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  1. Article ; Online: Monkeypox infection: Should we expect changes in its epidemiological and clinical features?

    Donà, Maria Gabriella / Giuliani, Eugenia / Zaccarelli, Mauro / Latini, Alessandra

    European journal of internal medicine

    2022  Volume 107, Page(s) 108–109

    MeSH term(s) Humans ; Mpox (monkeypox)/epidemiology
    Language English
    Publishing date 2022-10-19
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Interobserver agreement in the interpretation of anal cytology.

    Benevolo, Maria / Rollo, Francesca / Latini, Alessandra / Giuliani, Massimo / Giglio, Amalia / Giuliani, Eugenia / Donà, Maria Gabriella

    Cancer cytopathology

    2024  

    Abstract: Background: Anal cytology represents a tool for anal cancer screening in high-risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation ...

    Abstract Background: Anal cytology represents a tool for anal cancer screening in high-risk populations. In addition to accuracy, the reproducibility of the interpretation is of key importance. The authors evaluated the agreement of anal cytologic interpretation between two cytopathologists.
    Methods: Liquid-based cytologic slides from human immunodeficiency virus (HIV)-negative men who have sex with men (MSM) were evaluated by two readers with at least 10 years of expertise in cervical cytology. Cases with a discordant interpretation were reviewed, and a consensus was reached. Human papillomavirus (HPV) genotyping was performed using a proprietary HPV genotyping test. Unweighted and weighted Cohen kappa and 95% confidence interval (CI) values were calculated.
    Results: Overall, 713 slides that were adequate for interpretation were evaluated (MSM: median age, 33 years). An HPV test was performed on 620 samples (87.0%). Considering a dichotomous interpretation (negative for intraepithelial lesion or malignancy vs. atypical squamous cells of undetermined significance or worse), the crude agreement between the two readers was 93.3% (kappa = 0.82; 95% CI, 0.77-0.87). Once a consensus for discordant cases was reached, the best agreement was found for the negative for intraepithelial lesion or malignancy category (511 of 528 samples; 96.8%), whereas the atypical squamous cells of undetermined significance category showed the lowest agreement (90 of 117 samples, 76.9%). Considering the individual cytologic categories, overall agreement was 92.1% (kappa = 0.85; 95% CI, 0.81-0.89). The discordant interpretations were not associated with high-risk HPV infection, HPV16 infection, or MSM age.
    Conclusions: The results indicating excellent interobserver agreement in this study substantiate the use of anal cytology in the setting of human immunodeficiency virus-negative MSM.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22807
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    Zs.A 6893: Show issues Location:
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  3. Article ; Online: New-onset cutaneous kaposi's sarcoma following SARS-CoV-2 infection.

    Magri, Francesca / Giordano, Stefania / Latini, Alessandra / Muscianese, Marta

    Journal of cosmetic dermatology

    2021  Volume 20, Issue 12, Page(s) 3747–3750

    Abstract: Background: COVID-19 is associated with several cutaneous manifestations, including chilbain-like lesions, urticaria, erythema multiforme, and maculopapular lesions. Dermatoses may be directly linked to the viral infection or also represent a ... ...

    Abstract Background: COVID-19 is associated with several cutaneous manifestations, including chilbain-like lesions, urticaria, erythema multiforme, and maculopapular lesions. Dermatoses may be directly linked to the viral infection or also represent a consequence of systemic therapies administrated for COVID-19. A potential role of SARS-CoV-2 in triggering the reactivation of other viruses, such as HHV-6, HHV-7 and Epstein-Barr virus has been hypothesized.
    Objective: To better understand and hypothesize possible pathogenetic correlations of COVID-19 with other dermatological conditions.
    Methods: We report the case of an 83-year-old woman hospitalized in a nursing home for several years. On November 2020, the patient had been diagnosed with SARS-CoV-2 infection, with repeated positive swabs until January 2021. After a month, new-onset asymptomatic cutaneous purplish macular lesions and violaceous patches occurred bilaterally on the feet.
    Results: An incisional cutaneous biopsy and the histological examination of the plantar lesion revealed the diagnosis of Kaposi Sarcoma.
    Conclusion: We report a unique case of new-onset bilateral Kaposi's sarcoma following COVID-19, speculating on a possible role of SARS-CoV-2 in the reactivation of human herpes virus-8 (HHV-8) infection.
    MeSH term(s) Aged, 80 and over ; COVID-19 ; Epstein-Barr Virus Infections ; Female ; Herpesvirus 4, Human ; Humans ; SARS-CoV-2 ; Sarcoma, Kaposi
    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14549
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    Zs.A 6539: Show issues Location:
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  4. Article ; Online: Increasing trend in confirmed scabies cases in the only public dermatological institute of scientific research and care in Italy.

