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Article ; Online: PET/CT and SPECT/CT imaging of 90Y hepatic radioembolization at therapeutic and diagnostic activity levels: Anthropomorphic phantom study.

Budzyńska, Anna / Kubik, Agata / Kacperski, Krzysztof / Pastusiak, Patrycja / Kuć, Michał / Piasecki, Piotr / Konior, Marcin / Gryziński, Michał / Dziuk, Mirosław / Iller, Edward

PloS one

2024 Volume 19, Issue 2, Page(s) e0271711

Abstract: Purpose: Prior to 90Y radioembolization procedure, a pretherapy simulation using 99mTc-MAA is performed. Alternatively, a small dosage of 90Y microspheres could be used. We aimed to assess the accuracy of lung shunt fraction (LSF) estimation in both ... ...

Abstract	Purpose: Prior to 90Y radioembolization procedure, a pretherapy simulation using 99mTc-MAA is performed. Alternatively, a small dosage of 90Y microspheres could be used. We aimed to assess the accuracy of lung shunt fraction (LSF) estimation in both high activity 90Y posttreatment and pretreatment scans with isotope activity of ~100 MBq, using different imaging techniques. Additionally, we assessed the feasibility of visualising hot and cold hepatic tumours in PET/CT and Bremsstrahlung SPECT/CT images. Materials and methods: Anthropomorphic phantom including liver (with two spherical tumours) and lung inserts was filled with 90Y chloride to simulate an LSF of 9.8%. The total initial activity in the liver was 1451 MBq, including 19.4 MBq in the hot sphere. Nine measurement sessions including PET/CT, SPECT/CT, and planar images were acquired at activities in the whole phantom ranging from 1618 MBq down to 43 MBq. The visibility of the tumours was appraised based on independent observers' scores. Quantitatively, contrast-to-noise ratio (CNR) was calculated for both spheres in all images. Results: LSF estimation. For high activity in the phantom, PET reconstructions slightly underestimated the LSF; absolute difference was <1.5pp (percent point). For activity <100 MBq, the LSF was overestimated. Both SPECT and planar scintigraphy overestimated the LSF for all activities. Lesion visibility. For SPECT/CT, the cold tumour proved too small to be discernible (CNR <0.5) regardless of the 90Y activity in the liver, while hot sphere was visible for activity >200 MBq (CNR>4). For PET/CT, the cold tumour was only visible with the highest 90Y activity (CNR>4), whereas the hot one was seen for activity >100 MBq (CNR>5). Conclusions: PET/CT may accurately estimate the LSF in a 90Y posttreatment procedure. However, at low activities of about 100 MBq it seems to provide unreliable estimations. PET imaging provided better visualisation of both hot and cold tumours.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Yttrium Radioisotopes/therapeutic use ; Positron-Emission Tomography ; Tomography, Emission-Computed, Single-Photon ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy
Chemical Substances	Yttrium-90 (1K8M7UR6O1) ; Yttrium Radioisotopes
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0271711
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Article ; Online: Index of Body Inflammation for Maxillofacial Surgery Purpose-to Make the Soluble Urokinase-Type Plasminogen Activator Receptor Serum Level Independent on Patient Age

Marcin Kozakiewicz / Magdalena Trzcińska-Kubik / Rafał Nikodem Wlazeł

Applied Sciences, Vol 11, Iss 3, p

2021 Volume 1345

Abstract: Background: The serum suPAR level is affected in humans by it increases with age. Therefore it makes difficult interpretation and any comparison of age varied groups. The aim of this study is to find simple way to age independent presentation of suPAR ... ...

Abstract	Background: The serum suPAR level is affected in humans by it increases with age. Therefore it makes difficult interpretation and any comparison of age varied groups. The aim of this study is to find simple way to age independent presentation of suPAR serum level for maxillofacial surgery purpose. Methods: In generally healthy patients from 15 to 59 y.o. suPAR level was tested in serum before orthognathic or minor traumatologic procedures. Five ways to make the suPAR serum level assessment independent of age are proposed. Results: One way of making suPAR levels independent of age led to the result with the same statistical distribution as in the raw suPAR serum material and this distribution is the normal. Conclusion: The simple way for suPAR serum level analysis without its dependence on patient age is calculation of the index of body inflammation understood as square root of squared suPAR serum level divided by logarithm of patient age to base 10.
Keywords	age ; inflammation ; infection control ; maxillofacial surgery ; orthognathic surgery ; traumatology ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of observer-dependency on left ventricular hypertrabeculation mass measurement and its relationship with left ventricular volume and ejection fraction - comparison between manual and semiautomatic CMR image analysis methods.

