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  1. Article ; Online: Infographic. Cooling strategies to attenuate PPE-induced heat strain during the COVID-19 pandemic.

    Bongers, Coen Cwg / de Korte, Johannus Q / Catoire, Milene / Greefhorst, Job / Hopman, Maria T E / Kingma, Boris / Eijsvogels, Thijs M H

    British journal of sports medicine

    2020  Volume 55, Issue 1, Page(s) 69–70

    MeSH term(s) Body Temperature/physiology ; COVID-19/epidemiology ; Drinking ; Fluid Therapy ; Health Personnel ; Heat Exhaustion/etiology ; Heat Exhaustion/prevention & control ; Humans ; Pandemics ; Personal Protective Equipment/adverse effects ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 600592-5
    ISSN 1473-0480 ; 0306-3674
    ISSN (online) 1473-0480
    ISSN 0306-3674
    DOI 10.1136/bjsports-2020-102528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Infographic. Cooling strategies to attenuate PPE-induced heat strain during the COVID-19 pandemic

    Bongers, Coen Cwg / de Korte, Johannus Q / Catoire, Milene / Greefhorst, Job / Hopman, Maria T E / Kingma, Boris / Eijsvogels, Thijs M H

    Br. j. sports med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #596040
    Database COVID19

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  3. Article ; Online: Infographic. Cooling strategies to attenuate PPE-induced heat strain during the COVID-19 pandemic

    Bongers, Coen CWG / de Korte, Johannus Q / Catoire, Milene / Greefhorst, Job / Hopman, Maria T E / Kingma, Boris / Eijsvogels, Thijs M H

    British Journal of Sports Medicine

    2020  , Page(s) bjsports–2020–102528

    Keywords Physical Therapy, Sports Therapy and Rehabilitation ; Orthopedics and Sports Medicine ; General Medicine ; covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 600592-5
    ISSN 1473-0480 ; 0306-3674
    ISSN (online) 1473-0480
    ISSN 0306-3674
    DOI 10.1136/bjsports-2020-102528
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes.

    Spijkerman, Roy / Hesselink, Lillian / Bertinetto, Carlo / Bongers, Coen Cwg / Hietbrink, Falco / Vrisekoop, Nienke / Leenen, Luke Ph / Hopman, Maria Te / Jansen, Jeroen J / Koenderman, Leo

    Journal of leukocyte biology

    2020  Volume 109, Issue 4, Page(s) 833–842

    Abstract: The amplitude of the innate immune response reflects the degree of physiological stress imposed by exercise load. An optimal balance of exercise intensity and duration is essential for a balanced immune system and reduces the risk of dysfunction of the ... ...

    Abstract The amplitude of the innate immune response reflects the degree of physiological stress imposed by exercise load. An optimal balance of exercise intensity and duration is essential for a balanced immune system and reduces the risk of dysfunction of the immune system. Therefore, it is hypothesized that neutrophils, as key players in the innate immune system, can be used as biomarker in detecting overtraining. The aim was to monitor the state of the innate immune system by phenotyping neutrophils during consecutive bouts of prolonged exercise. Study subjects were recruited from a cohort of walkers participating in a walking event on 3 consecutive days. Participants with immune deficiencies were excluded. Questionnaires to determine the physiological status of the participants were completed. Analysis of neutrophil receptor expression was done by a point-of-care fully automated flow cytometer. A total of 45 participants were recruited, of whom 39 participants were included for data analysis. Study participants had a median age of 64 (58-70) years. The absolute numbers CD16
    MeSH term(s) Aged ; Antigens, CD/metabolism ; Biomarkers/metabolism ; Blood Cell Count ; Exercise/physiology ; Female ; Fluorescence ; Humans ; Immunity, Innate ; Male ; Middle Aged ; Neutrophils/immunology ; Phenotype ; Walking/physiology
    Chemical Substances Antigens, CD ; Biomarkers
    Language English
    Publishing date 2020-09-06
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.5A0820-436R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Infographic. Cooling strategies to attenuate PPE-induced heat strain during the COVID-19 pandemic

    Bongers, Coen CWG / de Korte, Johannus Q / Catoire, Milene / Greefhorst, Job / Hopman, Maria T E / Kingma, Boris / Eijsvogels, Thijs M H

    2020  

    Abstract: COVID-19 healthcare personnel (HCP) use personal protective equipment (PPE; ie, isolation gowns, eye protection, facemasks and respirators) to safely perform their medical duties. However, PPE creates a microenvironment around the skin due to a higher ... ...