    Donà, Maria Gabriella / Giuliani, Eugenia / Giglio, Amalia / Pimpinelli, Fulvia / Stingone, Christof / Giuliani, Massimo / Alei, Lavinia / Cota, Carlo / Iacovelli, Paolo / Frascione, Pasquale / Latini, Alessandra

    European journal of dermatology : EJD

    2024  Volume 33, Issue 6, Page(s) 709–710

    MeSH term(s) Humans ; Scabies/epidemiology ; Italy/epidemiology
    Language English
    Publishing date 2024-03-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2023.4622
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    Zs.A 3484: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T-cell counts in people living with HIV.

    Vergori, Alessandra / Cozzi-Lepri, Alessandro / Tavelli, Alessandro / Mazzotta, Valentina / Azzini, Anna Maria / Gagliardini, Roberta / Mastrorosa, Ilaria / Latini, Alessandra / Pellicanò, Giovanni / Taramasso, Lucia / Ceccherini-Silberstein, Francesca / Giannella, Maddalena / Tacconelli, Evelina / Marchetti, Giulia / Monforte, Antonella d'Arminio / Antinori, Andrea

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 144, Page(s) 107065

    Abstract: Objectives: To investigate whether SARS-CoV-2 messenger RNA (mRNA) vaccination has an impact on HIV-related viro-immunological parameters.: Methods: People with HIV (PWH) in the VAXICONA-ORCHESTRA cohort who received one or more doses of SARS-CoV-2 ... ...

    Abstract Objectives: To investigate whether SARS-CoV-2 messenger RNA (mRNA) vaccination has an impact on HIV-related viro-immunological parameters.
    Methods: People with HIV (PWH) in the VAXICONA-ORCHESTRA cohort who received one or more doses of SARS-CoV-2 mRNA vaccine and for whom paired measures of immuno-virological markers (viral load, clusters of differentiation [CD]4, and CD8 count 1 month before and after a vaccine dose [VD]) were available were included. Paired t-test and generalized estimating equation linear regression analyses were used to study changes over ± 1 month around the VD. Subgroup analyses were performed.
    Results: A total of 510 PWH were enrolled: the median age was 55 years (interquartile range 46-60 years), the CD4 and CD8 count were 489 (287-719) and 790 (59-1104) cells/mm
    Conclusions: A small significant increase in CD4 count and a negligible drop in HIV RNA were observed. Our findings are consistent with the hypothesis that SARS-CoV-2 mRNA vaccine can prime CD4 T spike-specific cells, even in the more immuno-compromised PWH.
    Language English
    Publishing date 2024-04-19
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107065
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    Zs.A 4516: Show issues Location:
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  6. Article ; Online: Effectiveness and safety of risankizumab in HIV patients with psoriasis: A case series.

    Orsini, Diego / Maramao, Fabio S / Gargiulo, Luigi / Ibba, Luciano / Piscazzi, Francesco / Pacifico, Alessia / Latini, Alessandra / Gianserra, Laura / Cristaudo, Antonio / Costanzo, Antonio / Narcisi, Alessandra

    International journal of STD & AIDS

    2023  Volume 35, Issue 1, Page(s) 67–70

    Abstract: Biological therapies represent the gold-standard treatment of severe forms of plaque psoriasis. However, people living with HIV are often under-treated for psoriasis because very limited data are available on the use of biologics in this population. We ... ...

    Abstract Biological therapies represent the gold-standard treatment of severe forms of plaque psoriasis. However, people living with HIV are often under-treated for psoriasis because very limited data are available on the use of biologics in this population. We report four cases of patients affected by HIV and moderate-to-severe plaque psoriasis, all treated with risankizumab, a monoclonal antibody that selectively targets interleukin-23. After 16 weeks, all patients experienced complete or almost complete skin clearance without any adverse events. Data on the effectiveness and safety of biological therapies in people living with HIV are limited to case reports or small case series, especially for the most recently approved inhibitors of interleukin-23. Our experienced, although limited, supports the role of risankizumab as a safe and effective therapy for psoriasis amongst patients living with HIV.
    MeSH term(s) Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Severity of Illness Index ; Antibodies, Monoclonal ; Interleukin-23 ; Psoriasis/complications ; Psoriasis/drug therapy ; Treatment Outcome
    Chemical Substances risankizumab (90ZX3Q3FR7) ; Antibodies, Monoclonal ; Interleukin-23
    Language English
    Publishing date 2023-09-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231199510
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    Zs.A 2829: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: LASER safety measures for the treatment of genital warts in HIV+ patients during the COVID-19 pandemic.