Kubik, Marcin / Dąbrowska-Kugacka, Alicja / Dorniak, Karolina / Kutniewska-Kubik, Marta / Daniłowicz-Szymanowicz, Ludmiła / Lewicka, Ewa / Szurowska, Edyta / Raczak, Grzegorz

PloS one

2020 Volume 15, Issue 3, Page(s) e0230134

Abstract: Background: Recent studies concerning left ventricular noncompaction (LVNC) suggest that the extent of left ventricular (LV) hypertrabeculation has no impact on prognosis. The variety of methods of LV noncompacted myocardial mass (NCM) assessment may ... ...

Abstract	Background: Recent studies concerning left ventricular noncompaction (LVNC) suggest that the extent of left ventricular (LV) hypertrabeculation has no impact on prognosis. The variety of methods of LV noncompacted myocardial mass (NCM) assessment may influence the results. Hence, we compared two methods of NCM estimation: largely observer-independent Hautvast's(H) computed algorithm-based approach and commonly used Jacquier's(J) method, and their associations with LV end-diastolic volume (EDV) and ejection fraction (EF). Methods: Cardiac magnetic resonance images of 77 persons (45±17yo) - 42 LVNC, 15 non-ischemic dilative cardiomyopathy, 20 control group were analyzed. LVNC patients were divided into the subgroup with normal (LVNCN) and high EDV (LVNCDCM). NCM and total left ventricular mass (LVM) were estimated by Hautvast's [excluding intertrabecular blood (ITB) and including papillary muscles (PMs) into NCM] and Jacquier's approach (including ITB and PMs, if unclearly distinguished, into NCM). Results: The cut-off value of NCM for LVNC diagnosis was 22% (AUC 0.933) for NCMH/LVMH and 26% (AUC 0.883) for NCMJ/LVMJ. Inter- and intra-observer variability (estimated by coefficient of variation [CoV] and intraclass correlation coefficient [ICC]) of NCMH/LVMH appeared better than of NCMJ/LVMJ (CoV 4.3%, ICC 0.981 and CoV 4.9%, ICC 0.978; respectively for NCMH/LVMH, while for NCMJ/LVMJ: CoV 19.7%, ICC 0.15 and CoV 12.9%, ICC 0.504). In LVNCN subgroup, the correlation between EDV and NCMH was stronger than NCMJ (r = 0.677, p<0.001 vs. r = 0.480, p = 0.038; respectively). In LVNC the EDV correlated with NCMH/LVMH (r = 0.391, p<0.01), but not with NCMJ/LVMJ. In the overall group a relationship was present between EF and NCMH/LVMH (r = -0.449, p<0.001), but not NCMJ/LVMJ. Only NCMH/LVMH explained the variability of EDV (b 0.434, p<0.001). Conclusions: Choosing a method of NCM assessment that is less observer-dependent might increase the reliability of results. The impact of method selection on the LV parameters and cut-off values for hypertrabeculation should be further investigated.
MeSH term(s)	Adult ; Aged ; Female ; Heart Defects, Congenital/physiopathology ; Heart Ventricles/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging, Cine/methods ; Male ; Middle Aged ; Observer Variation ; Reproducibility of Results ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function/physiology ; Ventricular Function, Left/physiology
Language	English
Publishing date	2020-03-11
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0230134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship between Telomere Length,

Dratwa, Marta / Wysoczanska, Barbara / Brankiewicz, Wioletta / Stachowicz-Suhs, Martyna / Wietrzyk, Joanna / Matkowski, Rafał / Ekiert, Marcin / Szelachowska, Jolanta / Maciejczyk, Adam / Szajewski, Mariusz / Baginski, Maciej / Bogunia-Kubik, Katarzyna

International journal of molecular sciences

2022 Volume 23, Issue 9

Abstract: The molecular mechanisms of telomerase reverse transcriptase ( ...

Abstract	The molecular mechanisms of telomerase reverse transcriptase (
MeSH term(s)	Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Genes, myc ; Humans ; Polymorphism, Single Nucleotide ; Sp1 Transcription Factor/genetics ; Telomerase/genetics ; Telomere/pathology ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Sp1 Transcription Factor ; SP1 protein, human ; TP53 protein, human ; Tumor Suppressor Protein p53 ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23095164
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Article ; Online: Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies.