    Abstract COVID-19 healthcare personnel (HCP) use personal protective equipment (PPE; ie, isolation gowns, eye protection, facemasks and respirators) to safely perform their medical duties. However, PPE creates a microenvironment around the skin due to a higher thermal resistance and lower water vapour permeability of the materials being used compared with the normal clothing ensemble of HCP.1 Consequently, heat loss capacity via the skin surface is greatly reduced. The metabolic energy expenditure from regular working activities could, therefore, not be completely lost to the surrounding environment, leading to heat strain, thermal discomfort, excessive sweating, faster dehydration and an increased cardiovascular strain. To accommodate heat loss, blood redistribution from central organs and skeletal muscle to the skin occurs, which will further exacerbate the physiological strain, ultimately leading to shorter work tolerance times and a reduced physical and cognitive performance. The most common recommendation for working in PPE is to adjust the work/rest schedule and incorporate more and longer breaks in order to alleviate heat strain. However, this recommendation is not always feasible in clinical settings as hospitals are often understaffed during the COVID-19 pandemic.
    Keywords COVID-19 ; Coronavirus ; covid19
    Language English
    Publishing date 2020-01-01
    Publishing country au
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trial

    Bongers, Coen C.W.G / Ten Haaf, Dominique S.M / Catoire, Milène / Kersten, Bregina / Wouters, Jeroen A / Eijsvogels, Thijs M.H / Hopman, Maria T.E

    Applied physiology, nutrition and metabolism. 2020, v. 45, no. 7

    2020  

    Abstract: The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167; aged 63 [interquartile range = ... ...

    Abstract The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167; aged 63 [interquartile range = 56–68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks. Knee pain and function were measured with the Visual Analog Scale (VAS), the Lysholm questionnaire, and the Knee injury and Osteoarthritis Outcome Score (KOOS). Furthermore, we assessed changes in inflammatory, cartilage, and bone (bio)markers. Measurements were conducted at baseline and after 12 weeks of supplementation. Baseline VAS did not differ between CP and placebo (4.7 [2.5–6.1] vs. 4.7 [2.8–6.2], p = 0.50), whereas a similar decrease in VAS was observed after supplementation (−1.6 ± 2.4 vs. −1.9 ± 2.6, p = 0.42). The KOOS and Lysholm scores increased after supplementation in both groups (p values < 0.001), whereas the increase in the KOOS and Lysholm scores did not differ between groups (p = 0.28 and p = 0.76, respectively). Furthermore, CP did not impact inflammatory, cartilage, and bone (bio)markers (p values > 0.05). A reduced knee pain and improved knee function were observed following supplementation, but changes were similar between groups. This suggests that CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. Novelty CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. CP supplementation over a 12-week period does not impact on inflammatory, cartilage, and bone (bio)markers in healthy, active, middle-aged to elderly individuals.
    Keywords cartilage ; collagen ; elderly ; metabolism ; nutrition ; osteoarthritis ; pain ; peptides ; placebos ; questionnaires ; randomized clinical trials
    Language English
    Size p. 793-800.
    Publishing place NRC Research Press
    Document type Article
    Note NAL-light
    ZDB-ID 2236708-1
    ISSN 1715-5320 ; 1715-5312
    ISSN (online) 1715-5320
    ISSN 1715-5312
    DOI 10.1139/apnm-2019-0654
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users

    Allard, Neeltje A.E. / Janssen, Lando / Lagerwaard, Bart / Nuijten, Malou A.H. / Bongers, Coen C.W.G. / Rodenburg, Richard J. / Thompson, Paul D. / Eijsvogels, Thijs M.H. / Assendelft, Willem J.J. / Schirris, Tom J.J. / Timmers, Silvie / Hopman, Maria T.E.

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 14

    Abstract: Background: Statin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postulated to produce mitochondrial dysfunction. Objectives: We determined the effect of prolonged moderate-intensity ... ...

    Abstract Background: Statin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postulated to produce mitochondrial dysfunction. Objectives: We determined the effect of prolonged moderate-intensity exercise on markers of muscle injury in statin users with and without statin-associated muscle symptoms. We also examined the association between leukocyte CoQ10 levels and muscle markers, muscle performance, and reported muscle symptoms. Methods: Symptomatic (n = 35; age 62 ± 7 years) and asymptomatic statin users (n = 34; age 66 ± 7 years) and control subjects (n = 31; age 66 ± 5 years) walked 30, 40, or 50 km/d for 4 consecutive days. Muscle injury markers (lactate dehydrogenase, creatine kinase, myoglobin, cardiac troponin I, and N-terminal pro-brain natriuretic peptide), muscle performance, and reported muscle symptoms were assessed at baseline and after exercise. Leukocyte CoQ10 was measured at baseline. Results: All muscle injury markers were comparable at baseline (P > 0.05) and increased following exercise (P < 0.001), with no differences in the magnitude of exercise-induced elevations among groups (P > 0.05). Muscle pain scores were higher at baseline in symptomatic statin users (P < 0.001) and increased similarly in all groups following exercise (P < 0.001). Muscle relaxation time increased more in symptomatic statin users than in control subjects following exercise (P = 0.035). CoQ10 levels did not differ among symptomatic (2.3 nmol/U; IQR: 1.8-2.9 nmol/U), asymptomatic statin users (2.1 nmol/U; IQR: 1.8-2.5 nmol/U), and control subjects (2.1 nmol/U; IQR: 1.8-2.3 nmol/U; P = 0.20), and did not relate to muscle injury markers, fatigue resistance, or reported muscle symptoms. Conclusions: Statin use and the presence of statin-associated muscle symptoms does not exacerbate exercise-induced muscle injury after moderate exercise. Muscle injury markers were not related to leukocyte CoQ10 levels.
    Keywords coenzyme Q10 ; moderate-intensity exercise ; muscle injury ; muscle performance ; statin-associated muscle symptoms
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Using an ingestible telemetric temperature pill to assess gastrointestinal temperature during exercise