    Cameli, Norma / Mariano, Maria / Latini, Alessandra / Morrone, Aldo / Cristaudo, Antonio

    Dermatologic therapy

    2020  Volume 33, Issue 4, Page(s) e13750

    MeSH term(s) Betacoronavirus ; COVID-19 ; Comorbidity ; Condylomata Acuminata/epidemiology ; Condylomata Acuminata/surgery ; Coronavirus Infections/epidemiology ; HIV ; HIV Infections/epidemiology ; Humans ; Laser Therapy/methods ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13750
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    Zs.A 5181: Show issues Location:
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  8. Article ; Online: Author Correction: Incidence and clearance of anal high-risk Human Papillomavirus infection and their risk factors in men who have sex with men living with HIV.

    Donà, Maria Gabriella / Giuliani, Massimo / Rollo, Francesca / Vescio, Maria Fenicia / Benevolo, Maria / Giglio, Amalia / Giuliani, Eugenia / Morrone, Aldo / Latini, Alessandra

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9527

    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14265-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evaluation of HPV-Related Biomarkers in Anal Cytological Samples from HIV-Uninfected and HIV-Infected MSM.

    Rollo, Francesca / Latini, Alessandra / Giuliani, Massimo / Giglio, Amalia / Donà, Maria Gabriella / Benevolo, Maria

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 7

    Abstract: Men who have sex with men (MSM) harbor the highest risk for anal carcinoma, mainly caused by Human Papillomavirus (HPV). The use of HPV-related biomarkers in the screening for this neoplasia is still debated. We assessed the association between high-risk ...

    Abstract Men who have sex with men (MSM) harbor the highest risk for anal carcinoma, mainly caused by Human Papillomavirus (HPV). The use of HPV-related biomarkers in the screening for this neoplasia is still debated. We assessed the association between high-risk (hr)HPV DNA, HPV16/18 DNA, hrHPV E6/E7 mRNA, and p16/Ki-67 with cytological abnormalities (any grade) and high-grade intraepithelial lesions (HSIL) in HIV-uninfected and HIV-infected MSM. Overall, 150 cytological samples in PreservCyt (Hologic), with a negative to HSIL report, were analyzed for hrHPV DNA, hrHPV E6/E7 mRNA, and p16/Ki-67 using the Linear Array (Roche), Aptima (Hologic), and CINtec
    Language English
    Publishing date 2021-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10070888
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  10. Article: Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma.

    Silvestri, Martina / Latini, Alessandra / Lesnoni La Parola, Ilaria / Messina, Claudia / Nisticò, Steven Paul / Cameli, Norma

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 3

    Abstract: Kaposi's sarcoma (KS) is a vascular neoplasm Herpes Virus 8 (HHV8), which can affect the skin, mucous membranes and viscera. There is currently no standard treatment for KS; this study evaluated the efficacy and safety of Neodymium:YAG (Nd:YAG) laser ... ...

    Abstract Kaposi's sarcoma (KS) is a vascular neoplasm Herpes Virus 8 (HHV8), which can affect the skin, mucous membranes and viscera. There is currently no standard treatment for KS; this study evaluated the efficacy and safety of Neodymium:YAG (Nd:YAG) laser 1064 nm treatment in patients with classic and HIV-associated KS. 15 patients with classic KS (group A) and 15 with epidemic KS (group B), with exclusively cutaneous localization, were treated with Nd:YAG laser 1064 nm. Four treatment sessions were performed at 4 weeks intervals. 24/30 (80%) of treated patients underwent clinical improvement. Better results have been obtained in HIV-positive patients, especially in terms of reduced lesion size and the flattening of elevated lesions. The 1064 nm Nd:YAG laser is effective and safe in the treatment of classic and epidemic KS, especially in patients with symptomatic, slow-progressing local disease, where other treatment options may be inappropriate.
    Language English
    Publishing date 2022-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9030106
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