Kubik, Agata / Budzyńska, Anna / Kacperski, Krzysztof / Maciak, Maciej / Kuć, Michał / Piasecki, Piotr / Wiliński, Maciej / Konior, Marcin / Dziuk, Mirosław / Iller, Edward

PloS one

2021 Volume 16, Issue 2, Page(s) e0246848

Abstract: Introduction: We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations.: Materials and methods: The data was acquired from the ... ...

Abstract	Introduction: We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations. Materials and methods: The data was acquired from the Jaszczak and NEMA phantoms. In the Jaszczak phantom Y-90 concentrations of 0.1 MBq/ml and 0.2 MBq/ml were used, while higher concentrations, up to 1.0 MBq/ml, were simulated by acquisition time extension with respect to the standard clinical protocol of 30 sec/projection for SPECT and 30 min/bed position for PET imaging. For NEMA phantom, the hot foci had concentrations of about 4 MB/ml and the background 0.1 or 0.0 MBq/ml. All of the acquired data was analysed both qualitatively and quantitatively. Qualitative assessment was conducted by six observers asked to identify the number of visible cold or hot foci. Inter-observer agreement was assessed. Quantitative analysis included calculations of contrast and contrast-to-noise ratio (CNR), and comparisons with the qualitative results. Results: For SPECT data up to two cold foci were discernible, while for PET four foci were visible. We have shown that CNR (with Rose criterion) is a good measure of foci visibility for both modalities. We also found good concordance of qualitative results for the Jaszczak phantom studies between the observers (corresponding Krippendorf's alpha coefficients of 0.76 to 0.84). In the NEMA phantom without background activity all foci were visible in SPECT/CT images. With isotope in the background, 5 of 6 spheres were discernible (CNR of 3.0 for the smallest foci). For PET studies all hot spheres were visible, regardless of the background activity. Conclusions: PET Y-90 imaging provided better results than Bremsstrahlung based SPECT imaging. This indicates that PET/CT might become the method of choice in Y-90 post radioembolization imaging for visualisation of both necrotic and hot lesions in the liver.
MeSH term(s)	Humans ; Phantoms, Imaging ; Positron Emission Tomography Computed Tomography/instrumentation ; Yttrium Radioisotopes
Chemical Substances	Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1)
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0246848
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Article: Post-marathon Decline in Right Ventricular Radial Motion Component Among Amateur Sportsmen.

Lewicka-Potocka, Zuzanna / Kaleta-Duss, Anna Maria / Lewicka, Ewa / Kubik, Marcin / Faran, Anna / Szymeczko, Paweł / Gała Ska, Rafał / Raczak, Grzegorz / Da Browska-Kugacka, Alicja

Frontiers in physiology

2022 Volume 12, Page(s) 811764

Abstract: Moderate physical activity has a positive impact on health, although extreme forms of sport such as marathon running may trigger exercise-induced cardiac fatigue. The explicit distinction between the right ventricular (RV) physiological response to ... ...

Abstract	Moderate physical activity has a positive impact on health, although extreme forms of sport such as marathon running may trigger exercise-induced cardiac fatigue. The explicit distinction between the right ventricular (RV) physiological response to training and maladaptive remodeling has not yet been determined. In this study, we aimed to analyze the impact of running a marathon on RV mechanics in amateur athletes using three-dimensional (3D) echocardiography (ECHO) and the ReVISION method (RV separate wall motion quantification). A group of 34 men with a mean age of 40 ± 8 years who successfully finished a marathon underwent ECHO three times, i.e., 2 weeks before the marathon (stage I), at the marathon finish line (stage II), and 2 weeks after the marathon (stage III). The ECHO findings were then correlated with the concentrations of biomarkers related to myocardial injury and overload and also obtained at the three stages. On finishing the marathon, the amateur athletes were found to have a significant (
Language	English
Publishing date	2022-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.811764
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Article ; Online: Influence of observer-dependency on left ventricular hypertrabeculation mass measurement and its relationship with left ventricular volume and ejection fraction - comparison between manual and semiautomatic CMR image analysis methods.

