Paul Frédéric / Holt, Anders / Scheike, Thomas

Lifetime data analysis

2022 Volume 29, Issue 2, Page(s) 441–482

Abstract: Simple logistic regression can be adapted to deal with right-censoring by inverse probability of censoring weighting (IPCW). We here compare two such IPCW approaches, one based on weighting the outcome, the other based on weighting the estimating ... ...

Abstract	Simple logistic regression can be adapted to deal with right-censoring by inverse probability of censoring weighting (IPCW). We here compare two such IPCW approaches, one based on weighting the outcome, the other based on weighting the estimating equations. We study the large sample properties of the two approaches and show that which of the two weighting methods is the most efficient depends on the censoring distribution. We show by theoretical computations that the methods can be surprisingly different in realistic settings. We further show how to use the two weighting approaches for logistic regression to estimate causal treatment effects, for both observational studies and randomized clinical trials (RCT). Several estimators for observational studies are compared and we present an application to registry data. We also revisit interesting robustness properties of logistic regression in the context of RCTs, with a particular focus on the IPCW weighting. We find that these robustness properties still hold when the censoring weights are correctly specified, but not necessarily otherwise.
MeSH term(s)	Humans ; Logistic Models ; Probability ; Causality ; Models, Statistical ; Computer Simulation
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1479719-7
ISSN	1572-9249 ; 1380-7870
ISSN (online)	1572-9249
ISSN	1380-7870
DOI	10.1007/s10985-022-09564-6
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Article ; Online: High-dose vitamin D

Wall-Gremstrup, Gustav / Holt, Rune / Yahyavi, Sam Kafai / Jorsal, Mads Joon / Juul, Anders / Jørgensen, Niels / Blomberg Jensen, Martin

Respiratory research

2024 Volume 25, Issue 1, Page(s) 11

Abstract: Background: Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has been associated with incidence and ...

Abstract	Background: Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has been associated with incidence and prognosis of some respiratory tract infections (RTI). Therefore, we investigated the effect of vitamin D Methods: A double-blinded, randomized, placebo-controlled clinical trial of 307 infertile men with multiple secondary immunological endpoints. The vitamin D Results: At baseline, stratification into clinically relevant groups of vitamin D status (< 25; 25-50; 50-75; >75 nmol/L), showed an inverse association with total leucocyte concentrations (7.0 vs. 6.0 vs. 6.0 vs. 5.5 (10 Conclusions: High-dose vitamin D Trial registration: NCT01304927 (ClinicalTrials.gov). Registered February 20, 2011.
MeSH term(s)	Male ; Humans ; Cholecalciferol ; Acute-Phase Proteins/therapeutic use ; Dietary Supplements ; Vitamin D ; Vitamin D Deficiency ; Leukocyte Count ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/epidemiology ; Double-Blind Method
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Acute-Phase Proteins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02642-9
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Article ; Online: Low-serum antimüllerian hormone is linked with poor semen quality in infertile men screened for participation in a randomized controlled trial.

Holt, Rune / Yahyavi, Sam Kafai / Wall-Gremstrup, Gustav / Jorsal, Mads Joon / Toft, Frederikke Bay / Jørgensen, Niels / Juul, Anders / Blomberg Jensen, Martin

Fertility and sterility

2024

Abstract: Objective: To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have ... ...

Abstract	Objective: To investigate possible associations between serum antimüllerian hormone (AMH) concentration and semen quality in infertile men. Studies investigating the associations between serum AMH concentration and semen quality in infertile men have shown conflicting results. Design: Infertile men were included during screening for participation in the First in Treating Male Infertility Study, a double-blinded, placebo-controlled, 1:1, single-center randomized controlled trial. Setting: Not applicable. Patients: At the screening visit, 400 participants produced a semen sample and had their serum analyzed for AMH concentration. Intervention: Not applicable. Main outcome measures: Serum AMH concentration and semen quality. Results: All men were stratified according to serum AMH concentrations in quartiles (Q1-Q4). Men in the lowest quartile had a lower sperm concentration (1 × 10 Conclusion: This study shows that low serum AMH concentration is associated with poor semen quality in infertile men, which implies that serum AMH concentration may have clinical value during the evaluation of male infertility. Clinical trial registration number: NCT05212337.
Language	English
Publishing date	2024-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2024.03.018
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Article ; Online: Temporal changes in myocardial infarction diagnostic criteria do not account for the lack of long-term beta-blocker effect on cardiovascular prognosis.