    Bongers, Coen C.W.G / Hopman, Maria T.E / Eijsvogels, Thijs M.H

    Journal of visualized experiments. 2015 Oct. 07, , no. 104

    2015  

    Abstract: Exercise results in an increase in core body temperature (Tc), which may reduce exercise performance and eventually can lead to the development of heat-related disorders. Therefore, accurate measurement of Tc during exercise is of great importance, ... ...

    Abstract Exercise results in an increase in core body temperature (Tc), which may reduce exercise performance and eventually can lead to the development of heat-related disorders. Therefore, accurate measurement of Tc during exercise is of great importance, especially in athletes who have to perform in challenging ambient conditions. In the current literature a number of methods have been described to measure the Tc (esophageal, external tympanic membrane, mouth or rectum). However, these methods are suboptimal to measure Tc during exercise since they are invasive, have a slow response or are influenced by environmental conditions. Studies described the use of an ingestible telemetric temperature pill as a reliable and valid method to assess gastrointestinal temperature (Tgi), which is a representative measurement of Tc. Therefore, the goal of this study was to provide a detailed description of the measurement of Tgi using an ingestible telemetric temperature pill. This study addresses important methodological factors that must be taken into account for an accurate measurement. It is recommended to read the instructions carefully in order to ensure that the ingestible telemetric temperature pill is a reliable method to assess Tgi at rest and during exercise.
    Keywords athletes ; athletic performance ; body temperature ; environmental factors ; exercise ; mouth ; rectum
    Language English
    Dates of publication 2015-1007
    Size p. e53258.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/53258
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Conference proceedings ; Online: Moderate Intensity Exercise Does Not Augment Muscle Damage Markers In Symptomatic And Asymptomatic Statin Users

    Allard, Neeltje Anne Ernestine / Janssen, Lando / Lagerwaard, Bart / Nuijten, Malou A.H. / Bongers, Coen C.W.G. / Rodenburg, Richard J. / Eijsvogels, Thijs M.H. / Schirris, Tom J.J. / Timmers, Silvie / Hopman, Maria T.E.

    2022  

    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Non-Invasive Monitoring of Inflammation in Inflammatory Bowel Disease Patients during Prolonged Exercise via Exhaled Breath Volatile Organic Compounds

    Henderson, Ben / Meurs, Joris / Lamers, Carlijn R. / Batista, Guilherme Lopes / Materić, Dušan / Bertinetto, Carlo G. / Bongers, Coen C.W.G. / Holzinger, Rupert / Harren, Frans J.M. / Jansen, Jeroen J. / Hopman, Maria T.E. / Cristescu, Simona M.

    Metabolites

    2022  Volume 12, Issue 3

    Abstract: The aim of this study was to investigate volatile organic compounds (VOCs) in exhaled breath as possible non-invasive markers to monitor the inflammatory response in inflammatory bowel disease (IBD) patients as a result of repeated and prolonged moderate- ...

    Abstract The aim of this study was to investigate volatile organic compounds (VOCs) in exhaled breath as possible non-invasive markers to monitor the inflammatory response in inflammatory bowel disease (IBD) patients as a result of repeated and prolonged moderate-intensity exercise. We included 18 IBD patients and 19 non-IBD individuals who each completed a 30, 40, or 50 km walking exercise over three consecutive days. Breath and blood samples were taken before the start of the exercise event and every day post-exercise to assess changes in the VOC profiles and cytokine concentrations. Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) was used to measure exhaled breath VOCs. Multivariate analysis, particularly ANOVA-simultaneous component analysis (ASCA), was employed to extract relevant ions related to exercise and IBD. Prolonged exercise induces a similar response in breath butanoic acid and plasma cytokines for participants with or without IBD. Butanoic acid showed a significant correlation with the cytokine IL-6, indicating that butanoic acid could be a potential non-invasive marker for exercise-induced inflammation. The findings are relevant in monitoring personalized IBD management.
    Keywords Breath analysis ; Butanoic acid ; Exercise ; Inflammatory bowel disease ; PTR-ToF-MS ; Volatile organic compounds
    Subject code 796
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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