Marcin Kubik / Alicja Dąbrowska-Kugacka / Karolina Dorniak / Marta Kutniewska-Kubik / Ludmiła Daniłowicz-Szymanowicz / Ewa Lewicka / Edyta Szurowska / Grzegorz Raczak

PLoS ONE, Vol 15, Iss 3, p e

2020 Volume 0230134

Abstract: BACKGROUND:Recent studies concerning left ventricular noncompaction (LVNC) suggest that the extent of left ventricular (LV) hypertrabeculation has no impact on prognosis. The variety of methods of LV noncompacted myocardial mass (NCM) assessment may ... ...

Abstract	BACKGROUND:Recent studies concerning left ventricular noncompaction (LVNC) suggest that the extent of left ventricular (LV) hypertrabeculation has no impact on prognosis. The variety of methods of LV noncompacted myocardial mass (NCM) assessment may influence the results. Hence, we compared two methods of NCM estimation: largely observer-independent Hautvast's(H) computed algorithm-based approach and commonly used Jacquier's(J) method, and their associations with LV end-diastolic volume (EDV) and ejection fraction (EF). METHODS:Cardiac magnetic resonance images of 77 persons (45±17yo) - 42 LVNC, 15 non-ischemic dilative cardiomyopathy, 20 control group were analyzed. LVNC patients were divided into the subgroup with normal (LVNCN) and high EDV (LVNCDCM). NCM and total left ventricular mass (LVM) were estimated by Hautvast's [excluding intertrabecular blood (ITB) and including papillary muscles (PMs) into NCM] and Jacquier's approach (including ITB and PMs, if unclearly distinguished, into NCM). RESULTS:The cut-off value of NCM for LVNC diagnosis was 22% (AUC 0.933) for NCMH/LVMH and 26% (AUC 0.883) for NCMJ/LVMJ. Inter- and intra-observer variability (estimated by coefficient of variation [CoV] and intraclass correlation coefficient [ICC]) of NCMH/LVMH appeared better than of NCMJ/LVMJ (CoV 4.3%, ICC 0.981 and CoV 4.9%, ICC 0.978; respectively for NCMH/LVMH, while for NCMJ/LVMJ: CoV 19.7%, ICC 0.15 and CoV 12.9%, ICC 0.504). In LVNCN subgroup, the correlation between EDV and NCMH was stronger than NCMJ (r = 0.677, p<0.001 vs. r = 0.480, p = 0.038; respectively). In LVNC the EDV correlated with NCMH/LVMH (r = 0.391, p<0.01), but not with NCMJ/LVMJ. In the overall group a relationship was present between EF and NCMH/LVMH (r = -0.449, p<0.001), but not NCMJ/LVMJ. Only NCMH/LVMH explained the variability of EDV (b 0.434, p<0.001). CONCLUSIONS:Choosing a method of NCM assessment that is less observer-dependent might increase the reliability of results. The impact of method selection on the LV parameters ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A careful choice of compatible pollinizers significantly improves the size of fruits in red raspberry (Rubus idaeus L.)

Żurawicz, Edward / Jolanta Kubik / Kris Pruski / Marcin Studnicki

Scientia horticulturae. 2018 May 17, v. 235

2018

Abstract: Good pollination (fertilization) of flowers is the key to high yields in most of the fruit crops grown in temperate zones. Detailed studies on influence of the pollen source on the berry size and the number of seeds in fruits of the red raspberry were ... ...

Abstract	Good pollination (fertilization) of flowers is the key to high yields in most of the fruit crops grown in temperate zones. Detailed studies on influence of the pollen source on the berry size and the number of seeds in fruits of the red raspberry were conducted at the Research Institute of Horticulture in Skierniewice, Poland. Studies were carried on under controlled conditions and were based on three separate greenhouse experiments conducted in 2015–2017. In these experiments flowers of red raspberries ’Canby’, ’Glen Ample’, ‘Laszka’, ‘Polana’, ’Polka’, ‘Radziejowa’, ‘Schönemann’ and’ Willamette’ were artificially pollinated (by hand) with pollen coming from either the same cultivar (self-pollination, self-fertilization) and/or with pollen collected from other cultivars (cross-pollination, cross-fertilization). It was found that cross-pollination resulted in increase of fruit size and number of seeds per fruit compared to fruits obtained from self-pollination. In majority of the cross-combinations (pollination treatments) the differences between cross-pollination and self-pollination were significant. The larger fruit size and the number of seeds per fruit from cross-pollinated flowers was depended on the particular pollinizer. The results confirm that the cross-fertilization is essential for high yield and improved mass of each berry. It is particularly important in cultivation of red raspberries under the high tunnels for early harvest, where predominantly single cultivar is grown in so called varietal monoculture. These findings suggest that selection of suitable pollinizer should be a new area of research for red raspberry production under cover for early or late crop.
Keywords	cross pollination ; cultivars ; flowers ; fruit crops ; fruits ; greenhouse experimentation ; harvest date ; pollen ; pollinators ; Rubus idaeus ; seeds ; selfing ; self-pollination ; temperate zones ; Poland
Language	English
Dates of publication	2018-0517
Size	p. 253-257.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2018.02.064
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies.