Holt, Anders / Blanche, Paul / McGettigan, Patricia / Lamberts, Morten

European heart journal

2021 Volume 43, Issue 8, Page(s) 836–838

MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Humans ; Myocardial Infarction/diagnosis ; Prognosis
Chemical Substances	Adrenergic beta-Antagonists
Language	English
Publishing date	2021-05-11
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehab260
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Article ; Online: Gait function improvements, using Cardiff Classifier, are related to patient-reported function and pain following hip arthroplasty.

Biggs, Paul / Holsgaard-Larsen, Anders / Holt, Cathy A / Naili, Josefine E

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2021 Volume 40, Issue 5, Page(s) 1182–1193

Abstract: Summarizing results of three-dimensional (3D) gait analysis into a comprehensive measure of overall gait function is valuable to discern to what extent gait function is affected, and later recovered after surgery and rehabilitation. This study aimed to ... ...

Abstract	Summarizing results of three-dimensional (3D) gait analysis into a comprehensive measure of overall gait function is valuable to discern to what extent gait function is affected, and later recovered after surgery and rehabilitation. This study aimed to investigate whether preoperative gait function, quantified and summarized using the Cardiff Classifier, can predict improvements in postoperative patient-reported activities of daily living, and overall gait function 1 year after total hip arthroplasty (THA). Secondly, to explore relationships between pre-to-post surgical change in gait function versus changes in patient-reported and performance-based function. Thirty-two patients scheduled for THA and 25 nonpathological individuals were included in this prospective cohort study. Patients were evaluated before THA and 1 year postoperatively using 3D gait analysis, patient-reported outcomes, and performance-based tests. Kinematic and kinetic gait parameters, derived from 3D gait analysis, were quantified using the Cardiff Classifier. Linear regressions investigated the predictive value of preoperative gait function on postoperative outcomes of function, and univariate correlations explored relationships between pre-to-post surgical changes in outcome measures. Preoperative gait function, by means of Cardiff Classifier, explained 35% and 30% of the total variance in change in patient-reported activities of daily living, and in gait function, respectively. Moderate-to-strong correlations were found between change in gait function and change in patient-reported function and pain, while no correlations were found between change in gait function and performance-based function. Clinical significance: Preoperative gait function predicts postsurgical function to a moderate degree, while improvements in gait function after surgery are more closely related to how patients perceive function than their maximal performance of functional tests.
MeSH term(s)	Activities of Daily Living ; Arthroplasty, Replacement, Hip/methods ; Gait ; Humans ; Osteoarthritis, Hip ; Pain ; Patient Reported Outcome Measures ; Prospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-08-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.25149
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Article ; Online: [No title information]

Andelius, Dea Kejlberg / Jessen, Nanna Holt / Løkke, Anders / Nielsen, Rasmus Østergaard / Jacobsen, Julie Sandell

Ugeskrift for laeger

2023 Volume 185, Issue 42

Abstract: Patients suffering from COPD are often treated with a substantial number of medications due to multimorbidity. The combination of multimorbidity and polypharmacy can make the treatment of individuals with COPD difficult. Although guidelines in recent ... ...

Title translation	Social prescribing to reduce polypharmacy in patients with COPD in general practice.
Abstract	Patients suffering from COPD are often treated with a substantial number of medications due to multimorbidity. The combination of multimorbidity and polypharmacy can make the treatment of individuals with COPD difficult. Although guidelines in recent years have focused on the reduction of inappropriate medication, there is still room for improvement. This review suggests an increased focus on smoking cessation and physical activity in terms of the use of social prescribing to prevent polypharmacy and thereby improve sustainability in patients with COPD.
MeSH term(s)	Humans ; Inappropriate Prescribing/prevention & control ; Polypharmacy ; Drug-Related Side Effects and Adverse Reactions ; Pulmonary Disease, Chronic Obstructive/drug therapy ; General Practice
Language	Danish
Publishing date	2023-10-23
Publishing country	Denmark
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: The Reply.

Holt, Anders / Strange, Jarl E / Nouhravesh, Nina / McGettigan, Patricia / Lamberts, Morten

The American journal of medicine

2022 Volume 135, Issue 10, Page(s) e407–e408

Language	English
Publishing date	2022-09-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.06.008
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Article ; Online: The effect of discontinuing beta-blockers after different treatment durations following acute myocardial infarction in optimally treated, stable patients without heart failure: a Danish, nationwide cohort study.