Agata Kubik / Anna Budzyńska / Krzysztof Kacperski / Maciej Maciak / Michał Kuć / Piotr Piasecki / Maciej Wiliński / Marcin Konior / Mirosław Dziuk / Edward Iller

PLoS ONE, Vol 16, Iss 2, p e

2021 Volume 0246848

Abstract: Introduction We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations. Materials and methods The data was acquired from the Jaszczak ... ...

Abstract	Introduction We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations. Materials and methods The data was acquired from the Jaszczak and NEMA phantoms. In the Jaszczak phantom Y-90 concentrations of 0.1 MBq/ml and 0.2 MBq/ml were used, while higher concentrations, up to 1.0 MBq/ml, were simulated by acquisition time extension with respect to the standard clinical protocol of 30 sec/projection for SPECT and 30 min/bed position for PET imaging. For NEMA phantom, the hot foci had concentrations of about 4 MB/ml and the background 0.1 or 0.0 MBq/ml. All of the acquired data was analysed both qualitatively and quantitatively. Qualitative assessment was conducted by six observers asked to identify the number of visible cold or hot foci. Inter-observer agreement was assessed. Quantitative analysis included calculations of contrast and contrast-to-noise ratio (CNR), and comparisons with the qualitative results. Results For SPECT data up to two cold foci were discernible, while for PET four foci were visible. We have shown that CNR (with Rose criterion) is a good measure of foci visibility for both modalities. We also found good concordance of qualitative results for the Jaszczak phantom studies between the observers (corresponding Krippendorf's alpha coefficients of 0.76 to 0.84). In the NEMA phantom without background activity all foci were visible in SPECT/CT images. With isotope in the background, 5 of 6 spheres were discernible (CNR of 3.0 for the smallest foci). For PET studies all hot spheres were visible, regardless of the background activity. Conclusions PET Y-90 imaging provided better results than Bremsstrahlung based SPECT imaging. This indicates that PET/CT might become the method of choice in Y-90 post radioembolization imaging for visualisation of both necrotic and hot lesions in the liver.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relationship between Telomere Length, TERT Genetic Variability and TERT , TP53 , SP1 , MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer

Marta Dratwa / Barbara Wysoczanska / Wioletta Brankiewicz / Martyna Stachowicz-Suhs / Joanna Wietrzyk / Rafał Matkowski / Marcin Ekiert / Jolanta Szelachowska / Adam Maciejczyk / Mariusz Szajewski / Maciej Baginski / Katarzyna Bogunia-Kubik

International Journal of Molecular Sciences, Vol 23, Iss 5164, p

2022 Volume 5164

Abstract: The molecular mechanisms of telomerase reverse transcriptase ( TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the ...

Abstract	The molecular mechanisms of telomerase reverse transcriptase ( TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT , MYC , TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same correlation in the blood of BC patients and in BC organoids between the expression of TERT and TP53 . Only in BC patients was a correlation found between the expression of the TERT and MYC genes and between TP53 and MYC . We found associations between TERT genotypes (rs2735940 and rs10069690) and TP53 expression and telomere length. BC patients with the TT genotype rs2735940 have a shorter telomere length, but patients with A allele rs10069690 have a longer telomere length. BC patients with a short allele VNTR-MNS16A showed higher expression of the SP1 and had a longer telomere. Our results bring new insight into the regulation of TERT , MYC , TP53 and SP1 gene expression related to TERT genetic variability and telomere length. Our study also showed for the first time a similar relationship in the expression of the above genes in BC patients and in BC organoids. These findings suggest that TERT genetic variability, expression and telomere length might be useful biomarkers for BC, but their prognostic value may vary depending on the clinical parameters of BC patients and tumor aggressiveness.
Keywords	breast cancer telomerase reverse transcriptase ( TERT ) ; telomere length ; expression of transcription factors genes ; single nucleotide polymorphism (SNP) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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