Halili, Andrim / Holt, Anders / Eroglu, Talip E / Haxha, Saranda / Zareini, Bochra / Torp-Pedersen, Christian / Bang, Casper N

European heart journal. Cardiovascular pharmacotherapy

2023 Volume 9, Issue 6, Page(s) 553–561

Abstract: Aims: We studied the effect of discontinuing beta-blockers following myocardial infarction in comparison to continuous beta-blocker use in optimally treated, stable patients without heart failure.: Methods and results: Using nationwide registers, we ... ...

Abstract	Aims: We studied the effect of discontinuing beta-blockers following myocardial infarction in comparison to continuous beta-blocker use in optimally treated, stable patients without heart failure. Methods and results: Using nationwide registers, we identified first-time myocardial infarction patients treated with beta-blockers following percutaneous coronary intervention or coronary angiography. The analysis was based on landmarks selected as 1, 2, 3, 4, and 5 years after the first redeemed beta-blocker prescription date. The outcomes included all-cause death, cardiovascular death, recurrent myocardial infarction, and a composite outcome of cardiovascular events and procedures. We used logistic regression and reported standardized absolute 5-year risks and risk differences at each landmark year. Among 21 220 first-time myocardial infarction patients, beta-blocker discontinuation was not associated with an increased risk of all-cause death, cardiovascular death, or recurrent myocardial infarction compared with patients continuing beta-blockers (landmark year 5; absolute risk difference [95% confidence interval]), correspondingly; -4.19% [-8.95%; 0.57%], -1.18% [-4.11%; 1.75%], and -0.37% [-4.56%; 3.82%]). Further, beta-blocker discontinuation within 2 years after myocardial infarction was associated with an increased risk of the composite outcome (landmark year 2; absolute risk [95% confidence interval] 19.87% [17.29%; 22.46%]) compared with continued beta-blocker use (landmark year 2; absolute risk [95% confidence interval] 17.10% [16.34%; 17.87%]), which yielded an absolute risk difference [95% confidence interval] at -2.8% [-5.4%; -0.1%], however, there was no risk difference associated with discontinuation hereafter. Conclusion: Discontinuation of beta-blockers 1 year or later after a myocardial infarction without heart failure was not associated with increased serious adverse events.
MeSH term(s)	Humans ; Cohort Studies ; Duration of Therapy ; Myocardial Infarction/diagnosis ; Myocardial Infarction/drug therapy ; Myocardial Infarction/complications ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/complications ; Denmark/epidemiology
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2808613-2
ISSN	2055-6845 ; 2055-6837
ISSN (online)	2055-6845
ISSN	2055-6837
DOI	10.1093/ehjcvp/pvad046
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Article ; Online: Calcium and vitamin D homoeostasis in male fertility.

Yahyavi, Sam Kafai / Boisen, Ida Marie / Cui, Zhihui / Jorsal, Mads Joon / Kooij, Ireen / Holt, Rune / Juul, Anders / Blomberg Jensen, Martin

The Proceedings of the Nutrition Society

2023 , Page(s) 1–14

Abstract: Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male ... ...

Abstract	Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male reproductive organs. The presence of calcium-sensing receptor, vitamin D receptor, vitamin D activating and inactivating enzymes and calcium channels in the testes, male reproductive tract and human spermatozoa suggests that vitamin D and calcium may modify male reproductive function. Functional animal models have shown that vitamin D deficiency in male rodents leads to a decrease in successful mating and fewer pregnancies, often caused by impaired sperm motility and poor sperm morphology. Human studies have to a lesser extent validated these findings; however, newer studies suggest a positive effect of vitamin D supplementation on semen quality in cases with vitamin D deficiency, which highlights the need for initiatives to prevent vitamin D deficiency. Calcium channels in male reproductive organs and spermatozoa contribute to the regulation of sperm motility and capacitation, both essential for successful fertilisation, which supports a need to avoid calcium deficiency. Studies have demonstrated that vitamin D, as a regulator of calcium homoeostasis, influences calcium influx in the testis and spermatozoa. Emerging evidence suggests a potential link between vitamin D deficiency and male infertility, although further investigation is needed to establish a definitive causal relationship. Understanding the interplay between vitamin D, calcium and male reproductive health may open new avenues for improving fertility outcomes in men.
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	391142-1
ISSN	1475-2719 ; 0029-6651
ISSN (online)	1475-2719
ISSN	0029-6651
DOI	10.1017/S002966512300486X
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